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"Implan gigi merupakan perawatan medis bagi gigi tanggal yang diakibatkan oleh berbagai kelainan periodontitis, maupun karies, trauma, serta kelainan pada perkembangan dan genetik, dengan tingkat keberhasilan mencapai 95% ditandai oleh kemampuan implan gigi melakukan osseointegrasi. Osseointegrasi dipengaruhi oleh beberapa hal, termasuk kualitas dan kuantitas tulang, serta desain implan gigi. Kegagalan implan gigi dapat terjadi pada tulang dengan kualitas lebih rendah akibat kelelahan yang berlebihan, serta desain implan gigi yang tidak memadai. Pada beberapa penelitian yang telah dilakukan, menunjukkan bahwa fitur self-tapping memiliki tingkat keberhasilan yang sama dengan implan gigi tanpa fitur ­­self-tapping, namun dengan torsi insersi yang lebih sederhana, sehingga dapat mengurangi risiko kerusakan tulang dan meningkatkan stabilitas primer dengan meminimalisir jumlah drilling yang digunakan. Penelitian ini dilakukan dengan melakukan simulasi finite element pada variasi desain cutting flute, berupa sudut kemiringan celah pemotong, panjang celah pemotong, dan jumlahnya, untuk menjalankan fungsi self-tapping. Simulasi ini dijalankan dengan memberikan pembebanan oklusal pada implan gigi yang dipasang pada tulang berdensitas rendah (tulang tipe III). Dari simulasi tersebut, dilakukan analisis distribusi tegangan dan strain yang terjadi pada implan gigi. Desain implan gigi dengan tiga buah celah pemotong dengan sudut kemiringan 5? di sepanjang badan implan yang berulir memiliki nilai tegangan Von Mises maksimum paling rendah, sebesar 92,127 MPa, bersesuaian dengan nilai strain maksimum paling rendah, yaitu 0,000555.

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Dental implant is a medical treatment for missing tooth caused by various conditions such as periodontitis, cavities, trauma, as well as abnormalities in growth and genetics, with a success rate of up to 95%, characterized by the ability of dental implants to achieve osseointegration. Osseointegration is affected by several factors, including the quality and quantity of bone, as well as the design of dental implants geometry. Dental implants failure can occur in lower quality bone due to excessive fatigue and inadequate implant design for acquired conditions. Research indicates that self-tapping features have the same success rate as dental implants without self-tapping features, but offer simpler insertion torque, reducing the risk of bone damage and improving primary stability by minimizing the drilling procedures. This study was conducted by performing finite element simulations on various cutting flute design, including the angle of the cutting flute, length of the cutting flute, and the number of cutting flute, to provide a self-tapping function. The simulation was conducted by applying occlusal loading to dental implants placed in low-density bone (bone type III). From the simulation, an analysis of stress distribution and strain in dental implants. Among the developed dental implant designs, the one featuring three cutting flutes at a 5? angle along the threaded implant body exhibits the lowest maximum Von Mises stress value of 92,127 MPa, as well as the lowest maximum strain value of 0,000555."

"Kehilangan gigi telah menjadi salah satu permasalahan yang umum untuk ditemukan di Indonesia, dengan angka sekitar 19% kasus gigi hilang akibat dicabut ataupun tanggal sendiri. Untuk mengatasi permasalahan kehilangan gigi, implan gigi merupakan alternatif yang banyak digunakan karena sudah terbukti dapat memberikan hasil yang baik secara jangka panjang. Keberhasilan pemasangan implan gigi dinilai berdasarkan tingkat stabilitasnya, yang terbagi kembali menjadi stabilitas primer dan stabilitas sekunder. Kedua jenis stabilitas tersebut saling berkaitan. Kekhawatiran akan pemasangan implan gigi banyak ditemukan pada kasus dimana pemasangan dilakukan pada pasien dengan tulang berkepadatan rendah. Tulang tempat terpasangnya implan gigi yang memiliki kualitas dan kepadatan yang kurang baik memiliki risiko kegagalan implan yang lebih tinggi. Untuk dapat meningkatkan tingkat stabilitas implan, banyak dilakukan proses modifikasi desain dan permukaan implan gigi, seperti penambahan fitur self-tapping dan peningkatan kekasaran permukaan badan implan. Fabrikasi dilakukan untuk menghasilkan purwarupa implan gigi dengan variasi sudut kemiringan dan panjang cutting flute, sebagai bagian dari fitur self-tapping. Purwarupa akan melalui proses surface treatment untuk mendapatkan tingkat kekasaran yang optimum untuk penggunaannya pada tulang berkepadatan rendah. Purwarupa akan diuji dengan uji torsi insersi dan uji pull-out test. Purwarupa 1 menunjukkan performa terbaik dengan nilai kekasaran permukaan sebesar 1,0636 μm, serta nilai insertion torque value dan pull-out load sebesar 22,4415 Ncm dan 317,068 N.

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Tooth loss has become a common health issue in Indonesia, with approximately 19% of cases resulting from extraction or natural loss. Dental implant are widely used as an alternative due to their proven long-term effectiveness. The success of dental implant placement is evaluated based on its stability, which can be categorized as primary stability and secondary stability. Both types of stability are interrelated with one another. Concerns about dental implant placement are often encountered when dealing with patients with low bone density. Poor quality and low-density bone in the implant insertion site might result in a higher risk of implant failure. To improve implant stability, various modifications are made to the design and surface of the implant body, such as adding self-tapping features and increasing the surface roughness of the implant body. Fabrication is done to produce dental implant prototypes with variations in in angulation and length of the cutting flute, as a part of the self-tapping feature. These prototypes will undergo surface treatment to achieve an optimal level of surface roughness for use in low bone density. Each prototypes are then tested using insertion torque test and pull-out tests. Prototype 1 showed the best performance with a surface roughness value of 1,0636 μm, as well as an insertion torque value of 22,4415 Ncm and a pull-out load of 317,068 N."

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Latar Belakang: Implan gigi sebagai alternatif perawatan kehilangan gigi dapat mengalami kegagalan akibat distribusi stress yang berlebihan. Desain implan berupa implant thread depth menjadi bagian penting dari struktur implan yang dapat mempengaruhi distribusi stress. Adapun arah pembebanan dan tulang dengan densitas rendah merupakan faktor lain yang dapat mempengaruhi distribusi stress. Tujuan: Untuk mengetahui gambaran distribusi stress pada single implant dengan variasi ukuran thread depth dan arah pembebanan di tulang densitas rendah. Metode: Penelitian ini adalah penelitian observasional deskriptif. Model 3D regio posterior tulang maksila  dan tiga implan dengan komponen implan berupa panjang 10 mm, diameter 4,1 mm, thread pitch 0,8 mm, thread shape berupa V-thread dan kedalaman thread depth yang terbagi menjadi 0,25 mm; 0,35mm; dan 0,45mm dibuat dengan modeling software dan disusun menjadi solid model. Dilakukan simulasi pemberian beban preload 200 N arah axial pada screw dan dilanjutkan dengan pemberian beban mastikasi sebesar 100 N arah axial dan oblique pada molar pertama. Dilakukan analisis dengan metode finite element untuk mengetahui distribusi stress berupa von Mises stress pada komponen implan dan tulang. Hasil : Nilai von Mises stress maksimum tertinggi pada pembebanan axial (abutment = 222,63 MPa, implant body = 179,68 MPa, dan screw = 154,97 MPa), pada pembebanan oblique (abutment = 1086,9 MPa, implant body = 852,46 MPa, dan screw = 628,56 MPa). Pada tulang alveolar, nilai von Mises stress maksimum dengan pembebanan axial pada masing-masing thread depth (0,25 mm = 29,421 MPa; 0,35 mm = 30,201 MPa; 0,45 mm = 31,091 MPa), dan dengan pembebanan oblique pada masing-masing thread depth (0,25 mm = 74,103 MPa; 0,35 mm = 75,102 MPa; 0,45 mm = 76,557 MPa). Kesimpulan : Hasil metode finite element menunjukkan bahwa pada pembebanan axial, abutment mengalami peningkatan stress seiring peningkatan thread depth. Pada pembebanan oblique seluruh komponen implan mengalami peningkatan stress seiring peningkatan thread depth. Nilai von Mises stress terbesar pada tulang ditemukan pada thread depth 0,45 mm dengan pembebanan oblique.

 

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Background: Dental implants as an alternative treatment for tooth loss can fail due to excessive stress distribution. Implant design in the form of implant thread depth is an important part of the implant structure that can affect stress distribution. The direction of loading and low-density bone are other factors that can affect stress distribution. Objective: To determine the overview of stress distribution of a single implant with varying thread depth in low-density bone. Methods: This study was a descriptive observational study. A 3D model of the posterior region of the maxillary bone and three implants with implant components of 10 mm length, 4 mm diameter, 0.8 mm thread pitch, V-thread thread shape, and thread depth divided into 0.25 mm; 0.35mm; and 0.45mm were created with modeling software and compiled into a solid model.  Simulation of 200 N axial preload was applied to the screw and followed by 100 N axial and oblique mastication load on the first molar. Finite element method analysis was performed to determine the stress distribution in the form of von Mises stress on the implant and bone components. Results: The highest maximum von Mises stress values under axial loading (abutment = 222.63 MPa, implant body = 179.68 MPa, and screw = 154.97 MPa), under oblique loading (abutment = 1086.9 MPa, implant body = 852.46 MPa, and screw = 628.56 MPa). In alveolar bone, the maximum von Mises stress value with axial loading at each thread depth (0.25 mm = 29.421 MPa; 0.35 mm = 30.201 MPa; 0.45 mm = 31.091 MPa), and with oblique loading at each thread depth (0.25 mm = 74.103 MPa; 0.35 mm = 75.102 MPa; 0.45 mm = 76.557 MPa). Conclusion: The results of the finite element analysis showed that in axial loading, the abutment experienced increased stress as thread depth increased. In oblique loading, all implant components experienced increased stress as thread depth increased. The largest von Mises stress value in the bone was found at a thread depth of 0.45 mm with oblique loading.

 

 

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"Latar belakang: Gigi tiruan dukungan implan, salah satu perawatan kehilangan gigi terbaik, diterima luas di seluruh dunia. Namun, penggunaannya di Indonesia masih relatif rendah. Studi terkait kesadaran (awareness), pengetahuan (knowledge), dan sikap (attitude) terhadap implan gigi telah banyak dilakukan di negara lain, tetapi belum pernah dilakukan di Indonesia. Tujuan: Mengembangkan kuesioner kesadaran, pengetahuan, dan sikap pasien terhadap implan gigi yang valid dan reliabel. Metode: Penelitian kualitatif melalui studi literatur pada 9 studi, wawancara semi-struktur 8 pakar implan dan 10 subjek kehilangan gigi, focus group discussion, dan uji-coba kuesioner. Penelitian kuantitatif pada 227 subjek untuk pengujian validitas dan reliabilitas kuesioner. Hasil: Kuesioner final 28 item (domain kesadaran, pengetahuan, dan sikap) berhasil dikembangkan dengan validitas isi (content validity) dan validitas muka (face validity) terpenuhi. Analisis faktor dapat dilakukan pada ketiga domain berdasarkan hasil Uji Kaiser-Meyer Olkin (KMO) dan Uji Bartlett (0,680;P<0,05| 0,922;P<0,05| 0,849;P<0,05). Uji validitas konvergen dan uji konsistensi internal Cronbach’s alpha menghasilkan nilai baik pada domain kesadaran (r=0,736; P<0,05; α=0,848), domain pengetahuan (r=0,616; P<0,05; α=0,922), dan domain sikap (r=0,658; P<0,05; α=0,794). Kesimpulan: Kuesioner kesadaran, pengetahuan, dan sikap pasien terhadap perawatan dengan implan gigi teruji valid dan reliabel untuk mengevaluasi kesadaran, pengetahuan, dan sikap pasien terhadap perawatan dengan implan gigi di Indonesia.

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Background: Implant-supported prosthesis, one of the best treatment for tooth loss, are widely accepted worldwide. However, its utilization is still relatively low in Indonesia. Studies related to awareness, knowledge, and attitude towards dental implants have been conducted in many other countries, but there has been no study in Indonesia. Objective: To develop a valid and reliable questionnaire on patient awareness, knowledge and attitudes towards dental implants. Methods: Qualitative study was done through literature review on 9 studies, semi-structured interviews with 8 implant experts and 10 tooth loss subjects, focus group discussion, and pre-testing. Quantitative study on 227 subjects for validity and reliability test. Results: The final questionnaire of 28 items (awareness, knowledge, and attitude domains) was successfully developed with achieved content validity and face validity. Factor analysis can be performed on all three domains based on the results of the Kaiser-Meyer-Olkin Test (KMO) and Bartlett Test (0.680;P<0.05| 0.922;P<0.05| 0.849;P<0.05). The convergent validity and Cronbach's alpha internal consistency were high in awareness domain (r=0.736; P<0.05; α=0.848), knowledge domain (r=0.616; P<0.05; α=0.922), and attitude domain (r=0.658; P<0.05; α=0.794). Conclusion: The questionnaire developed was valid and reliable to evaluate patient awareness, knowledge, and attitudes towards dental implant treatment in Indonesia."

"Penambahan dopan logam Cu dilakukan dalam modifikasi permukaan permukaan Ti6Al4V, untuk merancang fotokatalitik sistem dengan efisiensi tinggi di bawah cahaya tampak. Mendopankan logam Cu pada permukaan fotokatalis menggunakan metode photo-assisted deposition. Variasi konsentrasi logam Cu (0,05 M; 0,10 M; 0,15 M) dilakukan untuk memperoleh kondisi optimum fotokatalis yang aktif dibawah cahaya tampak. Hasil karakterisasi SEM-EDX dan XRD, menunjukkan bahwa sampel yang dianodisasi dengan elektrolit gliserol memiliki morfologi dan kristalinitas lebih baik dibandingkan sampel yang dianodisasi dengan elektrolit asam. Hasil uji pembentukan biofilm secara in vitro dengan bakteri Streptococcus mutans menunjukkan sampel yang didopankan dengan dopan Cu berkonsentrasi 0,15 M memiliki kinerja fotokatalitik yang paling baik, dengan hasil sebesar 99% persentase disinfeksi bakteri dibandingkan dengan model kontrol pada jam ke-16 pengukuran. Hasil ini menunjukkan sampel yang didopankan dengan dopan Cu berkonsentrasi 0,15 M merupakan kondisi optimum untuk menghambat pembentukan biofilm dalam penelitian ini

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Optimization of morphology and crystallinity of TiO2 nanotubes (TNT) fabricated on the surface of Ti6Al4V with anodizing method using a variation of the type of electrolyte. To design a system with high efficiency photocatalytic under visible light, the addition of a transition metal dopant antibacterial namely Cu (Copper). Cu-doped surface on the dental implat using photo-assisted deposition method. Variations in the concentration of Cu (0.05 M; 0.10 M; 0.15 M) were performed to obtain the optimum conditions photocatalysts active under visible light. Results of SEM-EDX and XRD characterization, indicate that the sample which is anodized with glycerol electrolyte, have better morphology and crystallinity than the sample which is anodized with acid electrolyte. The test results of in vitro biofilm formation test by Streptococcus mutans showed sample of which doped with Cu that have concentration of 0,15 M has the best photocatalytic performance, with percentage of disinfection of bacteria at 99% compared with the control model at 16th hour measurement. These results show the samples TNT/G/0,15 which doped with Cu dopant concentration of 0,15 M is an optimum condition to inhibit biofilm formation in the study"

"Untuk mengatasi kehilangan gigi diperlukan implan gigi yang tahan terhadap korosi. Penelitian ini bertujuan untuk mengetahui morfologi lapisan dan ketahanan korosi Hidroksiapatit (HAp)/Multi Walled Carbon Nanotube (MWCNT) pada substrat Stainless Steel (SS) 316L sebagai implan gigi. Metode yang digunakan untuk melapisi SS 316L dengan HAp/MWCNT adalah metode Electrophoretic Deposition (EPD). Tegangan EPD dilakukan pada 20, 30, dan 40 V selama 20 menit dengan pelarut aseton. Morfologi lapisan HAp/MWCNT dianalisis dengan Scanning Electron Microscope (SEM). Hasil SEM menunjukkan tegangan 20 dan 30 V memiliki morfologi lapisan yang homogen sedangkan tegangan 40 V mengalami terjadinya aglomerasi. Uji korosi dengan metode Potentiodynamic Polarization (PDP) dan Electrochemical Impedance Spectroscopy (EIS) menunjukkan pelapisan HAp/MWCNT melindungi substrat SS 316L dari korosi dalam larutan Simulated Body Fluid (SBF). Sampel dengan kualitas terbaik diperoleh pada tegangan 30 V karena memiliki morfologi lapisan yang homogen sehingga menghasilkan laju korosi yang rendah (0,0745 mpy).

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To address tooth loss, corrosion-resistant dental implants are required. This research aims to investigate the morphology and corrosion resistance of Hydroxyapatite (HAp)/ Multi Walled Carbon Nanotube (MWCNT) coatings on Stainless Steel (SS) 316L substrates for dental implants. The electrophoretic deposition (EPD) method was employed to coat SS 316L with HAp/MWCNT. EPD was carried out at 20, 30, and 40 V for 20 minutes using acetone as the solvent. The morphology of the HAp/MWCNT coatings was analyzed using Scanning Electron Microscopy (SEM). SEM results revealed that coatings at 20 and 30 V exhibited a homogeneous morphology, while agglomeration occurred at 40 V. Corrosion tests, conducted using Potentiodynamic Polarization (PDP) and Electrochemical Impedance Spectroscopy (EIS) methods in Simulated Body Fluid (SBF) solution, demonstrated that the HAp/MWCNT coatings protected the SS 316L substrate from corrosion. Samples coated at 30 V exhibited the highest quality due to their homogeneous morphology and low corrosion rate (0.0745 mpy)."

"Angiogenesis plays a key role in bone formation and maintenance. Bone formation has been reported to initiate in the concavities rather than the convexities in a hydroxyapatite substratum and the implant threads of dental implants. The aim of the present study was to evaluate the number of the blood vessels inside the concavities and around the convexities of the threads of implants in a rabbit tibia model. A total of 32 thread-shaped implants blasted with apatitic calcium phosphate (TCP/HA blend) (Resorbable Blast Texturing, RBT) (Maestro, BioHorizons®, Birmingham, AL, USA) were inserted in 8 rabbits. Each rabbit received 4 implants, 2 in the right and 2 in left tibia. Implants were retrieved after 1, 2, 4, and 8 weeks and treated to obtain thin ground sections. Statistically significant differences were found in the number of vessels that had formed in in the concavities rather than the convexities of the implants after 1 (p = 0.000), and 2 weeks (p = 0.000), whilst no significant differences after 4 (p = 0.546) and 8 weeks (p = 0.275) were detected. The present results supported the hypothesis that blood vessel formation was stimulated by the presence of the concavities, which may provide a suitable environment in which mechanical forces, concentrations and gradients of chemotactic molecules and blood clot retention may all drive vascular and bone cell migration."

"Because of its high predictability of success, implant therapy is a reliable treatment for replacement of missing teeth. The concept of immediate implant loading has been widely accepted in terms of early esthetic and functional recovery. However, there is little biological evidence to support this concept. The objective of this study was to examine the interactive effects of mechanical loading and surface roughness of immediately loaded titanium implants on bone formation in rats. Screw-shaped anodized titanium implants were either untreated (smooth) or acid-etched. Two implants were inserted parallel to each other in the tibiae of rats, and a closed coil spring (2.0 N) was immediately applied. Trabecular and cortical bone around both implants was analyzed using microtomographic images, and a removal torque test was performed at weeks 1, 2, and 4. Immediate loading of acid-etched implants resulted in significant decreases in bone mineral density, contact surface area, and cortical bone thickness. These effects were not observed after immediate loading of smooth implants. Conversely, loading did not influence acid-etched implant fixation; however, smooth implant fixation at week 1 was significantly reduced. These results imply that surface roughness regulates bone response to mechanical stress and that immediate loading might not inhibit osseointegration for smooth and rough implants in the late healing stages."

"Latar Belakang: Partikel mirip logam telah terdeteksi pada apusan mukosa peri-implan dari sampel klinis yang menderita peri-implantitis maupun sample yang tidzak menderita peri-implantitis dengan menggunakan sitologi eksfoliatif sel epitel dan makrofag. Ion metal titanium yang sudah terlepas dari ikatannya akan menginduksi kejadian dan reaksi biologis yang menyebabkan hilangnya stabilitas biologis dan meningkatnya osteolisis lokal di sekitar implan gigi. Penelitian in vitro menunjukkan bahwa peningkatan ekspresi sitokin inflamasi dan aktivasi osteoklas terjadi ketika ion titanium hadir. Berdasarkan penelitian yang dilakukan sebelumnya, diketahui terdapat perbedaan signifikan dari hasil polimorfisme gen CXCR2 antara pasien dengan peri-implantitis dan pasien control. Namun, kemampuan ekspresi gen CXCR2 pasien sehat pengguna Implan Gigi masih belum ditentukan. Tujuan: Menganalisis ekspresi gen pada pasien pengguna implan gigi dibandingkan dengan individu sehat yang tidak menggunakan implant gigi. Metode:Sampel RNA pasien pengguna implan (n=9), dan sample pasien control non-pengguna (n=9) diperoleh dan disimpan di Laboratorium Oral Biologi  Fakultas Kedokteran Gigi Universitas Indonesia. Kemudian, dilakukan esktraksi RNA, sintesis cDNA dan pengecekan konsentrasi sampel hasil sintesis cDNA. Selanjutnya, ekspresi gen CXCR2 dan gen referensi GAPDH diuji dengan quantitative reverse-transcription PCR (RT-qPCR). Hasil: Tidak   terdapat perbedaan bermakna ekspresi gen CXCR2, antara pasien pengguna implant gigi dan pasien yang tidak menggunakan implant gigi (p≥0,05). Kesimpulan: Tidak terdapat perbedaan bermakna secara statistik antara perbedaan ekspresi gen CXCR2 pada

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Background: Exfoliative cytology of epithelial cells and macrophages has been used to identify metal-like particles in peri-implant mucosal smears from clinical samples with and without peri-implantitis. Free titanium ions cause biological processes and reactions that result in localized osteolysis surrounding dental implants and a loss of biological stability. In vitro studies have shown that inflammatory cytokine expression and osteoclast activation increase when titanium ions are present. Based on previous studies, it is known that there are significant differences in the results of CXCR2 gene polymorphisms between patients with peri-implantitis and control patients. However, the expression ability of the CXCR2 gene in healthy patients using dental implant has not been determined.

Objective: To analyze gene expression in patients with dental implants compared to healthy individuals who do not use dental implants.

Methods: RNA samples from implant users (n=9), and non-user control patient samples (n=9) were obtained and stored at the Oral Biology Laboratory, Faculty of Dentistry, University of Indonesia. Then, RNA extraction, cDNA synthesis was carried out and checking the concentration of the cDNA synthesized samples. Next, the expression of the CXCR2 gene and the GAPDH reference gene were tested by quantitative reverse-transcription PCR (RT-qPCR).

Results: There was no significant difference in CXCR2 gene expression between patients with implants. Conclusion: There is no statistically significant difference between differences in gene expression in dental implant users and non-users."