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"This volume presents the proceedings of the Brazilian Congress on Biomedical Engineering (CBEB 2018). The conference was organised by the Brazilian Society on Biomedical Engineering (SBEB) and held in Armacao de Buzios, Rio de Janeiro, Brazil from 21-25 October, 2018.Topics of the proceedings include these 11 tracks:- Bioengineering- Biomaterials, Tissue Engineering and Artificial Organs- Biomechanics and Rehabilitation- Biomedical Devices and Instrumentation- Biomedical Robotics, Assistive Technologies and Health Informatics- Clinical Engineering and Health Technology Assessment- Metrology, Standardization, Testing and Quality in Health- Biomedical Signal and Image Processing- Neural Engineering- Special Topics- Systems and Technologies for Therapy and Diagnosis"

"This book gathers the best papers presented at the Fourth Italian National Conference on Sensors, held in Catania, Italy, from 21 to 23 February 2018. The book represents an invaluable and up-to-the-minute tool, providing an essential overview of recent findings, strategies and new directions in the area of sensor research. Further, it addresses various aspects based on the development of new chemical, physical or biological sensors, assembling and characterization, signal treatment and data handling. Lastly, the book applies electrochemical, optical and other detection strategies to relevant issues in the food and clinical environmental areas, as well as industry-oriented applications."

"These are the proceedings of the International Conference on ISMAC-CVB, held in Palladam, India, in May 2018. The book focuses on research to design new analysis paradigms and computational solutions for quantification of information provided by object recognition, scene understanding of computer vision and different algorithms like convolutional neural networks to allow computers to recognize and detect objects in images with unprecedented accuracy and to even understand the relationships between them.The proceedings treat the convergence of ISMAC in Computational Vision and Bioengineering technology and includes ideas and techniques like 3D sensing, human visual perception, scene understanding, human motion detection and analysis, visualization and graphical data presentation and a very wide range of sensor modalities in terms of surveillance, wearable applications, home automation etc.ISMAC-CVB is a forum for leading academic scientists, researchers and research scholars to exchange and share their experiences and research results about all aspects of computational vision and bioengineering."

"These are the proceedings of the International Conference on ISMAC-CVB, held in Palladam, India, in May 2018. The book focuses on research to design new analysis paradigms and computational solutions for quantification of information provided by object recognition, scene understanding of computer vision and different algorithms like convolutional neural networks to allow computers to recognize and detect objects in images with unprecedented accuracy and to even understand the relationships between them.The proceedings treat the convergence of ISMAC in Computational Vision and Bioengineering technology and includes ideas and techniques like 3D sensing, human visual perception, scene understanding, human motion detection and analysis, visualization and graphical data presentation and a very wide range of sensor modalities in terms of surveillance, wearable applications, home automation etc.ISMAC-CVB is a forum for leading academic scientists, researchers and research scholars to exchange and share their experiences and research results about all aspects of computational vision and bioengineering."

"Additive Manufacturing (AM) adalah kumpulan teknologi untuk fabrikasi komponen 3D dari sebuah model CAD dengan cara layar per layar. AM memiliki kelebihan seperti menghemat biaya material, waktu fabrikasi yang relatif cepat serta kemampuan untuk fabrikasi struktur rumit. Kelebihan – kelebihan tersebut menjadi AM sangat populer diaplikasikan pada area biomedical terutama bone grafting, scaffolding atau area trauma maxillofacial. Oleh karena itu, studi ini dilakukan untuk menelusuri lebih lanjut mengenai perancangan mesin 3d printer keramik dengan basis plunger type extrusion additive manufacturing serta pengaruh – pengaruh dari variasi parameter cetak guna menghasilkan cara untuk memproduksi biomedical implant basis keramik yang affordable dan sesuai spesifikasi yang didesain. Variasi terhadap nilai parameter cetak meliputi diameter nozzle dari ukuran 1.5 mm, 2 mm, 2.5 mm dan 3 mm, kecepatan cetak 5 mm/s, 10 mm/s, 15 mm/s, dan 20 mm/s serta extrusion flow rate 10 mm3/s, 15 mm3/s, 20 mm3/s, 25 mm3/s. Dari hasil penelitian lebih lanjut, penulis menemukan bahwa nilai optimal dari variasi parameter cetak yang menghasilkan spesimen terakurat dan presisi terhadap desain CAD semula adalah diameter nozzle 2.5 mm, kecepatan cetak 20 mm/s dan extrusion flow rate 25 mm3/s. Selain dari itu, melalui uji ANOVA, penulis juga menemukan bahwa extrusion flow rate memiliki pengaruh paling signifikan terhadap kualitas hasil cetak

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AM is a collection of technologies for fabricating 3D components from a screen-by-screen CAD model. AM has advantages such as saving material costs, relatively fast fabrication time, and the ability to fabricate complex structures. These advantages make AM very popular to be applied in biomedical areas, especially bone grafting, scaffolding, or areas of maxillofacial trauma. Therefore, this study was conducted to explore further the design of a ceramic 3d printer machine with a plunger-type extrusion additive manufacturing base and the effects of variations in printing parameters to generate a way to produce affordable ceramic-based biomedical implants according to the designed specifications. Variations in printing parameter values ​​include nozzle diameters of 1.5 mm, 2 mm, 2.5 mm, and 3 mm, print speeds of 5 mm/s, 10 mm/s, 15 mm/s, and 20 mm/s as well as an extrusion flow rate of 10 mm3 /s, 15 mm3/s, 20 mm3/s, 25 mm3/s. From the results of further research, the authors found that the optimal value of the variation of printing parameters that produce accurate and precise specimens against the original CAD design is a nozzle diameter of 2.5 mm, a print speed of 20 mm/s, and an extrusion flow rate of 25 mm3/s. Apart from that, the ANOVA test also found that the extrusion flow rate had the most significant effect on the quality of the printouts."

"This volume is the third in a textbook series and covers both the basics of continuum mechanics of biosolids and biofluids and the theoretical core of computational methods for continuum mechanics analyses. Several biomechanics problems are provided for better understanding of computational modeling and analysis. Topics include the mechanics of solid and fluid bodies, fundamental characteristics of biosolids and biofluids, computational methods in biomechanics analysis/simulation, practical problems in orthopedic biomechanics, dental biomechanics, ophthalmic biomechanics, cardiovascular biomechanics, hemodynamics, cell mechanics, and model, rule, and image-based methods in computational biomechanics analysis and simulation. "

"This book is an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine. Computational biomechanics for medicine : deformation and flow collects the papers from the Medical Image Computing and Computer Assisted Intervention conference (MICCAI 2011) dedicated to research in the field of medical image computing and computer assisted medical interventions. The topics covered include, medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, and medical robotics."

"Dalam upaya menginduksi kekebalan berspektrum luas yang responsif terhadap subtipe-subtipe HIV-1 yang berbeda, telah diteliti imunisasi vaksin DNA menggunakan vektor plasmid DNA dan virus fowlpox rekombinan dengan memanfaatkan gen-gen HIV-1 yang dirancang dari runutan konsensus turunan subtipe-subtipe HIV-1 di dunia yang mengekspresikan semua protein dari genom HIV-1 dengan peptida berukuran 30 asam amino yang overlapping dan tersusun secara acak (scrambled antigen vaccines, atau SAVINE).Tiga grup hewan coba yang terdiri dari masing-masing tujuh beruk (Macaca nemestrina) diimunisasi dengan regimen vaksin DNA standar dengan veklor plasmid DNA pHIS-64 dan vektor virus fowlpox rekombinan (rFPV) berbasis gen gag dan pol dan HIV-1 subtipe B, regimen vaksin DNA SAVINE dengan vektor pHIS-64 dan vektor rFPV berbasis genom HIV-1 yang diacak, serta vektor plasmid pHIS-64 dan FPV yang tidak mengandung gen sebagai grup kontrol. Respon kebal selular diamati dengan teknik ELiSpot dan pewamaan silokin intraselular, sedangkan respon kebal humoral diamati dengan teknik ELISA. Pada ketujuh hewan coba yang diimunisasi dengan vaksin DNA HIV-1 standar, secara umum hasil penelitian menunjukkan terinduksinya respon kebal selular terhadap protein Gag HIV-1 serta respon kebal humoral yang ditunjukkan dengan terdeteksinya antibodi terhadap protein p24 HIV-1. Respon kebal selular silang terhadap protein Gag HIV-1 dari subtipe yang berbeda juga ditunjukkan pada grup yang sama. Namun upaya melakukan imunisasi boosting ke-dua dengan vektor rFPV tidak menunjukkan perbaikan induksi respon kebal. Berbeda dari grup hewan coba yang menerima regimen vaksin DNA HIV-1 standar, pada grup yang menerima regimen vaksin DNA HIV-1 SAVINE secara umum tidak menunjukkan adanya induksi respon kebal, kecuali pada satu ekor hewan yang menunjukkan respon kebal selular yang lebih luas terhadap protein Pol dan protein-protein lain HIV-1 meski pada tingkat induksi yang amat rendah. Pengembangan teknologi vaksin SAVINE terus diperbaiki dan disempumakan dengan kemungkinan melibatkan vektor virus aktif yang lain sehingga induksi respon kebal yang diharapkan bisa tercapai.

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T cell immunity plays a critical role in controlling HIV-1 viremia, and encoding a limited set of HIV-1 genes within DNA and poxvirus vectors can, when used sequentially, induce high levels of T cell immunity in primates. However, a limited breadth of T cell immunity exposes the host to potential infection with either genetically diverse HIV-1 strains or T cell escape variants of HIV-1. In an attempt to induce maximally broad immunity, we examined DNA (prime) and recombinant Fowlpox virus (rFPV, boost) vaccines encoding all HIV-1 genes derived from a global HIV-1 consensus sequence, but expressed as multiple overlapping scrambled 30 amino acid segments (scrambled antigen vaccines, or SAVINEs).Three groups of 7 pigtail macaques (Macaca nemestrina) were immunized with sets of DNA and rFPV expressing Gag/Pol antigens only, the whole genome SAVINE antigens, or no HIV-1 antigens. T cell immunity was monitored by ELISpot and intracellular cytokine staining, while the humoral immune response was monitored by p24 antibody capture ELISA. High levels of cross-subtype HIV-specific T cell immunity to Gag were consistently induced in the 7 macaques primed with DNA and rFPV vaccines expressing Gag/Poi as intact proteins. The humoral immunity was also induced in the animals from the same group. It was however, difficult to repeatedly boost immunity with further rFPV immunizations, presumably reflecting high levels of anti-FPV immunity. Unfortunately, this vaccine study did not consistently achieve a broadened level of T cell immunity to multiple HIV genes utilizing the novel whole-virus SAVINE approach, with only one of 7 immunized animals generating broad T cell immunity to multiple HIV-1 proteins. Further refinements are planned with alternate vector strategies to evaluate the potential of the SAVINE technology."

"This book provides a comprehensive guide to the state-of-the-art in cardiovascular computing and highlights novel directions and challenges in this constantly evolving multidisciplinary field. The topics covered span a wide range of methods and clinical applications of cardiovascular computing, including advanced technologies for the acquisition and analysis of signals and images, cardiovascular informatics, and mathematical and computational modeling."

"This Briefs Series book illustrates in depth a concept of healthcare management engineering and its domain for hospital and clinic operations. Predictive and analytic decision-making power of management engineering methodology is systematically compared to traditional management reasoning by applying both side by side to analyze 26 concrete operational management problems adapted from hospital and clinic practice. The problem types include, clinic, bed and operating rooms capacity, patient flow, staffing and scheduling, resource allocation and optimization, forecasting of patient volumes and seasonal variability, business intelligence and data mining, and game theory application for allocating cost savings between cooperating providers."