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"Aim: The purpose of the study was to investigate the prevalence of diastolic dysfunction in patients with type II diabetes mellitus without overt cardiovascular disease, and to investigate whether its presence is associated with age, sex, onset of diabetes, glycemic control and obesity.Patient and methods: We studied 30 patients with type 2 diabetes; II were men and 19 were women; their ages ranged from 40 - 65 years; all patients had no evidence of hypertension, coronary artery disease, congestive heart failure, anatomical disease of heart, arrhythmia; and myocardiac ischemia at maximal treadmill exercise test. Diastolic dysfunction was evaluated using Doppler echocardiography.Results: Diastolic dysfunction was found in 22 subjects (73.3%) of whom 21 (70%) had abnormal relaxation and one (3.3%) had a pseudonormal pattern of ventricular filling. Systolic function was normal in all subjects, and there was no correlation between diastolic dysfunction and age, sex, onset of diabetes, glycemic control and obesity.Conclusion: Diastolic dysfunction is much more common than previously reported. The high prevalence of this phenomenon population suggests the importance of screening for diastolic dysfunction among such high-risk patients."

"Pada 28 kasus diabetes melitus ( DM ) tipe 2 tanpa kelainan kardiovaskular yang diperiksa di Bagian Metabolik Endokrin, Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Jakarta, mulai Oktober 2001 sampai Desember 2001, dilakukan pemeriksaan ekokardiografi untuk melihat fungsi diastolik ventrikel kiri dan dilakukan pemeriksaan urin mikroalbuminuria. Disfungsi diastolik ditemukan pada 73,7 % pasien DM tipe 2 tanpa mikroalbuminuria dan 66,7% pada DM tipe 2 dengan mikroalbuminuria. Tidak terdapat hubungan bermakna kejadian disfungsi diastolik pada kelompok DM tipe 2 dengan mikroalbuminuria maupun DM tipe 2 tanpa mikroalbuminuria. (Med J Indones 2005; 14: 169-72)

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Twenty-eight cases of type 2 diabetes mellitus (DM) without any cardiovascular disease were recruited from the Department of Metabolic-Endocrine, Faculty of Medicine, University of Indonesia / Dr. Cipto Mangunkusumo General Hospital, Jakarta. Recruitment of the study began in October 2001 and was completed by December 2001. Participants were examined for echocardiography and microalbuminuria urinary examination. Diastolic dysfunction was found in 73.7% of type 2 diabetic patients without microalbuminuria and 66.7% in type 2 diabetic patients with microalbuminuria. Neither type 2 diabetic groups with nor without microalbuminuria indicated any significant association to the occurrence of diastolic dysfunction. (Med J Indones 2005; 14: 169-72)"

"Background: thyroid dysfunction is more likely to occur in diabetes mellitus patients than general population. Until now, no study has been done to find prevalence of hypothyroidism and hyperthyroidism in Indonesian diabetics. This study aimed to find the proportion and characteristics of thyroid dysfunction in Indonesian type 2 diabetes mellitus patients. Methods: a cross-sectional study was conducted in Endocrine and Diabetes Polyclinic, Department of Internal Medicine, Cipto Mangunkusumo Hospital from July to September 2015. This study include type 2 diabetes mellitus patients, age ≥ 18 year-old, willing to undergo thyroid laboratory testing. In this study, hypothyroidism defined as TSH more than 4.0 mIU/L, while hyperthyroidism is defined as TSH less than 0.4 mIU/L with eCLIA. Results: from 364 subjects who were recruited from Endocrine and Diabetes Polyclinic, Cipto Mangunkusumo Hospital, 303 subjects underwent this study until analysis. Two hundred and three (273) subjects (90.1%) were euthyroid, 7 subjects (2.31%) were hyperthyroid, and 23 subjects (7.59%) were hypothyroid. Majority of the patients had subclinical hypothyroidism (56.5% based on Zulewski and Billewicz Score and 65.2% based on fT4 laboratory result), while 42.9% and 71.4% subjects had clinical hyperthyroidism based on clinical appearance and fT4 laboratory result respectively. Conclusion: proportion of hypothyroidism was 7.59% and hyperthyroidism was 2.31%, while the proportion of total thyroid dysfunction was 9.9% among diabetics. It is suggested that screening for thyroid dyscfunction can be done in high risk condition as a part of comprehensive management in type 2 diabetes mellitus patients."

"Latar Belakang: Gagal jantung adalah salah satu bentuk komplikasi kardiovaskular dan merupakan salah satu penyebab utama mortalitas dan morbiditas pada pasien DMT2. Disfungsi diastolik merupakan bentuk awal dari gagal jantung yang tidak bergejala dan seringkali terlambat terdiagnosis, sehingga deteksi dini penting untuk dilakukan. Guideline gagal jantung dari AHA merekomendasikan pemeriksaan NTproBNP dengan nilai batas >125 pg/ml sebagai salah satu upaya deteksi dini pada populasi berisiko. Penelitian-penelitian faktor klinis yang ada mayoritas dilakukan pada populasi kaukasia dengan hasil yang heterogen. Diketahui populasi DMT2 di Asia memiliki indeks massa tubuh lebih rendah, usia lebih muda, dan nilai dasar NTproBNP lebih rendah, namun memiliki prevalensi gagal jantung yang lebih tinggi. Belum ada penelitian yang meneliti hubungan faktor klinis dan kadar NTproBNP pada populasi DMT2 di IndonesiaTujuan: Penelitian ini dibuat untuk mengetahui hubungan faktor klinis dan kadar NTproBNP dengan kejadian disfungsi diastolik pada populasi DMT2 di IndonesiaMetode: Penelitian ini merupakan studi potong lintang (cross sectional study), menggunakan data sekunder dari follow up ke-30 Studi Kohort PTM Litbangkes. Subyek berusia dibawah 65 tahun yang terdiagnosis DMT2 selama pengamatan dan memenuhi kriteria inklusi dicatat, dilakukan pemeriksaan NTproBNP dan dilakukan analisis dengan kejadian disfungsi diastolik yang didapatkan dari ekhokardiografi. Uji bivariat dilakukan dengan uji chi square dan uji multivariat menggunakan uji regresi multipel. Kadar NTproBNP yang diperiksakan dilakukan penentuan titik potong menggunakan Receiver Operating Characteristics (ROC).Hasil: Subyek yang terinklusi didapatkan sebesar 91 orang. Uji multivariat menunjukkan baik kadar NTproBNP>125 pg/ml dan titik potong NTproBNP baru >62,5 pg/ml berhubungan bermakna dengan kejadian disfungsi diastolik dengan PRadj 2,791 (95% IK; 1,937-4,021; p<0,0001) dan PRadj 2,587 (IK 95%; 1,554 – 4,645; p:<0,0001) dengan Area under curve (AUC) 0,76. Pada penelitian kami, tidak ada faktor klinis yang berhubungan secara bermakna pada uji statistikSimpulan: Peningkatan kadar NTproBNP >125 pg/ml berhubungan dengan kejadian disfungsi diastolik pada populasi DMT2 di Indonesia.

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Background: Diastolic dysfunction is an early form of heart failure that is asymptomatic and often diagnosed late in T2DM patients, so early detection is encourage. The AHA heart failure guideline recommends NTproBNP testing with a cut-off value of >125 pg/ml as one of the early detection strategies. The majority of existing clinical factor studies have been conducted in Caucasian populations with heterogeneous results and it is known that T2DM populations in Asia have lower body mass index, younger age, lower baseline NTproBNP values with higher heart failure prevalence. To date, there have been no research determining the association between clinical factors and NTproBNP levels in the T2DM population in Indonesia.

Objective: This study was designed to determine the association of clinical factors and NTproBNP levels with the incidence of diastolic dysfunction in the T2DM population in Indonesia

Methods: This study is a cross sectional study, using secondary data from the 30th follow up of the Bogor NCD Cohort Study. Subjects under 65 years of age who are diagnosed with T2DM during observation and meet the inclusion criteria were being recorded, We will determine the association between clinical factors and NTproBNP examination results with the incidence of diastolic dysfunction obtained from echocardiography. Bivariate tests were performed using the chi square test and multivariate tests using multiple regression tests. The new NTproBNP cut off points were determined using Receiver Operating Characteristics (ROC).

Results: 91 subjects were included. Multivariate test showed that both NTproBNP level >125 pg/ml and new cut off >62,5 pg/ml was significantly associated with the incidence of diastolic dysfunction with PRadj 2,791 (95% IK; 1,937-4,021; p<0,0001) and PRadj 2.587 (95% CI; 1.554 - 4.645; p: <0.0001) respectively, with Area under curve (AUC) 0.76. In our study, No clinical factors were associated significantly with diastolic dysfunction incidence.

Conclusions: NTproBNP levels >125 pg/ml are associated with the incidence of diastolic dysfunction in the T2DM population in Indonesia."

"Disfungsi otonom kardiovaskular (DOK) merupakan komplikasi diabetes melitus tipe 1 (DMT1) yang menjadi penyebab kematian tersering pada dewasa. Gejala subklinis dapat berawal sejak remaja tetapi deteksi dini melalui pemeriksaan fungsi otonom kardiovaskular belum rutin dilakukan. Studi terdahulu menunjukkan bahwa kontrol glikemik dan lama sakit berpengaruh terhadap progresivitas DOK. Data di Indonesia mengenai masalah ini belum ada. Penelitian ini bertujuan untuk mengetahui prevalens DOK pada pasien DMT1 anak dan menilai hubungan DOK dengan rerata lama sakit dan kadar HbA1C. Tiga puluh delapan anak berusia 10-18 tahun dengan DMT1 yang terdiagnosis lebih dari 5 tahun menjalani 3 pemeriksaan uji refleks kardiovaskular (URK) di Poliklinik Endokrinologi Anak RSCM Kiara. Disfungsi otonom kardiovaskular dengan 1 nilai abnormal URK ditemukan pada 36,8% anak. Tidak ditemukan korelasi bermakna antara DOK dengan rerata lama sakit dan kadar HbA1C. Berdasarkan penelitian ini, prevalens DOK pada remaja cukup tinggi sehingga deteksi dini sebaiknya dilakukan secara rutin. Penelitian lanjutan dengan rentang sakit yang lebih panjang dan data HbA1C serial perlu dilakukan untuk mengevaluasi peran kontrol glikemik dan lama sakit terhadap kejadian DOK.

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Cardiovascular autonomic dysfunction (CAD) is a type 1 diabetes mellitus (T1DM) complication which becomes the most common cause of death in adults. Subclinical symptoms may have occurred since adolescence, yet early detection using cardiovascular autonomic function examination has not been performed routinely. Previous studies showed that glycemic control and duration of illness affected CAD progressivity. However, there is still no data regarding this issue in Indonesia. This study aimed to determine the prevalence of CAD in pediatric T1DM patients and the correlation between CAD and average length of illness, as well as HbA1C levels. Thirty-eight children aged 10-18 years who had been diagnosed with T1DM for more than 5 years underwent a series of three cardiovascular reflex test (CRT) at the Pediatric Endocrinology Polyclinic RSCM Kiara. Cardiovascular autonomic dysfunction which was defined by one abnormal CRT value was found in 36.8% children. No significant correlation was found between CAD and the average length of illness and HbA1C levels. Based on the study, CAD prevalence in adolescents is substantially high, which emphasize the need of routine early detection. Further research with a longer duration of illness and serial HbA1C data need to be carried out to evaluate the role of glycemic control and illness duration in CAD occurrence."

"Diabetes melitus merupakan faktor risiko berkembangnya disfungsi seksualitas pada wanita yang dapat mempengaruhi hasrat seksual, lubrikasi, dispareunia, dan menurunnya kemampuan mencapai orgasme. Masalah disfungsi seksualitas pada pasien diabetes melitus masih merupakan hal yang tabu untuk dibahas secara terbuka karena sulitnya pasien untuk mengungkapkan masalah seksualitasnya kepada petugas kesehatan. Tujuan penelitian adalah untuk mengeksplorasi pengalaman disfungsi seksualitas pasien wanita dengan diabetes melitus. Metode penelitian ini menggunakan desain kualitatif dengan pendekatan studi fenomenologi. Partisipan wanita sejumlah 6 orang dengan kriteria inklusi berusia 18-45 tahun, wanita diabetes melitus tipe 2 dengan disfungsi seksual, memiliki pasangan pernikahan yang masih hidup, yang diambil dengan menggunakan teknik purposive sampling. Pengumpulan data dilakukan dengan metode wawancara mendalam dan menggunakan catatan lapangan field note. Setiap partisipan diberikan kuesioner FSFI female sexual function index untuk menentukan status disfungsi seksualnya. Data dianalisa dengan metode konten analisis kualitatif. Tujuh tema yang ditemukan: 1 ketidaknyamanan fisik saat melakukan aktifitas seksual; 2 adanya penurunan hasrat seksual pada isteri usia lebih dari 30 tahun; 3 ketidakpuasan aktifitas seksual yang dilakukan; 4 keterpaksaan dalam mendiskusikan masalah seksual pada petugas kesehatan; 5 kurangnya informasi tentang aktifitas seksual; 6 ketidakberdayaan menjalani pengobatan masalah seksual; dan 7 penurunan peran seksual sebagai istri. Dapat disimpulkan bahwa disfungsi seksual pada wanita diabetes melitus tipe 2 ada dan mengganggu baik secara fisik maupun psikologis. Namun, masih terdapat keengganan bagi wanita untuk dapat mendiskusikan masalahnya secara terbuka. Oleh sebab itu, disarankan bagi perawat untuk memulai komunikasi secara terbuka mengani masalah seksualitas wanita dengan diabetes melitus tipe 2.

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Diabetes mellitus is a risk factor for developing female sexual dysfunction which affected sexual desire, lubrication, dispareunia sexual pain, and orgasm decreased. Sexual dysfunction problem in type 2 diabetic patients is still a taboo subject to be discussed because that was hard to be revealed to their healthcare personnel. The aim of the study was to explore sexual dysfunction experience of type 2 diabetes mellitus woman. A qualitative with a phenomenology design was used. This study was involved six women with type 2 diabetes mellitus who met the inclusion criterion ages 18 45 years, married, gathered using a purposive sampling method. Data were collected using an in depth interview and field notes. Each participant was screened using a FSFI quessionaire to determine sexual dysfunction status. Data were analyzed using qualitative content analysis. Seven themes emerged 1 physical discomfort while having sexual activities 2 presence of sexual desire decreased in spouse with ages more than 30 years old 3 dissatisfaction with sexual activity 4 hesitance feeling while discussing sexual problem with healthcare providers 5 lack of information about sexual activity 6 feeling powerlessness while undergone sexual problem treatment 7 decreased in sexual roles as a wife. In conclude that the sexual dysfunction among women with type 2 diabetes mellitus is existing and disturbing physically and psychology. But there has been hesitated of women to openly disccussed the problem. It is suggested for nurses to initiate open communication about sexual problem among women with type 2 diabetes mellitus."

"Sialolithiasis is a common disease of the submandibular glands or its duct but rare in parotids of patients, especially in male adults. The accessory of salivary glands are small, unsheathed masses with a small canaliculi. The irritant factors might be due to inflammation of the inner layer of the canaliculi, that often concomitant to saliva stasis. This process leads to development of calculus that it is related to secretive specificity of the submandibular gland. The essential factor for its calcification is the stagnation of secretory material rich in calcium. The accumulation of this material would cause swelling, further obstruction and atrophy until there is widespread inflammation that has been termed sialadenitis. Diabetes mellitus is one of the medically compromised diseases. Although there are many associations between diabetes mellitus and oral health, lack of investigation in this area has been done to study salivary gland alterations. Many diabetic patient complained xerostomia, a decreasing salivary flow and enlargement if the parotid gland due to a compensatory mechanism to xerostomia that has been termed sialadenosis. This review article summarized that there is no relationship between sialolithiasis and poorly controlled type 2 diabetes mellitus. "

"Type 2 diabetes mellitus (T2DM) is strongly associated with lower performance on multiple domains of cognitive function and with structural abnormalities of the brain. With the growing epidemic of diabetes and aging population, neural complications of diabetes are expected to rise and becoming a challenge for future health implications. Understanding pathophysiology, factors associated with this complication, manifestation of cognitive impairment and various metabolic and neuroradiologic markers suggestive of this pathologic condition is crucial for proper management of this potentially debilitating complication of T2DM. This review will discuss briefly important aspects of cognitive impairment in T2DM."

"[ABSTRAKLatar belakang: Prevalensi Diabetes Melitus Tipe (DM) tipe 2 semakin meningkat setiap tahun. Kontrol glisemik yang buruk, hipertensi, dislipidemia, dan kebiasaan merokok serta menopause dapat meningkatkan risiko komplikasi penyakit kardiovaskular. Komplikasi kardiovaskular merupakan komplikasi paling sering ditemukan dengan angka mortalitas yang tinggi. Oleh karena itu, untuk menekan progresivitas komplikasi kardiovaskular diperlukan suatu terapi nutrisi medik yang adekuat sesuai dengan kondisi klinis dan edukasi dalam memodifikasi gaya hidup.Metode: Pasien pada serial kasus berusia 55-65 tahun. Tiga pasien didiagnosis DM tipe 2 dengan gagal jantung, satu pasien dengan penyakit jantung hipertensi. Semua pasien memiliki skor skrining malnutrition screening tools (MST) ≥ 2. Dua pasien mempunyai status gizi obesitas, satu pasien berat badan dan pasien lainnya dengan berat badan normal. Kebutuhan energi basal (KEB) berdasarkan rumus Harris-Benedict dengan faktor stress 1,3-1,4 tergantung kondisi klinis dan penyakit penyerta. Komposisi makronutrien sesuai dengan rekomendasi American Diabetes Association dan Dietary Approach to Stop Hypertension. Pemberian mikronutrien dan nutrient spesifik diberikan pada satu dua kasus. Pasien dipantau selama 5-17 hari, meliputi keluhan subyektif, hemodinamik, toleransi dan analisis asupan, antropometri, pemeriksaan laboratorium, imbang cairan, dan kapasitas fungsional.Hasil: Selama pemantauan di RS, keempat pasien menunjukkan perbaikan klinis yaitu tekanan darah turun dan kapasitas fungsional membaik. Satu pasien kadar glukosa darah dipertahankan < 200 mg/dL.Kesimpulan: Terapi nutrisi medik yang adekuat dapat memperbaiki kondisi klinis pasien DM tipe 2 dengan komplikasi sistem kardiovaskular.

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ABSTRACTBackground: The prevalence of type 2 diabetes mellitus (DM) is increasing every year. Poor glycemic control, hypertension, dyslipidemia, smooking and menopause increase the risk for cardiovascular complications. Cardiovascular complications is the most common complications in type 2 DM with a significant high mortality rate. Therefore, a medical nutrition therapy is required to decreased the progresitivity of the cardiovascular complication in DM, based on improvement of clinical conditions and lifestyle modifications.Method: Patients in this case series were between 55-65 years old. There of those patients were diagnosed heart failure and one with hypertension heart disease. All patients had a screening score ≥ 2 with malnutrition screening tools (MST). Two of patients had nutritional status of obesity, one patients was overweight, and another patients was normoweight. Basal calorie requirement were calculating using Harris-Benedict formula with stress factor 1,3-1,4 adjusment according to clinical conditions and comorbidities. Macronutriens were given recommendations by The American Diabetes Association and Dietary Approach to Stop Hypertension. Two patients received micronutrien and specific nutrients. Monitoring was done for 5-17 days included subjective complaints, hemodynamic, tolerance and intake analysis, anthropometric measurement, laboratory test, fluid balance and functional capacity.Results : All the patients showed the improvement of clinical conditions, blood control and functional capacity. Blood glucose levels of one patients was maintained to below 200 mg/dLConclusion: Medical nutrition therapy can improved clinical conditions of patients type 2 DM with cardiovascular complications., Background:The prevalence of type 2 diabetes mellitus (DM) is increasing every year. Poor glycemic control, hypertension, dyslipidemia, smooking and menopause increase the risk for cardiovascular complications. Cardiovascular complications is the most common complications in type 2 DM with a significant high mortality rate. Therefore, a medical nutrition therapy is required to decreased the progresitivity of the cardiovascular complication in DM, based on improvement of clinical conditions and lifestyle modifications.Method:Patients in this case series were between 55-65 years old. There of those patients were diagnosed heart failure and one with hypertension heart disease. All patients had a screening score ≥ 2 with malnutrition screening tools (MST). Two of patients had nutritional status of obesity, one patients was overweight, and another patients was normoweight. Basal calorie requirement were calculating using Harris-Benedict formula with stress factor 1,3-1,4 adjusment according to clinical conditions and comorbidities. Macronutriens were given recommendations by The American Diabetes Association and Dietary Approach to Stop Hypertension. Two patients received micronutrien and specific nutrients. Monitoring was done for 5-17 days included subjective complaints, hemodynamic, tolerance and intake analysis, anthropometric measurement, laboratory test, fluid balance and functional capacity.Results :All the patients showed the improvement of clinical conditions, blood control and functional capacity. Blood glucose levels of one patients was maintained to below 200 mg/dLConclusion:Medical nutrition therapy can improved clinical conditions of patients type 2 DM with cardiovascular complications.]"