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"Film cepat hancur merupakan bentuk sediaan lapis tipis yang dapat segera hancur dalam mulut tanpa memerlukan air. Penelitian ini bertujuan untuk memformulasi dan mengevaluasi film cepat hancur ekstrak meniran, dengan protein kedelai tersuksinilasi (PKS) sebagai eksipien. Protein kedelai (PK) disuksinilasi dengan anhidrida suksinat sebanyak 100% b/b PK (PKS1) dan 250% b/b PK (PKS2), dalam suasana basa dengan medium berair. Film cepat hancur dibuat dengan metode solvent casting dan dievaluasi. Berdasarkan pengujian dengan FTIR, PKS memiliki intensitas yang lebih tinggi pada bilangan gelombang 1697,41 cm-1 yang menunjukkan gugus karboksilat, dan pada bilangan gelombang 1653,05 cm-1 yang menunjukkan gugus karboksil amida yang terbentuk pada ikatan antara gugus amin dari asam amino lisin dengan gugus karboksil dari suksinat, serta tidak ditemukannya spektrum untuk PKS2 pada 2359,02 cm-1 yang menunjukkan bahwa gugus amin primer pada PKS2 seluruhnya telah digantikan oleh suksinat. PKS1 memiliki derajat suksinilasi 35,741 ± 0,380%, dengan daya larut 0,3437 ± 0,0081 gr/100ml pada pH 6,8. Sementara PKS2 memiliki derajat suksinilasi 100,380 ± 0,380%, dengan daya larut yang lebih tinggi pada pH 6,8 yaitu 0,4390 ± 0,0111 gr/100ml. Evaluasi film cepat hancur menunjukkan bahwa F3 memiliki kriteria yang terbaik sebagai film cepat hancur, dengan waktu hancur in vitro 11,27 ± 1,050 detik. Hasil uji kesukaan menunjukkan 80% responden menyukai penampilan dan rasanya. Rata-rata waktu hancur di rongga mulut responden adalah 10,6 ± 2,513 detik. Berdasarkan hasil penelitian, dapat disimpulkan bahwa protein kedelai tersuksinilsi dapat digunakan sebagai eksipien untuk film cepat hancur.

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Fast disintegrating film (FDF) is a thin layer dosage form which is rapidly disintegrated without water in oral cavity. The aim of this study was to formulate and evaluate FDF containing Phyllanthus niruri extract, using succinylated soybean protein (SSP) as excipient. Soybean protein (SP) was succinylated using succinic anhydride 100% w/w SP (SSP1) and 250% w/w SP (SSP2), in basic condition of aqueous medium. FDF was formulated using solvent casting method and evaluated. FTIR results of SSP showed higher intensity at 1697.41 cm-1 which attribute to carboxylic group, and 1653.05 cm-1 which attribute to amide carbonyl group which is formed on bound between amine group from lysine, and carboxyl group from succinic, there was also no spectrum found for SSP2 at 2359.02 cm-1 which showed that all of primary amine from lysine has substituted by succinic. SSP1 has 35.741 ± 0.380% as its substitution degree, with 0.3437 ± 0.0081 g/100ml as its solubility at pH 6.8. SSP2 has 100.380 ± 0.380% as its substitution degree, with higher solubility with 0.4390 ± 0.0111 g/100ml as its solubility at pH 6.8. Evaluation of FDF showed that F3 had the best characteristics as FDF, with 11.27 ± 1.050 seconds disintegration time. The hedonic test results showed that 80% responders like FDF's appearance and taste. The average of FDF's disintegration time in responders' oral cavity was 10.6 ± 2.513 seconds. Based on the research results, it can be concluded that succinylated soybean protein can be used as excipient for FDF."

"Kegiatan PKP Praktek Kerja Profesi yang dilaksanakan di Suku Dinas Kesehatan Kota Administrasi Jakarta Pusat bertujuan untuk memahami peranan tugas dan tanggung jawab apoteker di instasi pemerintahan menambah pengalaman praktis mengenai pekerjaan kefarmasian di Suku Dinas Kesehatan serta memiliki gambaran nyata mengenai masalah kefarmasian di instansi pemerintahan Selama PKP calon apoteker ditempatkan di bawah Koordinator Farmasi Makanan dan Minuman sehingga memperoleh pengetahuan mengenai pelaksanaan Binwasdal Pembinaan Pengawasan dan Pengendalian di apotek rumah sakit UKOT UMOT dan PIRT serta melakukan kunjungan ke Mentjos yang merupakan suatu IKOT yang sedang dalam proses transisi menjadi UKOT Adapun tugas khusus dilaksanakan di Puskesmas Kecamatan Kemayoran yaitu Pembuatan Laporan Penggunaan Obat Rasional Periode Mei Desember 2014

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The aim of Professional Internship at Suku Dinas Kesehatan Kota Admnistrasi Jakarta Pusat are to understanding the role and responsibilities of pharmacists in government gain experience about pharmacy jobs in Suku Dinas Kesehatan and to have a real view about pharmaceutical problem in government instance During internship activity student was placed under Pharmacy Food and Beverages Coordinator so that student was able to gain knowledge about implementation of Development Monitoring dan Control Activities in pharmacies hospitals UKOT UMOT dan PIRT Students also visited Mentjos which is an IKOT that is in the transition into UKOT As for the special assignment was carried out in Puskesmas Kecamatan Kemayoran namely Pembuatan Laporan Penggunaan Obat Rasional from May to December 2014 "

"[Kegiatan PKP Praktek Kerja Profesi yang dilaksanakan di Apotek Erra Medika bertujuan untuk mengetahui tugas dan peran apoteker di apotek memiliki gambaran pekerjaan kefarmasian di apotek dan melihat gambaran nyata mengenai masalah kefarmasian di apotek Selama kegiatan PKP calon apoteker memperoleh kesempatan untuk melakukan pelayanan pemberian informasi obat pelayanan swamedikasi serta memperoleh pengetahuan mengenai pengelolaan perencanan pengadaan dan penyimpanan obat di apotek Diperoleh juga tugas tambahan yaitu pembuatan Laporan Generik Narkotika dan Psikotropika Bulan Januari 2015 Adapun tugas khusus yang diberikan adalah Pengkajian Resep di Apotek Erra Medika mulai dari 2 Februari hingga 15 Februari 2015 dengan total resep sebanyak 230 lembar ;The aim of Professional Internship at Apotek Erra Medika are to determine the role of the pharmacist in the drug store have a job description of pharmacy in drug store and to have the real view about the problem of implementation pharmaceutical care During internship activity students are given the opportunity to give drug information service self medication service and also gain knowledge about the management of planning procurement dan storage of drugs in drug store Students were also given task to create Generic Narcotics and Psychotropics for January 2015 As for the special assignment was namely Prescription Screening in Apotek Erra Medika from 2 to 15 of February 2015 with prescription total of 230 sheets ;The aim of Professional Internship at Apotek Erra Medika are to determine the role of the pharmacist in the drug store have a job description of pharmacy in drug store and to have the real view about the problem of implementation pharmaceutical care During internship activity students are given the opportunity to give drug information service self medication service and also gain knowledge about the management of planning procurement dan storage of drugs in drug store Students were also given task to create Generic Narcotics and Psychotropics for January 2015 As for the special assignment was namely Prescription Screening in Apotek Erra Medika from 2 to 15 of February 2015 with prescription total of 230 sheets , The aim of Professional Internship at Apotek Erra Medika are to determine the role of the pharmacist in the drug store have a job description of pharmacy in drug store and to have the real view about the problem of implementation pharmaceutical care During internship activity students are given the opportunity to give drug information service self medication service and also gain knowledge about the management of planning procurement dan storage of drugs in drug store Students were also given task to create Generic Narcotics and Psychotropics for January 2015 As for the special assignment was namely Prescription Screening in Apotek Erra Medika from 2 to 15 of February 2015 with prescription total of 230 sheets ]"

"[ABSTRAKKegiatan PKP Praktek Kerja Profesi yang dilaksanakan di industri farmasi yaitu PT Kalbe Farma Tbk Cikarang bertujuan agar calon apoteker dapat memahami penerapan CPOB Cara Pembuatan Obat yang Baik di industri farmasi mengetahui secara garis besar gambaran pekerjaan kefarmasian di industri farmasi dan mendapatkan pengetahuan wawasan serta pengalaman praktis secara langsung dalam penerapan pekerjaan kefarmasian di industri farmasi Selama kegiatan PKP calon apoteker ditempatkan di bagian Pemastian Mutu sehingga memperoleh kesempatan untuk membuat protokol dan laporan validasi proses QA Matrix serta mengikuti pelatihan dan kegiatan induksi ke bagian lain seperti QC R D Logistik dan Teknik Adapun tugas khusus yang diberikan adalah Pembuatan Laporan Validasi Proses Tablet Asam Traneksamat yang merupakan validasi ulang karena adanya perubahan alat pada proses pencampuran dan perubahan jumlah sampel pada evaluasi kebocoran kemasan

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ABSTRACTThe aim of Professional Internship in the pharmaceutical industry namely PT Kalbe Farma Tbk Cikarang are to understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry During internship activities student was placed under Quality Assurance Section so that student got opportunities to create validation process protocol and report QA Matrix and also participate in training dan induction to the other section such as QC R D Logistic and Technical Section As for the special assignment was namely Validation Process Report of Tranexamic Acid Tablet which was revalidated because of equipment changing in mixing process and total sample changing in leakage test ;The aim of Professional Internship in the pharmaceutical industry namely PT Kalbe Farma Tbk Cikarang are to understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry During internship activities student was placed under Quality Assurance Section so that student got opportunities to create validation process protocol and report QA Matrix and also participate in training dan induction to the other section such as QC R D Logistic and Technical Section As for the special assignment was namely Validation Process Report of Tranexamic Acid Tablet which was revalidated because of equipment changing in mixing process and total sample changing in leakage test , The aim of Professional Internship in the pharmaceutical industry namely PT Kalbe Farma Tbk Cikarang are to understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry During internship activities student was placed under Quality Assurance Section so that student got opportunities to create validation process protocol and report QA Matrix and also participate in training dan induction to the other section such as QC R D Logistic and Technical Section As for the special assignment was namely Validation Process Report of Tranexamic Acid Tablet which was revalidated because of equipment changing in mixing process and total sample changing in leakage test ]"