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"Kecepatan gelombang nadi (Pulse wave velocity, PWV) diukur pada 25 subyek laki-laki bukan perokok dan dibandingkan dengan subyek perokok sebelum dan segera sesudah merokok. Tekanan darah, frekuensi nadi dan PWV tidak berbeda pada kedua kelompok sebelum merokok. Setelah merokok terjadi peningkatan tekanan darah, frekuensi nadi dan PWV pada segmen Aorta-Radialis (Ao-Rad) dan Femoral-Dorsalis pedis (Fem-Dp), tapi pada segmen Aorta-Femoralis (Ao-Fem) terjadi penurunan PWV. Hal ini menunjukkan segmen arteri sentral dan perifer memberi respons yang berbeda terhadap merokok. (Med J Indones 2002; 11: 207-10)

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Pulse wave velocity (PWV) was recorded in different arterial segments in 25 male nonsmokers and compared with age and sex matched smokers before and after smoking. Blood pressure (BP), Heart rate (HR) and PWV were comparable between nonsmokers and smokers before smoking. Just after cigarette smoking there was rise in HR, BP and PWV in Aorta to Radial (Ao-Rad), and femoral to Dorsalis Pedis (Fem-Dp) arterial segments, but the PWV was reduced in Aorta to Femoral (Ao-Fem) arterial segment, indicating that both peripheral and central arterial segments show different response to smoking. (Med J Indones 2002; 11: 207-10)"

"[ABSTRAKLatar belakang : Kekakuan arteri berkaitan dengan peningkatan risiko kejadian kardiovaskular. Variabilitas tekanan darah dengan menggunakan ambulatory blood pressure monitoring telah terbukti sebagai prediktor prognosis kardiovaskular dan dapat menggambarkan kekakuan arteri. Penelitian ini bertujuan untuk menyelidiki hubungan variasi tekanan darah dengan menggunakan home blood pressure monitoring dengan pemeriksaan pulse wave velocity sebagai penilaian kekakuan arteri.Metode : Penelitian potong-lintang dilakukan terhadap 57 subyek hipertensi yang belum terobati berusia 30-50 tahun. Subyek menjalani pemeriksaan PWV dan dilakukan monitoring tekanan darah menggunakan HBPM sebanyak 3 hari (setiap pagi dan malam, masing-masing dua kali pengukuran). Dilakukan juga penilaian terhadap variabel perancu (obesitas, diabetes, dislipidemia, penurunan fungsi ginjal).Hasil : Sebanyak 21% subyek obesitas, 8,7% mengidap diabetes melitus, 60% mengalami dislipedemia, 14% merokok, tidak ada yang mengalami perburukan fungsi ginjal. Tidak ada hubungan antara obesitas, dislipidemia, merokok, jenis kelamin, merokok dengan kekakuan arteri. Diabetes melitus memliki hubungan yang signifikan dengan kekakuan arteri (p=0,01). Ada perbedaan antar pengukuran tekanan sistolik berdasarkan pengelompokan hari dan waktu, sebaliknya tidak ada perbedaan antar pengukuran tekanan diastolik. Terdapat korelasi antara kekakuan arteri dengan rata-rata tekanan darah diastolik (p=0,028), rata-rata tekanan darah diastolik pagi (p=0,015), koefisien variasi diastolik (p=0,030), koefisien variasi diastolik pagi (p=0,015).Kesimpulan : Tidak terdapat hubungan variabilitas tekanan darah sistolik terhadap kekakuan arteri namun terdapat kecenderungan hubungan yang positif. Terdapat hubungan berbanding terbalik yang signifikan antara variabilitas tekanan darah diastolik dengan kekakuan arteri.

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ABSTRACTBackground : Arterial stiffness is related to higher risk of cardiovascular events. Blood pressure variability using ambulatory blood pressure monitoring has proven as a cardiovascular prognosis predictor and also serves as predictor of arterial stiffness. The study aims to prove the correlation between blood pressure variability measurement using home blood pressure monitoring and arterial stiffness measurement using pulse wave velocityMethods : A cross-sectional study was conducted to 57 subjects with native hypertension between 30-50 years old. Subjects underwent PWV measurement and was monitored for their blood pressure using HBPM for three consecutive days (morning and night BP each repeated two times). Subjects also screened for related confoundings i.e., diabetes, obesity, dyslipidemia, renal function disturbance. Results : As many as 21% subjects is obese, 8.7% had diabetes melitus, 60% had dyslipidemia, 14% is smoker. There is no subjects with renal function disturbance. There is no correlation between obesity, dyslipidemia, smoking habit, and sex to arterial stiffness, whereas diabetes melitus has a strong correlation to arterial stiffness (p=0,01). There was a significant difference between sytolic blood pressure measurement at each group of blood pressure based on day and time, but no difference found between diastolic blood pressure. There is significant correlation between arterial stiffness and mean diastolic pressure, mean morning diastolic pressure, variance coefficient of diastolic pressure, variance coefficient of morning blood pressure.Conclusion : We conclude that HBPM is reliable in measuring blood pressure variability. There is no significant relation of systolic blood pressure variability to arterial stiffness, but there is a tendency of positive correlation. While there is a significant negative correlation between diastolic pressure to arterial stiffness., Background : Arterial stiffness is related to higher risk of cardiovascular events.Blood pressure variability using ambulatory blood pressure monitoring has proven asa cardiovascular prognosis predictor and also serves as predictor of arterial stiffness.The study aims to prove the correlation between blood pressure variabilitymeasurement using home blood pressure monitoring and arterial stiffnessmeasurement using pulse wave velocity Methods : A cross-sectional study was conducted to 57 subjects with nativehypertension between 30-50 years old. Subjects underwent PWV measurement andwas monitored for their blood pressure using HBPM for three consecutive days(morning and night BP each repeated two times). Subjects also screened for relatedconfoundings i.e., diabetes, obesity, dyslipidemia, renal function disturbance. Results : As many as 21% subjects is obese, 8.7% had diabetes melitus, 60% haddyslipidemia, 14% is smoker. There is no subjects with renal function disturbance.There is no correlation between obesity, dyslipidemia, smoking habit, and sex toarterial stiffness, whereas diabetes melitus has a strong correlation to arterial stiffness(p=0,01). There was a significant difference between sytolic blood pressuremeasurement at each group of blood pressure based on day and time, but nodifference found between diastolic blood pressure. There is significant correlationbetween arterial stiffness and mean diastolic pressure, mean morning diastolicpressure, variance coefficient of diastolic pressure, variance coefficient of morningblood pressure.Conclusion : We conclude that HBPM is reliable in measuring blood pressurevariability. There is no significant relation of systolic blood pressure variability toarterial stiffness, but there is a tendency of positive correlation. While there is a significant negative correlation between diastolic pressure to arterial stiffness. ]"

"Latar Belakang. Disfungsi endotel dan aterosklerosis merupakan kondisi yang terjadi secara sistemik. Bila ada aterosklerosis di aorta, maka kemungkinan juga terjadi aterosklerosis di arteri koroner. Kekakuan aorta akibat aterosklerosis tersebut dapat diketahui dari pulse wave velocity (PWV) aorta. Penelitian ini akan menilai hubungan antara PWV aorta dengan keberadaan penyakit arteri koroner (PAK) berdasarkan skor SYNTAX (Synergy between percutaneous coronary intervention with Taxus and cardiac surgery) angiografi koroner. Metode. Penelitian ini merupakan suatu penelitian observasional potong lintang. Evaluasi dilakukan pada 83 pasien yang menjalani angiografi koroner elektif di Pusat Jantung Nasional harapan Kita dan memenuhi kriteria inklusi sejak September hingga November 2013. Hubungan nilai PWV aorta dengan keberadaan PAK berdasarkan skor SYNTAX dinilai dengan analisis regresi logistik. Hasil. Setelah disesuaikan dengan usia, jenis kelamin, indeks massa tubuh, hipertensi, diabetes melitus, dislipidemia, penghambat enzim konverting angiotensin, penyekat reseptor angiotensin, penyekat kanal kalsium, diuretik, dan pasca infark miokard, tidak ditemukan hubungan antara PWV aorta dengan keberadaan PAK (Odds ratio 2,126; IK 95%: 0,744 – 6,072; p= 0,159). Pada kelompok PAK tidak ditemukan korelasi antara nilai PWV aorta dengan skor SYNTAX (r= -0,082; p= 0,539). Uji regresi logistik multinomial antara PWV aorta dengan skor pembuluh juga tidak menunjukkan hubungan yang bermakna. Kesimpulan. PWV aorta tidak memiliki hubungan yang bermakna dengan keberadaan dan beratnya stenosis PAK, tetapi pada kelompok PAK ada kecenderungan terjadi PWV aorta lebih tinggi.

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Background. Endothelial dysfunction and atherosclerosis are conditions that occurs systemically. If atherosclerosis occurred in the aorta, it may also occurred atherosclerosis in coronary artery. Aortic stiffness as a result of atherosclerosis can be known from the pulse wave velocity (PWV) of the aorta. This study will assess the relationship between aortic PWV with the presence of coronary artery disease (CAD) by SYNTAX (Synergy between percutaneous coronary intervention with TAXUS and cardiac surgery) score from coronary angiography.

Method. This study is a cross-sectional observational study. The evaluation was done on 83 patients who undergoing elective coronary angiography at the Harapan Kita National Heart Centre and met the inclusion criteria since September to November 2013. The relationship between aortic PWV values with the presence of CAD by SYNTAX score was assessed by logistic regression analysis.

Results. After adjusting for age, sex, body mass index, hypertension, diabetes mellitus, dyslipidemia, angiotensin converting enzym inhibitor, angiotensin reseptor blocker, calcium channel blocker, diuretic, and post myocardial infarction, analyses revealed there is no associated between aortic PWV with the presence of CAD (Odds ratio 2,126; IK 95%: 0,744 – 6,072; p= 0,159). In CAD group, there was no associated between aortic PWV value with SYNTAX score. After multinomial logistic regression between aortic PWV with vessel score, there is also no significantly associated.

Conclusion. Aortic PWV has no relation with the presence and severity of CAD, but there is a trend toward high aortic PWV in CAD group."

"Kondisi hipertiroidisme berkorelasi dengan kejadian atherosclerosis cardiovascular disease (ASCVD). Hal ini dapat terjadi melalui jalur resistensi insulin, metabolisme lipid, dan inflamasi yang dapat menyebabkan disfungsi endotel. Sebaliknya, pemberian obat antitiroid seperti propiltiourasil (PTU) atau metimazol memiliki potensi untuk memperbaiki disfungsi endotel yang terjadi. PTU memiliki keunggulan dibandingkan metimazol dalam hal menghambat migrasi dan proliferasi otot polos vaskular. Studi ini bertujuan untuk mempelajari peran hormon tiroid dan pengobatannya pada pasien Graves terhadap penanda dini aterosklerosis.Studi ini merupakan uji klinis tersamar tunggal yang dilakukan di RSUPN Dr. Cipto Mangunkusumo (RSCM) pada pasien Graves baru yang diberikan PTU atau metimazol selama 3 bulan. Kedua kelompok diperiksakan HOMA-IR,LDL-R, NF-kB, sICAM-1, sVCAM-1 dan sE-selektin serta pulse wave velocity (PWV) dan carotid intima media thickness (cIMT) saat sebelum terapi, setelah terapi 1 bulan dan 3 bulan. Dilakukan uji Pearson atau Spearman untuk menilai korelasi antar variabel. Perubahan variabel dalam 3 bulan dinilai dengan uji repeated ANOVA. Perbedaan pada kelompok PTU dan metimazol dinilai dengan uji general linear model.Selama bulan Juli 2019 hingga Agustus 2020, didapatkan 36 pasien Graves baru. Pada uji korelasi didapatkan konsentrasi T4 bebas berkorelasi dengan sICAM-1(r = 0,41; p = 0,013) dan sVCAM-1 (r = 0,458; p = 0,005), begitu juga T3 total berkorelasi dengan sICAM-1 (r = 0,513; p = 0,001) dan sVCAM-1 (r = 0,567;p < 0,001). Pada tindak lanjut 3 bulan, didapatkan 24 subjek (13 kelompok PTU dan 11 kelompok metimazol) yang menyelesaikan pemeriksaan dan mencapai eutiroid. Pada kelompok PTU, didapatkan penurunan LDL-R (p = 0,017),sICAM-1 (p = 0,001), sVCAM-1 (p < 0,001) dan sE-selektin (p = 0,045). Pada kelompok metimazol terjadi penurunan hanya pada LDL-R (p = 0,011) dan sVCAM-1 (p = 0,001). Namun pada perbandingan kedua kelompok tidak berbeda bermakna. Parameter PWV dan cIMT juga tidak berbeda bermakna.Simpulan: Pada penelitian ini kondisi hipertiroid pasien Graves berkorelasi dengan peningkatan sICAM-1 dan sVCAM-1 sebagai penyebab aterosklerosis. Pemberian obat antitiroid dapat menurunkan LDL-R, sICAM-1, sVCAM-1 dan sE-selektin. PTU memiliki mekanisme yang berbeda dari metimazol dalam patofisiologi aterosklerosis. Akan tetapi, belum didapatkan bukti pada perubahan PWV dan cIMT

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Hyperthyroidism is correlated with atherosclerosis cardiovascular disease (ASCVD). The basic mechanisms are through insulin resistance, lipid metabolism, and inflammation resulted in endothelial dysfunction. On the other hand, antithyroid drugs such as propiltiourasil (PTU) or methimazole have the potential to improve the endothelial dysfunction. PTU is believed to have a better profile than methimazole in reducing smooth muscle cells migration and proliferation. This study aims to investigate the effect of thyroid hormone and its treatment in Graves’ disease to early marker of atherosclerosis.

This study is a single-blinded clinical trial conducted in dr. Cipto Mangunkusumo General Hospital (RSCM) to newly diagnosed Graves’ patient treated with PTU or methimazole for 3 months. Both groups were examined for LDL-R, NF-ĸB, sICAM-1, sVCAM-1, sE-selectin, pulse wave velocity (PWV) and carotid intima media thickness (cIMT) at baseline, after 1 month and 3 months treatment. Pearson or Spearman test was done to analyze correlation between tested variables. Repeated ANOVA test was done to analyze the changes in those variables during 3 months treatment. Difference between PTU and methimazole groups was analyzed with general linear model test.

From July 2019 to August 2020, 36 newly diagnosed Graves’ patients were included in the study. Correlation test showed free T4 concentration correlated to sICAM-1 (r = 0.41; p = 0.013) and sVCAM-1 (r = 0.458; p = 0.005), and total T3 also correlated to sICAM-1 (r = 0.513; p = 0.001) and sVCAM-1 (r = 0.567; p < 0.001). After 3 months follow up, 24 subjects (13 from PTU group and 11 from methimazole group) reached euthyroid state and included in the analysis. In PTU group, we found reduction in LDL-R (p = 0.017), sICAM-1 (p = 0.001),

sVCAM-1 (p < 0.001) and sE-selectin (p = 0.045). While in methimazole groups, we only found reduction in LDL-R (p = 0.011) and sVCAM-1 (p = 0.001). However, after comparing both groups, the differences were not statistically significant. We found no significant changes in PWV and cIMT parameter.

In conclusions, this study found that hyperthyroidism in Graves’ patient correlated with increase in sICAM-1 and sVCAM-1, which are the early markers of atherosclerosis. Antithyroid drugs can lower LDL-R, sICAM-1, sVCAM-1 and sE-selectin. PTU had a different mechanism in pathophysiology of atherosclerosis compared to methimazole. However, we found no evidence in PWV and cIMT changes"

"Beton merupakan suatu material yang secara harfiah menjadi kebutuhan masyarakat terhadap fasilitas infrastruktur konstruksi yang semakin meningkat seiring dengan perkembangan zaman. Pengujian beton dengan metode non destructive test di zaman sekarang ini sangat dibutuhkan dalam mengevaluasi kondisi beton pada suatu konstruksi, sehingga bisa mengurangi resiko kerugian akibat pengujian dengan metode destructive test. Penelitian ini adalah penelitian eksperimental dengan mencari nilai shear wave velocity dan longitudinal wave velocity dengan kuat lentur beton. Nilai shear wave velocity didapatkan dari pengujian menggunakan alat A-1040 MIRA dan nilai longitudinal wave velocity didapakan dari pengujian menggunakan alat UPV. Pengujian ini dilakukan dengan beton yang memiliki mutu K-175, K-250, dan K-350. Hasil dari penelitian ini menunjukkan bahwa nilai shear wave velocity dan nilai longitudinal wave velocity berbanding lurus dengan kuat lentur beton.

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Concrete is a material that now becomes a communitys need for construction infrastructure facilities that are increasing along with the times. Concrete testing with non destructive test methods today is needed to evaluate concrete in a construction, so we can reduce the risk of loss due to testing with destructive methods. This research is experimental research by looking the value of shear wave velocity and longitudinal wave velocity with concrete flexural strength. The value of shear wave velocity were obtained from the test using the A-1040 MIRA and the value of longitudinal wave velocity were obtained from the test using UPV tool. Test were performed on concrete with quality K-175, K-250, and K-350. The results of this study indicate that the shear wave velocity and longitudinal wave velocity is directly proportional to the flexural strength of the concrete. "

"Hamburan K-p dihitung dengan menggunakan teknik partial wave dan teknik 3D. Perhitungan saling dibandingkan untuk berbagai energi. Perhitungan dengan menggunakan kinematika relativistik juga dilakukanuntuk melihat efek relativistik pada berbagai energi. Model potensial yang digunakan digambarkan sebagai model pertukaran meson dan hiperon. Observable yang dihitung yaitu penampang lintang diferensial, polarisasi, dan depolarisasi.

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K p scattering is calculated using partial wave technique and 3D technique. Both calculations are compared with each other for various energies. Calculations using relativistic kinematics are also performed to observe relativistic effect on various energies. The Interaction used is described as a potential model for meson and hiperon exchanges. The observables being calculated are differential cross section, polarization, depolarization."