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"Latar Belakang: TNF-α dan CXCL16 terlibat dalam patofisiologi endometriosis melalui regulasi respon inflamasi dan pengkode nyeri endometriosis. Peningkatan TNF-α berperan dalam jalur pensinyalan P53 untuk apoptosis. Darah menstruasi sebagai pelepasan jaringan endometrium dapat digunakan dalam mengidentifikasi biomarker untuk diagnosis penyakit endometriosis tanpa memerlukan biopsi. Metode: Sampel darah menstruasi subjek dikumpulkan dengan menggunakan pembalut kertas saring dan jaringan endometrium dikumpulkan dengan melakukan biopsi, yang kemudian diekstraksi DNA dan RNA-nya. Tingkat metilasi DNA diukur dengan menggunakan metode pyrosequencing. Tingkat ekspresi mRNA diukur dengan menggunakan metode qPCR dan dianalisis dengan metode Livak Hasil: Ekspresi mRNA gen TNF-α pada darah menstruasi pasien endometriosis meningkat signifikan 3,73 kali lipat dibandingkan ekspresi pada kontrol (p=0,005). Gen TNF-α mengalami hipermetilasi dan berbeda bermakna dalam darah menstruasi pasien endometriosis dibandingkan kontrol (p=0,008). Sedangkan ekspresi mRNA gen CXCL16 pada darah menstruasi pasien endometriosis meningkat 2,42 kali (p=0,030) dibandingkan ekspresi mRNA darah menstruasi pada kontrol. Gen CXCL16 mengalami hipometilasi (p=0,004). Pada P53 terjadi terjadi peningkatan ekspresi gen P53 1,52 kali. Ekspresi mRNA gen TNF-α dan CXCL16 pada subjek nyeri berat lebih tinggi dibandingkan subjek nyeri sedang, dan terdapat korelasi positive. Kesimpulan: Penelitian ini menunjukkan bahwa peningkatan ekspresi mRNA TNF-α dan CXCL16 dalam darah menstruasi pasien endometriosis dapat menjadi penanda langsung untuk mendiagnosis endometriosis. Namun, untuk memvalidasi lebih lanjut temuan ini dan mengeksplorasi potensi sebagai alat diagnostik, penelitian tambahan yang melibatkan kelompok pasien yang lebih besar diperlukan

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Background: TNF-α and CXCL16 are implicated in the pathophysiology of endometriosis through the regulation of inflammatory response and the coding of endometriosis pain. Elevated TNF-α is implicated in the P53 signaling pathway for apoptosis. Menstrual blood, as a discharge of endometrial tissue, presents an opportunity for identifying biomarkers for the diagnosis of endometriosis without resorting to biopsy. Method: Menstrual blood samples were collected using filter paper pads, and endometrial tissues were obtained via biopsy, from which DNA and RNA were extracted. DNA methylation levels were assessed using the pyrosequencing method after bisulfite conversion treatment. Meanwhile, mRNA expression levels were measured using the quantitative polymerase chain reaction (qPCR) method and analyzed using the Livak method. Results: The mRNA expression of the TNF-α gene in menstrual blood of endometriosis patients increased significantly by 3.73 times compared to controls (p=0.005). The TNF-α gene exhibited hypermethylation, significantly differing in menstrual blood of endometriosis patients compared to controls (p=0.008). The mRNA expression of the CXCL16 gene in menstrual blood of endometriosis patients increased by 2.42 times (p=0.030) compared to controls, although there was no significant difference in expression between menstrual blood and endometrial tissue in endometriosis patients (p=0.173). The CXCL16 gene displayed hypomethylation (p=0.004). There was an increase in P53 gene expression, which was 1.52 times higher than in control menstrual blood. The mRNA expression of TNF-α and CXCL16 genes in subjects experiencing severe pain was higher than in those with moderate pain, and there was a positive correlation. Conclusion: This study suggests that increased mRNA expression of TNF-α and CXCL16 in menstrual blood of endometriosis patients may serve as direct markers for diagnosing endometriosis. However, further validation of these findings and exploration of their potential as diagnostic tools requires additional studies involving larger patient cohorts."

"Banyak penelitian membuktikan bahwa insiden ISPA semakin meningkat. Salah satunya dipengaruhi oleh pemberian ASI eksklusif. Penelitian ini bertujuan untuk mengetahui hubungan antara pemberian ASI eksklusif dengan kejadian ISPA pada periode tahun pertama kehidupan anak di wilayah kerja Puskesmas Pancoran Mas, Depok. Desain penelitian deskriptif korelatif dengan pendekatan potong lintang (cross-sectional). Sampel penelitian sebanyak 62 orang ibu yang dipilih menggunakan metode consecutive sampling. Hasil penelitian mendapatkan ada hubungan yang bermakna antara pemberian ASI eksklusif dengan kejadian ISPA pada periode tahun pertama kehidupan anak (ρvalue = 0,021; α = 0,05). Sedangkan berdasarkan karakteristik, didapatkan tidak ada hubungan yang bermakna antara jenis kelamin anak, status gizi, berat badan lahir, status imunisasi, pemberian vitamin A, pendidikan ibu, pekerjaan ibu dan status ekonomi keluarga dengan kejadian ISPA.Penelitian ini merekomendasikan pentingnya sosialisasi terus-menerus mengenai pemberian ASI eksklusif untuk menurunkan kejadian ISPA pada anak.

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Many studies prove that incidence of acute respiratory infections (ARI) has increased. One of which is influenced by exclusive breastfeeding. The aims of this study were to identify the correlation between exclusive breastfeeding with ARI incidence in child's first year of life period in Puskesmas Pancoran Mas, Depok. The design of this study was correlative with the descriptive approach (cross-sectional). Thestudy using 62 samples of mothers that was recruited by consecutive sampling technique. The results showed that there was a significant correlation between exclusive breastfeeding with the incidence of ARI in child's first year period of life (ρ value = 0.021; < α = 0,05). Meanwhile,based on the characteristics,there were no significant correlations between genders of child, nutrition status, birth weight, and immunization status, administration of vitamin A, mother’s education, mother’s employment, and economic status of the family, with incidence of ARI.The study recommended the importance of sustained socialization of exclusive breastfeeding is in order to decrease the incidence of ARI in children."

"[ABSTRAKBatu ginjal merupakan penyakit urologi yang banyak ditemukan di wilayahperkotaan. Diet yang tidak sehat dan kurangnya asupan cairan merupakanpenyebab terbentuknya batu ginjal. Berulangnya penyakit sering terjadi pada klienbatu ginjal. Intervensi keperawatan berupa edukasi diet dan cairan perlu diberikankepada klien dengan batu ginjal. Hal ini dilakukan untuk mencegah kekambuhanyang sering terjadi pada klien dengan batu ginjal karena ketidakpatuhan terhadappola diet dan asupan cairan setelah dilakukan pengangkatan batu. Rekomendasidari tulisan ini adalah pemberian edukasi khususnya terkait diet dan cairan denganmenggunakan media edukasi dan prosedur yang jelas dapat dijadikan intervensirutin di rumah sakit untuk klien dengan batu ginjal untuk mencegah kekambuhan.

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ABSTRACTKidney stones are urologic diseases commonly found in urban areas. Unhealthydiets and lack of fluid intake are the cause of kidney stones formation. Recurrenceof the disease is common in clients with kidney stones. Nursing interventionssuch as diet and fluid intake education should be given to clients with kidneystones. This is done to prevent a recurrence that often occurs in clients withkidney stones because of poor adherence to diet and fluid intake after the removalof the stone. This paper recommend to provide education, especially related todiet and fluid by using educational media and a clear procedure can be used as a routine intervention in the hospital for clients with kidney stones to preventrecurrence.;Kidney stones are urologic diseases commonly found in urban areas. Unhealthydiets and lack of fluid intake are the cause of kidney stones formation. Recurrenceof the disease is common in clients with kidney stones. Nursing interventionssuch as diet and fluid intake education should be given to clients with kidneystones. This is done to prevent a recurrence that often occurs in clients withkidney stones because of poor adherence to diet and fluid intake after the removalof the stone. This paper recommend to provide education, especially related todiet and fluid by using educational media and a clear procedure can be used as aroutine intervention in the hospital for clients with kidney stones to preventrecurrence., Kidney stones are urologic diseases commonly found in urban areas. Unhealthydiets and lack of fluid intake are the cause of kidney stones formation. Recurrenceof the disease is common in clients with kidney stones. Nursing interventionssuch as diet and fluid intake education should be given to clients with kidneystones. This is done to prevent a recurrence that often occurs in clients withkidney stones because of poor adherence to diet and fluid intake after the removalof the stone. This paper recommend to provide education, especially related todiet and fluid by using educational media and a clear procedure can be used as aroutine intervention in the hospital for clients with kidney stones to preventrecurrence.]"

"Kemoterapi menyebabkan terjadinya penurunan nafsu makan sehingga berdampak pada kecukupan asupan, salah satunya yaitu kecukupan asupan yang meliputi asupan karbohidrat dan protein. Pada saat pengobatan kanker perlunya dilakukan penanganan yang tepat mengenai masalah pada nutrisi untuk mencegah penurunan status gizi pada anak dengan kanker. Mempertahankan nutrisi pada anak kanker memerlukan manajemen nutrisi yang tepat. Pemberian nutrisi yang tepat dan adekuat pada pasien kanker anak dapat membantu menurunkan morbiditas dan mortalitas. Pada orang tua dengan anak kanker yang bermasalah dengan nutrisi selama pengobatan perlunya pemberian edukasi mengenai pemenuhan nutrisi anak kanker selama menjalani kemoterapi. Metode dalam penelitian ini adalah quasi experiment. Penelitian ini menggunakan pre dan post test. Responden berjumlah 64 responden dengan rentang usia anak 3-18 tahun, 32 responden pada kelompok audiovisual dan 32 responden pada kelompok leaflet. Pengetahuan orang tua pada kedua klompok di lakukan pengukuran pre-post edukasi. intervensi edukasi pemenuhan nutrisi berdurasi 5 menit. Data pengetahuan ibu menggunakan kuesioner dan asupan makan anak kanker di ukur menggunakan food recall 3x24 jam Hasil analisis menunjukan bahwa edukasi pemenuhan nutrisi yang diberikan kepada orang tua terdapat perbedaan pengetahuan dan asupan makan pre- post edukasi kelompok audiovisual kelompok leaflet. (p<0,05). Berdasarkan hasil penelitian diketahui bahwa terjadinya peningkatan pengetahuan orang tua setelah mendapatkan edukasi pemenuhan nutrisi

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Chemotherapy causes a decrease in appetite so that it has an impact on the adequacy of intake, one of which is the adequacy of intake which includes carbohydrate and protein intake. At the time of cancer treatment, it is necessary to do proper handling of problems in nutrition to prevent a decrease in nutritional status in children with cancer. Maintaining nutrition in cancer children requires proper nutritional management. Provision of proper and adequate nutrition in pediatric cancer patients can help reduce morbidity and mortality. In parents with cancer children who have problems with nutrition during treatment, it is necessary to provide education regarding the fulfillment of nutrition for cancer children during chemotherapy. The method in this study is a quasi-experimental. This research uses pre and post test. Respondents amounted to 64 respondents with a child age range of 3-18 years, 32 respondents in the audiovisual group and 32 respondents in the leaflet group. Knowledge of parents in both groups was measured pre-post education. nutritional education intervention with a duration of 5 minutes. Mother's knowledge data using a questionnaire and food intake of cancer children was measured using a food recall of 3x24 hours. The results of the analysis showed that nutrition education provided to parents had differences in knowledge and food intake in the pre-post education audiovisual group in the leaflet group. (p<0.05). Based on the results of the study, it was found that there was an increase in parental knowledge after receiving education on nutrition fulfillment"

"Anak yang mengalami penyakit ginjal kronis (PGK) dapat mengalami gangguan ketidakseimbangan cairan. Karya ilmiah akhir ini bertujuan untuk memberikan gambaran aplikasi Model Adaptasi Roy (MAR) dalam memberikan asuhan keperawatan pada anak penyakit ginjal kronis yang mengalami ketidakseimbangan cairan. Teori Roy mengkonseptualisasikan proses keperawatan menjadi enam langkah yaitu pengkajian perilaku, pengkajian stimulus, diagnosis keperawatan, penetapan tujuan, intervensi, dan evaluasi. Metode karya ilmiah ini adalah studi kasus yang terdiri atas lima kasus anak PGK yang menjalani hemodialisis yang diberikan asuhan keperawatan dengan pendekatan Model Adaptasi Roy. Berdasarkan hasil pengkajian pala lima anak masalah yang muncul yaitu ketidakseimbangan cairan, selain itu masalah lainya seperti gangguan tumbuh kembang, penampilan peran tidak efektif, risiko penurunan curah jantung, risiko perdarahan, risiko infeksi, defisit pengetahuan. Intervensi keperawatan yang diberikan pada masalah ketidakseimbangan cairan yaitu menimbang berat badan pra HD, mengkaji berat badan kering, berat badan sebelumnya, melakukan perawatan akses kateter dan memberikan edukasi tentang edukasi kebutuhan gizi, cairan dan perawatan akses menggunakan video. Kesimpulan aplikasi teori Roy dapat diterapkan pada anak penyakit ginjal kronis dengan masalah ketidaseimbangan cairan.

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Children with chronic kidney disease (CKD) can experience imbalance disorders. Fluid restriction is one of the nursing interventions to overcome fluid balance disorders. This final scientific work aims to provide an overview of the application of the Roy Adaptation Model (MAR) in providing nursing care to children with chronic kidney disease who experience fluid imbalance. Roy's theory conceptualizes the nursing process into six steps, namely behavioral assessment, stimulus assessment, nursing diagnosis, goal setting, intervention, evaluation. Provides an overview of the application of nursing care to children with chronic kidney disease who experience fluid imbalance in the dialysis unit using the Roy Adaptation Model approach. The method of this scientific work is a case study consisting of five cases of CKD children undergoing hemodialysis who were given nursing care using the Roy Adaptation Model approach. The nursing intervention provided based on evidence-based practice is providing education about nutritional needs, fluids and access care using videos. Implementing a quality improvement project by providing effective education increases the knowledge of caregivers of children with chronic kidney disease undergoing hemolysis. The conclusion is that the application of Roy's theory can be applied to children with chronic kidney disease who have fluid imbalance problems."