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"The research to accelerate furosemide dissolution rate has been done through physical property modification by solid dispersion forming polyvinylpyrolidone (PVP) carrier with solvent method. Pure furosemide posses property of being practically insoluble in water and has low bioavailability. In current research, six weight ratio
of furosemide to PVP being used are 1:1; 1:3; 1:5; 1:9 and 1:15. Physical mixtures are made in equivalent weight ratio. The dissolution rate was examined by paddle method in phosphat buffer pH 5,8. Solid dispersion caracterised with in vitro dissolution
study, X-ray diffraction, infra red spectrophotometer and differential scanning calorimetric. The result shows that solid dispersion of furosemide with PVP carrier is higher compare to physical mixture dissolution rate and pure furosemide.
The ratio furosemide to PVP who has the highest dissolution rate is 1:15. The analyzing shows the existing of altering crystalline to amorphous state."
[Fakultas Farmasi Universitas Indonesia, Universitas Indonesia], 2005
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Artikel Jurnal  Universitas Indonesia Library
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Sutriyo
"The research to accelerate furosemide, dissolution rate has been done through physical property modification by solid dispersion forming polyvinylpyrolidone (PVP) carrier with solvent method.Pure furosemide prosses property of being practically insoluble in water and has low biovailability .In current research,six weight ratio of furosemide to PVP being used are 1:1;1:3;1:5;1:9 and 1:15.Physical mixtures are made in equivalent weight ratio. The dissolution rate was examined by paddle method in phosphat buffer pH5,8.Solid dispersion caracterised with in vitro dissolution study,X -ray diffraction,infra red spectrophometer and differential scanning calometric.The result shows that solid dispersion of furosemide with PVP carrier is lugher compare to physical mixture dissolution rate and pure furosemide.The ratio furosemide to PVP who has the lughest dissolution rate is 1:15.The analyzing shows the existing of altering crystaline to amorphous state."
2005
MIKE-II-1-Apr2005-30
Artikel Jurnal  Universitas Indonesia Library
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Universitas Indonesia, 2003
S32358
UI - Skripsi Membership  Universitas Indonesia Library
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Universitas Indonesia, 2004
S32416
UI - Skripsi Membership  Universitas Indonesia Library
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Lusi Octarina
Depok: Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Indonesia, 2010
S33127
UI - Skripsi Open  Universitas Indonesia Library
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Claudia Nelrima Evangelista
"Glimepirid merupakan obat yang praktis tidak larut dalam air. Oleh sebab itu perlu dilakukan upaya untuk meningkatkan laju larut dan laju disolusi glimepirid dalam air dengan cara-cara tertentu. Tujuan penelitian ini adalah untuk meningkatkan laju larut glimepiride menggunakan sistem dispersi padat dengan eksipien koproses polivinil pirolidon PVP , maltodekstrin MD , dan polietilen glikol PEG . Pada penelitian ini, dibuat tujuh jenis eksipien koproses PVP-MD-PEG dengan tujuh perbandingan berbeda yaitu 1:1:1, 1:1:2, 1:2:1, 2:1:1, 2:2:1, 2:1:2, dan 1:2:2. Ketujuh eksipien koproses tersebut dilakukan karakterisasi meliputi analisis gugus fungsi, morfologi partikel, distribusi ukuran partikel, kadar air, derajat keasaman, dan laju alir. Selanjutnya, dilakukan pembentukan dispersi padat dengan perbandingan 1:2 antara glimepirid dan eksipien koproses. Hasil dispersi padat yang diperoleh dievaluasi meliputi penampilan fisik, morfologi partikel, analisis gugus fungsi, analisis termal, uji difraksi sinar-X dan uji disolusi. Hasil penelitian menunjukkan bahwa eksipien PVP-MD-PEG 2:1:1 memiliki laju alir dan kadar air yang paling baik dibanding eksipien lainnya sementara dispersi padat yang menggunakan eksipien koproses 2:1:1 memiliki puncak endotermik 186,26oC, entalpi leburan 63,65 J/g, tinggi puncak difraksi sinar-X 4921,57 dan peningkatan laju disolusi 4,02 kali lebih besar pada menit ke 120 dibanding glimepirid murni dan memiliki laju disolusi tertinggi diantara dispersi padat lainnya.

Glimepiride is a third generation sulfonylurea drug used in the treatment of type II diabetes mellitus that practically insoluble in water. Its solubility needs to be increased by some methods which one of the methods is solid dispersion. The main objective of this study was to increase glimepiride rsquo s dissolution rate using solid dispersion method with coprocessed excipient of polyvinylpyrrolidon PVP , maltodextrin MD and polyethylene glycol PEG . In this study, seven kinds of the coprocessed excipients of PVP MD PEG were prepared in the ratio of 1 1 1, 1 1 2, 1 2 1, 2 1 1, 2 2 1, 2 1 2, and 1 2 2. Furthermore, the coprocessed excipients of PVP MD PEG were characterized in terms of morphology, particle size distribution, moisture content, pH, and flow rate. Moreover, the coprocessed excipients were used in solid dispersion with the ratio 1 2 for glimepiride and coprocessed excipient. Solid dispersions were characterized by dissolution rate test, x ray diffraction, differential scanning calorimetry, infrared spectrophotometry, and scanning electron microscopy. The results showed that coprocessed excipient with the ratio of 2 1 1 revealed good flow properties and water content. In conclusion, the solid dispersion with coprocessed excipient with the ration of 2 1 1 has endothermic peak 186.26oC, fused enthalpy 63,65J g, x ray diffraction peak 4921.57 and has the best dissolution rate on minute 120 increased by 4.02 times faster than pure glimepiride.
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Depok: Fakultas Farmasi Universitas Indonesia, 2017
S68983
UI - Skripsi Membership  Universitas Indonesia Library
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Yetti Farichati
"Masaiah disolusi. zat. aktif obat dalam sediaan: padat
oral banyak mendapat perhatian mengingat bahwa laju disolusi
obat memegang peranan yang penting daiwa merainaikan
" bi6avajlabjljtas dan bioekivalensi " obat secara in vitro.
Banyak metoda yang telah dilakukan dalam usaha menin
katkan laju disolusi dan obat, khususnya yang mernpunyai k
larutan yang rendah dalam air atau cairan lambung...
Dari sekian banyak metoda-metoda, kami memilih untuk me
mat pengaruh polisorbat. 80, dioktil sodium sulfo suksinat
dan glismn terhadap laju disolusi piroksikam dan kioramfe -
nikol..
Metoda yang kami lakukan dalam penelitian mi adaiah
metoda kristalisasi, metodapenambahan langsung dan metoda
granulasi basah. Adapun uji laju disolusi dilakukan dengan
metoda It basket ' pada kecepatan rotasi 100 rpm, sebagai m
dia disolusi digunakan HC1 0,1 N, pada temperatur 37°C
0,5°C. Sampel diambil pada menit ke 5, 10 1, 15, 20 9, 25, 30,
£4.5 dan 60 setelah percobaari dimulaTL. Jumlah obat yang me -
larut dalam media disolusi ditentukan dengan spektrofoto
meter u.v. pada panjang gelombang maksimumnya, dimana untuk
piroksikam pada A 334 nm, dan kloramfenikol pada A 278
mm diban.dingkan terhadap larutan standar pembanding.
Hasil penelitian menunjukkan bahwa pengaruh adanya..
polisorbat 80 pada piroksikam balk dengan metoda kristalisasi
dengan kadar 2,5 % atau metoda granulasi basah dan
pencampuran langsung dengan kadar 2,0 % meningkatkan laju
disolusinya, demikian pula metoda granulasi basah .glisin
kadar 2,,0 %.
Metoda kristalisasi kioramfenikol dalam larutan polisorbat
80 2 9 5 % maupun polisorbat 80, diokthl sodium sulfo suksi-
'nat dan glisin dengan kadar 17,5 % baik dengan metoda pencampuran
langsung maupun metoda granulasi basah tidak meningkatkan
laju disolusi kioramfenikol.

The problems in drug dissolution of solid, oral dosage
forms draw a. lot.. att.jxtion. because drug dissolution rate
plays important role in.predicting H bioavailabilty and
bioequivalent it of drug in vitro.
Many methods have been done to increase the drug
dissolution rate, especially for those which have slight
solubility in water or gastric liquid Amoung those me
thods, we chose to observe the effect of the addition of
polysorbate 80, dioctyl sodium sulfo succinate and glycine
in the increating the dissolution rate of piroxicam and
chioramphenicol.
The methods carried out in the experiment were crystallization
method, direct mixing method and wet granula -
tion method. Observation of the dissolution rate were done
using the U basket's method 11 on the rotation rate of 100
rpm, withHC1 0,1 N as medium at temperature of 370 LOV5°C
The sample were taken. on 5 th , 10tb , 15th , 20tb
1
25th
30th , kSth , and 60th minutes after the experiment had been
started The amount of drug that disolved in the dissolu -
tion medium were determined by using ultra violetspectrophotometer
at their maximum wave lenght, that is at 1 334
nm for piroxicam, and 278 nm for chioramphenicol by cog paring to the standard solution the original drug which
concentration had already been known.
The experiment showed that the addition of 2,5 %
solution of polysorbate 80 in the crystallization method
of piroxicam or 2,0 % concentration in wet granulation m
thod and direct mixing method could increase their dissolution
rate, and also the addition of glycine 2,0 % and
gave the same effect in wet granulation method.
While in chloram.phenicol the existence of surfactants
polysorbate 80 2,5 %, polysorbate 80, dioctyl sodium sulfa
succinate and glycine 17,5 % couldn't increase the disso -
lution rate in all three methods mentioned above
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Depok: Universitas Indonesia, 1986
S31691
UI - Skripsi Membership  Universitas Indonesia Library
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Rudiawan
Universitas Indonesia, 1996
S32121
UI - Skripsi Membership  Universitas Indonesia Library
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"Penelitian tentang pengaruh kitosan pada laju disolusi ketoprofen, suatu senyawa obat sukar larut dalam air, telah dilakukan. Campuran fisik dan dispersi padat ketoprofen-kitosan (metode pelarut) dibuat dengan perban-dingan 1:1,1:3 dan 1:5. Laju disolusi sampel ditentukan dengan alat disolusi tipe I dengan menggunakan air sebagai medium. Perubahan fisik yang terjadi diamati dengan menggunakan analisis termal (DSC) dan difraksi sinar-X. Hasil uji dengan analisis termal dan difraksi sinar-X menunjukkan dispersi padat ketoprofen-kitosan berada dalam bentuk amorf sementara campuran fisik masih menunjukkan sifat kristal dari obat dan sifat amorf dari kitosan. Campuran fisik dan dispersi padat ketoprofen-kitosan terbukti meningkatkan laju disolusi ketoprofen dibandingkan laju disolusi ketoprofen tunggal. Peningkatan laju disolusi ketoprofen dalam campuran fisik dan dispersi padat berkorelasi positif dengan konsentrasi kitosan. Laju disolusi ketoprofen dari campuran fisik dan dispersi padat ketoprofen-kitosan 1:5 selama 120 menit 2,7 dan 2,2 kali lebih tinggi daripada laju disolusi ketoprofen tunggal."
Universitas Indonesia, 2005
S32522
UI - Skripsi Membership  Universitas Indonesia Library
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