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"ABSTRAK Penggunaan transportasi tabung pneumatik di laboratorium berpotensi mengakibatkan kerusakan sel darah dan mempengaruhi hasil pemeriksaan Penelitian ini bertujuan mendapatkan data perbedaan hasil pemeriksaan jumlah eritrosit leukosit trombosit LDH kalium dan indeks hemolisis antara darah yang ditransportasi kurir dan tabung pneumatik Desain penelitian potong lintang dengan 58 subjek menggunakan darah K3EDTA berpasangan dan darah beku berpasangan Pada penelitian ini tidak ada perbedaan statistik pada jumlah eritrosit leukosit trombosit dan kalium antara kedua cara transportasi Terdapat peningkatan LDH dan indeks hemolisis yang bermakna secara statistik pada darah yang ditransportasi tabung pneumatik Peningkatan LDH melebihi batas ketelitian laboratorium tetapi tidak bermakna secara klinis ABSTRACT The use of pneumatic tube system has a possibility to induce damage on blood cells and affects laboratory result This study aim to obtain the difference between the result of erythrocyte leukocyte thrombocyte LDH kalium and hemolysis index in blood transported by courier and by pneumatic tube system The method used was a cross sectional study with 58 voluntary subjects using paired K3EDTA blood and paired coagulated blood There was no significant statistical difference between erythrocyte leukocyte thrombocyte count and kalium in blood transported by courier and by pneumatic tube system There was an increased in LDH and hemolysis index in blood transported by pneumatic tube The increase of LDH caused by pneumatic tube was higher than laboratory precision limit but not clinically significant "

"Latar Belakang: Skizofrenia adalah salah satu gangguan jiwa berat, Skizofrenia diderita oleh 21 juta orang di dunia. Anggota Rumah Tangga (ART) di Indonesia yang menderita Skizofrenia/ psikosis 6,7 per mil pada 2018. Cakupan pengobatan penderita Skizofrenia atau psikosis yang berobat ke RS Jiwa/fasilitas layanan kesehatan/Tenaga Kesehatan adalah pernah/seumur hidup (85%) dan yang minum obat rutin 1 bulan terakhir (48,9%). Sekalipun prevalensinyaya kecil namun dampaknya sangat besar biaya finansial Skizofrenia di Amerika Serikat diperkirakan melampaui biaya semua kanker bila digabungkan, karena Skizofrenia bermula pada awal kehidupan, menyebabkan hendaya/ketidakmampuan yang signifikan dan bertahan lama, membuat tuntutan perawatan rumah sakit yang berat, membutuhkan perawatan rawat jalan, rehabilitasi, dan layanan dukungan terus-menerus. Tujuan dari penelitian ini adalah diketahuinya determinan kepatuhan minum obat pada penderita Skizofrenia di Poli Rawat Jalan RSJ Daerah Propinsi Lampung tahun 2019.Metode: Penelitian Kuantitatif dengan desain Cross Sectional, sampel 192 responden diolah dengan chi square dan regresi logistik.Hasil: Sebagian dari penderita yang menjadi responden patuh minum obat (51,0%), berumur dewasa >30 tahun (70,3%), berpenghasilan dibawah UMP Lampung (82,3%), tingkat pendidikan dasar (46,9%), akses ke RSJ terjangkau (73,4%), persepsi dukungan keluarga sangat kuat (50,5%), wawasan terkait penyakit luas (94,3%), persepsi keparahan penyakit sedang (61,5%), persepsi tidak ada efek samping obat (54,7%), persepsi peran Dokter baik (35,9%) dan peran Apoteker sangat baik (80,2%). Kepatuhan berasosiasi secara positif dengan penghasilan (OR= 4,73), tingkat pendidikan, akses ke RSJ (OR=5), persepsi dukungan keluarga (OR=2,2), wawasan terkait penyakit (OR=5), persepsi keparahan penyakit, persepsi efek samping obat (OR=2,6), peran Dokter dan peran Apoteker (OR=2,7). Variabel yang paling dominan yang berhubungan dengan kepatuhan minum obat adalah akses dengan OR = 6,6.Rekomendasi: Meningkatkan akses pada penderita melalui optimalisasi pelayanan kesehatan mental rujukan berjenjang di PPK I, II, disertai sumber daya manusia (Dokter, Apoteker) serta obat-obatan terkait, mengaktifkan Website RSJ serta melakukan edukasi melalui video edukasi, leaflet, poster, banner terkait kepatuhan minum obat penderita Skizofrenia.

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Introduction: Skizophrenia is a severe mental disorder, it affects 21 Million people in the word. Household membersin Indonesia who suffer from schizophrenia/psychosis 6,7 per mile in 2018. Treatment coverage for schizophrenia/ psychosis patients who go to mental health/health care facilities/ health workers is ever/ for lifetime (85%) and who take routine medication for last month (48.9%). Even though the prevalence is small but the impact is enormous, financial costs of schizophrenia in the United States are estimated to exceed the costs of all cancers when combined, because schizophrenia starts early in life, causes significant and long-lasting health/disability, makes demands for severe hospital treatment, requires outpatient care, rehabilitation, and continuous support services. The purpose of this study was to determine the determinants of medication adherence in patients with paranoid schizophrenia in outpatient polyclinic in Lampung Province Regional Hospital in 2019

Method: a quantitative research with cross sectional design, 192 sample respondents, using chi square and logistic regression analysis.

Result: Some of the patients who became respondents obeyed taking medication (51.0%), having adult age > 30 years (70.3%), earning under the UMP Lampung (82.3%), basic education level (46.9%), access to RSJ affordable (73.4%), perception of family support was very strong (50.5%), good insight into illness (94.3%), perception of disease severity moderate (61.5%), perception of drug: no side effects (54.7%), perceptions of the role of the doctor good (35.9%) and the role of the Pharmacist is very good (80.2%). Compliance was positively associated with income (OR = 4.73), education level, access to RSJ (OR = 5), perceptions of family support (OR = 2.2), insight into illness (OR = 5), perception of disease severity, perception of drug side effects (OR = 2.6), the role of the doctor and the role of the pharmacist (OR = 2.7). The most dominant variable that is related to medication adherence is access with OR = 6.6

Recommendation: Increase access to patients through optimization of tiered referral mental health services in PPK I, II, along with human resources (Doctors, Pharmacists) and related medicines, activate the RSJ Website and conduct education through educational videos, leaflets, posters, related banners compliance with taking medication for patients with schizophrenia."

"Latar Belakang : Sarkoma sinovial adalah sarkoma jaringan lunak derajat tinggi. Modalitas terapi yang ada saat ini belum cukup memuaskan sehingga mendorong perlunya modalitas terapi baru, yaitu imunoterapi yang menargetkan NY-ESO-1 yang diekspresikan oleh sel tumor. Dalam penelitian, perbedaan ekspresi imunohistokimia NY-ESO-1 pada sarkoma sinovial dan diagnosis bandingnya yaitu malignant peripheral nerve sheath tumor (MPNST) dan dermatofibrosarcoma protuberans (DFSP) akan diteliti.Bahan dan Cara Kerja : Penelitian analitik potong lintang dilakukan terhadap 28 kasus sarkoma sinovial, 10 kasus MPNST dan 17 kasus DFSP yang berasal dari Departemen Patologi Anatomik FKUI/RSCM selama Januari 2013 sampai Juni 2019. Dilakukan pulasan NY-ESO-1 pada ketiga kelompok dan dikategorikan sebagai positif apabila terpulas pada lebih dari 50% sel tumor dengan intensitas positif sedang sampai kuat.Hasil : Ditemukan perbedaan bermakna ekspresi NY-ESO-1 pada kelompok sarkoma sinovial (18/28), MPNST (2/10) dan DFSP (1/17) (p<0,001). Pada analisis lebih lanjut sarkoma sinovial memiliki ekspresi NY-ESO-1 lebih tinggi secara signifikan terhadap MPNST (OR 7,2; p = 0,016; power  68,7%) dan terhadap DFSP (OR 28.8; p<0,001; power 98,9%).Kesimpulan : Sarkoma sinovial yang mengekspresikan NY-ESO-1 berpotensi untuk mendapat pemberian imunoterapi. Terdapat perbedaan ekspresi imunohistokimia NY-ESO-1 pada sarkoma sinovial terhadap MPNST dan DFSP.

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Background : Synovial sarcoma is a rare high grade soft tissue sarcoma. Nowdays, the available therapeutic modalities has not given a satisfactory result yet. Currently, there is a promising therapeutic strategy through immunotherapy targeting NY-ESO-1 which is expressed on tumor. The aim of this study was comparing NY-ESO-1 immunoexpression between synovial sarcoma and its histologic mimics i.e. malignant peripheral nerve sheath tumor (MPNST) and dermatofibrosarcoma protuberans (DFSP)Material and Methode : A cross sectional study was done in 28 cases of synovial sarcoma, 10 cases of MPNST and 17 cases of DFSP from archieval material in Department Anatomical Pathology, FMUI/RSCM from January 2013 to June 2019. Immunohistohemical stainning was performed using an antibody NY-ESO-1 and it was described positive if it was expressed in more than 50% of tumor with moderate to strong positive intensity.Results : There is a significant difference p<0,001) in NY-ESO-1 immunoexpression among synovial sarcoma (18/28), MPNST (2/10) and DFSP (1/17). Furthermore, synovial sarcoma showed a significantly higher immunoexpression compared to MPNST (OR 7,2; p = 0,016; power 68,7%) and DFSP (OR 28,8; p<0,001; power 98,9%).Conclusion : Synovial sarcoma showed a higher expression of NY-ESO-1 thus makes it as a good candidates for immunotherapy. There are differences in the expression of NY-ESO-1 in synovial sarcoma against MPNST and DFSP."

"Kontraktur leher sebagian besar timbul akibat komplikasi luka bakar sebelumnya atau akibat trauma asam atau basa di daerah leher. Kontraktur leher atau kontraktur mentostemal ini sering terjadi dan merupakan salah satu tantangan bagi ahli bedah plastik dan rekonstruksi terutama ahli bedah plastik Indonesia yang jumlahnya masih sedikit.

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Neck contractures mostly arise as a result of complications previous burns or as a result of acid trauma or alkaline in the neck area. Neck contractures or mentostemal contractures often occur and are one of the challenges for plastic and reconstructive surgeons, especially Indonesian plastic surgeons who are still few in number."