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"The risk of cancer increases with age, and the number of older adults seeking treatment is increasing dramatically in line with the aging population. The care of older patients differs from that of younger adults because of differences in the biology of the tumor, age-related differences in host physiology, comorbidity burden and psychosocial issues, which might impact the efficacy and side effects of cancer therapy. Practical Geriatric Oncology is a comprehensive, evidence-based text that synthesizes the growing literature in this field and provides practical guidelines to the care of older adults with cancer. Coverage includes patient assessment, management of solid tumors and hematologic malignancies, the impact of age on the pharmacology of cancer therapy, surgical oncology and radiation oncology in the older adult, symptom management and supportive care. In addition to serving as core reading for oncologists and hematologists, the book will also be a useful work for other healthcare professionals who provide oncology care, including surgeons, radiation oncologists, palliative care doctors, primary care providers, geriatricians and nurses."

"Over the past decade, PET-CT has achieved great success owing to its ability to simultaneously image structure and function, and show how the two are related. More recently, PET-MRI has also been developed, and it represents an exciting novel option that promises to have applications in oncology as well as neurology. The first part of this book discusses the basics of these dual-modality techniques, including the scanners themselves, radiotracers, scan performance, quantitation, and scan interpretation. As a result, the reader will learn how to perform the techniques to maximum benefit. The second part of the book then presents in detail the PET-CT and PET-MRI findings in cancers of the different body systems. The final two chapters address the use of PET/CT in radiotherapy planning and examine areas of controversy. The authors are world-renowned experts from North America, Europe, and Australia, and the lucid text is complemented by numerous high-quality illustrations."

"Interventional oncology is a fast-growing new field, as well as an emerging specialty. Many minimally-invasive, imaging-guided procedures seem set to replace more traditional open surgical techniques of treating solid tumors in a variety of organs. The aim of this book is to describe new interventional radiological methods in a succinct and practical form. Diagnostic radiological considerations relevant to the selection and follow-up of patients are also covered. The book begins with an overview of the basic principles of current interventional techniques, including thermal ablation, high intensity focused ultrasound, and embolization. Later chapters focus on tumors of the liver, kidney, lung, and bone, placing new interventional techniques in context by referring to the surgical and oncologic methods of treating the same conditions. With an emphasis on best practices."

"Latar Belakang. Pasien kanker usia lanjut dapat memiliki luaran yang buruk akibat intoleransi terhadap terapi standar, hingga mortalitas, terutama pada stadium lanjut (III dan IV). Memprediksi mortalitas merupakan hal yang penting dalam menentukan pemberian terapi. Hingga saat ini ECOG (Eastern Cooperative Oncology Group) masih digunakan di RSUPN dr. Cipto Mangunkusumo (RSCM). Geriatric 8 (G8) merupakan salah satu instrumen penapis yang dikembangkan untuk memprediksi frailty. Namun, beberapa studi menunjukkan bahwa G8 dapat memprediksi mortalitas.Tujuan. Penelitian ini bertujuan untuk menilai performa ECOG dan G8 dalam memprediksi mortalitas 6 bulan pada pasien usia lanjut dengan kanker stadium III dan IV.Metode. Metode penelitian ini adalah kohort retrospektif, menggunakan data rekam medis pasien berusia > 60 tahun dengan kanker stadium III dan IV yang belum atau sudah menjalani terapi kanker, di Poliklinik Hematologi Onkologi Medik RSCM sejak Oktober 2019-Maret 2021. Peneliti menilai ECOG dan G8, serta melakukan follow-up dalam 6 bulan untuk mengetahui luaran subjek berupa meninggal atau tidak. Peneliti menganalisis uji kalibrasi dengan Hosmer-Lemeshow dan uji diskriminasi dengan Area Under the Curve (AUC).Hasil. Peneliti mendapatkan 230 subjek. Proporsi mortalitas dalam 6 bulan adalah 40,9%, dengan kanker terbanyak adalah kanker kepala dan leher (11,3%). ECOG memiliki performa kalibrasi yang baik (p = 0,085), dan performa diskriminasi yang baik (AUC 0,705; IK95% 0,570 - 0,841), sensitivitas 70,2%, dan nilai prediksi negatif (NPN) 49,3%. Performa kalibrasi skor G8 menunjukkan hasil yang juga baik (p = 0,687), dan performa diskriminasi yang baik (AUC 0,777; IK95% 0,683 - 0,872), sensitivitas 89,4% dan NPN 76%.Kesimpulan. Skor G8 memiliki performa kalibrasi dan diskriminasi yang lebih baik untuk memprediksi mortalitas 6 bulan pada pasien usia lanjut dengan kanker stadium III dan IV.

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Background: Elderly cancer patients can have a poor outcome due to intolerance to standard therapy, up to mortality, especially in advanced stages (III and IV). Predicting mortality is important to determine treatment. ECOG is still being used at dr. Cipto Mangunkusumo General Hospital (RSCM). G8 is one of the screening instruments developed to predict frailty. However, several studies have shown that the G8 can predict mortality.

Aim. To assess the performance of ECOG and G8 in predicting six months mortality in elderly cancer patients with stage III and IV.

Methods: In this study, a retrospective cohort design was used using medical records of patients aged > 60 years old with stage III and IV cancer who had not or had undergone cancer therapy at the Medical Oncology Hematologic Polyclinic of RSCM since October 2019-March 2021. Collected data were analyzed using the Hosmer-Lemeshow test for the calibration performance and the Area Under the Curve (AUC) test for the discrimination performance in predicting mortality.

Results. Among 230 subjects, mortality in 6 months was 40.9%, with the most common types of cancer was head and neck cancer (11.3%). ECOG had good calibration (p = 0.085), and good discrimination performance (AUC 0.705; 95% CI 0.570 - 0.841). G8 also had good calibration (p = 0.687), and good discrimination performance (AUC 0.777; 95% CI 0.683 - 0.872). G8 had higher sensitivity and negative predictive value than ECOG (89,4% vs 70,2%; 76% vs 49,3%).

Conclusion. G8 has better calibration and discrimination performance for predicting six months mortality in elderly cancer patients with stages III and IV."

"This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. "