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Arrahman
"[ABSTRAK
Tesis ini membahas kebijakan Aparatur Negara dalam dugaan tindak
pidana korupsi. Dengan mengkaji konsep dan kewenangan kebijakan Aparatur Negara dalam Hukum Administrasi dan Hukum pidana. Kebijakan tersebut dinilai dari kedua pendekatan ilmu hukum tersebut untuk menilai kebijakan Aparatur yang bagaimana dapat dikriminalisasikan sebagai tindak pidana korupsi. Dalam tesis ini yang ingin didapatkan oleh penulis adalah (1) Apakah suatu kebijakan
Aparatur Negara yang melanggar ketentuan peraturan perundang-undangan dapat dimungkinkan untuk dikenakan sanksi pidana; (2) Bagaimana terhadap suatu kebijakan Aparatur Negara yang di dalamnya mengandung unsur perbuatan melawan hukum atau unsur penyalahgunaan wewenang dalam tindak pidana korupsi; (3) Apakah terhadap kebijakan yang dikeluarkan oleh Aparatur Negara yang memberikan keuntungan kepada orang lain atau korporasi dan menimbulkan kerugian negara dapat dikenakan tindak pidana korupsi sedangkan dia tidak ada menikmati hasil tindakannya. Penelitian ini mengunakan metode penelitian dengan pendekatan yuridis normatif dengan mengunakan data sekunder seperti dari buku-buku dan peraturan perundang-undangan yang terkait dengan tindak pidana korupsi, kerugian negara, penyalahgunaan wewenag dan literatur-literatur terkait lainnya. Kebijakan Aparatur Negara harus berdasarkan peraturan perundang-undangan. Seorang pejabat dilarang melakukan penyalahgunaan wewenang yang melanggar ketentuan perundang-undangan. Namun disisi lain pejabat juga diberikan hak kebebasan dalam mengambil kebijakan untuk kepentingan orang banyak bahkan kalaupun undang-undang tidak mengaturnya dapat diterapkan berdasarkan AAUPB. Namun apabila kebijakan tersebut ada unsur mens rea (niat jahat) dan dilakukan dengan sengaja maka kebijakan
Aparatur Negara tersebut dapat diminta pertanggungjawab pribadi bukan jabatan atas perbuatannya tersebut. Kalau perbuatan itu tidak ada unsur mens rea maka masuk kedalam ranah hukum administrasi atau hukum perdata. Pada saat ini kebijakan Aparatur Negara telah masuk dalam kategori kriminalisasi. Hal ini terjadi karena adanya kesalahan dalam pemahaman dimana kerugian negara ditempat sebagai bukti utama telah terjadi korupsi atas perbuatannya yang
melawan hukum atau menyalahgunakan wewenang tanpa diikuti adanya unsur koruptif. Padahal dalam banyak kasus kerugian negara ini terjadi karena adanya kesalahan administratif atau kecurangan dari pihak pemenang tender yang memanipulasi barang dan data sehingga tidak sesuai spesifikasi yang mana dokumen tersebut dipalsukan dan dibuat seolah-olah sah dan legal. Oleh karenanya, dengan lahirnya Undang-Undang No. 30 Tahun 2014 tentang Administrasi Negara diharapkan dapat memberikan perlindungan akan kriminalisasi terhadap putusan dan/atau tindakan Aparatur Negara yang di
dalamnya tidak ada unsur koruptifnya.

ABSTRACT
This thesis examines the policy of the State Apparatus in alleged corruption. To examines the concept and authority policy of the State Apparatus in Administrative Law and Criminal Law. The such policy is assessed from two approach the science of law to assessing how policies Apparatus which can be
criminalized as an act of corruption. In this thesis that want achieved by the author are (1) Does a State Apparatus policies that violate the provisions of the legislation can be subject to criminal sanctions; (2) When is a policy of the State Apparatus can be regarded fulfill the elements of tort or elements of abuse of power in corruption; (3) A State Apparatus policies that provide benefits to another person or corporation and causing state losses while he did not get to enjoy the results of his conduct, whether such conduct may be subject to
corruption. This research uses research methods with normative juridical approach by using secondary data as the basis for this research as from books and legislation relating to corruption, state losses, abuse of power and other related literature and also supported by directly interviews to some of prosecutor in corruption. State Apparatus policy should be based law and legislation. A government official is prohibited do abuse of power that violate the statutory
provisions. On the other hand the government official also granted the right of freedom in making decisions for the public good even if the law does not yet set such, the government official can make policy based on the Good Governance Principles. However, if the such policy has element of mens rea (malice) and there is deliberate and realized then the policies of the State Apparatus may be subject to responsibility in corruption. If the conduct did not have element mens rea then
his conduct entered into the administrative law or civil law. At this time the policy of the State Apparatus has been included in the category of criminalization in corruption. This occurs because of an error in understanding where state losses in place as the primary evidence of corruption has occurred for his conduct against the law or abuse of power while his conduct without being followed by the corrupt elements. Therefore, there are cases of state losses caused to
administrative error or fraud, or because of defective juridical. To publication of Law No. 30 Year 2014 on the State Administration as a form protection to the criminalization of the decision and / or conduct of State Apparatus in which there is no element of corruptive;This thesis examines the policy of the State Apparatus in alleged corruption. To
examines the concept and authority policy of the State Apparatus in
Administrative Law and Criminal Law. The such policy is assessed from two
approach the science of law to assessing how policies Apparatus which can be
criminalized as an act of corruption. In this thesis that want achieved by the author
are (1) Does a State Apparatus policies that violate the provisions of the
legislation can be subject to criminal sanctions; (2) When is a policy of the State
Apparatus can be regarded fulfill the elements of tort or elements of abuse of
power in corruption; (3) A State Apparatus policies that provide benefits to
another person or corporation and causing state losses while he did not get to
enjoy the results of his conduct, whether such conduct may be subject to
corruption. This research uses research methods with normative juridical approach
by using secondary data as the basis for this research as from books and
legislation relating to corruption, state losses, abuse of power and other related
literature and also supported by directly interviews to some of prosecutor in
corruption. State Apparatus policy should be based law and legislation. A
government official is prohibited do abuse of power that violate the statutory
provisions. On the other hand the government official also granted the right of
freedom in making decisions for the public good even if the law does not yet set
such, the government official can make policy based on the Good Governance
Principles. However, if the such policy has element of mens rea (malice) and there
is deliberate and realized then the policies of the State Apparatus may be subject
to responsibility in corruption. If the conduct did not have element mens rea then
his conduct entered into the administrative law or civil law. At this time the policy
of the State Apparatus has been included in the category of criminalization in
corruption. This occurs because of an error in understanding where state losses in
place as the primary evidence of corruption has occurred for his conduct against
the law or abuse of power while his conduct without being followed by the
corrupt elements. Therefore, there are cases of state losses caused to
administrative error or fraud, or because of defective juridical. To publication of
Law No. 30 Year 2014 on the State Administration as a form protection to the
criminalization of the decision and / or conduct of State Apparatus in which there
is no element of corruptive;This thesis examines the policy of the State Apparatus in alleged corruption. To
examines the concept and authority policy of the State Apparatus in
Administrative Law and Criminal Law. The such policy is assessed from two
approach the science of law to assessing how policies Apparatus which can be
criminalized as an act of corruption. In this thesis that want achieved by the author
are (1) Does a State Apparatus policies that violate the provisions of the
legislation can be subject to criminal sanctions; (2) When is a policy of the State
Apparatus can be regarded fulfill the elements of tort or elements of abuse of
power in corruption; (3) A State Apparatus policies that provide benefits to
another person or corporation and causing state losses while he did not get to
enjoy the results of his conduct, whether such conduct may be subject to
corruption. This research uses research methods with normative juridical approach
by using secondary data as the basis for this research as from books and
legislation relating to corruption, state losses, abuse of power and other related
literature and also supported by directly interviews to some of prosecutor in
corruption. State Apparatus policy should be based law and legislation. A
government official is prohibited do abuse of power that violate the statutory
provisions. On the other hand the government official also granted the right of
freedom in making decisions for the public good even if the law does not yet set
such, the government official can make policy based on the Good Governance
Principles. However, if the such policy has element of mens rea (malice) and there
is deliberate and realized then the policies of the State Apparatus may be subject
to responsibility in corruption. If the conduct did not have element mens rea then
his conduct entered into the administrative law or civil law. At this time the policy
of the State Apparatus has been included in the category of criminalization in
corruption. This occurs because of an error in understanding where state losses in
place as the primary evidence of corruption has occurred for his conduct against
the law or abuse of power while his conduct without being followed by the
corrupt elements. Therefore, there are cases of state losses caused to
administrative error or fraud, or because of defective juridical. To publication of
Law No. 30 Year 2014 on the State Administration as a form protection to the
criminalization of the decision and / or conduct of State Apparatus in which there
is no element of corruptive, This thesis examines the policy of the State Apparatus in alleged corruption. To
examines the concept and authority policy of the State Apparatus in
Administrative Law and Criminal Law. The such policy is assessed from two
approach the science of law to assessing how policies Apparatus which can be
criminalized as an act of corruption. In this thesis that want achieved by the author
are (1) Does a State Apparatus policies that violate the provisions of the
legislation can be subject to criminal sanctions; (2) When is a policy of the State
Apparatus can be regarded fulfill the elements of tort or elements of abuse of
power in corruption; (3) A State Apparatus policies that provide benefits to
another person or corporation and causing state losses while he did not get to
enjoy the results of his conduct, whether such conduct may be subject to
corruption. This research uses research methods with normative juridical approach
by using secondary data as the basis for this research as from books and
legislation relating to corruption, state losses, abuse of power and other related
literature and also supported by directly interviews to some of prosecutor in
corruption. State Apparatus policy should be based law and legislation. A
government official is prohibited do abuse of power that violate the statutory
provisions. On the other hand the government official also granted the right of
freedom in making decisions for the public good even if the law does not yet set
such, the government official can make policy based on the Good Governance
Principles. However, if the such policy has element of mens rea (malice) and there
is deliberate and realized then the policies of the State Apparatus may be subject
to responsibility in corruption. If the conduct did not have element mens rea then
his conduct entered into the administrative law or civil law. At this time the policy
of the State Apparatus has been included in the category of criminalization in
corruption. This occurs because of an error in understanding where state losses in
place as the primary evidence of corruption has occurred for his conduct against
the law or abuse of power while his conduct without being followed by the
corrupt elements. Therefore, there are cases of state losses caused to
administrative error or fraud, or because of defective juridical. To publication of
Law No. 30 Year 2014 on the State Administration as a form protection to the
criminalization of the decision and / or conduct of State Apparatus in which there
is no element of corruptive]"
Universitas Indonesia, 2015
T43878
UI - Tesis Membership  Universitas Indonesia Library
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Arif Arrahman
"ABSTRAK
Resistensi yang terjadi pada trimetoprim dan beberapa antibiotika konvensional
lainnya menyebabkan pencarian akan molekul antibakteri baru dari golongan
senyawa yang berbeda sangat dibutuhkan. Senyawa turunan kuinazolinon
diketahui memiliki aktivitas antibakteri, oleh karena itu sintesis senyawa 6-amino-
2-[(E)-(4-hidroksi-3-metoksifenil)etenil]-3,4-dihidrokuinazolin-4-on dan senyawa
antaranya yang diujikan sebagai antibakteri perlu dilakukan. Senyawa 6-amino-2-
[(E)-(4-hidroksi-3-metoksifenil)etenil]-3,4-dihidrokuinazolin-4-on disintesis dengan
empat tahap reaksi. Tahap pertama adalah sintesis 2-metil-3,4-dihidrokuinazolin-4-
on, tahap kedua adalah sintesis 2-metil-6-nitro-3,4-dihidrokuinazolin-4-on, tahap
ketiga adalah sintesis 2-[(E)-(4-hidroksi-3-metoksifenil)etenil]-6-nitro-3,4-
dihidrokuinazolin-4-on dan tahap keempat adalah sintesis 6-amino-2-[(E)-(4-
hidroksi-3-metoksifenil)etenil]-3,4-dihidrokuinazolin-4-on. produk yang dihasilkan
dari setiap tahapan dimurnikan dengan cara pencucian dan rekristalisasi, kemudian
diuji kemurniannya dengan jarak lebur dan kromatografi lapis tipis. Bobot molekul
senyawa dianalsis dengan LC-MS, Struktur senyawa dielusidasi menggunakan
spektrofotometri UV-Vis, FT-IR, 1H-NMR dan 13C-NMR, COSY, HMQC dan
HMBC. Uji aktivitas antibakteri dilakukan pada bakteri Staphylococcus aureus
ATCC 25923, Salmonella typhimurium ATCC 14028 dan Escherichia coli ATCC
25922. Hasil penelitian menunjukkan bahwa senyawa target telah berhasil disintesis
dan dimurnikan berdasarkan metode kimia organik. Struktur senyawa telah
dibuktikan kebenarannya melalui elusidasi struktur. Hasil uji aktivitas antibakteri
senyawa 6-amino-2-[(E)-(4-hidroksi-3-metoksifenil)etenil]-3,4-dihidrokuinazolin-4-
on tidak menunjukkan aktivitas antibakteri.

ABSTRACT
Resistance in trimethoprim and several conventional antibacetria, made the
searching for new antibacterial agent from different groups of compound became
nescessary. Quinazolinone derivate was known having antibacterial activity, for
those reasons, synthesis of compound 6-Amino-2-[(E)-(4-hydroxy-3-
methoxyphenyl)ethenyl)-6-nitro-3,4-dihydroquinazolin-4-one and its intermediate
as antibacteria was necessary to be conducted. The titled compound was
synthesized via four steps. First step was synthesis of 2-methyl-3,4-
dihydroquinazolin-4-one. Second step was syhtesis of 2-methyl-6-nitro-3,4-
dihydroquinazolin-4-one. Third step was synthesis of 2-[(E)-(4-hydroxy-3-
methoxyphenyl)ethenyl]-6-nitro-3,4-dihydroquinazolin-4-one. Forth step was
synthesis of 6-Amino-2-[(E)-(4-hydroxy-3-methoxy phenyl)ethenyl)-6-nitro-3,4-
dihydroquinazolin-4-one. The synthesized product from each step was purified by
washing and recrystalization. The purity testing was performed by examining
melting range and thin layer chromatography. Mollecuar mass of synthezised
compound was determined using LC-MS. Structure of synthesized compound was
elucidated using UV-Vis, FT-IR, 1H-NMR dan 13C-NMR, COSY, HMQC and
HMBC. Screening for antibacterial activity was performed against Staphylococcus
aureus ATCC 25923, Salmonella typhimurium ATCC 14028 and Escherichia coli
ATCC 25922. The result indicated that titled compound has sucsessfully been
synthesized and purified using organic chemistry method. Structure of desired
compound was confirmed based on structural elucidation analysis. The result of
antibacterial activity of compound 6-Amino-2-[(E)-(4-hydroxy-3-methoxyphenyl)
ethenyl)-6-nitro-3,4-dihydroquina-zolin-4-one did not perform antibacterial
acitivity."
Depok: Fakultas Farmasi Universitas Indonesia, 2014
T42081
UI - Tesis Membership  Universitas Indonesia Library
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Arif Arrahman
"Senyawa 4-(4-metoksibenzilidena)-2-metiloksazol-5-on adalah senyawa turunan oksazol. Senyawa oksazolon memiliki aktivitas farmakologis yang beragam, bergantung pada substituen yang terikat pada cincin oksazolon. Senyawa oksazolon juga merupakan prekursor yang penting untuk mensintesis senyawa yang memiliki aktivitas farmakologis lain. Oleh karena itu, percobaan sintesis senyawa 4-(4-metoksibenzilidena)-2-metiloksazol-5-on dari asetilglisin dan 4-metoksibenzaldehid sebagai senyawa turunan oksazolon perlu dilakukan. Senyawa 4-(4-metoksibenzilidena)-2-metiloksazol-5-on disintesis melalui dua tahap reaksi. Tahap pertama adalah mereaksikan glisin dengan anhidrida asetat dalam suasana asam menghasilkan asetilglisin. Tahap kedua adalah merekasikan asetilglisin dengan 4metoksibenzaldehid menghasilkan 4-(4-metoksibenzilidena)-2-metiloksazol-5-on. Produk yang dihasilkan dari tiap tahapan dimurnikan dengan cara pencucian dan rekristalisasi kemudian diuji kemurniannya dengan pemeriksaan jarak lebur dan kromatografi lapis tipis. Selanjutnya dielusidasi strukturnya menggunakan spektrofotometri UV-Vis, spektrofotometri inframerah dan spektrofotometri HNMR. Sintesis 4-(4-metoksibenzilidena)-2-metiloksazol-5-on menghasilkan padatan berwarna kuning dengan rendemen sebanyak 0,54%. Interpretasi spektrum inframerah dan spektrum UV-Vis mengindikasikan senyawa hasil sintesis berbeda dengan senyawa pemula namun, hasil interpretasi spektrum 1H-NMR mengindikasikan senyawa hasil sintesis belum dapat dipastikan merupakan senyawa yang diharapkan, yaitu 4-(4-metoksibenzilidena)-2-metiloksazol-5-on dikarenakan masih terdapat banyak cemaran.

Compound 4-(4-methoxybenzylidene)-2-methyloxazole-5-one was one of oxazolone moety derivative. Oxazolones had several different pharmacological activity depend on substituent which was bonded to oxazolone ring. Oxazolones was an important precursor for synthesizing several compounds which had pharmacological activity. For that reason, experiment to synthesize 4-(4-methoxybenzylidene)-2-methyloxazole-5-one from acetylglicine and 4-methoxybenzaldehyde as an oxazolone derivative become necessary. Compound 4-(4-methoxybenzylidene)-2-methyloxazole-5-one was synthesized over two step of reaction. First step was reacted glycine with acetic anhydride in acidic environment yielded acetylglycine. Second step was reacted acetylglycine with 4-methoxybenzaldehyde yielded 4-(4-methoxybenzylidene)-2-methyloxazole-5-one. The product, which was collected in every step, was purified by washing and recrystalization then the purification to be tested by examining melting range and thin layer chromatography. The compound was elucidated by using UV-Vis spectrophotometry, infrared spectrophotometry and 1H-NMR spectrophotometry. Synthesis of 4-(4-methoxybenzylidene)-2-methyloxazole-5-one yielded rendement over 0,54%. The interpretation of UV-Vis spectrum and infrared spectrum indicated that the compound which synthesized was different from the former compound but the interpretation of 1H-NMR spectrum indicated that the compound could not be ascertained as 4-(4-methoxybenzylidene)-2-methyloxazole-5-one because of there were impurities. "
Depok: Fakultas Farmasi Universitas Indonesia, 2011
S686
UI - Skripsi Open  Universitas Indonesia Library
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M. Raihan Yusuf Arrahman
"Osteoporosis adalah kelainan umum dengan komponen genetik yang kuat. Osteoporosis dapat terjadi pada wanita pasca menopause dan lansia di atas 70 tahun. Osteoporosis disebabkan oleh penurunan BMD (Bone Mineral Density) pada individu. Penelitian ini bertujuan untuk mengetahui distribusi polimorfisme gen BGLAP pada pasien osteoporosis. BGLAP -298 C > T (rs 1800247), ddH2O, dan MyTaq dicampur pada template DNA (sampel osteoporosis dan non-osteoporosis), kemudian dianalisis menggunakan teknik PCR-RFLP menggunakan HindIII sebagai enzim restriksi dilanjutkan dengan elektroforesis. Kemudian dianalisis menggunakan uji Pearson Chi - Square dan Continuity Correction. Frekuensi alel untuk osteoporosis dan non-osteoporosis dalam penelitian ini adalah 110% untuk h dan 90% untuk H. Prevalensi masing-masing genotipe dalam populasi penelitian adalah 35% hh, 40% Hh, dan 25% HH. Subjek dengan genotipe hh memiliki BMD terbesar dan subjek dengan HH memiliki BMD terkecil. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan dalam distribusi frekuensi polimorfisme genotipe BGLAP antara osteoporosis dan non-osteoporosis. Kesimpulannya, polimorfisme gen BGLAP dikaitkan dengan penurunan BMD dan merupakan faktor predisposisi osteoporosis.
Osteoporosis is a common disorder with a strong genetic component. Osteoporosis can occur in postmenopausal women and the elderly over 70 years. Osteoporosis is caused by a decrease in BMD (Bone Mineral Density) in individuals. This study aims to determine the distribution of BGLAP gene polymorphisms in osteoporosis patients. BGLAP -298 C > T (rs 1800247), ddH2O, and MyTaq were mixed on DNA templates (osteoporosis and non-osteoporosis samples), then analyzed using PCR-RFLP technique using HindIII as a restriction enzyme followed by electrophoresis. Then analyzed using the Pearson Chi - Square test and Continuity Correction. The allele frequencies for osteoporosis and non-osteoporosis in this study were 110% for h and 90% for H. The prevalence of each genotype in the study population was 35% hh, 40% hh, and 25% hh. Subjects with the hh genotype had the largest BMD and subjects with HH had the smallest BMD. The results showed that there was a significant difference in the frequency distribution of BGLAP genotype polymorphisms between osteoporosis and non-osteoporosis. In conclusion, BGLAP gene polymorphism is associated with decreased BMD and is a predisposing factor for osteoporosis."
Depok: Fakultas Kedokteran Gigi Universitas Indonesia, 2019
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UI - Skripsi Membership  Universitas Indonesia Library