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"Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. This book addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice"

"Penelitian ini bertujuan untuk menentukan clinical pathway dan biaya perawatan odontectomy M3 impaksi tanpa penyakit penyerta di RS Islam Jakarta Cempaka Putih pada tahun 2009, dengan melakukan riset operasional secara kualitatif dan kuantitatif dengan rancangan retrospective. Terdapat 72 sampel yang memenuhi kriteria inklusi dan eksklusi. Data yang diolah adalah data morbiditas tahun 2008- 2009 dan data keuangan tahun 2009. Biaya odontectomy M3 impaksi tanpa penyakit penyerta dihitung dengan metode ABC (Activity Based Costing) dengan struktur biaya investasi, operasional, pemeliharaan dan biaya tidak langsung. Berdasarkan clinical pathway, biaya odontectomy M3 impaksi tanpa penyakit penyerta adalah Rp. 1.057.163,- (mesio angular), Rp. 1.241.810,- (horizontal), Rp. 1.445.210,- (terpendam) untuk odontectomy anesthesi lokal rawat jalan dan Rp. 6.540.846,- untuk odontectomy anesthesi umum one day care. Sedangkan CRR (Cost Revenue Rate) masing-masing adalah 72 % (mesio angular), 72 % (horizontal), 77 % (terpendam) dan 65 % (odontectomy anestesi umum-one day care).

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This research is aimed to obtain clinical pathway and cost of treatment third-molar impaction odontectomy at RS Islam Jakarta Cempaka Putih in 2009, by doing operational research qualitatively and quantitatively, using retrospective methode. There are 72 samples which comply with included and excluded criteria. Data that used in this research are morbidity data in 2008-2009 and financial data in 2009.

The cost is accounted by ABC (Activity Based Costing) method, which the cost structures are investation, operational, maintainance and indirect cost. Based on clinical pathway at RS Islam Jakarta Cempaka Putih, costs of treatment third molar impaction odontectomy are Rp. 1.057.163,- (mesio angular), Rp. 1.241.810,- (horizontal), Rp. 1.445.210,- (embedeed) for local anesthesiaambulatory treatment and Rp. 6.540.846,- for general anesthesia- one day care treatment. In addition, CRR (Cost Revenue Rate) of each treatment are 72 % (mesio angular), 72 % (horizontal), 77 % (embedded) dan 65 % (odontectomy anestesi umum-one day care)."