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"The Use of Maltodextrin from Wheat Starch as an Exipient in Formula Tablet and Niosom dosage form. Wheat starch normally can be used as a tablet filler only, because the flow rate and binding capacity are not good enough. The wheat starch should be treated as follows : protein and amine free Bogasari wheat flour starch were hydrolyzed by á-amylase enzyme (Liquezym EX®) at variable temperature andtime incubation to produce maltodextrin with different Dextrose Equivalent (DE) value. The maltodextrin could be used as tablet binder on wet granulation, tablet filler and binder on direct compress, a proniosom carrier to prepare niosom, a tabletfiller, binder and disintegrator on direct compress tablet, a sugar coated tablet material. All of the product used active compound as amodel and the quality were evaluated according to the 4thed. of Indonesian Pharmacopeae and other valid references. The result shows that maltodextrin DE 1?5 could be used as a tablet binder whichwas processed by wet granulation on 2-5% concentration, as a tablet binder and filler which was processed by direct compress on 30-35%; maltodextrin DE 10-15 could be used as a proniosom carrier then continued to niosom preparation with surfactant composition of 2 mmol (1 mmol for span 60 and 1 mmol for cholesterol). The surfactant and drug concentration of 100 mmol/lt and 5 mmol/lt subsequentlywas proved to loading the drug as much as 81.28%. Maltodextrin DE 15-20 could be used as a tablet filler, binder and disintegrator at 84%, and starch hydrolyzed of DE 35-40 as a sugar coating which was more economical than sugar."

"Pragelatinisasi pati singkong propionat (PPSP) merupakan pati singkong termodifikasi secara fisika dan kimia. PPSP memiliki karakteristik yang memungkinkan untuk digunakan sebagai bahan pengikat dalam formulasi tablet secara granulasi basah tanpa harus melalui proses pemanasan. Pada penelitian ini telah dilakukan optimisasi formula tablet yang menggunakan PSPP sebagai bahan pengikat dan primojel® sebagai bahan penghancur dengan diltiazem HCl sebagai model obat. Optimisasi dilakukan dengan metode permukaan respon (response surface methodology). Konsentrasi PPSP dan Primojel® (sodium starch glycolate) dalam formula tablet ditetapkan sebagai faktor formulasi farmasetika, sedangkan sebagai variabel respon farmasetik dipilih parameter – parameter kekerasan, keregasan dan waktu hancur. Untuk pengolahan data, digunakan software Design Expert 7.1.4 trial version. Hasil optimisasi konsentrasi PPSP dan Primojel® pada ke tiga variabel respon diperoleh konsentrasi optimum PPSP 4,06% dan Primojel® 6,03%. Formula dengan konsentrasi PPSP dan Primojel® yang optimum ini diprediksikan akan memberikan parameter kekerasan, keregasan dan waktu hancur berturut - turut 5,92Kp, 0,46%, dan 11,68 menit, dengan nilai diserability 0,34.

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Pregelatinized cassava starch propionate (PCSP) is a physically and chemically modified starch. PCSP is possible to be used as a binder in tablet formulation by wet granulation process. The optimization of tablet formulation, which is using PCSP as a binder, Primojel® as a disintegrant and diltiazem HCl as a drug model, have been studied by response surface method. The concentration of PCSP and Primojel® in tablet formulation was determined as the pharmaceutical formulation factors, whereas the pharmaceutical response were the tablet hardness, friability and disintegration time. A set of data was analyzed using Design Expert 7.1.4 trial version software. The results showed that the optimum concentration of PCSP and Primojel® are 4.06% and 6.03% respectively, in the tablet formulation. The predicted value of hardness, friability and disintegration time of the tablet which formulated at the optimum concentration of PCSP and Primojel® , are 5.92Kp, 0.46% and 11.68 minute, respectively; and the value of diserability is 0.34."

"Salah satu produk modifi kasi pati yang dapat digunakan sebagai bahan penyalut lapis tipis (fi lm coating) tablet adalah maltodekstrin. Penelitian ini bertujuan mengetahui kemampuan maltodekstrin DE 5-10 sebagai bahan penyalut lapis tipis tablet. Maltodekstrin DE 5-10 diperoleh dengan cara hidrolisis pati singkong menggunakan enzim α-amilase dari NOVO (Termamyl L120®) pada suhu 85°C selama 65 menit. Maltodekstrin DE 5-10 digunakan sebagai bahan penyalut pada konsentrasi 10, 15, 20 dan 25%, sebagai bahan salut pembanding digunakan hidroksimetil selulosa (HPMC). Evaluasi tablet salut dilakukan berdasarkan ketentuan yang tertera pada Farmakope Indonesia Edisi III dan IV. Hasil penelitian menunjukkan bahwa maltodekstrin DE 5-10 dari pati singkong dapat digunakan sebagai bahan penyalut lapis tipis dengan hasil yang cukup baik pada konsentrasi 10-25%, bahkan pada konsentrasi 10% hasilnya lebih baik dari tablet yang disalut dengan hidroksimetil selulosa.

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The Use of Maltodextrin from Tapioca Starch as a Film Coating Tablet Material. Maltodexrin is a modifi ed starch product which can be use as a material fi lm coating tablet. The aim of the research was to study the capability of maltodextrin as a material fi lm coating exipient. Maltodextrin DE 5-10 was made by hidrolysis of tapioca starch with α-amylase enzyme from NOVO (Termamyl L120®), at 80° C, for 65 minute. Maltodextrin was used as a fi lm coating material at concentration 10%,15%,20% dan 25%. As a comparative fi lm coating material was used HPMC. The evaluation of the coating tablet was done accordance to Farmacope Indonesia third and fourth edition. The result show that maltodextrin DE 5-10 from tapioca starch can be used as fi lm coating at concentration 10-25% with concentration 10% gave better result a HPMC."