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"Epigenetics in psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry.The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms."

"This book explores how Germans perceived and reacted to how Americans publicly commemorated the Holocaust. It argues that a network of mostly conservative West German officials and their associates in private organizations and foundations, with Chancellor Kohl located at its center, perceived themselves as the victims of the afterlife of the Holocaust in America. They were concerned that public manifestations of Holocaust memory-e.g., museums, monuments, and movies-could severely damage the Federal Republics reputation in the United States and even cause Americans to call into question the Federal Republics status as an ally. The book uncovers the fears of German officials-some of whom were former Nazis or World War II veterans-about the impact of Holocaust memory on the reputation of the Federal Republic and reveals their at times negative perceptions of American Jews. Focusing on a variety of fields of interaction, ranging from the diplomatic to the scholarly and public spheres, the book unearths the complicated and often contradictory process of managing the legacies of genocide on an international stage. Over the course of the 1980s and 1990s, West German decision-makers realized that American Holocaust memory was not an anti-German plot by American Jews and acknowledged that they could not significantly change American Holocaust discourse. In the end, German confrontation with American Holocaust memory contributed to a more open engagement on the part of the West German government with this memory and eventually rendered it a positive resource for German self-representation abroad."

"This book explains why AI is unique, what legal and ethical problems it could cause, and how we can address them. It argues that AI is unlike any other previous technology, owing to its ability to take decisions independently and unpredictably. This gives rise to three issues: responsibility--who is liable if AI causes harm; rights--the disputed moral and pragmatic grounds for granting AI legal personality; and the ethics surrounding the decision-making of AI. The book suggests that in order to address these questions we need to develop new institutions and regulations on a cross-industry and international level. Incorporating clear explanations of complex topics, Robot Rules will appeal to a multi-disciplinary audience, from those with an interest in law, politics and philosophy, to computer programming, engineering and neuroscience. "

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Biaya logistik memiliki dampak yang signifikan terhadap daya saing perusahaan. Bagi perusahaan, biaya logistik memiliki pengaruh langsung terhadap penetapan harga jual produk akhir. Semakin efisien biaya logistik dalam proses rantai pasok, maka harga produk akhir akan semakin kompetitif. Penentuan rute merupakan salah satu faktor penting yang dapat mempengaruhi biaya logistik. Pada industri makanan cepat saji, terdapat jumlah cabang restoran yang banyak, permintaan yang tinggi, serta dibutuhkan dalam waktu yang singkat sehingga diperlukan metode penentuan rute yang optimal.

Penelitian ini dilakukan pada perusahaan logistik yang mendistribusikan produk bahan makanan restoran cepat saji di Indonesia. Perusahaan ini masih menggunakan sistem penentuan rute pengiriman secara manual atau belum menggunakan model optimasi. Selain itu, perusahaan juga mengalami kendala seperti waktu pendistribusian yang terbatas serta lokasi pelanggan yang banyak dan berjauhan sehingga terkadang menyebabkan kendaraan terlambat untuk melayani pelanggan maupun kembali ke pusat distribusi. Pada penelitian ini, peneliti menggunakan pendekatan Capacitated Vehicle Routing Problem with Time Windows (CVRPTW) dengan tujuan menghasilkan rute yang memiliki total jarak perjalanan terpendek dalam memenuhi permintaan pelanggan sesuai batasan waktu dan kapasitas kendaraan, sehingga dapat meminimalkan biaya distribusi dan meningkatkan kualitas pelayanan kepada pelanggan dari segi ketepatan waktu. Perubahan yang dihasilkan dari perhitungan optimasi dapat menurunkan jarak tempuh kendaraan hingga 12,16% dan menghasilkan total penghematan hingga Rp10,266,891 dalam 40 jadwal pengiriman.

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Logistics costs are a crucial factor that significantly influences a company's competitiveness. For companies, logistics costs directly impact the selling price of the final product. Logistics costs include all components of expenses involved in the movement of goods throughout the supply chain process. The more efficient the logistics costs within the supply chain process, the more competitive the price of the final product becomes. Vehicle routing is one of the critical components that can affect logistics costs. In the fast-food industry, with numerous restaurant branches, high demand, and the need for prompt delivery, an optimal route determination method is essential.

This research was conducted at a logistic company that distributes products to fast-food restaurant in Indonesia. The company currently uses a manual vehicle routing system and has not yet implemented an optimization model. The company faces challenges such as limited distribution time and numerous distant customer locations, resulting in occasional delays in serving customers or returning to the distribution center. In this research, the researcher adopts the Capacitated Vehicle Routing Problem with Time Windows (CVRPTW) approach with the aim of generating routes with the shortest total travel distance while meeting customer demands within time constraints and vehicle capacity. This approach aims to minimize distribution costs and improve service quality to customers in terms of timeliness. The optimization calculations produced significant changes, reducing vehicle travel distances by up to 12,16% and resulting in total savings of up to Rp10,266,891 across the 40 delivery schedules."