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"Latar Belakang. Pasien autoimun rentan terhadap infeksi COVID-19 dan luaran yang lebih berat, sehingga penting untuk mendapat vaksinasi. Namun, terdapat kekhawatiran efek samping, kekambuhan penyakit, serta efektivitas dan imunogenitas vaksin. Tujuan. Mengetahui cakupan vaksinasi COVID-19 di Poli Alergi Imunologi RSCM dan faktor-faktor yang berhubungan. Metode. Studi potong lintang ini melibatkan 260 pasien autoimun dari Poli Alergi Imunologi RSCM periode Juli-Agustus 2023. Pengambilan data menggunakan kuesioner. Analisis bivariat dengan Uji Chi-Square atau Fischer dan analisis multivariat dengan regresi Poisson. Hasil. Cakupan vaksinasi COVID-19 pasien autoimun untuk dosis pertama 60%, dosis kedua 57.3%, dan dosis ketiga 40%. Melalui analisis bivariat, didapatkan faktor yang berhubungan dengan cakupan berupa pekerjaan tenaga kesehatan (PR 1,68; p < 0,001), rekomendasi dokter yang merawat (PR 6,47; p<0,001), dan skala persepsi pasien terhadap keparahan penyakit (p<0,001). Analisis multivariat menunjukkan hubungan antara rekomendasi dokter yang merawat (PR 4,67; p<0,001), pekerjaan tenaga kesehatan (PR 1,56; p=0,01), diagnosis SLE (PR 0,81; p=0,003) dan skala persepsi pasien terhadap keparahan penyakit (PR 0,88; p<0,001). Simpulan. Cakupan vaksinasi COVID-19 dosis pertama pada pasien autoimun di Poli Alergi-Imunologi RSCM adalah 60%. Studi ini menemukan hubungan cakupan vaksinasi dengan rekomendasi dokter yang merawat, pekerjaan sebagai tenaga kesehatan, diagnosis SLE, dan persepsi pasien terhadap keparahan penyakit.

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Background. Autoimmune patients are susceptible to COVID-19 infection and severe outcomes, so it is important to receive vaccination. However, there are concerns about side effects, disease recurrence, and vaccine effectiveness and immunogenicity.

Objective. To explore uptake of COVID-19 vaccination at RSCM Allergy Immunology Clinic and related factors.

Method. This cross-sectional study involved 260 autoimmune patients from the RSCM Allergy Immunology Clinic for July-August 2023. Data was collected with questionnaire. Bivariate analysis with Chi-Square or Fischer Test and multivariate analysis with Poisson regression.

Results. COVID-19 vaccination coverage for autoimmune patients for the first dose is 60%, the second dose is 57.3%, and third dose is 40%. Through bivariate analysis, associated factors were health worker employment (PR 1.68; p < 0.001), recommendation of treating doctor (PR 6.47; p < 0.001), and patients’ perception of their illness (p< 0.001). Multivariate analysis showed association between recommendation of treating doctor (PR 4.67;p<0.001), health worker's occupation (PR 1.56;p=0.01), SLE diagnosis (PR 0.81;p=0.003) and the scale patient perception of disease severity (PR 0.88;p<0.001).

Conclusion. Coverage first dose COVID-19 vaccination in autoimmune patients at RSCM Allergy-Immunology Clinic is 60%. This study found association between recommendation of treating doctor, healthcare workers, SLE diagnosis, and patients’ perception of their illness."

"ABSTRAKLatar Belakang: Penyakit autoimun terjadi karena tubuh tidak mampu untuk mengenali sel atau jaringan tubuh sendiri, sehingga tubuh memberikan respons seperti proses eliminasi antigen terhadap sel atau jaringan tubuh sendiri. Berbagai faktor risiko, antara lain genetik, lingkungan dan nutrisi berperan pada perkembangan penyakit autoimun. Saat penyakit autoimun telah menimbulkan gejala, pasien memiliki risiko mendapat nutrisi yang tidak adekuat. Selain itu, kondisi autoimun akan menimbulkan respons inflamasi terus-menerus di dalam tubuh. Bila kondisi ini terus berlanjut akan menyebabkan peningkatan status metabolisme, status nutrisi, status imun dan menimbulkan gangguan kapasitas fungsional pada pasien. Pasien dengan penyakit autoimun harus didukung dengan edukasi dan mendapat terapi nutrisi yang tepat dan adekuat, terutama saat menjalani proses terapi sehingga kebutuhan nutrisi dapat terpenuhi sesuai dengan kondisi pasien. Metode: Laporan serial kasus ini menguraikan empat kasus penyakit autoimun. Dua kasus merupakan kasus neurologi, sementara dua kasus lain adalah kasus penyakit kulit. Dua pasien memiliki status nutrisi malnutrisi berat, satu pasien berat badan normal berisiko malnutrisi dan satu pasien obes I berisiko malnutrisi. Terapi nutrisi sesuai mengacu pada diet seimbang. Semua pasien mendapat terapi nutrisi sejak dikonsulkan ke Departemen Medik Ilmu Gizi hingga hari terakhir perawatan di RS. Asupan energi dan protein diberikan meningkat bertahap sesuai dengan kondisi klinis dan toleransi pasien. Suplementasi mikronutrien diberikan kepada pasien. Pemantauan pasien meliputi keluhan subjektif, hemodinamik, analisis dan toleransi asupan, pemeriksaan laboratorium, antropometri, imbang cairan, dan kapasitas fungsional. Hasil: Selama pemantauan di RS, asupan pasien dapat mencapai kebutuhan energi total dan mikronutrien diterima oleh pasien. Perbaikan klinis dan perbaikan kapasitas fungsional terjadi pada 3 pasien. Satu pasien mengalami perburukan dan meninggal akibat sepsis pada hari perawatan ke-33. Kesimpulan: Terapi nutrisi pada pasien autoimun dapat mendukung proses pengobatan berupa perbaikan kapasitas fungsional dan lama rawat 3 pasien.

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ABSTRACTObjective Autoimmune disease is a condition of body inability to recognize the cells or tissues itself. It will response as antigen elimination process against the cells or tissue itself. Autoimmune risk factors, such as genetic, enviromental and nutrients play a role in the development of autoimmune diseases. When the symptoms occur, the patient have a risk of inadequate nutrition. In addition, autoimmune condition will cause continuous inflammatory response. This situation will increase patients rsquo s metabolic, nutritional, and immune status. Thus, reduce the patient rsquo s functional capacity. Patient with autoimmune disease should be supported by appropriate and adequate nutrition education and therapy, especially during the therapeutic process so that the nutrition requirements can be fulfilled according to the patient 39 s condition. Methods These case report outlines four cases of autoimmune disease. Two cases are cases of neurology, while the other two cases are cases of skin disease. Two patients had severe malnutrition, one normoweight patient at risk for malnutrition and one obese patient at risk of malnutrition. Management of appropriate nutrition refers to a balanced diet. All patients received nutritional therapy from the Clinical Nutrition Department until the last day of hospitalization. The energy and protein intake increase gradually in accordance with improved clinical conditions and patient rsquo s tolerance. Supplementation of micronutrients is given to the patient. Patient monitoring includes subjective, hemodynamics, analysis and tolerance of intake, laboratory examination, anthropometry, fluid balance, and functional capacity Results During hospital monitoring, the patient 39 s nutrition intake can achieve the total energy and protein requirement as well as the micronutrients. Clinical condition and functional capacity improvements occurred in 3 patients. One patient had worsening condition and died due to sepsis in the 33rd day of treatment. Conclusion Nutritional therapy for patients with autoimmune disease can support the treatment process in improvement of functional capacity and length of stay."

"Penyakit autoimun berisiko mengalami komplikasi yang berujung pada sakit kritis. Hal ini dapat menyebabkan peningkatan morbiditas dan mortalitas. Tata laksana nutrisi dapat membantu mencegah malnutrisi, meningkatkan status nutrisi, dan memperbaiki status metabolik, sehingga dapat memperbaiki luaran klinis, mempersingkat fase sakit kritis, dan lama rawat rumah sakit (RS). Pasien dalam serial kasus ini mengalami komplikasi penyakit autoimun yang menyebabkan pasien mengalami sakit kritis, danmembutuhkan perawatan intensif. Keempat pasien adalah perempuan, dengan rentang usia 19−37 tahun, dengan status gizi obes 1 pada dua pasien, dan malnutrisi berat pada pasien lainnya. Dua dari empat pasien mendapatkan tata laksana nutrisi sejak awal fase sakit kritis, sedangkan sisanya setelah lebih dari tujuh hari perawatan intensif. Terapi medik gizi diberikan selama berada di ruang perawatan intensif, meliputi pemenuhanenergi, makronutrien, dan mikronutrien, sesuai kondisi klinis dan toleransi pasien. Asupan energi pada keempat pasien saat perawatan intensif mencapai 25−47 kkal/kg BB/hari, dengan asupan protein tertinggi sebesar 1,4−2,7 g/kg BB/hari. Durasi pemakaian ventilator mekanik, hari perawatan intensif dan RS terpanjang, terdapat pada pasien yang mengalami malnutrisi berat. Tiga dari empat pasien dengan toleransi asupan yang baik mengalami perbaikan luaran klinis, peningkatan kapasitas fungsional,dan diizinkan untuk rawat jalan. Satu pasien pulang atas permintaan sendiri sebelum perbaikan kondisi klinis. Tingkat keparahan penyakit, komplikasi, dan status gizi pada pasien autoimun yang mengalami sakit kritis, mempengaruhi luaran klinis. Tata laksana nutrisi dapat meningkatkan status gizi, sehingga membantu memperbaiki kondisi klinis, menurunkan morbiditas dan mortalitas pasien

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Autoimmune diseases pose risks for complications, leading to critical illnesses, thus increase the morbidity and mortality rate. Nutritional management can prevent malnutrition, improve metabolic and nutritional status, thereby, improve clinical outcomes, shorten critical illness phase, and reduce hospital length of stay. In these case series, all patients had autoimmune diseases with complications, leading to critically ill conditions that required intensive care. All patients were women, aged of 19−37 years. There were two patients with obesity and others with severe malnutrition. Two patients received nutritional management starting from the acute phase, while the rest were at the late period. Medical nutrition therapy was given while in the intensive care unit (ICU), including the energy fulfillment, macro- and micro-nutrients, according to the clinical condition and patient’s tolerance. The energy intake of patients during the critical ilness was 25−47 kcal/kg BW/day, with the protein intake was 1.4−2.7 g/kg BW/day. The longest duration of mechanical ventilator use, length of ICU and hospital stay, were found in patients who were severely malnourished. Three patients with good nutritional intake, had better improvement in clinical conditions, complications, and functional capacity. They were allowed to be discharged and followed up at outpatient unit, while one patient returned home on her own request, before required improvement of clinical conditions. Severity of the diseases, complications, and the nutritional status of autoimmune patients with critical illnesses affected overall clinical outcomes. Medical nutrition therapy can improve metabolic and nutritional status, thereby improve clinical conditions, reduce morbidity and mortality of the patient"

"Background: autoimmune patients can be more susceptible to infection. Proper knowledge, perception, and practices towards COVID-19 are essential for these patients during pandemic. This study aimed to know their knowledge, perception, and practices regarding COVID-19. Methods: cross sectional study using online survey was conducted from April to May 2020. Patients with autoimmune disease were asked about demographic characteristics, diagnosis, history of treatment, knowledge, perception, and practice regarding COVID-19. Results: there were 685 respondents. Most of them were female and had systemic lupus erythematosus with median age of 37 years old. Almost all respondents had good knowledge regarding transmission of COVID-19 and did proper prevention practices. Adequacy of information and steroid or mycophenolate mofetil/mycophenolic acid (MMF/MPA) use were related to perception of the effect of pandemic to their own health. Visiting private clinic and receiving hydroxychloroquine/chloroquine sulfate or sulfasalazine were related to perception that autoimmune conditions would make them more prone to COVID-19. Work from home was related to perception that when contracting COVID-19, the symptoms would be more severe. Living in Sumatra region and getting hydroxychloroquine/ chloroquine sulfate or MMF/MPA were related to perception that autoimmune medications could reduce risk of getting COVID-19. Adequate information, university education, private clinic visit, and hydroxychloroquine/ chloroquine sulfate use were related to perception that COVID-19 pandemic would cause difficulties in getting medications. Conclusion: almost all respondents had good knowledge and practices regarding COVID-19. Adequacy of information, autoimmune treatment, work from home, educational background, area of living, and health care facilities contributed to perception regarding COVID-19 pandemic."

"Latar belakang: Artritis idiopatik juvenil (AIJ) adalah penyakit autoimun yang ditandai dengan peradangan sendi kronis. Anak dengan AIJ akan mengalami hambatan pertumbuhan tulang yang disebabkan beberapa mekanisme langsung maupun tidak langsung. Sebanyak 40-50 % pasien AIJ memiliki densitas mineral tulang yang rendah pada tulang belakang lumbal dan panggul. Densitas mineral tulang yang rendah dipengaruhi beberapa faktor yaitu klasifikasi penyakit, lama sakit, indeks masa tubuh, status pubertas, aktivitas penyakit, aktivitas fisik, kadar 25(OH)D, dosis kumulatif kortikosteroid, dan dosis metotreksat.Tujuan: Penelitian ini dilakukan untuk mengetahui densitas mineral tulang pada pasien AIJ dan faktor-faktor yang berhubungan.Metode: Penelitian ini merupakan studi potong lintang dengan melibatkan 32 pasien AIJ. Pemilihan subjek dilakukan berdasarkan data registri pasien AIJ di poliklinik Alergi-Imunologi RSCM dan RSAB Harapan Kita tahun 2014-2019. Densitas mineral tulang diperiksa dengan Dual X-ray Absorbtiometry (DEXA) dengan melihat skor Z. Dilakukan analisis bivariat untuk mencari hubungan antara variabel terhadap densitas mineral tulang.Hasil: Densitas mineral tulang total rerata adalah 0,86 g/cm2. Sebanyak 22 subjek mempunyai densitas mineral tulang rendah (osteopenia) dengan nilai skor-Z L1-L4 ≤-2 sedangkan 10 subjek menunjukkan hasil normal. Tidak ditemukan fraktur tulang belakang pada seluruh subjek. Osteopenia banyak ditemukan pada anak dengan dosis kumulatif metotreksat yang lebih banyak (p=0,016). Faktor-faktor lainnya tidak terbukti berhubungan dengan densitas mineral tulang yang rendah.Simpulan: Sebagian besar pasien AIJ mengalami gangguan densitas mineral tulang. Dosis metotreksat yang dihubungkan dengan aktivitas penyakit merupakan faktor yang berperan untuk terjadinya osteopenia.

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Background: Juvenile Idiopathic Arthritis (JIA) is an autoimmune disease characterized by chronic inflammatory arthritis. The disease will affect bone development in children with JIA through direct and indirect mechanisms. About 40-50 % patient with JIA have low bone mineral density in the spine. The low bone mineral density is associated with disease classification, disease duration, body mass index, puberty status, disease activity, physical activity, 25(OH)D level, cumulative doses of corticosteroid and methotrexate.

Objective: This study aimed to investigate bone mineral density in children with JIA and its associated factors.

Method: A cross-sectional study involving 32 children with JIA. Patients were selected based on registry data in the outpatient clinic, subdivision of Allergy and Immunology, Department of Child Health, Dr. Cipto Mangunkusumo General Hospital and Harapan Kita Women and Children Hospital between 2014-2019. Bone mineral density was measured using Dual X-ray Absorbtiometry (DEXA) and reported using Z score. Bivariate analysis was used to identify factors associated with bone mineral density.

Result: The mean bone mineral density was 0,86 g/cm2. Low bone mineral density (osteopenia) occurred among 22 patients (Z score ≤-2 at L1-L4). 10 patients have normal bone mineral density. No vertebral fracture was seen on x-ray. Osteopenia was mainly found in patients with higher cumulative doses of methotrexate (p=0,016). The other factors were not associated with low bone mineral density.

Conclusion: Most patients with JIA have low bone mineral density. Low bone mineral density tends to occur among patients with higher cumulative doses of methotrexate treatment."

"Pandemi COVID-19 telah terbukti menjadi musuh besar bagi kesehatan global. Kedatangan vaksin membawa angin segar untuk mengembalikan kondisi ke normal. DKI Jakarta sebagai Provinsi dengan jumlah kasus COVID-19 tertinggi di Indonesia merupakan salah satu provinsi prioritas dalam pelaksanaan vaksinasi COVID-19. Capaian vaksinasi Booster ke-I belum sesuai target sedangkan pemerintah sudah melaksanakan vaksinasi Booster ke-II kepada tenaga kesehatan dan lansia. Tujuan Penelitian adalah untuk mengetahui faktor-faktor yang berhubungan dengan kesiapan vaksinasi Booster COVID-19 bagi Masyarakat DKI Jakarta ditinjau dari Health Belief Model. Penelitian ini menggunakan desain studi potong lintang, dilakukan pada November hingga Desember 2022 dengan melibatkan sampel penelitian sebanyak 175 responden. Analisis yang digunakan adalah analisis univariat dan bivariat dengan level kepercayaan 95%. Hasil penelitian menunjukkan bahwa persentase kesiapan vaksinasi pada responden adalah sebesar 84%. Pada faktor pemodifikasi terdapat hubungan antara Usia (p-value 0,000), Pendidikan (p-value 0,727), Pekerjaan (p-value 0,046), dan Pengetahuan (p-value 0,000) dengan kesiapan vaksinasi Booster COVID-19, sedangkan jenis kelamin (p-value 0,727) tidak memiliki hubungan. Pada faktor persepsi terdapat hubungan antara persepsi manfaat (p-value 0,002) dan persepsi hambatan (p-value 0,000) dengan kesiapan vaksinasi Booster COVID-19. Sedangkan persepsi kerentanan (p-value 0,636) dan persepsi keparahan (p-value 0,418) tidak memiliki hubungan. Pada faktor isyarat untuk bertindak terdapat hubungan pada faktor kepercayaan terhadap vaksinasi Booster COVID-19 (p-value 0,000) dan kepercayaan terhadap sumber informasi (p-value 0,000). Sedangkan faktor pengalaman terhadap COVID-19 didapatkan tidak memilki hubungan yang kuat dengan kesiapan Vaksinasi Booster COVID-19 (p-value 1,000). Dari hasil penelitian ini, terdapat beberapa hal yang disarankan, diantaranya menekankan ke masyarakat bahwa pandemi COVID-19 belum berakhir, mengembangkan metode penyebaran informasi yang berkesinambungan dan terus berupaya meluruskan informasi yang menyimpang (hoaks) di kalangan masyarakat.

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The COVID-19 pandemic has proven to be a formidable enemy for global health. The arrival of the vaccine brings fresh air to return conditions to normal. DKI Jakarta as the province with the highest number of COVID-19 cases in Indonesia is one of the priority provinces in the implementation of COVID-19 vaccination. The achievements of the 1st Booster vaccination have not met the target, while the government has carried out the 2nd Booster vaccination for health workers and the elderly. The aim of the study was to determine the factors related to the readiness of the COVID-19 Booster vaccination for the DKI Jakarta Community in terms of the Health Belief Model. This study used a cross-sectional study design, conducted from November to December 2022 involving a research sample of 175 respondents. The analysis used was univariate and bivariate analysis with a 95% confidence level. The results showed that the percentage of readiness for vaccination in the respondents was 84%. In the modifying factors there is a relationship between Age (p-value 0.000), Education (p-value 0.727), Occupation (p-value 0.046), and Knowledge (p-value 0.000) with the readiness of the COVID-19 Booster vaccination, while gender ( p-value 0.727) has no relationship. In the perception factor, there is a relationship between perceived benefits (p-value 0.002) and perceived barriers (p-value 0.000) with the readiness of the COVID-19 Booster vaccination. Meanwhile, perceived susceptibility (p-value 0.636) and perceived severity (p-value 0.418) had no relationship. In cues to action factors there is a relationship between the trust factor of the COVID-19 Booster vaccination (p-value 0.000) and trust of information sources (p-value 0.000). Meanwhile, the experience factor for COVID-19 did not have a strong relationship with the readiness of the COVID-19 Booster Vaccination (p-value 1,000). From the results of this study, there are several suggestions, including emphasizing to the public that the COVID-19 pandemic is not over, developing sustainable and coordinated information dissemination methods, and continuing to work on rectifying distorted information (hoaxes) among the public."

"Vaksinasi COVID-19 pada anak di Indonesia tidak terlepas dari orang tua yang menyetujui dan tidak menyetujui vaksinasi COVID-19 pada anak. Penelitian bertujuan untuk mengetahui faktor yang berhubungan dengan kesediaan orang tua menyetujui vaksinasi COVID-19 pada anak di Indonesia. Responden merupakan orang tua yang memiliki anak berusia 6-18 tahun. Penelitian ini menggunakan desain penelitian deskriptif, korelasi dan cross-sectional dengan sampel 428 responden. Instrumen penelitian menggunakan kuesioner karakteristik orang tua dan anak, serta kuesioner pengetahuan terkait vaksin COVID-19. Penelitian ini menunjukkan adanya faktor yang berhubungan dengan kesediaan orang tua menyetujui vaksin COVID-19 pada anak meliputi keterkaitan dengan anak (p = 0.003, α = 0.05), riwayat pengobatan anak (p = 0.008, α = 0.05), status vaksin influenza, dan status vaksinasi COVID-19 anak, khawatir keparahan COVID-19, penjelasan ilmiah, akses ke pelayanan kesehatan, dan pengetahuan orang tua/wali (p=0.000, α = 0.05). Penelitian selanjutnya diharapkan untuk meneliti faktor lain yang berkaitan dengan kesediaan orang tua menyetujui vaksin COVID-19 pada anak.

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Vaccination against COVID-19 in children in Indonesia is inseparable from parents agreeing and not agreeing to vaccination of COVID-19 in children. The study aims to determine the factors associated with the willingness of parents to agree to vaccination against COVID-19 in children in Indonesia. Respondents are parents who have children aged 6-18 years. This study used a descriptive, correlation and cross-sectional research design with a sample of 428 respondents. The research instrument used a questionnaire on the characteristics of parents and children, as well as a knowledge questionnaire related to the COVID-19 vaccine.

This study showed that there were factors associated with the willingness of parents to agree to the COVID-19 vaccine in children including association with the child (p = 0.003, α = 0.05), history of child medication (p = 0.008, α = 0.05), influenza vaccine status, and children's COVID-19 vaccination status, concern about the severity of COVID-19, scientific explanation, access to health services, and knowledge of parents/guardians (p=0.000, α = 0.05). Future research is expected to examine other factors related to the willingness of parents to approve the COVID-19 vaccine for children."

"Latar belakang : Inflamatory Bowel disease (IBD) merupakan penyakit autoimun yang insidens dan prevalensinya meningkat terus setiap tahunnya. Modernisasi dan kemajuan industri suatu wilayah selalu diikuti dengan perubahan pola hidup termasuk pola diet cepat saji (western diet) yang tinggi protein dan karbohidrat serta rendah serat dan buah. Diet, dapat merubah komposisi mikrobiota usus (dysbiosis), suatu bakteri komensal yang menjaga homeostasis dan sistim imun mukosa usus sehingga dapat memicu timbulnya IBD serta peningkatan aktifitas penyakitnya (flare).IgG yang meningkat setelah makan, merupakan suatu antibody neutralisasi sebagai bagian toleransi imun pada orang sehat dimana pada IBD makanan dapat dikenali sebagai antigen yang melalui ikatan antigen-antibodi reaksi hypersensitivitas tipe III, kemungkinan dapat menyebabkan inflamasi usus terus menerus dan mempengaruhi aktifitas penyakit.Tujuan : Untuk mengetahui hubungan antara IgG antibodi spesifik makanan dan aktivitas penyakit klinis pada pasien IBDMetode: Studi potong lintang, melibatkan 113 pasien IBD yang diagnosisnya telah dikonfirmasi dengan kolonoskopi. Pada pasien yang setuju dilakukan pemeriksaan serum IgG spesifik makanan untuk 220 jenis makanan menggunakan teknik Elisa dan Immunoarray. Aktivitas klinis pada Kolitis Ulseratif (KU) dinilai menggunakan Indeks Mayo sedangkan pada Penyakit Crohn dinilai menggunakan Indeks Aktivitas Penyakit Chrons (Crohn Disease Activity Index)Hasil: Proporsi antibodi IgG spesifik makanan tertinggi pada kelompok penyakit Crohn adalah kacang polong (100%), barley (97,9%), telur (95,9%), susu (81,6%), jagung (75,5%), agar-agar (69,4). %), kacang mede (69,4%) gandum (67,3%), oat (61,2%) dan almond (59,2%), sedangkan pada Kolitis Ulseratif adalah jelai (98,4%), kacang polong (96,8%), putih telur (92,2%), jagung (82,8%), plum (78,1%), kacang mede (67,2%), susu sapi (65,6%), gelatin (59,4%), almond (50%), kacang merah (48,4%) dan gandum (46,9%). Dari 220 jenis antigen makanan, pada KU didapatkan korelasi negatif yang cukup kuat pada jenis kacang mede dengan r = -0,347 (p=0,041) dan kacang Arab dengan r = -0.473 ( p=0.017); sementara di kelompok PC didapatkan korelasi positif yang cukup kuat pada jenis jelai dengan r = 0,261 ( p= 0,042).Kesimpulan: Terdapat hubungan korelasi negative lemah antara antibodi IgG spesifik kacang mede, dan kacang Arab dengan aktifitas IBD, serta korelasi positive lemah antara antibody IgG spesifik jelai dengan aktivitas klinis IBD

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Background : Inflammatory Bowel disease (IBD) is an autoimmune disease whose incidence and prevalence is increasing every year. Modernization and industrial progress of a region are always followed by changes in lifestyle, including a fast food diet (western diet) which is high in protein and carbohydrates and low in fiber and fruit. Diet, can change the composition of the gut microbiota (dysbiosis), a commensal bacteria that maintains homeostasis and the intestinal mucosal immune system so that it can trigger IBD and increase its disease activity (flare). IgG which increases after eating, is a neutralizing antibody as part of immune tolerance in humans. In healthy people, food IBD can be recognized as an antigen by triggering the antigen-antibody binding type III hypersensitivity reaction, possibly causing persistent intestinal inflammation and influencing disease activity.

Objective : To determine the relationship between food-specific IgG antibody and clinical disease activity in IBD patients

Methods: Cross-sectional study, involving 113 IBD patients whose diagnosis was confirmed by colonoscopy. In patients who agreed, food-specific IgG serum was examined for 220 types of food using the Elisa and Immunoarray technique. Clinical activity in Ulcerative Colitis (KU) was assessed using the Mayo Index while in Crohn's Disease was assessed using the Crohn Disease Activity Index.

Results: The highest proportion of food-specific IgG antibodies in the Crohn's disease group were peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), corn (75.5%), agar (69,4). %), cashews (69.4%) wheat (67.3%), oats (61.2%) and almonds (59.2%), while in Ulcerative Colitis were barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), plums (78.1%), cashews (67.2%), cow's milk (65.6%), gelatin (59.4%), almonds (50%), kidney beans (48.4%) and wheat (46.9%). Of the 220 types of food antigens, the KU showed a strong negative correlation with cashew nuts with r = -0.347 (p=0.041) and chickpeas with r = - 0.473 (p=0.017); while in the PC group, there was a fairly strong positive correlation on the type of barley with r = 0.261 (p = 0.042).

Conclusion: There is a weak negative correlation between cashew and chickpea specific IgG antibodies and IBD activity, and a weak positive correlation between barley specific IgG antibodies and IBD clinical activity"

"Penelitian ini membahas tentang gambaran kualitas hidup yang berhubungan dengan kesehatan (Health Related Quality of Life) pada penderita autoimun jenis Sindrom Sjögren. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian eksploratif. Penderita Sindrom Sjögren memiliki gangguan gejala fisik seperti kekeringan pada mulut, sakit pada persendian, dan kelelahan. Gejala fisik tersebut berpengaruh terhadap kualitas hidup penderita dalam dimensi physical well-being, psychological well-being, dan social well-being. Hasil penelitian menunjukkan bahwa penderita Sindrom Sjögren memiliki gangguan terhadap physical well-being dengan gejala fisik dan gejala kekeringan yang dimiliki dan berdampak terhadpa fungsi tubuh dan aktivitas serta partisipasi penderita. Dalam dimensi psychological well-being, penderita Sindrom Sjögren memiliki tingkat kecemasan dan stres yang tinggi, kepercayaan diri dan kurangnya pemahamanan terhadap penyakit berimplikasi terhadap depresi dan kemampuan kontrol diri yang kurang memadai. Selain itu, Sindrom Sjögren juga berdampak pada domain social well-being penderita yaitu pada gangguan kehidupan sosial, gangguan keberfungsian peran sosial dalam keluarga dan pekerjaan, beban finansial, dan permasalahan yang terjadi di rumah sakit yang menimbulkan stres bagi penderita. Penderita Sindrom Sjögren memiliki dukugan sosial melalui pasangan, sahabat, dan dokter jiwa yang berdampak positif terhadap social well-being.

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This study discusses the description of Health Related Quality of Life in autoimmune patients with Sjögren's Syndrome. This study uses a qualitative approach with an exploratory research type. People with Sjögren's Syndrome have physical symptoms such as dryness of the mouth, joint pain, and fatigue. These physical symptoms affect the patient's quality of life in the dimensions of physical well-being, psychological well-being, and social well-being. The results showed that patients with Sjögren's Syndrome had disturbances in physical well-being with physical symptoms and dryness that had an impact on body functions, activities, and participation of patients. In the dimension of psychological well-being, patients with Sjögren's Syndrome have high levels of anxiety and stress, lack of self-confidence, and lack of understanding of the disease have implications for depression and inadequate self-control abilities. In addition, Sjögren's Syndrome also has an impact on the social well-being of the patients, social life disturbances, impaired functioning of social roles in family and work, financial burdens, and problems that occur in hospitals that cause stress for patients. Patients with Sjögren's Syndrome have social support through their partners, friends, and psychiatrists which have a positive impact on their social well-being."