Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Pendahuluan: Gen Interleukin 6 IL-6 merupakan gen yang mengkode protein sitokin yang menjaga homeostasis imun dan memainkan peran penting dalam inflamasi dan patogenesis berbagai penyakit. Dalam beberapa penelitian sebelumnya, polimorfisme pada promoter gen IL-6 dibuktikan memiliki hubungan bermakna dengan risiko terjadinya karsinoma sel skuamosa regio kepala dan leher. Tujuan: Mendeteksi polimorfisme gen IL-6 -174G/C pada penderita karsinoma sel skuamosa populasi Indonesia. Metode: Metode PCR-RFLP dilakukan pada 85 sampel penderita KSSKL dengan enzim restriksi Nla III yang divisualisasi dengan elektroforesis. Hasil: Polimorfisme gen IL-6 -174G/C ditemukan pada sampel yang diteliti sebesar 2.3. Kesimpulan: Polimorfisme genetik interleukin 6 meningkatkan risiko KSSKL di populasi Indonesia.

---

Introduction: Interleukin 6 IL 6 gene encodes a cytokine protein which maintains immune homeostasis and plays essential roles in inflammation and diseases rsquo pathogenesis. In previous studies, polymorphism of interleukin 6 gene promoter was found significantly associated with the head and neck squamous cell carcinoma risk. Objectives: To detect the polymorphism of IL 6 174G C in Indonesian head and neck squamous cell carcinoma HNSCC patients. Methods: PCR RFLP method was used to analyze 85 samples of HNSCC patients, using Nla III restriction enzyme and the results were visualized by electrophoresis. Results: IL 6 174G C gene polymorphisms were found in the studied samples 2.3 . Conclusion: IL 6 174G C gene polymorphisms increased the risk of HNSCC in Indonesian population.