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"Southeast Asian Ovalocytosis (SAO), thalassemia α, serta defisiensi enzim G6PD (Glukosa-6-Fosfat Dehidrogenase) merupakan kelainan sel darah merah yang terjadi akibat adanya mutasi. Kelainan sel darah merah tersebut banyak ditemukan pada daerah endemik malaria. Hal tersebut diduga terkait dengan adanya mekanisme proteksi terhadap parasit malaria. Penelitian bertujuan untuk mengetahui frekuensi penderita SAO, thalassemia α, G6PDd/SAO dan G6PDd/thalassemia α. Metode deteksi yang dilakukan yaitu dengan pengamatan morfologi eritrosit, perhitungan sel darah total (CBC), serta biologi molekuler menggunakan Polymerase Chain Reaction (PCR). Berdasarkan hasil PCR, didapatkan frekuensi penderita SAO sebesar 11,4%, thalassemia α sebesar 15,2%, G6PDd/SAO sebesar 0,8%, serta penderita G6PDd/thalassemia α sebesar 0,32%. Manifestasi klinis dapat dilihat dari nilai perhitungan sel darah total (CBC) penderita G6PDd/SAO dan G6PDd/thalassemia α yang cenderung rendah.

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Southeast Asian Ovalocytosis (SAO), α thalassemia, and G6PD (Glucose-6-Phosphate- Dehydrogenase) enzyme deficiency are red blood cell disorders that occur due to mutations in the DNA. These red blood cell disorders are commonly found in malaria endemic areas. That lead to the asumption that may provide protection against malaria parasite. The research done in order to determine the frequency of SAO, α thalassemia, G6PDd/SAO, and also G6PDd/ α thalassemia.

Detection method used by erythrocytes morphological observation and also from haematological profile. In addition, for more accurate result used moleculer method detection by Polymerase Chain Reaction (PCR). Based on PCR, result showed frequency for SAO 11,4%, α thalassemia 15,2%, G6PDd/SAO 0,8% , and for G6PDd/ α thalassemia 0,32%. Haematological profile from suffered showed tend to be lower."

"Kanker kolorektal merupakan salah satu kanker yang paling umum terjadi di Indonesia. Mutasi gen KRAS banyak terjadi pada kanker kolorektal dan diduga berkaitan dengan berkembangnya kanker tersebut. Tujuan dari penelitian ini adalah untuk mengetahui jenis mutasi gen KRAS pada ekson 2 kodon 12 dan 13 pada spesimen jaringan kanker kolorektal menggunakan metode Sanger sequencing. Sampel jaringan segar dari 50 pasien di Rumah Sakit Kanker Dharmais yang sudah terkonfirmasi kanker kolorektal oleh dokter patologi anatomi dikumpulkan di Laboratorium Biobank Rumah Sakit Kanker Dharmais. Sampel dikoleksi dari tahun 2018-2020. Hasil penelitian menunjukkan terdapat 13 sampel terdeteksi positif mutasi titik pada ekson 2 kodon 12 (9) dan kodon 13 (4). Mutasi pada kodon 12 ditemukan 2 jenis yaitu GGT>GAT dan GGT>GCT. Mutasi pada kodon 13 ditemukan 2 jenis yaitu GGC>GAC dan GGC>GCC. Berdasarkan hasil yang didapatkan, dapat disimpulkan bahwa terdapat 4 jenis mutasi yang ditemukan pada penelitian ini

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Colorectal cancer is one of the most occurred cancers in Indonesia. KRAS gene mutation often occurred in colorectal cancer and has been presumed to be related to development of this cancer. The aim of this study is to discover the mutation types of the KRAS gene exon 2 codon 12 and 13 in colorectal cancer tissue specimens in Dharmais Cancer Hospital. The fresh tissue from fifty patients in Dharmais Cancer Hospital confirmed colorectal cancer by pathology anatomy doctor were collected in Biobank Laboratory Dharmais Cancer Hospital. KRAS gene mutations were analyzed from fresh tissue using the Sanger Sequencing method. The result shows that 13 samples detected positive on KRAS gene mutation on exon 2 codon 12 (9) and codon 13 (4). Two types of KRAS gene mutation detected in codon 12 are GGT>GAT and GGT>GCT. Two types of KRAS gene mutation also detected in codon 13 are GGC>GAC and GGC>GCC. The conclusion of this study is four types of mutation has been discovered in this study."

"Pulau Timor merupakan salah satu pulau yang masuk kedalam kawasan timur Indonesia dan memiliki potensi minyak dan gas bumi. Kompleksitas struktur yang dimiliki Pulau Timor menjadi salah satu tantangan dalam melakukan kegiatan eksplorasi, untuk itu penelitian dilakukan guna mengembangkan informasi mengenai potensi area jebakan hidrokarbon berdasarkan penerapan ilmu geofisika. Penerapan ilmu tersebut dilakukan dengan mengintegrasikan metode seismik dan metode gravitasi untuk menggambarkan struktur bawah permukaan di area penelitian. Integrasi kedua metode menghasilkan model penampang struktur bawah permukaan yang cukup sesuai. Kesesuaian tersebut terlihat oleh model penampang struktur yang dibuat dengan data gravitasi dan berdasarkan model penampang seismik menghasilkan nilai error yang cukup kecil yaitu, pada lintasan A-C memiliki error 3,93% dan pada lintasan D-F memiliki error 4,63%. Selain itu tiga garis (x,y dan z) identifikasi struktur hasil analisis derivative memiliki korelasi dengan hasil pemodelan, yang mana struktur yang teridentifikasi dapat terlihat dan tergambarkan dengan baik. Model penampang struktur yang ditelah dibuat dapat memberikan gambaran rekontruksi pembentukan Pulau Timor dan informasi mengenai element petroleum system berdasarkan struktur geologi. Sehingga semua informasi tersebut dapat digunakan untuk menentukan potensi area jebakan hidrokarbon dan sebagai infomasi awal guna mengurangi kegagalan dalam kegiatan eksplorasi.

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Timor Island is one of the islands that is included in the eastern of Indonesia and has oil and gas potential. The complexity of the structure owned by Timor Island is one of the challenges in conducting exploration activities, for that research is carried out to develop information on potential hydrocarbon trap areas based on the application of geophysical method. The application of this method is carried out by integrating seismic methods and gravity methods to describe subsurface structures in the research area. The integration of the two methods produces a cross-sectional model of the subsurface structure that is quite suitable. This conformity can be seen by the cross-sectional model of the structure made with gravity data and based on the seismic cross-sectional model which produces a fairly small error value, namely :  the A-C path has an error of 3.93% and the D-F path has an error of 4.63%. In addition, three lines (x, y and z) identification of the structure of the derivative analysis have a correlation with the modeling results, in which the identified structure can be seen and described well. The cross-sectional model of the structure that has been made can provide an overview of the reconstruction of the formation of Timor Island and information about the elements of the petroleum system based on the geological structure. So that all of this information can be used to determine potential hydrocarbon trap areas and as initial information to reduce failures in exploration activities. "

"The Timor problem consists of an avalanche of closely related subjects. The majority, common in all underdeveloped countries, is not new. They emanate from a combination of factors - unfavorable physical conditions, simple technologies, and a social setting, which impedes progress and modernization and result in an alarming agrarian situation, marked by malnutrition and soil erosion.

On Timor, as elsewhere in the world, the solution of these matters is exceedingly difficult and is retarded by a general lack of data, concerning both physical environment and social factors. Specialists in various fields have studied several facets of the Timor problem, and valuable suggestions have been put forward. The objection of the latter is that, made by single-minded specialists, they are rarely coordinated and do not sufficiently consider the multiple correlation in the interplay between man and nature. Co-ordination between the results of specialized enquiries, in order to show the area's real nature and critical features, is desirable.

As a geographer the author does not intend to invade the fields of other sciences, and he is not under the illusion that he can provide the answer to the Timor problem. He realizes, however, that the geographical approach has been found of value in area planning projects in many parts of the world during the last decades. Geographers' advice has been sought to in increasing degree and their practical aid welcomed. Few of them, however, have yet been employed in the gigantic project of which the present generation should form the foundation, i.e. development of newborn areas. That is just where geographers could give considerable assistance. With their training, they are often able to apply the required co-ordination and correlation. By providing the present situation's historical background, by analyzing the methods man has used to develop his environment and giving a synthetic interpretation of all phenomena found in the area, he can supply the basic overall information necessary in the formulation of plans for future development. An attempt will be made to demonstrate this in the following study regarding the Timor problem."

"Sistem Tenaga Listrik (STL) Indonesia saat ini masih berkaca pada Negara Kontinental(daratan) dan tidak cocok jika terus diterapkan di Negara Kepulauan seperti Indonesia.Maka dengan membuat konsep Island Charging pada studi kasus Pulau Timor baik darisisi teknologi storage, supply chain dan keekonomian kiranya menjadi alternatif sertasolusi orisinil dalam memecahkan masalah energi seperti pemerataan elektrifikasi,terciptanya lingkungan bersih dan meningkatnya nilai tambah ekonomi serta benefituntuk daerah sekitarnya. Dimana metodologi yang digunakan mulai dari analisa teknistransportasi dan teknologi Mobile Energy Storage System (MESS), kemudian dilanjutkandengan analisa ekonomi menggunakan Livelized Cost of Storage (LCOS) pada MESSyang dominan dipengaruhi oleh moda transportasi. Hasil dari perhitungan tersebut akandibandingkan terhadap keekonomian Generator Setting (Genset) diesel di Pulau Wetarsehingga diperoleh kesimpulan bahwa konsep Island Charging ini dapat dikatakanfeasible apabila faktor eksternalitas ikut diperhitungkan dan adanya subsidi dariPemerintah jika menggunakan energi terbarukan

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The current Indonesian Electric Power System (STL) still reflects on the Continental

Country (mainland) and is not suitable if it continues to be applied in an archipelago

country like Indonesia. So by making the concept of Island Charging in the case study of

Timor Island, both in terms of storage technology, supply chain, and economics, it is

likely to be an alternative and original solution in solving energy problems such as

equalization of electrification, creating a clean environment and increasing economic

added value and benefits to the surrounding area. The methodology used starts from

technical analysis of Mobile Energy Storage System (MESS) transportation and

technology, then continues with economic analysis using Levelized Cost of Storage

(LCOS) in MESS, which is dominantly influenced by the mode of transportation. The

results of these calculations will be compared to the economy of the Diesel Generator

Setting (Genset) on Wetar Island so that the conclusion is that the Island Charging concept

can be said to be feasible if externalities are taken into account, and there is a subsidy

from the Government when using renewable energy"