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"The dynamic of Zinc (Zn) concentration was determined in saliva and blood serum related to periodontal treatment need of student Faculty of Dentistry. The Zn concentration was determined by using atomic absorption spectrometer, and questionnaire was used to measure stress condition and CPITN index was examined by using the standard hand instruments and WHO probe. Almost of concentration of Zn in saliva and blood serum were decrease significantly (p<0,001 & p<0.0S)) in stress condition. While CPITN index was increase significantly in stress condition (p<0.000I). These results suggest that Zn is linked to oral saliva ecosystem under physiological stimuli, and than Zn accumulates in the salivary gland during saliva enzyme activities. This condition supported the occur of periodontal disease."

"The Zinc (Zn) concentration was determined from salivary gland of Wistar King A (WKA) rats. The salivary glands are divided in to sub-lingual, sub-mandible and parotis. The Zn concentration was determined within 15-60 minutes of restraint stress. Concentration of Zn in sub-mandible, parotis and sub-Lingual glands was significantly higher (p<0.001) than in the control group. Further more at Zinc concentration in sub-mandible gland at 30 min restraint stress was increase (p<0.001), and decrease significantly at 49 min by restraint stress. By the way, Zn concentration in parotis gland was increase significantly (p<0.0001) after 60 min restraint stress. The results suggest that Zn is linked to oral saliva under physiological stimuli, and that Zn accumulates in the salivary gland during salivary enzyme activity."

"ABSTRAKTujuan penelitian ini adalah untuk mengetahui hubungan antara pemberian zinc (Zn) per oral dan aktivitas 'alkaline phosphatase' (ALP) dalam `gingival crevicular fluid' (GCF) saat pasca 'flap operation' (FO) guna mendapatkan data dalam mempercepat penyembuhan luka bedah. Kepada 12 pria dewasa diberikan ZnSO4 220 mg 3 x 1 sehari selama 14 hari. F0 dilakukan pada hari ke 5. Pemeriksaan 'papillary bleeding index' (PBI), kedalaman poket periodontal, kegoyangan gigi, produksi GCF, konsentrasi protein dalam GCF, aktivitas ALP dalam GCF, konsentrasi Zn plasma, dilakukan pada hari ke 5, 12, 19, dan 26. Kesehatan dan status grzi subyek diperiksa dengan meneliti konsentrasi kreatinin serum serta melakukan '3 days recall dietary survey'. Sebagai kontrol adalah 11 pria dewasa yang diberi 'saceharum lactis' 50 mg dan perlakuan yang sama. Ternyata pemberian Zn tersebut sudah berpengaruh terhadap aktivitas ALP GCF sejak hari ke 5 dan aktivitas ini menurun terus mengikuti waktu penelitian.

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ABSTRACT

The Relationship Between Zinc Preparation Given Per Oral and Post Periodontal Surgical Alkaline Phosphatase Activity in the Gingival Crevicular FluidThe purpose of this study was to investigate the relationship between zinc preparation given per oral and post flap operation alkaline phosphatase (ALP) activity in the gingival crevicular fluid, (GCF). This study investigated the zinc effect on periodontal surgical healing process. 12 men taken 220 mg ZnSO4 3 times a day for 14 days. The FO performed at day 5. The assessment of papillary bleeding index (PBI), periodontal pocket depth, tooth mobility, GCF production, protein concentration in the GCF, ALP activity in the GCF, plasma Zn concentration were performed at day 5, 12, 19, 26. The subject health and nutritional status were studied by assessing the serum creatinine concentration and performed the 3 days recall dietary survey. As the control group there was 11 men given 50 mg saccharum lactis and the same treatments. The effect of Zn given on GCF ALP activity has been seen on day 5 and this activity continued to decrease along the investigation time."

"This cross sectional study was conducted on 304 elderly, aged 55 years and over, who were randomly selected at the Public Health Center levels in South Jakarta. The prevalence of CHD risk factors for the total population indicated by dyslipidemia and abdominal over fatness in this study were high (76% and 48°1o, respectively). Differences between gender were found with respect to body fat distribution as determinant of serum lipid profiles. In the elderly women, AHR were positively correlated with serum triglycerides and total cholesterol (p<0.05) but not in the elderly men. Energy, fat and cholesterol intakes did not show correlation with any serum lipid status in this population group. Energy intake of the elderly was low. Percent energy from fat and cholesterol intake were in accordance with the Indonesian Consensus of Dyslipidemia and NCEP (National Cholesterol Education Program). Generally, the elderly men and women had similar scores for several aspects of later life status. However cognitive function, well being, and later life status in the elderly men were higher than those in the elderly women. It was demonstrated that there was a significant negative association between physical activity score and selected serum lipid profiles (TC and TG), especially in the elderly women. Similar findings were also observed for social activity scores. No associations were found between alcohol consumption and serum lipid profiles in this study. On the other hand, smoking which was prevalent in the elderly men contributed to the elevation of serum triglycerides concentration. "

"Aim: To determine the prevalence of peripheral arterial disease and to its risk factors in patients with type 2 diabetes mellitus.Subjects and Methods: A cross sectional study was conducted on HO subjects with type 2 diabetes mellitus. Subjects underwent comprehensive medical examinations, including lipid profile, body mass index, Hemoglobin Ale and Ankle Brachial index.Results: The prevalence of PAD in diabetic subjects was 35.5%. In multivariate analysis: cholesterol levels of > 200 mg/dL, history of smoking, a duration of diabetes of> 5 yean, hypertension, triglyceride levels of > 150 mg/dL, and body mass index of > 150 mg/dL are significant risk factors for PA D in diabetic subjects. Gender, age of > 50 years old, LDL levels of> !00 mg/dL, HDL levels of< 40 mg/dL, and HbA Ic levels of > 7% were not significant risk factors for PAD in diabetic subjects.Conclusion: In this study, the prevalence rate of PAD in diabetic subjects was approximately 35.5%. Total cholesterol levels, history of smoking, duration of diabetes, hypertension, triglyceride, and body mass index were significant risk factors for PAD in diabetic subjects."

"ABSTRACTCoronary Heart Disease (CHD) morbidity and mortality rate is increasing dramatically in the last 15 years in Indonesia. Available data show that among the contribution factor changes in life style and demographic transition are prominent.A hypothetical risk factor for CHD is lipid peroxidation, a reaction between oxygen free radical and lipid parts of cell membranes and low density lipoprotein (LDL). Food habit is following a pattern of nutrient and non-nutrient intakes, including fatty acids and antioxidants. Fatty acid intakes determine the susceptibility of the lipid parts of eell membranes and LDL to peroxidation by free radicals. Theoretically, antioxidants will protect against oxidative damage caused by oxygen free radicals. Commercially available and advertised antioxidants such as vitamin E are widely used inspite of limited information on the interrelation between lipid peroxide levels in the Indonesian elderly with CHD risk factors such as food habits, dyslipidemia and obesity.A two-phase study on the elderly (55-85 years.) guided by the health centers was undertaken in Jakarta. Data for both phases were collected through interviews, anthropometric measurements, blood analysis and blood pressure measurements. Univariate, bivariate and multivariate analysis were done using SPSS and WorldFood 2 programs.The first phase was a cross-sectional study to see the association between lipid peroxides and fatty acids, vegetables, fruits, tempe intakes, obesity, smoking, dyslipidemia and hypertension. The samples were 394 elderly. The variables found correlated with lipid peroxides were LDL, intake of mono and poly-unsaturated fatty acids, tempe, and vitamin E. The study showed an increase level of lipid peroxides with age and ethnic differences with the highest level of lipid peroxides among the Minangkabau.The second phase is a randomized double-blind trial giving 600 mg/day vitamin E supplementation or placebo for 12 weeks to 152 elderly with the high level of lipid peroxides found in the cross-sectional study. The objective was to see if there was a change of lipid peroxide levels after the intervention. The results showed a significant decrease of lipid peroxides level in the vitamin E group compared to placebo after being adjusted with age, waist-hip ratio (WHR), plasma cholesterol, and saturated fatty acids (SAFA) intake. The high density lipoprotein (HDL) was also increased significantly in the vitamin E group compared to placebo group.Randomized controlled trial taking into account the confounding variables such as age, sex, ethnic, waist-hip ratio, saturated fat intake, carbohydrate intake and plasma cholesterol might be able to elucidate the specific beneficial effect of vitamin E supplementation. Health education and information concerning foods that have effect on lipid peroxidation, such as tempe should be endorsed. More studies should be undertaken to find other food or beverage that have protecting effects against lipid peroxides."