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"For the first time the lay public can benefit from the anti-aging secrets discovered by the Life Extension Foundation, the world’s largest, most respected organization dedicated to anti-aging research. Working with the Life Extension Foundation, renowned anti-aging physician Philip Lee Miller shows you how to retain your physical health and vigor, mental clarity, and youthful appearance–for life.This groundbreaking book translates cutting-edge anti-aging advances into a practical, easy-to-use program that will maximize your chances of living not only a long life–but a healthy, vibrant life. Drawing on his own clinical experience as well as the latest research from the Life Extension Foundation, Dr. Miller demystifies the aging process and provides you with:•Detailed strategies integrating the most advanced mainstream therapies with nutrients, hormones, and holistic approaches from around the world•A comprehensive plan to protect yourself from cancer, heart disease, arthritis, and Alzheimer’s disease at the cellular level by controlling inflammation and oxidation–two degenerative processes that cause us to age prematurely•A guide to individualizing this lifesaving program, including the Longevity Diet for maximum vitality and effortless weight loss and a unique supplement regimen–plus how to use medical tests to monitor your progress•An inspiring vision of the future of life extension science and what your future will be like without disease, premature death and aging–with novel strategies to help you get thereThis far-reaching anti-aging program will change your life forever. Like many of Dr. Miller’s patients, your physical and mental health will actually soar as you age chronologically. Your new longer, healthier life begins now as you embark o"

"The Handbook of the Psychology of Aging has become the definitive reference source for information on the psychology of adult development and aging. It provides comprehensive reviews of research on biological and social influences on behavior and age-related changes in psychological function. The seventh edition of the Handbook will contain all new material and include an entirely new section devoted to what neuroscience has discovered on cognitive aging. Contains all the main areas of psychological gerontological research in one volume Entire section on neuroscience and aging Begins with a section on theory and methods Edited by one of the father of gerontology (Schaie) and contributors represent top scholars in gerontology"

"Latar BelakangPenuaan merupakan suatu proses yang tidak dapat dihindari. Namun, pencegahan penyakit terkait usia yang seringkali menyertainya dapat dilakukan dengan memodifikasi faktor risiko utamanya, termasuk inflamasi. Salah satu pendekatan yang dapat digunakan adalah dengan memanfaatkan tanaman yang kaya antioksidan. Rosella (Hibiscus sabdariffa Linn.), terbukti memiliki aktivitas antioksidan yang tinggi. Namun, saat ini belum ada penelitian spesifik yang menilai dampaknya terhadap biomarker khusus penuaan seperti Sirtuin 1.MetodePenelitian eksperimental in vivo ini dilakukan pada 18 tikus Sprague Dawley jantan yang dibagi secara acak kedalam 3 kelompok: kontrol (K) yang merupakan tikus muda normal yang diberi pakan standar; Accelerated Aging (AA) yang diberi pakan tinggi lemak dan D-galaktosa; dan Hibiscus sabdariffa Linn. (HSL) yang diberi pakan tinggi lemak, D-galaktosa, dan ekstrak etanol bunga H. sabdariffa dengan dosis 400 mg/KgBB. Perlakuan dilakukan selama 6 minggu. Pada akhir penelitian, kadar SIRT1 diukur menggunakan kit ELISA standar.HasilPerbedaan rerata kadar SIRT1 yang diperoleh antar kelompok tidak signifikan secara statistik.KesimpulanEkstrak HSL belum mampu meningkatkan kadar SIRT1.

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Introduction

Aging is an inevitable process. However, prevention of age-related diseases that often follows can be done by modifying its main risk factors, including inflammation. One approach that can be used is to utilize plants that are rich in antioxidants. Rosella (Hibiscus sabdariffa Linn.), has been shown to have high antioxidant activity. However, there is currently no specific study that assesses its impact on a specific aging biomarker like Sirtuin 1.

Method:

This in vivo experimental study was conducted on 18 male Sprague Dawley rats that were randomly divided into 3 groups: control (K) which were normal young rats that are fed with standard feed; Accelerated Aging (AA) which were fed high fat feed and D-galactose; and Hibiscus sabdariffa Linn. (HSL) which were fed high fat feed, D-galactose, and the ethanol extract of H. sabdariffa flowers at a dose of 400 mg/KgBW. The treatment was carried out for 6 weeks. At the end of the study, SIRT1 levels were measured using a standard ELISA kit.

Results:

The difference in mean SIRT1 levels obtained between groups was not statistically significant.

Conclusion:

HSL extract has not yet been able to increase SIRT1 levels."

"It provides a foundation for understanding and reflecting on key demographic and social trends, together with related theoretical and policy frameworks that are important in explaining changes and designing informed responses. With particular reference to countries that have the oldest or largest aged populations, the book presents a synthesis of research on population aging, new analyses of trends and a discussion of the major social policy strategies. Key topics include the new demography of aging, population health, family change, the third age, international policy concepts and strategies, and comparisons of countries."