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Ditemukan 48 dokumen yang sesuai dengan query
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Chang, David W.
New York: Thomson/Delmar Learning, 2006
615.836 2 CHA i
Buku Teks SO  Universitas Indonesia Library
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Sri Widia Jusman
"Adaptation mechanism to hypoxia in living organisms increases reactive oxygen species (ROS) formation that could exceed the capacity of anti oxidant. Gluthatione (GSH) in which highest concentration present in liver, plays an important role in maintaining the intracellular redox equilibrium and protect tissues from oxidative stress. The aim of this study was to observe tissue response of rat that was exposed to chronic systemic hypoxia by analyzing the oxidative stress in liver tissue. Twenty male Sprague-Dawley rats were induced by chronic systemic hypoxia by kept them in hypoxic chamber (10% O2:90% N2) for 1, 3, 7 and 14 day(s). All rats were sacrificed with ether anesthesia after hypoxia treatment. Liver tissues were analyzed using parameters of oxidative stress, malondialdehyde (MDA) with tBARS test, and endogenous antioxidant, glutathione reduced form (GSH). The study showed that chronic systemic hypoxia induction caused oxidative stress in liver tissue, which was shown by increased concentration of MDA in liver tissue (nmol/mg liver tissue). Concentration of MDA in liver tissue was increased significantly on day-1, day-3, day-7 and day-14 compared to control group (ANOVA, LSD, p<0.05). The differences between day-3, day-7 and day-14 was not significant. In contrast, liver GSH content (μg/mg liver protein) was progressively decreased significantly since day-1 of hypoxia until the end of experiment (ANOVA, LSD, p<0.05). Statistical analysis revealed that there is a strong correlation between MDA and GSH concentration in liver tissue (Pearson = - 0.993). It was concluded that oxidative stress present in liver tissue of rat induced by chronic systemic hypoxia."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2009
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Artikel Jurnal  Universitas Indonesia Library
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Budiaman
"Respiration illness has some different symptoms basically is caused of
irritation, failure of transparent muccociliari, more rekresi lender and respiration
stricture. Children under tive years old at Primary Heath Care of Pangkalan Kerinci
in Pelalawan District risk of respiration problem and based on result of annual report
at Primary Health Care, respiration trouble illness is the tirst of ten illnesses at this
area. lt is because of most public spend 90 % their time in room (house). Therefore
research is pointed by the way of looking for relationship between PMN rate at
house, house physical environment factor and children under tive years old
characteristic which related to respiration problem occurrence becoming a reason.
WHO estimated that there were 400-500 millions people who faced air pollution
problem of variation room including headache, head cold, drought red lane, drought
coughs, eye irritation, skin irritation, influenza, breathless and tuberculosis.
This research purpose to know prevalence between respiration problem illness
among children under tive years old, relationship of PMN rate at house, house
physical environment factor (10 variables) and children under tive years old
characteristic (5 variables) with respiration problem illness occurrence among
children under tive years old, and looking for factor which is most dominance effect
of respiration problem illness among children under tive years old at Primary Health
Care of Pangkalan Kerinci, Pelalawan District in Riau Province, time period of Measurement appliance which is used to measure PM", rate at house consists of
Haz Dust Sampler, EPAM S000 model, temperature by thennometer, dampness by
hygrometer, illumination by luxmeter, and appliance which is used to get primary
data of children under tive years old characteristic by questionnaire and checklist.
'l`his research used a cross sectional design which participating population of
615 Head of Family (KK) by sample number of 261 children under five years old,
where data was collected at the same time of PMN, rate, house physic environment
and children under five years old characteristic and there were not respiration
problem illness occurrence among children under five years old.
Based on research result which has been done it was indicated that: l).
Prevalence of children under tive years old who faced of respiration problem illness
was 78,2 % _ 2). Children under five years old house with PMN rate which did not
fulfill requirement was 55,6 %, 3). There is no meaning ditference of PM", rate at
house (p value = 0,393) with respiration problem among children under tive years
old. 4). Habit of children under tive years old out of house has a meaning difference
of respiration problem illness occurrence among children under tive years old by p-
value = 0,007 and OR = 2,59 (95 % CI: 1,333-5,083). Children under ive years old
who are out of house have risk of respiration problem illness 2,59 times compared
with children under tive years old are out of house for long time. 5). Factor which is
most dominance influencing respiration problem iilness occurrence among children
under five years old are usage of fuel for cooking and children under tive years old
who are out of house. Children under tive years old who are out of house have risk of
respiration problem illness 2,59 times compared with children under five years old
who are at house for long time, and also usage of fuel for cooking which became
smoke has risk 2,32 times of reqriration problem illness compared with usage of Riel
for cooking which did not become smoke (gas and electricity). 6). Probability of
respiration problem illness occurrence among children under tive years old where
they used fuel which will become smoke at their house and children under five years
oId who have habit out of house 83,5 %. 7). Children under five years old who used
fuel for cooking which became smoke (wood, charcoal and kerosene) and many
activities of children under tive years old out of house have probabiiity of respiration
problem illness occurrence 1,5 times bigger than children under five years old which used fuel for cooking which did not become smoke (gas and electrics) and many
activities of children under five years old out of house."
Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2008
T34306
UI - Tesis Open  Universitas Indonesia Library
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Orpa Diana Suek
"Permasalahan yang sering muncul dalam merawat klien dengan ventilasi mekanik di PICU adalah masalah keperawatan ketidakefektifan bersihan jalan napas. Salah satu teori keperawatan yang dapat diaplikasikan di ruang perawatan intensif adalah Model Konservasi Myra E. Levine yang mempunyai 3 konsep dasar yaitu konservasi, adaptasi dan keutuhan (wholeness). Tahapan proses keperawatan yang dilakukan adalah melakukan pengkajian, merumuskan trophicognosis dan hypothesis yang tepat, mengimplementasikan rencana dan melakukan evaluasi terhadap setiap respon organismik klien yang bertujuan untuk membantu klien beradaptasi selama dalam perawatan dan mencapai wholeness sebagai seorang individu yang unik. Intervensi yang dapat dilaksanakan untuk mempertahankan bersihan jalan napas yang efektif, antara lain fisioterapi dada, penghisapan lendir, humidifikasi, inhalasi, dan mobilisasi. Peran Ners Spesialis Keperawatan Anak selama merawat anak dengan ventilasi mekanik adalah sebagai praktisi, pendidik, advokat dan peneliti. Ners Spesialis Keperawatan Anak diharapkan terus mengembangkan ilmu pengetahuan dan teknologi dibidang keperawatan untuk meningkatkan kualitas asuhan keperawatan pada klien dan keluarga.

Nursing problem that often arises in caring of pediatric patient with mechanical ventilation at PICU is ineffectiveness of airway clearance. One of the nursing theories that can be applied in intensive care unit is Myra E. Levine Conservation Model which has 3 basic concepts. Those concepts are conservation, adaptation and wholeness. Stages of the nursing process are assesment, formulate appropriate trophicognosis and hypothesis, implementing the intervention and evaluating every client organismic response that is aimed to help clients adapting during the treatment and achieving wholeness as a unique individual. Interventions that can be implemented to maintain an effective airway clearance are chest physiotherapy, mucus suction, humidification, inhalation, and mobilization. The Role of Ners Specialist of Pediatric Nursing for caring of a pediatric patient with mechanical ventilation is as practitioner, educator, advocate and researcher. Ners specialist of pediatric nursing are expected to continue develop knowledge and technology in the field of nursing to improve the quality of nursing care to clients and families."
Depok: Fakultas Ilmu Keperawatan Universitas Indonesia, 2013
SP-Pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Nurul Fajriyah
"PM2,5 atau partikulat halus adalah partikulat dengan diameter kurang dari 2,5 μm dan salah satu sumber utamanya adalah emisi gas buang dari kendaraan. Sifat dari partikulat ini dapat masuk ke alveolus dan terdifusi ke pembuluh darah kemudian dapat menyebabkan inflamasi pada sel dan mengganggu kadar normal dari beberapa biokimia tubuh yang terkandung dalam darah, seperti glukosa, insulin, hs-CRP dan biomarker pendukung berupa MDA serta TNF-α.
Tujuan penelitian ini adalah mengetahui perbedaan antara kelompok terpajan dan tidak terpajan PM2,5 dengan keluhan gangguan pernapasan serta kadar glukosa, insulin, hs-CRP, MDA serta TNF-α. Penelitian ini bersifat deskriptif analitik dengan desain studi cross sectional. Sampel yang digunakan adalah petugas kebersihan Jalana Raya Jenderal Sudirman sebagai kelompok terpajan PM2,5 dan petugas kebersihan FKM UI sebagai kelompok tidak terpajan PM2,5. Dilakukan pengukuran konsentrasi PM2,5 secara personal sampling, kuesioner dan tes darah sampel oleh laboratorium.
Uji statistic yang digunakan, yaitu uji kai kuadrat dan uji t. Dari hasil penelitian didapatkan perbedaan antara glukosa (p=0,025), insulin (p=0,001), MDA (p=0,006) dan TNF-α (p=0,039) pada petugas kebersihan jalan raya dan petugas kebersihan FKM UI. Tidak terdapat perbedaan antara keluhan pernapasan (p=0,156) dan hs-CRP (p=0,169) petugas kebersihan jalan raya dan petugas kebersihan FKM UI.

PM2,5 or fine particles are particles with diameter less than 2,5 μm and one of the source is gas emission from vehicles. The character of these particles can enter until in alveoli and diffuse into artery and causing cell inflammation and distract the normal biochemistry blood like amount of glucose, insulin and hs-CRP also using support biomarker MDA and TNF-α. The aim of this research is to know the differentiation between exposure group and un-exposure group of PM2,5 with respiration symptoms, glucose, insulin, hs-CRP, MDA and TNF-α in cleaning service at highway.
This research is analytic descriptive with cross sectional design study. The samples are cleaning service at highway as exposure group and cleaning service at FKM UI as unexposure group. Personal sampling is used to measuring the particles, questionnair and sample blood tested by laboratorium.
This research used statistical chi square test and t test. Based on research, I found a differentiation in glucose (p=0,025), insulin (p=0,001), MDA (p=0,006) and TNF-α (p=0,039) in exposure group and un-exposure group. I did not found a differentiation in respiration symptoms (p=0,156) and hs-CRP (p=0,169) in exposure group and un-exposure group.
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Depok: Fakultas Kesehatan Masyarakat Universitas Indonesia, 2014
S54458
UI - Skripsi Membership  Universitas Indonesia Library
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Vania Tryanni
"Gangguan respirasi merupakan masalah kesehatan yang perlu menjadi perhatian. Selain angka mortalitas yang tinggi, gangguan ini juga menunjukkan angka morbiditas yang tinggi. Rumah susun sendiri merupakan salah satu alternatif tempat tinggal untuk kota padat seperti Jakarta. Tujuan dari penelitian ini adalah untuk mengetahui prevalensi gangguan respirasi dengan perilaku warga rumah susun di wilayah rumah susun Jakarta. Selain itu diliat juga faktor yang mempengaruhi perilaku seseorang, dengan demikian dapat diketahui cara modifikasi perilaku paling efektif.
Metode: Metode yang digunakkan dalam penelitian ini adalah cross-sectional dimana pengumpulan data dilakukan dengan pengisian kuesioner dan pengukuran keadaan lingkungan. Penelitian ini melibatkan 120 keluarga yang tinggal di daerah rumah susun di Jakarta.
Hasil: Dari 513 penghuni rumah susun didapatkan prevalensi gangguan respirasinya adalah 44.2%. Dimana gangguan yang paling sering dialami adalah gangguan saluran nafas atas termasuk ISPA, rhinitis,sinusitis, faringitis mencapai 32.9%. Setelah itu disusul oleh TBC (7.6%) , PPOK (1.8%) dan asma (1%). Keluhan yang paling sering dialami diluar batuk adalah sesak nafas yang mencapai 4.1% . Dari hasil analisis didapatkan tidak ada hubungan yang bermakna antara gangguan respirasi baik. Analisis juga menunjukkan tidak terdapat hubungan antara perilaku seseorang dengan jenis kelamin, pekerjaan serta pendidikan.
Diskusi: Perilaku dan indikator tidak menunjukkan hal yang bermakna mungkin dikarenakan analisis ini menilai hubungan perilaku respondent dan gangguan respirasi pada keluarga, padahal belum tentu semua anggota keluarga memiliki perilaku yang sama. Hal ini akhirnya kurang menggambarkan hubungan perilaku seseorang dengan gangguan respirasi yang dialaminya.

Respiratory disorder is a health problem that needs our attention. In addition to the high mortality rate, this disorder also show high morbidity number. The purpose of this study is to determine the prevalence of respiratory disorder and its relationship with human behavior in residents of flat in Jakarta. Other than that this study also looked for factor that influence a person?s behavior, thus it can be seen most efficient way to modify behavior.
Method:This study methodology is cross sectional. The data is obtanaid by quostionare filling and measurement for some indicator. This study involved 120 family that live in flats in Jakarta.
Results: Of 513 residents of the apartement the prevalence of respiratory disorder was 44.2%. Where the most often experienced disorder is upper respiratory illness, includeig upper respiratory infections, rhinitis, sinusitis, phrayngitis wich reach 32.9%. Follow by lung tuberculosis (7.6%), COPD (1.8%), and asthma (1%). The most experienced symptoms is shortness of breath (4.1%) beyond cough. From the analysis found no significant relationship between repiratory disorder and overall behavior. The analysis also showed there was no correlation between the behavior of a person with gender, occupation and education.
Discussion: Overall behavioral and each indicators do not show significant correlation may caused by this analysis assessing the relationship of respondent behavior and respiration disoreder in the family, though not necessarily all members of the family have the same behavior. It is less describes the relationship between human behavior and respiratory disorder they going through."
Depok: Universitas Indonesia, 2013
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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Beevers, Harry
New York: Harper & Row, 1961
581.12 BEE r
Buku Teks  Universitas Indonesia Library
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Iqbal Farhan Elfajri
"Penentuan kadar glukosa secara elektrokimia menggunakan oksida logam sebagai pengganti enzim mulai dikembangkan beberapa tahun terakhir. Pada penelitian ini, oksida tembaga digunakan sebagai sensor glukosa non-enzimatik dengan mengoksidasi glukosa menjadi glukonolakton. Oksida tembaga diperoleh dengan elektrodeposisi larutan CuSO4 0,1 M dalam H2SO4 0,1 M pada elektroda kerja karbon pasta dengan variasi waktu dan potensial deposisi untuk menperoleh kondisi deposit Cu yang optimum. Untuk mendeteksi glukosa, deposit Cu digunakan sebagai elektroda kerja dengan metode siklik voltametri dalam larutan NaOH 1 M. Deposit Cu yang dielektrodeposisi pada potensial -0,366 V selama 120 detik merupakan kondisi optimum untuk pendeteksian glukosa karena mempunyai sensitivitas yang tertinggi sebesar 1183,5996 μA mM-1 cm-2, batas deteksi paling rendah sebesar 0,6728 mM, dan nilai linearitas paling baik r2 = 0,9988 pada rentang konsentrasi 1,664 ? 62,5 mM. Sensor ini mempunyai repeatabilitas yang baik dengan %RSD = 1,32 % (n=10), stabil dalam waktu pengujian selama 5 hari dengan %RSD = 1,51 % (n=5), dan sangat selektif terhadap glukosa dari zat pengganggu seperti asam askorbat, asam urat, sukrosa dan fruktosa. Sensor dengan oksida tembaga ini dibandingkan dengan sensor non-enzimatik pada pengujian kadar glukosa dalam darah dan menunjukkan perbedaan hasil sebesar 21,45 %.

The electrochemical determination of glucose concentration using metal oxide as a substitute of enzyme is being developed in recent years. In this research, copper oxide is used as a non-enzymatic glucose sensor by oxidating glucose to gluconolactone. Copper oxide was obtained by electrodeposition using CuSO4 0,1 M in H2SO4 0,1 M solution at carbon paste electrode with the variation of potensial and time of deposition to show the optimum condition of copper deposit. For detecting glucose, Copper deposit was used as working electrode by voltammetry cyclic method in NaOH 1 M solution. Copper deposit which was deposited in -0,366 V potential for two minutes was the optimum condition because of the highest sensitivity 1183,5996 μA mM-1 cm-2 , the lowest limit of detection 0,6728 mM, and the best linearity r2 = 0,9988 in concentration range 1,664 -62,5 mM. This sensor exhibited a good repeatability with %RSD = 1,32 % (n=10), showed high stability in five consecutive days of detection with %RSD = 1,51 % (n=5), and had a good selectivity of glucose in the presence of interfering spesies such as ascorbic acid, uric acid, fructose, and sucrose. This copper oxide-based glucose sensor was compared by enzymatic glucose sensor in blood-sugar detection and exhibited % relative error = 21,45 %."
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2015
S60940
UI - Skripsi Membership  Universitas Indonesia Library
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Yuni Shahroh
"ABSTRAK
Salah satu upaya dalam mencegah terjadinya komplikasi infeksi di intensive care unit dengan memonitoring pH cairan lambung khususnya pada pasien terpasang ventilasi mekanik. Penelitian ini bertujuan mengidentifikasi perbedaan pemberian nutrisi enteral metode intermittent dan bolus feeding terhadap pH cairan lambung pasien dengan ventilasi mekanik. Penelitian ini menggunakan desain quasi experiment pada 30 responden. Kelompok pertama (15 responden) mendapatkan intervensi intermittent feeding dan kelompok kedua (15 responden) mendapatkan intervensi bolus feeding. Uji perbedaan hasil menggunakan chi-square, pooled t test dan paired t test. Hasil penelitian (between groups) menunjukkan adanya perbedaan pH cairan lambung yang bermakna pada kelompok yang mendapatkan terapi nutrisi enteral metode intermittent dan bolus feeding pada pasien dengan ventilasi mekanik (p < 0,05). Penelitian merekomendasi perawat untuk dapat melakukan tindakan pemberian nutrisi enteral dengan metode yang tepat dan berupaya menerapkan tindakan pencegahan terhadap komplikasi lebih lanjut akibat pemberian nutrisi enteral sehingga akan memperbaiki sistem layanan asuhan keperawatan.

ABSTRACT
One of the most common strategy to prevent infection complications in intensive care unit by monitoring pH gastric especially to patients with mechanical ventilation. The purpose of this study is to identify the difference intermittent and bolus feeding to pH gastric in patients with mechanical ventilation. The study design quacy experiment with sample of 30 respondents. First group (15 respondents) getting intermittent feeding and second group (15 respondents) getting bolus feeding. Data were analyzed using chi-square, pooled t test and paired t test. The results showed that there is a significant different of pH gastric between intermittent feeding and bolus feeding in patient with mechanical ventilation (p <0.05). Further study recommends nurses to provision enteral nutrition with right method and sought to apply complication preventive by the result of enteral nutrition."
2016
T46064
UI - Tesis Membership  Universitas Indonesia Library
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Rendy
"ABSTRAK
Residu unit pengolahan instalasi perlu diolah untuk dapat dilakukan pemanfaatan atau pembuangan secara langsung yang sudah aman. Kondisi residu/lumpur yang stabil mutlak diperlukan untuk menjamin tidak terjadi kontaminasi lingkungan. Metode dalam mengukur kestabilan yang dapat digunakan adalah pengukuran nilai indeks respirometri, baik secara statis (SRI) maupun dinamis (DRI). Indikator stabilitas respirometri mengukur oksigen yang diperlukan dalam mengurai bahan organik biodegradable. Tujuan penelitian ini adalah mengindentifikasi karakterististik dan menganalisis kestabilan sampel lumur dari beberapa instalasi pengolahan, pengolahan bahan organik, dan limbah industri berdasarkan pendekatan kadar air, volatile solids, rasio C/N, nilai SRI dan DRI serta rekomendasi pengolahan lanjutan lumpur yang tidak stabil. Hasil pengujian menunjukkan sampel IPAL Muara Baru dan IPAL PT Toyota memiliki salah satu nilai SRI tertinggi, yaitu 76,621 mgO2g-1OM-1h-1 dan 16,332 mgO2g-1OM-1h-1. Pengolahan lanjutan menggunakan pengomposan keranjang Takakura selama 14 hari dengan bulking agent cangkang kelapa. Hasil akhir pengomposan menunjukkan adanya penurunan nilai SRI dan DRI pada sampel lumpur IPAL Muara Baru dan IPAL PT Toyota dengan persentase pengurangan lebih dari 95%.

ABSTRACT
The residue of the installation processing unit needs to be processed in order to be able to directly utilize or dispose of it safely. Stable residual/sludge condition are absolutely necessary to ensure no environmental contamination occurs. The mthod of measuring stability that can be used is the measurement of respirometry index value, both statilyc (SRI) and dynamicly (DRI). The stability indicators of resprometry measure the oxygen needed in breaking down biodegradable organic matters. The purpose of this study is to identify the characteristics and analyze the stability sample of sludge/digestat from several processing plant, processing organic matter, and instrial waste based on water content approach, volatile solids, C/N ratio, SRI and DRI values and recommendations for continued processing of unstable sludge/mud/digestat. The test result showed samples of Muara Baru WWTP and PT Toyota WWTP had one of the highes SRI values, namely 76,621 mgO2g-1OM-1h-1 and 16,332 mgO2g-1OM-1h-1. Further processing uses composting of Takakura baskets for 14 days with coconut shell bulking agents. The final result of composting showed a descrease in the value of SRI and DRI in Muara Baru WWTP and PT Toyota WTP with a percentage reduction of more than 95%."
2019
S-Pdf
UI - Skripsi Membership  Universitas Indonesia Library
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