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"Tujuan: Mengurangi risiko PKV di Indonesia dengan menurunkan kadar kolesterol dan apolipoprotein B melalui pemberian serat larut β-glukan Tempat: P.T. National Gobel, Bogor. Bahan dan Cara: Penelitian eksperimental dengan disain pre dan post test, dengan subyek penelitian pria, usia > 40 tahun, kadar kolesterol total 220-300 mg/dL, tidak menderita hipotiroid, gangguan hati, sindroma nefrotik, diabetes melitus dan tidak mengkonsumsi obat penurun kolesterol. Subyek penelitian diberikan 75 g oatmeal yang mengandung 3,5 g serat larut β-glukan setiap hari selama 42 hari. Data yang dikumpulkan meliputi data sosiodemografi, pemeriksaan antropometri, data asupan makan sebelum dan selama penelitian, pola makan dan pemeriksaan kadar kolesterol total, kolesterol LDL dan apolipoprotein B plasma sebelum dan sesudah penelitian. Hasil : Data sosiodemografi menunjukkan sebagian besar subyek mempunyai aktivitas ringan, berpendidikan sedang dan mempunyai penghasilan di atas garis kemiskinan. Data antropometri menunjukkan IMT dan rasio Lpe/Lpa sebelum dan sesudah penelitian tidak berbeda bermakna (p>0,05), sedangkan pada Lpe terjadi penurunan yang bermakna (p<0,05). Penilaian pola makan subyek penelitian menunjukkan sebagian besar subyek mempunyai pola makan yang cukup. Asupan energi dan zat gizi sebelum dan selama penelitian tidak berbeda bermakna (p>0,05), kecuali asupan serat yang meningkat bermakna (p<0,05) selama penelitian. Persentase asupan energi dan zat gizi bila dibandingkan dengan yang dianjurkan, antara lain didapatkan persentase asupan lemak jenuh lebih dari yang dianjurkan sedangkan asupan serat kurang dari yang dianjurkan. Hasil pemeriksaan kadar kolesterol total, kolesterol LDL dan apolipoprotein B sesudah penelitian menunjukkan penurunan yang bermakna (p<0,01). Kesimpulan: Kadar kolesterol yang tinggi pada subyek penelitian kemungkinan disebabkan asupan lemak jenuh yang tinggi dan asupan serat yang rendah. Pemberian 75 g oatmeal selama 42 hari terbukti dapat menurunkan kadar kolesterol total, kolesterol LDL dan apolipoprotein B.

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SubjectsObjectives: To reduce CVD risks in Indonesia by reducing the elevated plasma cholesterol and apolipoprotien B level with β-glucan soluble fiber. Location: P.T. National Gabel, Bogor.

Material and Method: Experimental study with pre and post test design bad been carried out on male subjects age > 40 years, with total cholesterol concentration 220 to 300 mg/dl, not suffer from hypothyroid, liver disorder, nephritic syndrome, diabetes mellitus, and did not take any cholesterol reducing agents. Subjects were given 75 g of oatmeal (contain 3.5 g β-glucan soluble fiber) daily for 42 days. The data collected before and during the study were sociodemographic data, anthropometric and food intake. Eating pattern, total cholesterol, LDL cholesterol, and apolipoprotein B plasma level were also recorded before and after the study.

Result: Socio-demographic data showed that most of the subjects have light activities, moderate education and have monthly income per capita above the poverty line. Anthropometric data showed that BMI and WHR did not differ significantly before and after the study. Eating pattern assessment showed that most of the subjects had moderate eating pattern. Energy and nutrient intake before and after the study did not significantly different (p>0,05) except for fiber intake which increased significantly (p<0,05) during the study. Percentage of nutrient and energy intake compared with recommended showed that saturated fat intake is higher while fiber intake is lower. The study showed a significant decrease in the concentration of plasma total cholesterol, LDL-cholesterol and apolipoprotein B.

Conclusion: High cholesterol level in the subjects was likely brought about by high saturated fat and low fiber intakes consumption of 75 g oatmeal daily for 42 days showed to lower the concentration of the plasma total cholesterol, LDL cholesterol and apolipoprotein B."

"Peningkatan kadar kolesterol dan lemak dalam darah yang menyebabkan penyempitan atau pengapuran pada pembuluh darah arteri merupakan penyebab utama dari penyakit kardiovaskular. Tingkat persaingan hidup yang tinggi kemungkinan berdampak pada munculnya aneka pergeseran gaya hidup, mulai dari perilaku makan, aktivitas fisik, stres, kebiasaan merokok dan konsumsi alkohol. Gaya hidup yang tidak sehat merupakan pencentus hiperkolesterolemia di usia produktif. Penelitian ini bertujuan untuk mengetahui pengaruh gaya hidup terhadap hiperkolesterolemia di Provinsi DKI Jakarta tahun 2015-2016. Metode penelitian yang digunakan adalah cross sectional dengan sampel penelitian 1090 orang peserta Posbindu Penyakit Tidak Menular di DKI Jakarta tahun 2015-2016. Hasil penelitian menunjukkan ada pengaruh antara kebiasaan merokok dan aktivitas fisik terhadap hiperkolesterolemia, namun tidak untukkonsumsi sayur dan buah. Responden dengan aktivitas fisik kurang memiliki risiko 5,9 kali lebih tinggi (95% CI 4,0-8,4), sedangkan yang memiliki kebiasaan merokok memiliki risiko 1,4 kali lebih tinggi (95% CI 1,3-1,6) menderita hiperkolesterolemia setelah dikontrol oleh tekanan darah dan status gizi. Promosi kesehatan sangat diperlukan untuk menyampaikan informasi tentang hiperkolesterolemia dan msyarakat secara pro aktif melakukan pemeriksaan kesehatan secara rutin sehingga memperkecil risiko terkena penyakit tidak menular.

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Increased levels of cholesterol and fat in the blood that cause narrowing or calcification of the arteries are the main cause of cardiovascular disease. High levels of life competition may have an impact on the emergence of various lifestyle, ranging from eating behavior, physical activity, stress, smoking and alcohol consumption. Unhealthy lifestyle is a trigger Hypercholesterolemia in the productive age. The purpose of this study is to know the relationship between smoking habits and physical activity with hypercholesterolaemia in DKI Jakarta Province 2015-2016. The methods of this this study is cross-sectional with 1090 samples of participants of Non-Communicable Disease Posbindu in DKI Jakarta 2015-2016.

The results showed there was an influence between smoking and physical activity on hypercholesterolemia, but not for consumption of vegetables and fruits. Individuals with less physical activity 5.9 times higher (95% CI 4.0-8.8), whereas those with smoking habits 1.4 times higher (95% CI 1.3-1 , 6) suffers from hypercholesterolemia after being controlled by blood pressure and nutritional status. Health promotion is needed to convey information about hypercholesterolemia and the community pro-actively carry out routine health checks thereby minimizing the risk of non-communicable diseases."

"Hiperlipidemia dan atherosklerosis berperan dalam patogenesis penyakit kardiovaskular, yang merupakan penyebab mortalitas tertinggi di Indonesia dalam kategori penyakit tidak menular (PTM). Pengobatan standar bagi hiperlipidemia, yaitu golongan statin dan fibrat, memiliki banyak efek samping. Ekstrak etanol akar Acalypha indica Linn. memiliki aktivitas antioksidan yang memiliki efek hipolipidemik namun belum diketahui efeknya pada jaringan adiposa. Oleh karena itu, pada penelitian ini akan diteliti aktivitas hipolipidemik ekstrak etanol akar Acalypha indica Linn. pada jaringan adiposa viseral tikus jika dibandingkan dengan simvastatin dan gemfibrozil. Penelitian ini memiliki desain studi eksperimental dengan membandingkan jaringan adiposa viseral tikus jantan Sprague-Dawley yang telah diinduksi diit tinggi kolesterol-fruktosa dan diberi terapi ekstrak, simvastatin, gemfibrozil, kombinasi ekstrak dan simvastatin, serta kombinasi ekstrak dan gemfibrozil selama 4 minggu. Penelitian dilakukan di Departemen Farmasi dan Histologi Fakultas Kedokteran Universitas Indonesia, Jakarta, pada Juli-November 2015. Selularitas jaringan adiposa yang diwarnai dengan Hematoxylin-Eosin (HE) dinilai dengan diameter reratanya menggunakan perangkat lunak Adiposoft®. Data yang diperoleh diuji dengan uji one-way ANOVA yang diikuti post-hoc atau uji Kruskal-Wallis. Tikus yang diberi terapi ekstrak memiliki berat lemak viseral dan diameter adiposit yang paling rendah serta jumlah sel/lapang pandang yang paling banyak. Namun secara statistik, tidak ada perbedaan bermakna antara terapi ekstrak, simvastatin dan gemfibrozil untuk menurunkan deposisi lemak pada jaringan adiposa viseral (p>0,05).

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Hyperlipidemia and atherosclerosis have a role in pathogenesis of cardiovascular disease, the biggest non-communicable cause of mortality. Its standard therapy, statin and fibrate, have several side effects. Ethanolic root extract of Acalypha indica Linn. has antioxidant properties that can act as hypolipidemic agent. But then, its effect on visceral adipose tissue (VAT) is not known yet. Therefore, this research will seek the comparison of hypolipidemic activity between ethanolic root extract of Acalypha indica Linn., simvastatin and gemfibrozil towards fat deposit in VAT.

This research compares VAT in Sprague-Dawley male rat induced with high cholesterol-fructose diet and given 5 types of therapy (extract, simvastatin, gemfibrozil, extract + simvastatin, and extract + gemfibrozil). The research was conducted in Faculty of Medicine Universitas Indonesia, Jakarta, on July- November 2015. Adipose is then stained with Hematoxylin-Eosin and its cellularity is measured digitally by using Adiposoft®. Data is analyzed with one-way ANOVA with post-hoc Tukey or Kruskal-Wallis test. Rats given with extract have the lowest fat mass, lowest adipocyte diameter, and highest number of cell/field of all therapy group. There is no significant difference in extract, simvastatin, and gemfibrozil therapy in minimising fat deposition in VAT (p>0.05)."

"Hiperkolesterolemia merupakan penyakit yang memiliki beberapa faktor resiko. Faktor-faktor tersebut antara lain peningkatan usia, kebiasaan merokok, tekanan darah tinggi, rendahnya kadar kolesterol High Density Lipoprotein (HDL), serta peningkatan kadar trigliserida. Penanganan hiperkolesterolemia secara modern menggunakan obat-obatan sintetik sering menyebabkan beberapa resiko efek samping. Penggunaan obat tradisional yang salah satunya jamu dapat digunakan sebagai alternatif dari obat-obatan sintetik dengan efek samping yang minim. Oleh karena itu, diformulasikan penggunaan tanaman herbal yang bertujuan untuk menggantikan proses pengobatan salah satunya adalah tanaman keji beling. Perolehan ekstrak dari tanaman keji beling dapat menggunakan metode Microwave Ultrasound Assisted Enzymatic Extraction-Aqueous Two-Phase System sebagai teknik yang dapat meningkatkan konsentrasi kuersetin dalam ekstrak tanaman keji beling. Uji kandungan kuersetin menggunakan spektrofotometri UV-Vis pada panjang gelombang 415 nm. Variasi yang dilakukan pada ATPS terhadap kuersetin yaitu jenis garam, konsentrasi garam dan konsentrasi etanol. Pada penelitian ini juga dilakukan penentuan kada kuersetin dalam ekstrak tanaman keji beling. Kuersetin dengan recovery tertinggi didapatkan pada jenis garam ammonium sulfat dengan konsentrasi etanol 31% dan konsentrasi garam 17%. Kandungan flavonoid total ekstrak tanaman keji beling yang didapatkan dengan menggunakan kondisi optimum ATPS sebesar 1,6157 mg/g. Aktivitas penurunan kolesterol untuk senyawa aktif tanaman keji beling didapatkan senyawa kuersetin memiliki  hasil yang baik sebagai inhibitor enzim HMG-CoA Reduktase dengan hasil afinitas sebesar -7,8 kcal/mol

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Hypercholesterolemia is a disease that has several risk factors. These factors include increased age, smoking habits, high blood pressure, low levels of High Density Lipoprotein (HDL) cholesterol, and increased levels of triglycerides. Modern hypercholesterolemia management using synthetic drugs often causes several risks of side effects. The use of traditional medicine, one of which is herbal medicine, can be used as an alternative to synthetic medicines with minimal side effects. Therefore, it is formulated to use herbal plants that aim to replace the treatment process, one of which is keji beling plants. Acquiring extracts from keji beling plants can use the method of Microwave Ultrasound Assisted Enzymatic Extraction-Aqueous Two-Phase System as a technique that can increase the concentration of quercetin in extracts of keji beling plants. Quercetin content test using UV-Vis spectrophotometry at a wavelength of 415 nm. Variations made on ATPS to quercetin are salt type, salt concentration and ethanol concentration. In this study also determined the determination of quercetin in extracts of keji beling. Quercetin with the highest recovery was found in the type of ammonium sulfate salt with an ethanol concentration of 31% and a salt concentration of 17%. The total flavonoid content of the keji beling plant extract obtained using the optimum ATPS conditions was 1,6157 mg/g. Cholesterol-lowering activity for the active compound of shardy plant obtained quercetin compound has good results as an inhibitor of the HMG-CoA Reductase enzyme with a affinity score of -7,8 kcal/mol."

"ABSTRAK

Hiperkolesterolemia adalah kondisi gangguan metabolik yang sering dijumpai pada masyarakat dunia. Karena berkaitan erat dengan insidensi dislipidemia dan penyakit kardiovaskular, berbagai peneliti telah mencoba untuk menemukan terapi farmakologi terbaik untuk menurunkan kadar kolesterol. Diantara beberapa obat pilihan utama adalah asam fibrat. Saat ini dikembangkan pengobatan dengan tanaman tradisional, salah satunya adalah Acalypha indica. Tanaman ini terbukti untuk penyembuhkan pneumonia, artritis, dan infeksi. Polifenol dan flavonoid yang terdapat dalam Acalypha indica diduga berperan penting dalam efek antihiperkolesterolemia yang dimilikinya. Diharapkan juga kandungan pada tanaman ini dapat menurunkan efek samping penggunaan obat konvensional. Uji preklinis ini bertujuan untuk mengetahui efek antihiperkolesterolemia dari ekstrak etanol akar Acalypha indica pada perlemakan hati, dibandingkan dengan terapi asam fibrat. Dua puluh dari dua puluh lima tikus Sprague-Dawley diinduki diit tinggi kolesterol-fruktosa selama empat minggu hingga mencapai kondisi tinggi kolesterol. Sampel dibagi menjadi lima grup berdasasrkan intervensinya, yakni kontrol positif, kontrol negatif, terapi gemfibrozil, terapi ekstrak Acalypha indica, dan terapi kombinasi gemfibrozil dan ekstrak Acalypha indica. Tikus kemudian diterminasi pada akhir periode intervensi. Hati tikus diambil dan diproses dengan blok parafin dan pewarnaan hematoksilin-eosin. Jaringan hati dinilai dengan kriteria Clinical Research Network Scoring untuk Steatohepatitis non alkoholik (NASH). Ekstrak Acalypha indica menurunkan deposisi lemak secara signifikan (p = 0,014), sama baiknya dengan terapi gemfibrozil (p = 0,003) dan terapi kombinasi (p = 0,003). Ekstrak etanol akar Acalypha indica merupakan agen antihiperkolesterolemia yang cukup menjanjikan untuk mengurangi deposisi lipid dan kejadian steatohepatitis non alkoholik pada jaringan hati tikus.

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ABSTRACT

Hypercholesterolemia is a common metabolic disorder found worldwide. As it is highly associated with dyslipidemia and cardiovascular disease incidence, researchers have been trying to find the best pharmacological therapy to lower cholesterol level. Among the first line choices drugs are fibrate. Acalypha indica, known as ?Akar Kucing? in Indonesian language, is a traditional plant used as medicine in most Asia countries. Previously, it has been proved to help to cure pneumonia, arthritis, and infection. Polyphenol and flavonoid found in Acalypha indica are considered to play an important role in its antihypercholesterolemia effect. It is also expected to have lower side effect than conventional drugs. This preclinical trial was aimed to investigate antihypercholesterolemia effect of Acalypha indicaroot extract on fatty liver tissue, compared to fibrate treatment. Sixteen from twenty Sprague-Dawley rats were induced with high cholesterol-fructose diet for four weeks to reach fatty liver state. Samples were divided into four groups based on its intervention. Each group was processed with a four-week therapy with Acalypha indicaroot extract, gemfibrozil, combination of Acalypha indicaroot extract and gemfibrozil, and without any therapy, respectively. Rats were terminated at the end of intervention period. Liver were taken and processed with paraffin block and hematoxylin-eosin stain. Liver tissues were assessed using Clinical Research Network Scoring for Non Alcoholic Steatohepatitis (NASH). Result: Acalypha indicaroot extract significantly reduced lipid deposition in fatty liver tissue (p = 0,014), as good as fibrate therapy using gemfibrozil (p = 0,003) and fibrate-Acalypha indica therapy (p = 0,003). Acalypha indica root extract is promising for use as antihypercholesterolemia agent to reduce lipid deposition and Non Alcoholic Steatohepatitis incidence in fatty liver tissue."

"ABSTRAKHiperkolesterolemia adalah peningkatan kadar kolesterol dalam darah diatas nilainormal. Angka kejadian hiperkolesterolemia akan terus bertambah seiring denganmeningkatnya pola hidup tidak sehat seperti kebiasaan merokok, obesitas, kurangberolahraga, dan asupan makanan tinggi lemak. Tanaman mengkudu (Morindacitrifolia L.) adalah salah satu tanaman yang buahnya dapat menurunkan kadarkolesterol total dan kolesterol LDL melalui penghambatan aktivitas HMG Co-Areductase yang sudah diteliti pada tikus.Penelitian bertujuan untuk membuktikan efek menurunkan kadar kolesterol total dankolesterol LDL pada pasien hiperkolesterolemia. Metode penelitian menggunakandesain double blind randomized controlled trial pada 60 pasien. Pasien dibagi duakelompok sama banyak menjadi kelompok perlakuan (kapsul ekstrak buah M. citrifolia)dan kelompok kontrol (plasebo) serta mendapat 3x2 kapsul sehari selama 21 hari. Hasilpenelitian menunjukkan kapsul ekstrak buah M. citrifolia pada kelompok perlakuansecara bermakna menurunkan kadar kolesterol total dan kolesterol LDL (p<0,05) dalamwaktu dua minggu dibandingkan kelompok kontrol. Faktor umur, indeks massa tubuh,olahraga, pola makan, dan kebiasaan merokok pada pasien kelompok perlakuan secarabermakna (p<0,05) bermanfaat dalam penurunan kadar kolesterol total. Kapsul ekstrakbuah M. citrifolia memiliki efek menurunkan kadar kolesterol total dan kolesterol LDLpada pasien hiperkolesterolemia.

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ABSTRACTHypercholestrolemia is characterized by elevated blood cholesterol level above normalvalues. The incidence of hypercholesterolemia will continue to grow unanymous as theunhealthy lifestyle such as smoking, obesity, lack of exercise, and high fat diet increased.Morinda citrifolia L. is one of many kind of plant which its fruit could decrease totalcholesterol and LDL-cholesterol by detaining cholesterol biosynthesis through theactivity of HMG Co-A reductase which has been studied in mouse.This study has a purpose to prove the reducing effect in total cholesterol andLDL-cholesterol in hypercholesterolemia patients. This study design used double blindrandomized controlled trial of 60 patients. Patients were divided into same number,including the intervention group (M. Citrifolia fruit extract capsule) and the controlgroup (placebo) that received 2 capsules 3 times daily for 21 days. The result showed theM. citrifolia fruit extract capsule in the intervention group significantly could decreasetotal cholesterol and LDL-cholesterol (p<0,05) in two weeks compared to the controlgroup. The age, body mass index, exercise, diet, and smoking habits of patients inintervention group has significant effect in decreasing total cholesterol. M. citrifolia fruitextract capsules has the reducing effect in total cholesterol and LDL-cholesterol inhypercholesterolemia patients."

"[ABSTRAKLatar belakang. Individu dewasa di masyarakat menunjukkan perubahan pola makan dan kurang aktivitas sehingga berisiko untuk menderita hiperkolesterolemia dan obesitas. Hiperkolesterolemia dapat diatasi dengan terapi nutrisi. Minyak bekatul mengandung zat aktif yang bekerja secara sinergis dan telah terbukti dari penelitian sebelumnya berperan dalam pengendalian lipid yaitu gamma-oryzanol, fitosterol, dan derivat vitamin E (tokotrienol dan tokoferol). Penelitian ini bertujuan untuk menilai perbaikan profil lipid pada pemberian minyak bekatul dengan jumlah yang berbeda tanpa merubah pola makan subyek. Metode. Uji klinis, desain paralel, alokasi acak selama 4 minggu pada laki-laki usia 19-55 tahun, kolesterol total 200-300 mg/dl, dan IMT 20-30 kg/m2. Subyek diambil secara konsekutif dan dibagi menjadi kelompok 45 ml/hari dan kelompok 15 ml/hari minyak bekatul. Sebelum perlakuan dilakukan wawancara data demografi, aktifitas fisik dan pemeriksaan antropometri. Asupan makan dinilai sebelum dan setelah perlakuan. Pemeriksaan laboratorium profil lipid dilakukan sebelum dan setelah perlakuan 4 minggu.Hasil. Dari total 20 subyek (10 subyek kelompok 45 ml/hari dan 10 subyek kelompok 15 ml/hari) didapatkan karakteristik yang setara antara kedua kelompok menurut usia, tingkat pendidikan, status gizi, aktivitas fisik, kebiasaan merokok, riwayat hiperkolesterolemia keluarga, antropometri dan profil lipid. Asupan makanan meliputi asupan energi, karbohidrat, protein, lemak dan serat sebelum perlakuan tidak berbeda bermakna antara kelompok. Asupan lemak setelah perlakuan berbeda bermakna antara kedua kelompok dikarenakan perbedaan pemberian jumlah minyak.Setelah perlakuan selama 4 minggu, didapatkan penurunan kolesterol total secara statistik berbeda bermakna antara kedua kelompok (p=0,049). Pada kelompok 45 ml/hari kadar kolesterol total turun sebanyak 14% dan pada kelompok 15 ml/hari terjadi penurunan kadar kolesterol total 7,8%. Penurunan LDL dan trigliserida serta peningkatan HDL secara statistik tidak berbeda bermakna antara dua kelompok (p >0,05). Pada penelitian ini tidak terjadi perubahan berat badan yang bermakna pada kedua kelompok.Kesimpulan. Konsumsi minyak bekatul 45 ml/hari menyebabkan perbaikan profil lipid yang lebih baik dibandingkan konsumsi minyak bekatul 15 ml.hari.

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ABSTRACTBackground. Adult individuals in Indonesian society showed changes in diet pattern and lack of physical activity that increasing risk for hypercholesterolemia and obesity. Hypercholesterolemia would be treated with nutritional therapy. Rice bran oil contains active substances (gamma-oryzanol, phytosterols, and derivatives of vitamin E (tocotrienols and tocopherols) that work in synergy and have been proven on previous research controlling lipid profil. This study aimed to assess the lipid profile improvement in intake of rice bran oil with different amounts without changing the eating patterns of the subjects.Methods. It was parallel and randomized clinical trial for 4 weeks in male with 19-55 years of age, total cholesterol level 200-300 mg/dl, and BMI of 20−30 kg/m2. All subjects were recruited consecutively and classified into two groups that received 45 ml/day or 15 ml/day rice bran oil for 4 weeks. The demographic data interviews, physical activity and anthropometric examination were taken before intervention. Food intake were assessed before and after intervention. Laboratory test of lipid profile performed before and after 4 weeks of treatment. Results. A total of 20 subjects consisting of 10 subjects with 45 ml/day rice bran oil and 10 subjects with 15 ml/day had obtained similar characteristics in age, education level, nutritional status, physical activity, smoking, family history of hypercholesterolemia, BMI and lipid profiles. Food intake includes intake of energy, carbohydrate, protein, fat and fiber before treatment did not significantly difference between two groups. Fat intake after treatment was significantly different between the two groups due to differences in the amount of oil.After 4 weeks treatment, there was a decrease in total cholesterol significantly different between the two groups (p = 0,049). In the group that received 45 ml/ day of rice bran oil total cholesterol level decreased 14% and in the group of 15 ml/day total cholesterol level decreased 7,8%. The reduction of LDL and triglycerides and the increasing of HDL was not significantly different between the two groups (p >0,05). In this study, no changes in body weight were significant in both groups.Conclusion. Rice bran oil consumption 45 ml/day led to improvements in lipid profiles better than consumption 15 ml/day;Background. Adult individuals in Indonesian society showed changes in diet pattern and lack of physical activity that increasing risk for hypercholesterolemia and obesity. Hypercholesterolemia would be treated with nutritional therapy. Rice bran oil contains active substances (gamma-oryzanol, phytosterols, and derivatives of vitamin E (tocotrienols and tocopherols) that work in synergy and have been proven on previous research controlling lipid profil. This study aimed to assess the lipid profile improvement in intake of rice bran oil with different amounts without changing the eating patterns of the subjects.Methods. It was parallel and randomized clinical trial for 4 weeks in male with 19-55 years of age, total cholesterol level 200-300 mg/dl, and BMI of 20−30 kg/m2. All subjects were recruited consecutively and classified into two groups that received 45 ml/day or 15 ml/day rice bran oil for 4 weeks. The demographic data interviews, physical activity and anthropometric examination were taken before intervention. Food intake were assessed before and after intervention. Laboratory test of lipid profile performed before and after 4 weeks of treatment. Results. A total of 20 subjects consisting of 10 subjects with 45 ml/day rice bran oil and 10 subjects with 15 ml/day had obtained similar characteristics in age, education level, nutritional status, physical activity, smoking, family history of hypercholesterolemia, BMI and lipid profiles. Food intake includes intake of energy, carbohydrate, protein, fat and fiber before treatment did not significantly difference between two groups. Fat intake after treatment was significantly different between the two groups due to differences in the amount of oil.After 4 weeks treatment, there was a decrease in total cholesterol significantly different between the two groups (p = 0,049). In the group that received 45 ml/ day of rice bran oil total cholesterol level decreased 14% and in the group of 15 ml/day total cholesterol level decreased 7,8%. The reduction of LDL and triglycerides and the increasing of HDL was not significantly different between the two groups (p >0,05). In this study, no changes in body weight were significant in both groups.Conclusion. Rice bran oil consumption 45 ml/day led to improvements in lipid profiles better than consumption 15 ml/day, Background. Adult individuals in Indonesian society showed changes in diet pattern and lack of physical activity that increasing risk for hypercholesterolemia and obesity. Hypercholesterolemia would be treated with nutritional therapy. Rice bran oil contains active substances (gamma-oryzanol, phytosterols, and derivatives of vitamin E (tocotrienols and tocopherols) that work in synergy and have been proven on previous research controlling lipid profil. This study aimed to assess the lipid profile improvement in intake of rice bran oil with different amounts without changing the eating patterns of the subjects.Methods. It was parallel and randomized clinical trial for 4 weeks in male with 19-55 years of age, total cholesterol level 200-300 mg/dl, and BMI of 20−30 kg/m2. All subjects were recruited consecutively and classified into two groups that received 45 ml/day or 15 ml/day rice bran oil for 4 weeks. The demographic data interviews, physical activity and anthropometric examination were taken before intervention. Food intake were assessed before and after intervention. Laboratory test of lipid profile performed before and after 4 weeks of treatment. Results. A total of 20 subjects consisting of 10 subjects with 45 ml/day rice bran oil and 10 subjects with 15 ml/day had obtained similar characteristics in age, education level, nutritional status, physical activity, smoking, family history of hypercholesterolemia, BMI and lipid profiles. Food intake includes intake of energy, carbohydrate, protein, fat and fiber before treatment did not significantly difference between two groups. Fat intake after treatment was significantly different between the two groups due to differences in the amount of oil.After 4 weeks treatment, there was a decrease in total cholesterol significantly different between the two groups (p = 0,049). In the group that received 45 ml/ day of rice bran oil total cholesterol level decreased 14% and in the group of 15 ml/day total cholesterol level decreased 7,8%. The reduction of LDL and triglycerides and the increasing of HDL was not significantly different between the two groups (p >0,05). In this study, no changes in body weight were significant in both groups.Conclusion. Rice bran oil consumption 45 ml/day led to improvements in lipid profiles better than consumption 15 ml/day]"