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"The determination of pseudoephedrine hydrochloride and triprolidine hydrochloride in influenza syrup medicine has been performed using TLC densitometric method. Pseudoephedrine hydrochloride and triprolidine hydrochloride were extracted using chloroform at pH 12 from the syrup, and separated using HPTLC silica Kieselguhr glass plates 60 F 254, 20x10 cm2 as stationary phase, and a mixture of methanol, ammonia and chloroform (40:2:30) as mobile phase. The plates were analyzed using Camag TLC Scanner 3 with UV-detector at 257 nm for pseudoephedrine hydrochloride and at 290 nm for triprolidine hydrochloride. The results showed that the linearity, limit of detection, and limit of quantitation of the method for pseudoephedrine hydrochloride were 0.9999, 0.0064 ìg, and 0.2124 ìg respectively; while for triprolidine hydrochloride were 0.9999, 0.0076 ìg, and 0.0254 ìg respectively. The coefficient of variance (CV) of repeatability for the two substances were less than 2.0%; and the recovery values for pseudoepherine hydrochloride and triprolidine hydrochloride were 99.98 + 1.05% and 99.73 + 1,54% respectively. The result showed that the samples analysed contained pseudoephedrine hydrochloride 94.36% of the labeled ammount, and triprolidine hydrochloride 94.44% of the labeled ammount."

"Many type of starch from various plants can be exploited as an alternative for additional materials in tablet formulation. One of the source that have been developed as a pharmaceutical excipient is durian seed starch, which relatively easy to find in tropic area such as Indonesia. The objective of this research was to observe theability of durio seed starch as binder in wet granulation of ketoprofen tablet formulation. Durio seed starch obtained by extraction and drying methode. Starch as a paste used in wet granulation as a binder. Tablet made by wet granulation withketoprofen (25%) as a drug model; calcium phosphate dihidrate as a diluent; Avicel® PH 102 as a disintegrant; magnesium stearat (1%) and talc (2%) as a lubricant. Placebo formula with various durio seed starch concentration (5%, 6%, 8%, 10%) in tablet compared to other binder that is cassava starch. Placebo tablet formula withbetter hardness and friability used in ketoprofen tablet formula and compared to cassava starch as a binder with the same concentration. Formula with durio seed starch as binder have smaller hardness and more friable than cassava starch as a binder. Thereby tablet with durio seed starch as binder have faster disintegration time than tablet with cassava starch as a binder. The dissolution test for both ketoprofen formula did not meet the pharmacopeial requirements."

"Proses pengadaan pebekalan farmasi di RSUP Dr. Kariadi sebagai upaya untuk memenuhi kebutuhan perbekalan farmasi yang digunakanan untuk pelayanan kesehatan pada pasien. Proses tersebut dilaksanakan oleh Unit Layanan Pengadaan dan Pembayaran dilaksanakan oleh Bagian Perbendaharaan dan Mobilisasi Dana. Penelitian ini merupakan penelitian kualitatif riset operasional untuk mengidentifikasi faktor-faktor yang mempengaruhi keterlambatan proses pembayaran pengadaan perbekalan farmasi. Data sekunder diambil dari alur proses pembayaran pengadaan perbekalan farmasi. Data primer diperoleh dari informan yang terlibat dalam proses pengadaan perbekalan farmasi. Hasil penelitian didapatkan bahwa waktu penyelesaian berita acara 20 hari, waktu pengajuan kuitansi tagihan 8 hari, verifikasi dokumen tagihan sampai pembayaran 9 hari. Faktor-faktor yang mempengaruhi keterlambatan proses pembayaran antara lain Berita Acara Penerimaan Barang tidak segera dibuat, masih ditemukannya kesalahan penulisan dalam dokumen pengadaan maupun kuitansi tagihan, pembuatan dokumen-dokumen pengadaan belum dibantu dengan software yang untuk meningkatkan efisiensi pembuatan dokumen, belum pusatkan penyelesaian dokumen pengadaan.

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Procurement process in pharmaceutical Supplies in the Dr. Kariadi Hospital as an effort to meet the needs of pharmaceutical supplies used for health care on the patient. The process implemented by the Procurement Services Unit and the payment is carried out by The Treasury and the mobilization of funds Department.

This research is qualitative operational research to identify the factors which affect the delay of the payment process. Secondary Data taken from flow of procurement payment process of pharmaceutical supplies. The primary Data were obtained from the informan involved in the procurement of pharmaceutical supplies.

The research found that the time resolution of news events 20 days, the time of the filing receipt 8 days, verification Bill documents until payment 9 days. Factors that affect the delay of the payment process between the other News Shows Acceptance of goods not immediately made, still finds the write error in the procurement documents or receipts bills, making procurement documents have not been helped by the software to improve the efficiency of document creation, not to centralize the completion of procurement documents."