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"A simple and comprehensive guide to the key factors associated with aging and the steps involved to slowing down the process, complete with mental health advice, nutritional tips, physical fitness suggestions and more."

"Pendahuluan: Data Susenas tahun 2022 yang dikeluarkan oleh Badan Pusat Statistik (BPS) mencatat bahwa 10,48% penduduk Indonesia adalah lansia dengan 2 dari 5 lansia memiliki keluhan kesehatan. Hal ini bisa disebabkan karena banyaknya faktor ekstrinstik maupun intrinsik yang menyebabkan kerusakan seluler sehingga menginduksi protein p53 untuk melakukan cellular senescence. Senyawa thymol, carvacrol, dan flavonoid (quercetin, luteolin, apigenin, rutin, eriodictyol) dalam ekstrak tanaman Plectranthus amboinicus yang kaya akan antioksidan dipercaya dapat menghambat proses cellular senescence sehingga dapat menekan proses penuaan. Dengan itu, tujuan dari penelitian ini adalah untuk mengetahui interaksi antara komponen ligan pada senyawa aktif thymol, carvacrol, dan flavonoid yang terkandung dalam Plectranthus amboinicus dengan protein target p53 yang berkaitan dengan aktivitas cellular senescence pada proses penuaan. Metode: Studi in silico melalui molecular docking (penambatan molekuler) untuk menguji interaksi molekuler dari ligan senyawa thymol, carvacrol, dan flavonoid (quercetin, luteolin, apigenin, rutin, eriodictyol) dari tanaman Plectranthus amboinicus terhadap reseptor protein target p53 yang bertanggung jawab dalam proses cellular senescence. Hasil interaksi yang didapat merupakan sebuah histogram yang akan dianalisis dan diinterpretasikan untuk mengetahui afinitas ikatan (binding affinity) dari interaksi yang terjadi. Hasil: Terjadi interaksi antara ligan senyawa thymol, carvacrol, dan flavonoid (quercetin, luteolin, apigenin, rutin, eriodictyol) dari tanaman Plectranthus amboinicus terhadap reseptor protein target p53. Kesimpulan: Plectranthus amboinicus berpotensi menjadi agen anti-aging yang dapat menghambat dan memperlambat proses dari penuaan melalui studi in silico. Akan tetapi, perlu dilakukan penelitian lebih lanjut mengenai mengenai sifat-sifat dari Plectranthus amboinicus untuk mengetahui potensi tanaman ini terhadap tubuh manusia yang belum diketahui.

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Introduction: The 2022 Susenas data stated by the Central Statistics Agency (BPS) notes that 10.48% of Indonesia’s population are elderly with 2 out of 5 having health complaints. This could be due to the many extrinsic and intrinsic factors that causes cellular damage thereby inducing the p53 protein to perform cellular senescence. Compounds of thymol, carvacrol, and flavonoids (quercetin, luteolin, apigenin, rutin, eriodictyol) from the extract of the Plectranthus amboinicus plant which are rich in antioxidants are believed to have the potential to inhibit the cellular senescence process so as to suppress the aging process. The purpose of this research is to investigate the interaction between the ligand of thymol, carvacrol, and flavonoid compounds from Plectranthus amboinicus with the p53 target protein which is associated with cellular senescence activity in the aging procress. Methods: In silico study through molecular docking to examine the molecular interactions of the ligands of thymol, carvacrol, and flavonoids (quercetin, luteolin, apigenin, rutin, eriodictyol) from the Plectranthus amboinicus plant against the target protein receptor p53 which is responsible for the process of cellular senescence. The interaction results obtained is a histogram which will be analyzed and interpreted to determine the binding affinity of the interactions that occured. Results: Interactions existed between the ligands of thymol, carvacrol, and flavonoids (quercetin, luteolin, apigenin, rutin, eriodictyol) from the Plectranthus amboinicus plant against the target protein receptor p53. Conclusion: Plectranthus amboinicus has the potential to be an anti-aging agent that can inhibit and slow down the process of aging through in silico studies. However, it is necessary to carry out further research regarding the properties of Plectranthus amboinicus to determine the unknown potential of this plant to the human body.

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"No one wants to get old or show the signs of age. In fact, for centuries many have searched for, and often promised, the fountain of youth. So what makes The Anti-Aging Zone different?In this new, breakthrough book. Dr. Sears goes beyond looking at food as simply a source of calories and explains the incredibly powerful biological effects it has on your hormones. From this unique perspective, food is more than a source of sustenance; it becomes the most powerful drug known to man. More important, it is the only drug proven to reverse the aging process. In addition to unraveling the mysteries of your hormones and their role in aging, Dr. Sears reveals the essential dietary information you need to start your own age-reversal journey. Using his simple and easy-to-follow program, you will be able to live longer and live better beginning with your very next meal.As Dr. Sears explains, the aging process isn't caused as much by the depletion or lack of hormones as we get older, but rather by their impaired ability to communicate with each other. Little-known "super-hormones" called eicosanoids can reestablish the critical communications links between your hormones, which is the key to age reversal. The brilliance of this anti-aging approach is that these exceptionally powerful super-hormones can be altered by the foods you eat, and, in particular, by the Zone Diet.Your body is a vast, complex biological Internet whose hormonal communication can be orchestrated with great precision by the Zone Diet. Hormones from melatonin to serotonin, from estrogen to testosterone, from cortisol to DHEA, can all be controlled if you are willing to treat food with the same respect as you would any prescription drug. Ultimately, hormonal miscommunication is the underlying cause of many conditions associated with "getting older" such as insomnia, wrinkles, dry and dull skin, waning sex drive, depression, chronic pain, obesity, diabetes, heart disease, and cancer. Using The Anti-Aging Zone as your guide, you can look and feel better that you ever imagined.Millions of people like you are now facing the hard realities involved with getting older. Dr. Sears separates the hormonal hype from reality and gives you the necessary tools to add years to your life and improve your appearance. The Anti-Aging Zone is your passport to a longer and better life."

"Exploring the four greatest hidden threats to health - sugar, parasites, heavy metals and radiation - this guide provides a comprehensive toxic invaders questionnaire, which the reader can use to create a personal programme for detoxification and healing."

"For millennia, people have been searching for the elusive fountain of youth - the key to living a long, healthy, productive and fulfilling life. Is it merely a matter of luck or good genes that some of us reach advanced years free of disease, debility and disability? Or are there proven strategies that we can adopt to make our lives longer, stronger and altogether more rewarding? In THE FOUNTAIN, pioneers and leaders in the fields of healing, wellness, nutrition, vitamin and mineral therapy, exercise physiology and beauty share the wisdom they've gained to guide all of us to the fountain of youth. Among the topics addressed in these easy-to-read, succinct essays are: � How the interaction among nutrition, vitamins, exercise and meaningful work and relationship enhances wellness at every stage � How vitamin therapy can guard against chronic disease, even into old age � How proper nutrition prevents the onset of disease and boosts well-being � How cultivating relationships assuages stress and serves as a buffer against disease � How meditation and other relaxation practices set the state for lifelong wellness � How natural strategies enhance beauty at all ages A book you'll return to again and again in your own quest for natural, holistic ways to make each day count, as you count more days of healthy life."

"SynopsisA medically proven program to prevent and reverse the DNA damage that causes aging You have it in your power to retain the health, beauty, and vitality of youth well past fifty or sixty and beyond. All of us grow older, but it's a medically proven fact that how we age is a choice. With a few simple lifestyle changes, you can reap amazing visible and tangible benefits in just a few days--and this groundbreaking book shows you how. Written by an all-star team of internationally acclaimed anti-aging experts, The Anti-Aging Solution is the first guide to reveal how you can reverse aging on a genetic level. By following a uniquely effective five-step program--which includes stress-reduction techniques, easy-to-follow dietary guidelines, moderate exercise, inexpensive skin treatments, and supplements--you can reverse DNA damage, enhance DNA repair, and start to look younger, feel younger, and be younger right away. The Anti-Aging Solution shows you how to: * Say goodbye to aching joints, sagging skin, and fatigue * Improve the quality and function of the genetic material in your cells * Ramp up your body's self-repair functions * Increase your stamina, endurance, and sex drive * Dramatically improve your resistance to disease, including many cancers * Have more youthful, radiant skin "synopsis" may belong to another edition of this title."