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"The Cambridge Workshops on Universal Access and Assistive Technology (CWUAAT) are a series of workshops held at a Cambridge University College every two years. The workshop theme: “Designing inclusion for real-world applications” refers to the emerging potential and relevance of the latest generations of inclusive design thinking, tools, techniques, and data, to mainstream project applications such as healthcare and the design of working environments. Inclusive Design research involves developing tools and guidance enabling product designers to design for the widest possible population, for a given range of capabilities. There are five main themes, designing for the real-world, measuring demand and capabilities, designing cognitive interaction with emerging technologies, design for inclusion, and designing inclusive architecture."

"The volumes present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.Volumes 1 and 2 are devoted to cell organization and fate, as well as activities that are autoregulated and/or controlled by the cell environment. Volume 1 examined cellular features that allow adaptation to environmental conditions. Volume 2 begins with a survey of the cell types of the nervous and endocrine systems involved in the regulation of the vasculature and respiratory tract and growth factors. It then describes major cell events in the circulatory and ventilatory systems, such as cell growth, proliferation, migration, and death. Circadian cycles that drive rhythmic gene transcription are also covered."

"The first volume is devoted to the interface between physiologic mechanisms and arising biosignals, whereas the second volume is focussed on the interface between biosignals and biomedical sensors. The physiologic mechanisms behind the biosignals are described from the basic cellular level up to their advanced mutual coordination level during sleep. The arising biosignals are discussed within the scope of vital physiologic phenomena to foster their understanding and comprehensive analysis."

"Dalam upaya menginduksi kekebalan berspektrum luas yang responsif terhadap subtipe-subtipe HIV-1 yang berbeda, telah diteliti imunisasi vaksin DNA menggunakan vektor plasmid DNA dan virus fowlpox rekombinan dengan memanfaatkan gen-gen HIV-1 yang dirancang dari runutan konsensus turunan subtipe-subtipe HIV-1 di dunia yang mengekspresikan semua protein dari genom HIV-1 dengan peptida berukuran 30 asam amino yang overlapping dan tersusun secara acak (scrambled antigen vaccines, atau SAVINE).Tiga grup hewan coba yang terdiri dari masing-masing tujuh beruk (Macaca nemestrina) diimunisasi dengan regimen vaksin DNA standar dengan veklor plasmid DNA pHIS-64 dan vektor virus fowlpox rekombinan (rFPV) berbasis gen gag dan pol dan HIV-1 subtipe B, regimen vaksin DNA SAVINE dengan vektor pHIS-64 dan vektor rFPV berbasis genom HIV-1 yang diacak, serta vektor plasmid pHIS-64 dan FPV yang tidak mengandung gen sebagai grup kontrol. Respon kebal selular diamati dengan teknik ELiSpot dan pewamaan silokin intraselular, sedangkan respon kebal humoral diamati dengan teknik ELISA. Pada ketujuh hewan coba yang diimunisasi dengan vaksin DNA HIV-1 standar, secara umum hasil penelitian menunjukkan terinduksinya respon kebal selular terhadap protein Gag HIV-1 serta respon kebal humoral yang ditunjukkan dengan terdeteksinya antibodi terhadap protein p24 HIV-1. Respon kebal selular silang terhadap protein Gag HIV-1 dari subtipe yang berbeda juga ditunjukkan pada grup yang sama. Namun upaya melakukan imunisasi boosting ke-dua dengan vektor rFPV tidak menunjukkan perbaikan induksi respon kebal. Berbeda dari grup hewan coba yang menerima regimen vaksin DNA HIV-1 standar, pada grup yang menerima regimen vaksin DNA HIV-1 SAVINE secara umum tidak menunjukkan adanya induksi respon kebal, kecuali pada satu ekor hewan yang menunjukkan respon kebal selular yang lebih luas terhadap protein Pol dan protein-protein lain HIV-1 meski pada tingkat induksi yang amat rendah. Pengembangan teknologi vaksin SAVINE terus diperbaiki dan disempumakan dengan kemungkinan melibatkan vektor virus aktif yang lain sehingga induksi respon kebal yang diharapkan bisa tercapai.Specific Immune Responses to the Human Immunodeficiency Virus Type-1 (HIV-1) Proteins In Pigtail Macaque (Macaca nemestrina) Immunized with Whole Gene and Whole Virus Scrambled Antigen Vaccines

T cell immunity plays a critical role in controlling HIV-1 viremia, and encoding a limited set of HIV-1 genes within DNA and poxvirus vectors can, when used sequentially, induce high levels of T cell immunity in primates. However, a limited breadth of T cell immunity exposes the host to potential infection with either genetically diverse HIV-1 strains or T cell escape variants of HIV-1. In an attempt to induce maximally broad immunity, we examined DNA (prime) and recombinant Fowlpox virus (rFPV, boost) vaccines encoding all HIV-1 genes derived from a global HIV-1 consensus sequence, but expressed as multiple overlapping scrambled 30 amino acid segments (scrambled antigen vaccines, or SAVINEs).

Three groups of 7 pigtail macaques (Macaca nemestrina) were immunized with sets of DNA and rFPV expressing Gag/Pol antigens only, the whole genome SAVINE antigens, or no HIV-1 antigens. T cell immunity was monitored by ELISpot and intracellular cytokine staining, while the humoral immune response was monitored by p24 antibody capture ELISA. High levels of cross-subtype HIV-specific T cell immunity to Gag were consistently induced in the 7 macaques primed with DNA and rFPV vaccines expressing Gag/Poi as intact proteins. The humoral immunity was also induced in the animals from the same group. It was however, difficult to repeatedly boost immunity with further rFPV immunizations, presumably reflecting high levels of anti-FPV immunity. Unfortunately, this vaccine study did not consistently achieve a broadened level of T cell immunity to multiple HIV genes utilizing the novel whole-virus SAVINE approach, with only one of 7 immunized animals generating broad T cell immunity to multiple HIV-1 proteins. Further refinements are planned with alternate vector strategies to evaluate the potential of the SAVINE technology."

"This book presents an approach to postmortem human identification using dental image processing based on dental features and characteristics, and provides information on various identification systems based on dental features using image processing operations. The book also provides information on a novel human identification approach that uses Infinite Symmetric Exponential Filter (ISEF) based edge detection and contouring algorithms."

"This book introduces advanced and hybrid compression techniques specifically used for medical images. The book discusses conventional compression and compressive sensing (CS) theory based approaches that are designed and implemented using various image transforms, such as: Discrete Fourier Transform (DFT), Discrete Cosine Transform (DCT), Discrete Wavelet Transform (DWT), and Singular Value Decomposition (SVD) and greedy based recovery algorithm. The authors show how these techniques provide simulation results of various compression techniques for different types of medical images, such as MRI, CT, US, and x-ray images. Future research directions are provided for medical imaging science. The book will be a welcomed reference for engineers, clinicians, and research students working with medical image compression in the biomedical imaging field. Covers various algorithms for data compression and medical image compression;Provides simulation results of compression algorithms for different types of medical images;Provides study of compressive sensing theory for compression of medical images."

"This book presents the overall vision and research outcomes of Nano-Tera.ch, which is a landmark Swiss federal program to advance engineering system and device technologies with applications to Health and the Environment, including smart Energy generation and consumption. The authors discuss this unprecedented nation-wide program, with a lifetime of almost 10 years and a public funding of more than 120 MCHF, which helped to position Switzerland at the forefront of the research on multi-scale engineering of complex systems and networks, and strongly impacted the Swiss landscape in Engineering Sciences. "

"​This book describes an ECG processing architecture that guides biomedical SoC developers, from theory to implementation and testing. The authors provide complete coverage of the digital circuit implementation of an ultra-low power biomedical SoC, comprised of a detailed description of an ECG processor implemented and fabricated on chip. Coverage also includes the challenges and tradeoffs of designing ECG processors.- Describes digital circuit architecture for implementing ECG processing algorithms on chip;- Includes coverage of signal processing techniques for ECG processing;- Features ultra-low power circuit design techniques;- Enables design of ECG processing architectures and their respective on-chip implementation."

"This book offers a mathematical update of the state of the art of the research in the field of mathematical and numerical models of the circulatory system. It is structured into different chapters, written by outstanding experts in the field. Many fundamental issues are considered, such as : the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls, and the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and efficient simulation techniques, and pay constant attention to applications of relevant clinical interest. "

"This book presents the fundamental physics of optical interferometry as applied to biophysical, biological and medical research. Interference is at the core of many types of optical detection and is a powerful probe of cellular and tissue structure in interfererence microscopy and in optical coherence tomography. It is also the root cause of speckle and other imaging artefacts that limit range and resolution. For biosensor applications, the inherent sensitivity of interferometry enables ultrasensitive detection of molecules in biological samples for medical diagnostics. In this book, emphasis is placed on the physics of light scattering, beginning with the molecular origins of refraction as light propagates through matter, and then treating the stochastic nature of random fields that ultimately dominate optical imaging in cells and tissue. The physics of partial coherence plays a central role in the text, with a focus on coherence detection techniques that allow information to be selectively detected out of incoherent and heterogeneous backgrounds.Optical Interferometry for Biology and Medicine is divided into four sections. The first covers fundamental principles, and the next three move up successive scales, beginning with molecular interferometry (biosensors), moving to cellular interferometry (microscopy), and ending with tissue interferometry (biomedical). "