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Abstrak :
Telah dilakukan penelitian yang bertujuan untuk mengetahui potensi madu PS (Pollen Substitute) sebagai penurun kadar glukosa darah puasa dan post-prandial mencit (Mus musculus L.) jantan galur DDY. Dua puluh empat ekor mencit jantan dibagi ke dalam 4 kelompok hewan uji, yaitu kelompok kontrol normal (KK1) yang diberikan pakan standar dan akuades, kelompok kontrol perlakuan (KK2) yang diberikan aloksan dan akuades, dan 2 kelompok perlakuan (KP1 dan KP2) yang diberikan aloksan serta madu PS 10% dan 20%selama 14 hari berturut-turut. Pengukuran kadar glukosa darah dilakukan pada awal (t0) dan akhir penelitian (t14)dengan menggunakan glukometer. Hasil uji anava satu arah (P<0,05) menunjukkan adanya pengaruh nyata pemberian madu PS terhadap kadar glukosa darah semua hewan uji. Hasil uji LSD (P<0,05) menunjukkan bahwa kadar glukosa darah KP2 tidak berbeda nyata dengan KK1. Penurunan kadar glukosa darah puasa dan post-prandialKP2 secara berturut-turut mencapai 42,5% dan 39,75%.Berdasarkan hasil tersebut, maka dapat disimpulkan bahwa pemberian madu PS 20% dapat menurunkan kadar glukosa darah mendekati normal (mengacu pada KK1). ...... The study has been conducted to know the hypoglycemic effect of PS (Pollen Susbtitute) honey administration on fasting and post-prandial blood glucose level of male-DDY mice (Mus musculus L.). Twenty four male mice were divided to four groups consisting of normal control group (KK1) which was administered with neither alloxan or PS honey; treatment control group (KK2) which was administered with alloxan; and two treatment groups (KP1 and KP2) which was administered with alloxan and PS honey 10% and 20%, respectively, within 14 consecutive days. Fasting (16 hours) and post-prandial (2 hours after eating) blood glucose level were measured using glucometer. One-way anova test (P<0,05) showed that fasting and post-prandial blood glucose level decreased significantly. Least significant difference (LSD) (P<0,05) test showed that only the administration of 20% PS honey (KP2) cause the significant decrease in both fasting and post-prandial blood glucose level. According to normal control group (KK1), the blood glucose level of KP2 has been reduced to its normal range. It is concluded that administration of 20% PS honey significantly lowered blood glucose level (fasting and post-prandial).