"[
ABSTRAKGangguan depresi mayor merupakan suatu gangguan kejiwaan ditandai dengan
kemurungan, ketiadaan gairah hidup, perasaan tidak berguna dan putus asa dan
mengalami minimal empat dari gejala berikut yaitu perubahan berat badan dan
nafsu makan, perubahan tidur dan aktivitas, tidak ada energi, rasa bersalah,
masalah dalam berfikir dan membuat keputusan, berfikir berulang tentang
kematian dan bunuh diri tampa riwayat episode manik, campuran atau hipomanik,
sekurang-kurangnya telah dirasakan selama 2 minggu. Survei kesehatan mental
dunia pada 17 negara menemukan sekitar 1 dari 20 orang dilaporkan menderita
episode depresi setiap tahunnya, paling sering terjadi adalah gangguan depresi
mayor. Pengobatan dengan farmakoterapi golongan antidepresan hanya
menunjukkan efektifitas 60-70% disertai efek samping yang serius sehingga
berbagai modalitas terapi dikembangkan, salah satunya akupunktur. Penelitian ini
bertujuan untuk mengetahui efektivitas terapi kombinasi akupunktur dengan
antidepresan dibandingkan kombinasi akupunktur sham dengan antidepresan
terhadap perubahan skor Hamilton Rating Scale for Depression (HAM-D 17)
pada penderita gangguan depresi mayor. Uji klinis acak tersamar tunggal
dilakukan pada 48 pasien gangguan depresi mayor dialokasikan ke dalam
kelompok kombinasi akupunktur dengan antidepresan dan kelompok kombinasi
akupunktur sham dengan antidepresan. Penilaian kemajuan terapi digunakan skor
HAM-D 17. Hasil penelitian menunjukkan rerata skor HAM-D 17 pada kelompok
kasus sebelum terapi 22,2±3,38 dan setelah terapi ke-12 turun menjadi 7,3±2,64.
Sedangkan pada kelompok kontrol rerata skor HAM-D 17 sebelum terapi
21,4±3,10 dan setelah terapi ke-12 turun menjadi 9,3±3,33. Terdapat perbedaan
bermakna antara selisih rerata penurunan skor HAM-D 17 sebelum dan setelah 12
kali terapi pada kelompok kasus 14,9±2,45 dibandingan dengan kelompok kontrol
12,2±4,30 (p<0,005). Terapi kombinasi akupunktur dengan antidepresan lebih
efektif mengurangi gejala gangguan depresi mayor dibandingkan kombinasi
akupunktur sham dengan antidepresan.
ABSTRACTMajor depressive disorder is a psychiatric disorder that is characterized at least
four of the following symptoms, loss of weight and appetite, sleep disturbance and
loss of interest of activity, low energy level, guilt, difficulty concentrating and
making decisions, recurrent death or suicide, without a history of manic
episodes, mixed or hypomanic. These sings and symptoms have been felt at least
for 2 weeks. The mental health survey conducted in 17 countries found that about
1 in 20 people are reported to suffer from a depressive episode each year and
most are major depressive disorder. The effectiveness of antidepressant
medication only 60-70% with serious side effects, so that various therapeutic
modalities developed, one of which is acupuncture. This study aims to determine
the effectiveness of combination therapy of acupuncture with antidepressants
compared to combination of sham acupuncture with antidepressants in patients
with major depressive disorder and the outcome was the score Hamilton Rating
Scale for Depression (HAM-D 17). Single-blind randomized clinical trial
conducted in 48 patients with major depressive disorder and the patients were
allocated into two groups, intervention (acupuncture with antidepressants) and
control (sham acupuncture with antidepressant). The mean of HAM-D 17 score in
the intervention group before treatment was 22,2±3,38 and after treatment was
7,3±2,64. The mean of HAM-D 17 score in control group before treatment was
21,4±3,10 and after treatment was 9,3±3,33. There was significant differences
between intervention and control group before and after 12 times of therapy in the
mean decrease of score on HAM-D 1714.9±2.45 to12.2±4.30 (p<0.005). A
combination of acupuncture therapy with antidepressants is more effective in
reducing the symptoms of major depressive disorder compared to sham
acupuncture combination with antidepressants, Major depressive disorder is a psychiatric disorder that is characterized at least
four of the following symptoms, loss of weight and appetite, sleep disturbance and
loss of interest of activity, low energy level, guilt, difficulty concentrating and
making decisions, recurrent death or suicide, without a history of manic
episodes, mixed or hypomanic. These sings and symptoms have been felt at least
for 2 weeks. The mental health survey conducted in 17 countries found that about
1 in 20 people are reported to suffer from a depressive episode each year and
most are major depressive disorder. The effectiveness of antidepressant
medication only 60-70% with serious side effects, so that various therapeutic
modalities developed, one of which is acupuncture. This study aims to determine
the effectiveness of combination therapy of acupuncture with antidepressants
compared to combination of sham acupuncture with antidepressants in patients
with major depressive disorder and the outcome was the score Hamilton Rating
Scale for Depression (HAM-D 17). Single-blind randomized clinical trial
conducted in 48 patients with major depressive disorder and the patients were
allocated into two groups, intervention (acupuncture with antidepressants) and
control (sham acupuncture with antidepressant). The mean of HAM-D 17 score in
the intervention group before treatment was 22,2±3,38 and after treatment was
7,3±2,64. The mean of HAM-D 17 score in control group before treatment was
21,4±3,10 and after treatment was 9,3±3,33. There was significant differences
between intervention and control group before and after 12 times of therapy in the
mean decrease of score on HAM-D 1714.9±2.45 to12.2±4.30 (p<0.005). A
combination of acupuncture therapy with antidepressants is more effective in
reducing the symptoms of major depressive disorder compared to sham
acupuncture combination with antidepressants]"
