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"The industrialization has taken a significant part in an increase of-The-Gross Domestic Product (GDP), particularly in The Third World Countries. During 1970?s and 1980?s some cases in Indonesia had showed that the mainly input of GDP is given by manufacturing industries. It means that industrialization offers an increase of the economic growth, both regionally and domestically, including decreases in the level of poverty. Moreover, the economic improvement is still an aggregate and involved marry complicated components. According to these reasons, problem above is very attractive and then will be clearer if it is solved by a spatial approach.The case study in this research is the manufacturing industries and the poverty in the Medan City (The Capital of North Sumatra Province) in 1993-/999 period The objectives of the research are a review about the correlation between industries of manufacture (big and middle) to poverty and an identification of factors that influence it.This research uses 'Tumpang Susun Peta method' as an approach and supported by 'Statistical Correlation Method' resulting an integrated method As a consequence, the results will be found more accurately.The findings of this research are: in general, in Medan City, there was no strong correlation between the number of manufacturing industries and the poverty. An increase of amount for manufacturing industries is not followed by a decline in poverty. The ratio of the manufacture industry in manpower to the people in productive age was relatively small, e.g. 3.58 %. The level of the education was very low. On the other hand the industrial location is not located in the over-populated region.In regional area, North and South, a different pattern was illustrated. In the North, there was no strong correlation between percentage of the industry and the level of poverty. On the other hand in the South, there was a relatively strong correlation between percentage of industry and the no poverty area, especially Kecamatan Medan Johor, Denai, Area, Swigged, Petisah, and Barat. Above all, the basic quantitative of the study is viewed that industrial locations as employment highly absorbed, encourage the level of poverty to be wealthier especially in the South of Medan City."

"Latar Belakang: Tipe terbanyak dari limfoma non-Hodgkin (LNH) sel B adalah Diffuse Large B-cell Lymphoma (DLBCL) yang merupakan entitas heterogen. Hans membagi DLBCL menjadi subtipe Germinal Center B-cell like (GCB) dan non-Germinal Center B-cell like (non-GCB) dengan tehnik pemeriksaan imunohistokimia menggunakan CD10, BCL6 dan MUM1. Caspase-3 adalah protein yang berperan utama dalam mekanisme apoptosis dan dapat mengalami mutasi somatik pada LNH. Imunoekspresi Caspase-3 dapat berhubungan dengan kesintasan pasien DLBCL. Tujuan penelitian ini untuk mengetahui perbedaan imunoekspresi Caspase-3 pada DLBCL subtipe GCB dan non-GCB. Bahan dan Metode: Pemeriksaaan imunoekspresi Caspase-3 pada 41 kasus DLBCL yang terdiri atas 18 kasus subtipe GCB dan 23 kasus non-GCB dilakukan dengan tehnik imunohistokimia . Subjek penelitian berasal dari RSCM dan enam rumah sakit lainnya di Jakarta. Hasil: Kasus DLBCL subtipe GCB memberikan hasil positif pada pulasan Caspase-3 berjumlah 13 kasus (72%) dan negatif berjumlah 5 kasus (28%). Hasil yang didapatkan dari subtipe non-GCB yaitu positif berjumlah 5 kasus (22%) dan negatif berjumlah 18 kasus (78%). Terdapat perbedaan bermakna imunoekspresi Caspase-3 antara DLBCL subtipe GCB dengan subtipe non-GCB (p = 0,002). Kesimpulan: Imunoekspresi Caspase-3 menunjukkan positivitas yang lebih tinggi pada DLBCL subtipe GCB dibandingkan dengan subtipe non-GCB.

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Background: The most common type of B-cell non-Hodgkin lymphoma (NHL) is diffuse large B-cell lymphoma (DLBCL) which is heterogeneous. Hans divided DLBCL into Germinal Center B-cell-like (GCB) and non-Germinal Center B-cell-like (non-GCB) subtypes by using immunohistochemistry staining with CD10, BCL6 and MUM1. Caspase-3 is a protein that functions as a key role in the mechanism of apoptosis and may have somatic mutation in NHL. Immunoexpression of Caspase-3 could be associated with the survival of DLBCL patient. This study was performed to analyze the difference of Caspase-3 immunoexpression between GCB and non-GCB subtypes of DLBCL.

Materials and Methods: Caspase-3 immunoexpression examination was performed in 41 DLBCL cases, consisted of 18 cases of GCB and 23 cases of non-GCB subtypes by using immunohistochemistry technique. The cases came from RSCM and 6 other hospitals in Jakarta.

Result: The number of GCB subtype which showed positive Caspase-3 staining was 13 cases (72%) and negative in 5 cases (28%). The number of non-GCB subtype which showed positive Caspase-3 staining was 5 cases (22%) and negative in 18 cases (78%). There was significant difference of Caspase-3 immunoexpression between GCB and non-GCB subtype of DLBCL (p = 0,002).

Conclusion: The positivity of Caspase-3 expression was higher in GCB subtype than non-GCB subtype."