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Abstrak :
Senyawa gula poliol, seperti maltitol, manitol, xilitol dan sorbitol, merupakan bahan kimia yang sering ditambahkan ke dalam produk makanan maupun farmasi sebagai pemanis, sehingga diperlukan metode analisis untuk identifikasi dan penetapan kadar senyawa tersebut. Penelitian ini bertujuan untuk memperoleh kondisi yang optimal pada analisis campuran keempat senyawa gula poliol dan menetapkan kadar beberapa produk pemanis buatan yang beredar dengan menggunakan Kromatografi Cair Kinerja Tinggi (KCKT). Analisis dilakukan dengan menggunakan kolom Shodex Sugar SZ5532 (150 x 6,0 mm), detektor indeks bias RID-10A, fase gerak asetonitril-air (85:15) dengan laju alir 1,2 mL/menit pada suhu kolom sebesar 65°C. Didapatkan koefisien korelasi (r) untuk xilitol, manitol, sorbitol, dan maltitol berturut-turut 0,9985; 0,9980; 0,9975; dan 0,9990 dengan rentang konsentrasi 2.000 μg/mL sampai dengan 7.000 μg/mL. Metode ini juga memenuhi kriteria uji selektivitas. Pada penetapan kadar sampel, sampel A, B, C, D, dan E yang dipreparasi menggunakan pelarut air, dilakukan pada kondisi analisis yang terpilih. Didapatkan bahwa sampel B dan C yang beredar di pasaran tidak memenuhi persyaratan kadar zat dalam sediaan, sedangkan sampel A, D, dan E memenuhi syarat. ......Polyol compounds, such as maltitol, mannitol, xylitol, and sorbitol, are chemical substances that often added into food and pharmaceutical products, therefore analytical method is required for its identification and for determining its concentration. This study is aimed to obtain an optimum analytical condition of the mixture of four polyol compounds and to determine its content in a few artificial sweetener products using High Performance Liquid Chromatography (HPLC). Analysis was done by using Shodex Sugar SZ5532 column (150 x 6.0 mm) with refractive index detector RID-10A, acetonitrile-water (85:15) as the mobile phase, flow rate 1.2 mL/min, and the temperature of the column was 65°C. Correlation coefficient was obtained for xylitol, mannitol, sorbitol, and maltitol consecutively 0.9985; 0.9980; 0.9975; and 0.9990 with the range of concentration from 2,000 μg/mL to 7,000 μg/mL. This method has also passed the criteria of selectivity test. Assay of the five samples which was prepared by dissolving each sample contained polyol compounds with water, was determined using the chosen analytical condition. Sample B and C didn't meet the requirement of a chemical substance’s content in dosage form, whereas sample A, D, and E met the requirement of a chemical substance's content in dosage form.

Abstrak :
ABSTRAK
Paradigma pelayanan kefarmasian dari orientasi produk menjadi orientasi pasien harus direalisasikan dan diimplementasikan oleh apoteker yang bekerja di rumah sakit sehingga adanya Praktek Kerja Profesi Apoteker dapat memberikan calon apoteker pengetahuan dan pengalaman bagaimana peran dan tugas apoteker di rumah sakit berbasis orientasi keselamatan pasien Praktek kerja profesi ini bertujuan untuk memahami peran tugas dan tanggung jawab apoteker di rumah sakit sesuai dengan ketentuan dan etika pelayanan farmasi khususnya dan pelayanan kesehatan umumnya memiliki wawasan pengetahuan keterampilan dan pengalaman praktis untuk melakukan praktik kefarmasian di rumah sakit dan memiliki gambaran nyata tentang permasalahan praktek kefarmasian serta mempelajari strategi dan kegiatan kegiatan yang dapat dilakukan dalam rangka pengembangan praktek kefarmasian di rumah sakit Praktek kerja profesi dilakukan selama 2 bulan dan kegiatan yang dilakukan antara lain mempelajari aspek manajerial dan klinis serta mengunjungi bagian rekam medik instalasi sentral sterilisasi dan binatu dan bagian kesehatan lingkungan serta keselamatan dan kesehatan kerja Rumah Sakit Kanker ldquo Dharmais rdquo sudah memenuhi persyaratan sesuai peraturan yang berlaku dimulai dari aspek sarana dan prasarana sampai aspek manajerial dan klinis yang harus dilakukan oleh apoteker berbasis standar pelayanan kefarmasian di rumah sakit Calon apoteker sudah memahami peran tugas dan tanggung jawab apoteker di rumah sakit yaitu mengelola perbekalan farmasi dan melakukan pelayanan farmasi klinik serta mendapatkan pengalaman praktis dan gambaran nyata menjadi seorang apoteker di rumah sakit ABSTRACT Pharmaceutical care paradigm from product oriented to become patient oriented must be implemented and applied by pharmacist who works in hospital therefore pharmacy student who attends profession internship will get knowledge and experiences about pharmacist rsquo s roles and responsibilities in hospital based on patient safety orientation This profession internship is aimed to understand general and specific pharmacist rsquo s roles and responsibilities in hospital such as giving health care and pharmaceutical care based on ethics and rules consecutively to have knowledge skills and practical experiences to do pharmaceutical care in hospital and to have real pharmacist rsquo s problem solving act experiences with corrective actions in order to develop pharmaceutical care in hospital This profession internship lasted approximately 2 months and learnt about aspects of managerial and clinical also visited medical record division central sterile supply department environmental health division and occupational health and safety division Rumah Sakit Kanker ldquo Dharmais rdquo has applied pharmaceutical care standards in hospital including all aspects from facilities and infrastructures to managerial and clinical aspects which have to be done by a pharmacist After attending the profession internship pharmacy student who will become a pharmacist has learnt about pharmacist rsquo s roles and responsibilities in hospital such as pharmaceutical supplies management how to apply clinical pharmaceutical care and got real practical experiences in hospital ;Pharmaceutical care paradigm from product oriented to become patient oriented must be implemented and applied by pharmacist who works in hospital therefore pharmacy student who attends profession internship will get knowledge and experiences about pharmacist rsquo s roles and responsibilities in hospital based on patient safety orientation This profession internship is aimed to understand general and specific pharmacist rsquo s roles and responsibilities in hospital such as giving health care and pharmaceutical care based on ethics and rules consecutively to have knowledge skills and practical experiences to do pharmaceutical care in hospital and to have real pharmacist rsquo s problem solving act experiences with corrective actions in order to develop pharmaceutical care in hospital This profession internship lasted approximately 2 months and learnt about aspects of managerial and clinical also visited medical record division central sterile supply department environmental health division and occupational health and safety division Rumah Sakit Kanker ldquo Dharmais rdquo has applied pharmaceutical care standards in hospital including all aspects from facilities and infrastructures to managerial and clinical aspects which have to be done by a pharmacist After attending the profession internship pharmacy student who will become a pharmacist has learnt about pharmacist rsquo s roles and responsibilities in hospital such as pharmaceutical supplies management how to apply clinical pharmaceutical care and got real practical experiences in hospital