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Radifan Abrar Tahrizi
Evaluasi Sifat Mekanik Perancah Biopolimer Poly-Lactic Acid (PLA) dan Acrylonitrile Butadiene Styrene (ABS) sebagai Tissue Engineered Medical Products (TEMP) Melalui Fused Deposition Modeling 3D Printing = Mechanical Properties Evaluation on Poly-Lactic Acid (PLA) and Acrylonitrile Butadiene Styrene (ABS) Biopolymer Scaffold as Tissue Engineered Medical Products (TEMP) Through Fused Deposition Modeling 3D Printing
"Fused depositiom modeling (FDM) menawarkan keuntungan unik menuju manufaktur fleksibel, yang dapat digunakan untuk membuat scaffold dengan geometris kompleks dan struktur internal yang berpori. Untuk meningkatkan kinerja biologis printedscaffold, sangat penting untuk menentukan biomaterial yang sesuai dan sifat mekanisnya yang terikat. Sifat mekanik memiliki peran penting dalam menentukan kinerja scaffold medis, sehingga mempengaruhi kinerja produk medis rekayasa jaringan. Akibatnya, pengaruh parameter printing pada berbagai jenis biopolimer yang berbeda untuk pembuatan scaffold masih bervariasi dan memerlukan pendalaman lebih lanjut. Penelitian yang diusulkan bertujuan untuk mempelajari pengaruh dan kelayakan parameter printing 3D dalam meningkatkan sifat mekanik, sekaligus memahami faktor biologis perancah TEMP (Tissue Engineered Medical Product) berdasarkan bahan biopolimer yang berbeda. Tujuannya adalah langkah awal menuju pemanfaatan pendekatan baru dalam pembuatan TEMP dengan cara yang lebih canggih melalui penggunaan teknik 3D pemodelan deposisi fusi. Penelitian dilakukan dengan membandingkan berbagai kinerja mekanik dan aspek biologis yang sesuai antara ABS (acrylonitrile butadiene styrene) dengan PLA (poly-lactic acid).
Fused deposition modeling (FDM) offers unique advantages for flexible manufacturing, which can be employed to fabricate scaffolds with complex shapes and internal porous structures. To improve the biological performance of printed scaffolds, it is crucial to determine suitable biomaterials and their mechanical attached properties. Mechanical properties have a significant role in establishing the functionality of a medical scaffold, thus affecting the performance of the tissue-engineered medical product. Consequently, the influence of printing parameters in different biopolymer for scaffold manufacturing still varies and require further investigation. The proposed research aims to study the influence and feasibility of 3D printing parameters in improving mechanical properties, while also understanding biological factors of TEMP (Tissue Engineered Medical Product) scaffold based on different biopolymer materials. The aim is an initial step toward utilizing a novel approach in manufacturing TEMP in a more sophisticated manner through employing the fused deposition modeling 3D technique. Research is conducted by comparing various mechanical performances and the corresponding"
Depok: Fakultas Teknik Universitas Indonesia, 2023
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UI - Skripsi Membership  Universitas Indonesia Library
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Yulfina Bimawanti
Aplikasi polimer untuk formulasi tablet 3D printing dengan metode fused deposition modeling = Polymer applications for 3D printed tablet by fused deposition modeling
"Saat ini teknologi 3D printing telah dikembangkan pada bidang farmasi khususnya teknologi produksi sediaan padat yang disebut tablet 3D printing. Hal ini dapat mendukung tujuan personalisasi sediaan farmasi khususnya terkait dosis obat. Salah satu metode yang dapat digunakan untuk personalisasi dosis obat untuk pasien yaitu tablet 3D printing. Penetapan dosis dibuat dengan merancang tablet 3D printing dengan volume tertentu menggunakan perangkat lunak untuk menyesuaikan dosis yang dibutuhkan. Penulisan ini bertujuan untuk mengkaji beberapa polimer yang dapat digunakan sebagai filamen dengan metode fused deposition modeling untuk pembuatan tablet 3D printing dan menganalisis profil pelepasan obat dari tablet 3D printing tersebut. Kajian ini berfokus untuk mempelajari karakteristik yang terdapat pada beberapa polimer yaitu poli asam laktat, polivinil alkohol, poli kaprolakton, polivinil pirolidon, poletilen oksida, etilen vinil asetat, etil selulosa, hidroksipropilmetil selulosa, dan hidroksipropil selulosa berupa sifat termoplastik, biodegradasi, dan sifat mekaniknya agar dapat diaplikasikan pada fused deposition modeling 3D printing. Selain itu, dipelajari pula pelepasan obat dari matriks tablet 3D printing. Hasil-hasil penelitian menunjukkan bahwa polimer yang dapat digunakan harus memiliki sifat termoplastik dan biodegradable. Polimer di atas dapat digunakan untuk membentuk filamen untuk pembuatan tablet 3D printing. Pilihan polimer yang digunakan berpengaruh pada profil pelepasan obat dari tablet 3D printing. Oleh karena itu, diajukan gagasan untuk membuat tablet dengan teknologi 3D printing dapat memfasilitasi modifikasi bentuk, ukuran, dosis dan profil pelepasan obat dari tablet. Tablet 3D printing dapat dikembangkan lebih lanjut menggunakan metode ini sehingga tujuan personalisasi obat dapat terwujud.
Currently 3D printing technology has been developed into the pharmaceutical field, especially solid preparations technology namely 3D printed tablets. This can support the purpose of personalizing medicine, especially related to drug dosages. Determination of dosage is made by designing tablets with certain volume using software to adjust the required dose. The purpose of this paper is to review several polymers that can be used in 3D printing with the fused deposition modeling as filament forming for the manufacture of 3D printed tablets and to analyze various types of drug release profiles. This review focuses on studying the characteristics found in several polymers, polylactic acid, polyvinyl alcohol, polycaprolactone, polyvinyl pyrrolidone, polyethylene oxide, ethylene vinyl acetate, ethyl cellulose, hydroxypropylmethyl cellulose, and hydroxypropyl cellulose in the form of thermoplastic, biodegradable, and mechanical properties so that they can applied in fused deposition modeling 3D printing technique. In addition, the drug release profile from 3D printed tablet is also studied. Research results show that polymers that can be used must have thermoplastic properties and are biodegradable. The polymers that have been mentioned can be used to form filaments for making 3D printed tablets. Drug release profile is very dependent on the polymer used on 3D printed tablets. Tablets made with this technology can be modified in both shape and size that affect the drug release profile from the matrix. 3D printed tablets has the potential to be developed using this method so that the goal of drug personalization can be realized."
Depok: Fakultas Farmasi Universitas Indonesia, 2020
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UI - Skripsi Membership  Universitas Indonesia Library
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Nindya Aprilia Alief
Studi Pengembangan dan Pemodelan Struktur 4D Printing untuk Aplikasi Biomedik = Development Study and Modelling 4D Printed Structure for Biomedical Application
"

Perkembangan additive manufacturing dan/atau 3D printing yang sangat pesat tidak hanya memengaruhi bidang manufaktur saja tetapi turut serta memberi pengaruh terhadap bidang kesehatan. Hal ini ditunjukkan dengan mulainya 3D printing diperkenalkan secara klinis untuk pengembangan biomaterial dan biofabrikasi. Adapun keberadaan alat fabrikasi 3D printing, terutama Fused Deposition Modelling (FDM), semakin mudah dijumpai. Sehingga, 3D printing ini menjadi teknologi yang semakin bernilai terutama untuk menghadapi era yang serba cepat. 4D printing merupakan konsep dimana fabrikasi struktur dilakukan secara lapis dan kemudian mengalami perubahan bentuk pasca pemberian stimulus eksternal. Konsep tersebut turut memiliki peluang untuk diimplementasikan terutama pada aplikasi biomedik. Sehingga, diharapkan bahwa 4D printing dapat mengoptimalkan fabrikasi dan pengaplikasian alat kesehatan saat perawatan dilakukan. Di samping itu, Polylactic acid (PLA) sebagai salah satu polimer yang populer digunakan dalam struktur 4D printing memiliki karakteristik yang tepat untuk aplikasi tersebut. Dengan demikian, agar dapat mengetahui konsistensi hasil fabrikasi dan fenomena yang terjadi pada struktur 4D printing dengan material PLA, kalibrasi alat fabrikasi FDM serta perancangan dan fabrikasi struktur dilakukan. Kedua hal tersebut mengindikasikan bahwa parameter proses yang lebih rinci dapat menghasilkan struktur yang sesuai dengan desain. Selain itu, struktur yang dihasilkan memiliki kemampuan untuk bertransformasi secara melengkung pada dua dimensi (bending 2D).

 

The rapid development of additive manufacturing and/or 3D printing not only affects manufacturing sector but also giving influence towards healthcare field. This is indicated by the beginning of 3D printing introduced clinically for the development of biomaterials and bio fabrication. The presence of 3D printing fabrication machine, especially the Fused Deposition Modelling (FDM) printer, even easier to find. This makes the 3D printing becomes increasingly valuable technology while facing this fast-paced era. 4D printing is a fabrication concept by building the structure layer by layer and then undergoes such a shape transformation due to external stimulus. The concept also has a chance to be applied in biomedical application. Therefore, it is expected that 4D printing could optimize the fabrication and application of medical devices when treatment is carried out. In addition, Polylactic acid (PLA), one of the popular polymers used in the 4D printing, has excellent characteristics for the application. Thus, in order to know the consistency of fabrication results and the phenomena that occur in the PLA 4D printed structure, the calibration of FDM fabrication tools, structural design and fabrication is conducted. Both of those indicate that more detailed process parameters can produce structures that are in accordance with the design. In addition, the resulting structure has the ability in order to transform in a curved manner (bending 2D).

"
2019
T53139
UI - Tesis Membership  Universitas Indonesia Library
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Rendria Arsyan Labde
Pengembangan sistem Direct Cell Extruder pada aplikasi organ printing = Developing Direct Sell Extruder system in organ printing application
"Dalam penyembuhan jaringan yang rusak dalam tubuh manusia, sebuah teknik bernama tissue engineering digunakan sebagai “jalur” yang di implantasikan kedalam tubuh sebagai jalur untuk regenerasi. Ini disebut dengan scaffold. Dalam bidang tissue engineering, sebuah metode bernama Organ Printing dikembangkan oleh Dr. Gabor Forgasc. Organ printing adalah sebuah teknik yang dikembangkan untuk mencetak sel baru yang dapat diimplantasikan ke dalam tubuh manusia untuk menggantikan fungsi jaringan organ yang rusak. Tujuan utama dari penelitian ini adalah untuk mencetak organ dengan material hydrogel gelatin. Sebuah system esktrusi dibuat untuk mencetak scaffold berbahan gelatin. Gelatin yang terekstrusi di karakterisasi dengan mengatur kecepatan dan konsentrasinya. Hasil yang optimal didapat pada kecepatan 800 mm/min dan konsentrasi 25%. Setelah itu, parameter yang optimal tersebut digunakan untuk memfabrikasi scaffold 2 dimensi dengan pola heksagonal dan kuadratik.Lebar garis dan ketebalan yang didapatkan adalah 364 μm dan 8.83 μm.
In the healing of damaged tissue in humans, a technique called tissue engineering uses a "track" that is implanted in the body as a pathway for regenerating. This “track” is called scaffold. In the field of tissue engineering, a method called Organ Printing was developed by Dr. Gabor Forgasc. Organ printing is a technique that was developed to print new cells that can be implanted inside human body to replace the function of the damaged organ tissue. The main purpose of this research is to print organs with gelatin hydrogel material. An extrusion system is realized to print gelatin scaffold. The extruded gelatin is characterized by modifying its speed and concentration. An optimal result is achieved at the speed of 800 mm/min and 25% concentration. Moreover, the optimal parameter is used to fabricate a 2-dimensional scaffold with hexagonal and quadratic patterns. The line width and thickness that is achieved are 364 !m and 8.83 !m respectively."
Depok: Fakultas Teknik Universitas Indonesia, 2013
S46397
UI - Skripsi Membership  Universitas Indonesia Library
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Tissue-Engineered Vascular Grafts
"Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone.
Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery.
Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications.
The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment.
Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences."
Switzerland: Springer Cham, 2019
e20503357
eBooks  Universitas Indonesia Library
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Muhammad Maulana Ghiffary
Pengaruh penambahan graphite, graphene oxide, dan carbon nanotube terhadap karakteristik fisikokimia perancah chitosan/hyaluronic acid/hydroxyapatite untuk aplikasi rekayasa jaringan = Effect of graphite, graphene oxide, and carbon nanotubes on the physicochemical characteristics of chitosan/hyaluronic acid/hydroxyapatite scaffolds for tissue engineering applications
"Osteoartritis merupakan penyakit kronis yang ditandai dengan kemunduran tulang rawan dan menyebabkan kekakuan, nyeri, dan gangguan pergerakan. Strategi rekayasa jaringan tulang menggunakan perancah dapat menjadi alternatif yang menjanjikan untuk regenerasi jaringan tulang yang rusak. Penelitian ini bertujuan untuk fabrikasi dan karakterisasi perancah dengan material chitosan (CS), hyaluronic acid (HA), hydroxyapatite (Hap) dengan kombinasi penambahan graphite (Gr), graphene oxide (GO), dan multiwalled carbon nanotube (MWNCT) untuk aplikasi rekayasa jaringan tulang. Dalam penelitian ini, dilakukan sintesis GO dan fungsionalisasi kimia dari material Gr dan MWNCT. Fabrikasi perancah dilakukan dengan metode freeze drying. Seluruh kelompok perancah dilakukan karakterisasi SEM dan FTIR, uji tekan dan porositas, uji swelling, wettability, dan laju degradasi. Fabrikasi perancah dibagi menjadi empat kelompok yaitu CS/HA/HAp, CS/HA/HAp/GO, CS/HA/HAp/f-Gr, dan CS/HA/HAp/f-MWNCT dengan ukuran diameter 1 cm, tinggi 1,5 cm, dan luas permukaan luas permukaan 4,71-6,28 cm2. Keseluruhan perancah memiliki ukuran pori yang bervariasi dan terdistribusi pada permukaan. Berdasarkan hasil FTIR, perancah mengandung gugus fungsi O-H, C=O, C-O-C, amida I, amida II, dan fosfat (PO43-). Pada uji kekuatan tekan, keseluruhan perancah memiliki CS/HA/HAp memiliki kekuatan tekan dan young modulus yang serupa dengan cancellous bone sebesar 5,76-6,14 MPa dan 3,95-471 MPa. Perancah memiliki laju porositas dengan rentang 13,8- 86,6%. Perancah memiliki kemampuan wettabiliy yang baik dengan rentang persentase 726-1069%. Rasio swelling perancah berada pada rentang 25,2-39,3%. Laju degradasi perancah cukup terkontrol dengan rentang 16,7-35,5%. Berdasarkan seluruh hasil karakterisitik, perancah CS/HA/HAp dengan penambahan GO merupakan kandidat terkuat sebagai perancah ideal pada penelitian ini. Perancah GO mempunyai karakteristik yang berada diantara perancah kontrol dan perancah f-MWNCT/f-Gr.
Osteoarthritis is a chronic disease characterized by the deterioration of cartilage and causes stiffness, pain, and impaired movement. The bone tissue engineering strategy using scaffolds can be a promising alternative for the regeneration of damaged bone tissue. This study aims to fabricate and characterize scaffolds with chitosan (CS), hyaluronic acid (HA), hydroxyapatite (Hap) with a combination of addition of graphite (Gr), graphene oxide (GO), and multiwalled carbon nanotubes (MWNCT) for tissue engineering applications. In this study, GO synthesis and chemical functionalization of Gr and MWNCT materials were carried out. Scaffolding was done by freeze drying method. All groups of scaffolds were characterized by SEM and FTIR, compressive and porosity tests, swelling, wettability, and rate of degradation tests. Scaffolding was divided into four groups, namely CS/HA/HAp, CS/HA/HAp/GO, CS/HA/HAp/f-Gr, and CS/HA/HAp/f-MWNCT with a diameter of 1 cm, height 1, 5 cm, and a surface area of ​​4.71-6.28 cm2. The entire scaffold has varying pore sizes and is distributed over the surface. Based on the results of FTIR, the scaffold contains functional groups O-H, C=O, C-O-C, amide I, amide II, and phosphate (PO43-). In the compressive strength test, all scaffolds having CS/HA/HAp had similar compressive strength and young modulus with cancellous bone of 5.76-6.14 MPa and 3.95-471 MPa. Scaffolds have porosity rates in the range of 13.8-86.6%. Scaffolds have good wetability with a percentage range of 726-1069%. The swelling ratio of the scaffolds was in the range of 25.2-39.3%. The rate of degradation of the scaffold was quite controlled with a range of 16.7-35.5%. Based on all the characteristic results, the CS/HA/HAp scaffold with the addition of GO was the strongest candidate as the ideal scaffold in this study. The GO scaffold has characteristics that are between the control scaffold and the f-MWNCT/f-Gr scaffold."
Depok: Fakultas Teknik Universitas Indonesia, 2022
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UI - Skripsi Membership  Universitas Indonesia Library
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Harahap, Ahmad Indra Sakti
Investigasi awal photo-patterning untuk realisasi biodegradable scaffold 3d = Initial investigation of photo-patterning methods to realize 3d biodegradable scaffold / Ahmad Indra Sakti Harahap
"ABSTRAK
Fabrikasi mikro merupakan teknologi advanced untuk manufaktur produk ukuran kecil yang kini telah diaplikasikan luas dalam berbagai bidang termasuk kesehatan. Tissue engineering adalah salah satu bidang dari aplikasi teknologi ini dengan berfokus pada rekayasa fabrikasi scaffold. Scaffold yang ideal dipersyaratkan memiliki konstruksi yang mirip dengan lingkungan jaringan target dengan struktur 3D, biodegradable, berpori dan vaskularis. Saat ini, hidrogel gelatin merupakan salah satu material biomatriks yang tepat untuk fabrikasi scaffold. Gelatin tersebut dibentuk dengan metode photo-patterning menggunakan sensitizer rose bengal pada panjang gelombang cahaya tampak. Penelitian ini bertujuan untuk mengembangkan dan merealisasikan bentuk scaffold 2D sebagai dasar pembentukan struktur jaringan 3D. Karakterisasi hasil photo-patterning dilakukan dengan mengukur dimensi pattern width, ketebalan resolusi dan intensitas. Proses ini menghasilkan daerah kerja optimum pada konsentrasi 2% dengan waktu 3 menit.
ABSTRACT
Microfabrication is an advanced technology for manufacturing products of small size that has now been widely applied in various fields including health area. Tissue engineering becomes ones application of this technology focused on engineering scaffold fabrication. The ideal scaffold required to have a construction similar to the target network environment with a 3D structure, biodegradable, porous and vaskularize. At present, the gelatin hydrogel is appropriate biomatrix material for fabricating the scaffold. Gelatin is formed by photo-patterning method using the sensitizer rose bengal at visible light’s wavelength. This study aims to develop and realize the basic shape of the scaffold 2D as 3D tissue structure formation. Characterization results of photo-patterning is done by measuring the dimensions of the pattern width, thickness and intensity resolution. This process resulted in optimum working area at a concentration of 2% with a time of 3 minutes."
Fakultas Teknik Universitas Indonesia, 2014
S53262
UI - Skripsi Membership  Universitas Indonesia Library
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Rahmat Rizqi Susanto
Perubahan Sifat Shape Memory Effect (SME) dan Bioaktivitas Scaffold Poly-Lactic Acid (PLA) Produk 3D Print akibat Variasi Konsentrasi Hidroksiapatit sebagai Modifikator Permukaan = Changes in Shape Memory Effect (SME) Properties and Bioactivity of 3D Printed Poly-Lactic Acid (PLA) Scaffolds due to Varying Hydroxyapatite Concentration as Surface Modifiers
"Perkembangan teknologi 3D print telah merevolusi bidang rekayasa jaringan dalam manufaktur scaffold dengan struktur yang kompleks. Penggunaan poly-lactic acid (PLA) sebagai bahan dasar scaffold telah umum digunakan karena sifatnya yang biokompatibel dan bioresorbable. Di sisi lain, PLA memiliki sifat unik berupa shape memory effect (SME) sehingga membuka peluang dalam pengembangan self-fitting scaffold. Namun, permukaan PLA yang bersifat hidrofobik menghambat interaksi scaffold dengan jaringan sekitar. Sebagai upaya untuk meningkatkan hidrofilisitas permukaan, scaffold PLA dilakukan modifikasi permukaan menggunakan alkali treatment dan pelapisan hidroksiapatit (HAp). Hidroksiapatit merupakan utama penyusun tulang sehingga diharapkan mampu meningkatkan fungsi biologis scaffold. Untuk mengetahui konsentrasi pelapisan HAp yang optimal dilakukan variasi konsentrasi HAp dalam dispersi HAp-etanol sebesar 0,5, 1, dan 2% (w/v). Pengaruhnya terhadap SME dan bioaktivitas scaffold PLA akan dievaluasi menggunakan uji imersi r-SBF, observasi visual, uji kompresi, dan karakterisasi SEM-EDS. Hasil uji imersi menunjukkan bahwa pemberian dan peningkatan konsentrasi HAp pada permukaan mampu meningkatkan kemampuan absorpsi air scaffold secara signifikan. Selain itu, scaffold juga terukur mengalami tren peningkatan massa selama pengujian. Observasi visual menunjukkan adanya kristal putih terpresipitasi. Melalui karakterisasi SEM-EDS diketahui komposisi kristal yang terbentuk adalah CaP. Dengan demikian, dapat diketahui bahwa peningkatan konsentrasi lapisan HAp akan meningkatkan bioaktivitas scaffold melalui peningkatan laju presipitasi CaP. Namun, hal ini juga akan berdampak pada penurunan kekuatan kompresi serta kemampuan strain recovery akibat adanya penetrasi HAp ke dalam scaffold sehingga mengalami aglomerasi dan menyebabkan terjadinya embrittlement pada scaffold.
The development of 3D printing technology has revolutionized the field of tissue engineering in manufacturing scaffolds with complex structures. The use of poly-lactic acid (PLA) as the base material for scaffolds has been widely adopted due to its biocompatible and bioresorbable properties. However, PLA has a unique property known as shape memory effect (SME), which opens up opportunities for the development of self-fitting scaffolds. On the other hand, the hydrophobic nature of PLA surfaces inhibits the interaction between the scaffold and the surrounding tissue. In an effort to enhance the hydrophilicity of the surface, surface modifications are performed on PLA scaffolds using alkali treatment and hydroxyapatite (HAp) coating. Hydroxyapatite, being the main component of bone, is expected to improve the biological function of the scaffold. To determine the optimal concentration of HAp coating, variations in HAp concentration in the HAp-ethanol dispersion are conducted at 0.5%, 1%, and 2% (w/v). Their influence on the SME and bioactivity of the PLA scaffold will be evaluated using r-SBF immersion tests, visual observations, compression tests, and SEM-EDS characterization. The immersion test results show that the addition and increased concentration of HAp on the surface significantly enhance the water absorption capacity of the scaffold. Additionally, the scaffold's measured mass shows an increasing trend during the testing. Visual observations reveal the presence of white crystals that precipitate. Through SEM-EDS characterization, it is determined that the composition of the formed crystals is CaP. Thus, it can be concluded that increasing the concentration of the HAp layer enhances the scaffold's bioactivity by increasing the rate of CaP precipitation. However, this also leads to a decrease in compressive strength and strain recovery ability due to HAp penetration into the scaffold, causing agglomeration and resulting in scaffold embrittlement."
Depok: Fakultas Teknik Universitas Indonesia, 2023
S-pdf
UI - Skripsi Membership  Universitas Indonesia Library
cover
Cornelia Kasper, editor
Tissue engineering III : cell–surface interactions for tissue culture
"This book about the cell-surface interaction, studying cell-surface interactions In vitro : a survey of experimental approaches and techniques, harnessing cell-biomaterial interactions for obsteochondral tissue regeneration, interaction of cells with decellularized biological materials, evaluation of biocompatibility using In vitro methods : interpretation and limitations, artificial scaffolds and mesenchymal stem cells for hard tissues, bioactive glass-based scaffolds for bone tissue engineering, microenvironment design for stem cell fate determination, stem cell differentiation depending on different surfaces, designing the biocompatibility of biohybrids, interaction of cartilage and ceramic matrix, and bioresorption and degradation of biomaterials."
Heidelberg : Springer, 2012
e20406231
eBooks  Universitas Indonesia Library
cover
Lacroix, Damien
Multiscale Mechanobiology in Tissue Engineering
"This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic."
Singapore: Springer Singapore, 2019
e20502131
eBooks  Universitas Indonesia Library
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