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"Tesis ini disusun untuk menilai pengaruh latihan penguatan otot-otot ekspirasi dalam mengurangi gejala sleep apnea pada pasien Obstructive Sleep Apnea dengan obesitas menggunakan metode penelitian Evidence-Based Case Report (EBCR). Pencarian literatur dilakukan pada Pubmed, ProQuest, EBSCOHost, Scopus dan Cochrane sesuai dengan pertanyaan klinis. Penelitian ini menggunakan Randomized Controlled Trial pada satu jurnal yang didapat untuk menilai kualitasnya berdasarkan validitas, kepentingan dan aplikabilitasnya. Dari hasil Randomized Controlled Trial didapatkan bahwa subjek penelitian adalah pasien Obstructive Sleep Apnea dengan obesitas. Kesimpulan penelitian ini adalah latihan penguatan otot-otot ekspirasi dapat mengurangi gejala sleep apnea dengan menurunkan nilai Apnea-Hypopnea Index pada pasien Obstructive Sleep Apnea

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This thesis was designed to assess the effect of expiratory muscle strengthening exercises in reducing sleep apnea symptoms in Obstructive Sleep Apnea patients with obesity using an evidence-based case report (EBCR) research method. A literature search was performed on Pubmed, ProQuest, EBSCOHost, Scopus and Cochrane according to clinical questions. This study uses a Randomized Controlled Trial in one journal obtained to assess its quality based on its validity, importance and applicability. From the results of the Randomized Controlled Trial, it was found that the research subjects were Obstructive Sleep Apnea patients with obesity. The conclusion of this study is that expiratory muscle strengthening exercises can reduce sleep apnea symptoms by reducing the Apnea-Hypopnea Index value in Obstructive Sleep Apnea patients"

"Latar belakang: Obstructive Sleep Apnea OSA berkorelasi dengan hipertensi. Pada OSA dengan hipertensi resisten ditemukan hiperaldosteronisme primer. Disfungsi gen Cryptochrome-1 Cry1 dan Cry2 menyebabkan peningkatan aldosteron dan hipertensi pada mencit. Neuroglobin Ngb diketahui mempengaruhi gen Per. Peneliti menduga penurunan kadar Cry pada OSA menyebabkan peningkatan aldosteron dan hipertensi, dan kadar neuroglobin serum mempengaruhi Cry.Metodologi: Subyek dikumpulkan secara konsekutif dari survei populasi Jakarta berusia 30-65 tahun yang menderita OSA sedang-berat dan hipertensi. OSA didiagnosis menggunakan portable monitor tipe 2 Alice Pdx unattended. Subyek didiagnosis hipertensi bila tekanan darah pagi hari lebih dari 140/90 mmHg atau minum obat anti hipertensi. Konsentrasi aldosteron, renin, neuroglobin, Cry1 dan Cry2 serum ditentukan dengan metode ELISA. Hiperaldosteronisme ditentukan dengan Aldosterone Renin Ratio ARR >20.Hasil Penelitian: Terdapat 40 subyek yang memenuhi kriteria, 26 laki-laki dan 14 perempuan dengan median usia 52,5 tahun, BMI 27,46 kg/m2, AHI 34.8 kali/jam. Ditemukan 16 subyek dengan hiperaldosteronisme primer HP dan 24 subyek nonHP. Tidak ditemukan perbedaan bermakna Cry1, Cry2 dan Ngb pada kedua kelompok. Walaupun secara statistik tidak bermakna terdapat kecenderungan penurunan kadar Cry1 dan Cry2 pada ARR tinggi pada HP, terutama Cry1. Ditemukan korelasi positif antara kadar Ngb dengan Cry1 pada HP Spearman rsquo;s rho= 0.455, p= 0.038 . Selain itu ditemukan hubungan bermakna antara Cry1 dan O2 nadir p= 0.026 . Cry1 menurun pada hipoksia berat. Pada HP terdapat kecenderungan penurunan Ngb pada kadar O2 nadir rendah, walaupun secara statistik tidak bermakna.Kesimpulan: Penurunan kadar Cry1 mungkin berhubungan dengan terjadinya kelebihan aldosteron pada OSA. Ngb tampak berperan pada penurunan Cry1.

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Background Obstructive Sleep Apnea OSA patients with resistant hypertension also had primary hyperaldosteronism. Cryptochrome 1 Cry1 and Cry2 dysfunction were associated with increased aldosterone and hypertension. Neuroglobin Ngb is known to influence Per gene. In this study we want to investigate whether Cry decrease in moderate to severe OSA causes aldosterone increase and hypertension, also the possible role of Ngb on Cry expression.Methods Subjects were recruited consecutively from a population study of OSA in Jakarta, subjects aged 30 65 years with moderate to severe OSA and hypertension. OSA was diagnosed using unattended type 2 portable monitor Alice Pdx , hypertension was established when morning blood pressure exceed 140 90 mmHg or on anti hypertensive drugs. Serum aldosterone, renin, neuroglobin, Cry1 and Cry2 were determined using ELISA method. Primary hyperaldosteronism was determined by Aldosterone Renin Ratio ARR 20.Results Of the 40 subjects recruited, there were 26 males and 14 females, with median age 52.5 years, BMI 27.46 kg m2, and AHI 34.8 times hour. We found 16 subjects with primary hyperaldosteronism PH and 24 nonPH. No difference in Cry1, Cry2 and Ngb levels was found in these groups. Although statistically not significant Cry1 and Cry2 concentration decrease with higher ARR in PH, especially Cry1. There was a positive correlation between Ngb and Cry1 in PH Spearman rsquo s rho 0.455, p 0.038 . There was relationship between Cry1 and nadir O2 p 0.026 . Cry1 was decreased in severe hypoxia. Although statistically not significant, serum Ngb decreased in severe hypoxia.Conclusions Cry1 decrease might be the cause of increased aldosterone in OSA. Ngb decrease is associated with Cry1 decrease."

"Bruxism merupakan aktivitas pergerakan otot rahang yang dapat menyebabkan berbagai dampak negatif baik bagi kondisi intraoral maupun ektstraoral. Aktivitas ini memiliki beberapa kemungkinan etiologi, salah satunya adalah gangguan tidur. Penelitian sebelumnya menunjukkan tingginya prevalensi kualitas tidur buruk pada mahasiswa Rumpun Ilmu Kesehatan Universitas Indonesia. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara sleep bruxism dengan kualitas tidur, sleep bruxism dengan jenis kelamin, dan kualitas tidur dengan jenis kelamin pada mahasiswa program sarjana Rumpun Ilmu Kesehatan Universitas Indonesia. Metode: Sebanyak 152 mahasiswa program sarjana Rumpun Ilmu Kesehatan Universitas Indonesia memenuhi kriteria inklusi dan eksklusi. Responden mengisi kuesioner secara onlinemelalui google form mengenai Sleep Bruxism Questionnaire dan Pittsburgh Sleep Quality Index. Data dianalisis secara univariat dan bivariat (Chi-Square) menggunakan perangkat lunak Statistical Package for the Social Sciences (SPSS). Hasil Penelitian: Hasil uji Chi-Square menunjukkan tidak ada hubungan antara sleep bruxism dengan kualitas tidur (p=1,00), sleep bruxism dengan jenis kelamin (p=0.525), dan kualitas tidur dengan jenis kelamin(p=0.201). Kesimpulan:Penelitian ini menunjukkan tidak terdapat hubungan antara sleep bruxism dengan kualitas tidur, sleep bruxism dengan jenis kelamin, dan kualitas tidur dengan jenis kelamin pada mahasiswa program sarjana rumpun ilmu kesehatan Universitas Indonesia TA 2022/2023

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Bruxism is a jaw muscle activity that can cause various negative impacts on intraoral and extraoral conditions. This activity has several possible etiologies, one of which is sleep disturbance. Previous study has found a high prevalence of poor sleep quality in students of health sciences cluster Universitas Indonesia. Objectives: The aim of this study was to determine the relationship between sleep bruxism and sleep quality, sleep bruxism and gender, and sleep quality and gender among students of the health sciences cluster Universitas Indonesia. Method: A total of 152 students from the health sciences cluster Universitas Indonesia met the inclusion and exclusion criteria. Respondents then filled out online questionnaires via the Google form regarding the Sleep Bruxism Questionnaire and the Pittsburgh Sleep Quality Index. The data were analyzed univariately and bivariately (Chi-Square) using the Statistical Package for the Social Sciences (SPSS) software. Results: The results of the Chi-Square test showed that there is no relationship between sleep bruxism and sleep quality (p=1.00), sleep bruxism and gender (p=0.525), and sleep quality and gender (p=0.201). Conclusion: This study shows that there is no relationship between sleep bruxism and sleep quality, sleep bruxism and gender, and sleep quality and gender among undergraduate students of the Health Sciences Cluster Program Universitas Indonesia during 2022/2023 academic year. "

"ABSTRAKObstructive sleep apnea (OSA) is a disease with recurrent episodic of partial or total upper airway collapse during sleep. Snoring is a main symptom of OSA because it may be caused by upper airway collapse during sleep. Several risk factors has been identified as risk factors for OSA. They are male gender, increased of age, overweight or obesity, big neck, craniofacial abnormality, upper airway disease or abnormality, smoking, gene, menopause, nasal congestion, and alcohol consumption. Overweight or obesity are major risk factor of OSA. Obesity also increased progressivity of OSA. "

"Latar Belakang. Multipel sklerosis merupakan penyakit kronik progresif dimana selain dari berbagai gejala neurologis yang ada, gangguan tidur merupakan masalah yang juga memiliki dampak terhadap penyandang penyakit multipel skeloris. Beberapa penelitian telah menunjukkan bahwa prevalensi gangguan tidur ditemukan lebih tinggi pada penyandang penyakit multipel skeloris dibandingkan populasi normal. Penelitian ini bertujuan untuk mengetahui prevalensi serta pola gangguan tidur pada penyandang penyakit multipel sklerosis di Indonesia.Metode. Penelitian ini merupakan studi deskritptif potong lintang. Populasi penelitian merupakan pasien dengan penyakit multiple sklerosis yang berobat di RSCM Jakarta yang memenuhi kriteria inklusi, dan dilakukan pengambilan data klinis dan pengambilan sampel dengan mengisi kuesioner Pittsburgh Sleep Quality Assessment (PSQI) dan STOP-BANG Sleep Apnea Questionnaire, serta The Mini International Neuropsychiatric Interview ICD-10 (MINI ICD-10). Data yang didapat kemudian dilakukan pengolahan dan analisis data.Hasil. Dari empat puluh dua subjek MS yang diikutsertakan pada penelitian ini, 32 (76,2%) subjek berusia kurang dari 35 tahun, 34 (81,0%) berjenis kelamin perempuan, 23 (54,8%) subjek tidak bekerja, 9 (21,4%) mengalami depresi, dan 9 (21,4%) memiliki EDSS 6 ke atas. Insomnia ditemukan pada 32 (76,2%) subjek, dengan proporsi yang lebih besar ditemukan pada subjek berusia 35 tahun ke atas (80% vs 75%, p=0,556), berjenis kelamin laki-laki (87,5% vs 73,5%, p=0,374), kelompok yang tidak bekerja (78,3% vs 73,7%, p=0,504), kelompok dengan depresi (77,8% vs 75,8%, p=0,638), dan kelompok dengan EDSS lebih dari sama dengan 6 (77,8% vs 75,8%, p=0,638). Seluruh subjek memiliki risiko OSA dengan 39 (92,9%) subjek memiliki risiko ringan-sedang dan 3 (7,1%) subjek memiliki risiko berat. Hanya laki-laki yang memiliki risiko terhadap kejadian OSA (37,5% vs 0%, p=0,005), tetapi tidak berkaitan terhadap kejadian insomnia.Kesimpulan. Prevalensi gangguan tidur pada penyandang penyakit multipel skeloris di Indonesia sangat tingi. Untuk itu perlu dilakukan evaluasi dan pemeriksaan lebih lanjut guna menunjang diagnosis.

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Background. Multiple sclerosis (MS) is a chronic progressive disease in which sleep disorder, besides various neurologic manifestations, highly impacts the patients but is often neglected in clinical settings. Several studies had discovered that sleep disorder was more prevalent in MS than general population. This study aimed to investigate the prevalence and characteristics of sleep disorder in MS patients in Indonesia.Methods. A descriptive cross-sectional study involving MS patients was conducted at Dr. Cipto Mangunkusumo National General Hospital Jakarta. In addition to clinicodemographic data collection, data regarding sleep quality, obstructive sleep apnea (OSA), and depression state were assessed using Indonesian previously-validated Pittsburgh Sleep Quality Index, STOP-BANG Sleep Apnea Questionnaire, and The Mini International Neuropsychiatric Interview ICD-10, respectively.Results. Of forty MS participants included in this study, 29 (72.5%) aged less than 35 years, 32 (80.0%) were women, 20 (50.0%) were unemployed, 10 (25.0%) had depression, and 10 (25.0%) had Expanded Disability Scoring Scale (EDSS) of ≥6. Insomnia was found in 33 (82.5%) participants, of which larger proportion were male (100.0% vs 78.1%, p=0.309. Three (7,1%) participants had moderate risk of OSA. Only male had significant risk of OSA (moderate risk 25.0% vs 0%, p=0.036), but it did not associate with insomnia.Conclusion. Sleep disorder in MS patients in Indonesia is prevalent. There was potencies of the risk of OSA in MS, especially in male. Detection of insomnia and risk OSA is important in MS comprehensive care."

"Latar belakang: Sindrom Down merupakan kelainan kromosom tersering. Anak dengan SD memiliki beberapa faktor risiko terhadap OSA dengan prevalens di berbagai negara yaitu antara 30-60 , dibandingkan 0,7-2 pada populasi umum. Hingga saat ini belum ada data mengenai OSA pada anak sindrom Down di Indonesia. Tujuan: Mengidentifikasi prevalens OSA pada anak sindrom Down dan menganalisis hubungan antara habitual snoring, obesitas, penyakit alergi di saluran napas, hipertrofi tonsil, dan hipertrofi adenoid sebagai faktor risiko OSA pada anak sindrom Down. Metode: Penelitian potong lintang dilakukan pada anak sindrom Down berusia 3-18 tahun yang tergabung dalam Yayasan POTADS. Penelitian dilakukan di Poliklinik Respirologi IKA FKUI RSCM dari bulan Juli 2016 hingga Juli 2017. Penegakkan diagnosis OSA menggunakan nilai batas AHI 3 pada pemeriksaan poligrafi. Faktor-faktor risiko yang dianggap berpengaruh dianalisis secara multivariat. Hasil: Penelitian dilakukan terhadap 42 subjek dengan hasil prevalens OSA pada anak dengan SD sebesar 61,9 . Sebesar 42,9 merupakan OSA derajat ringan, 14,3 OSA sedang, dan 4,8 OSA berat. Pada analisis multivariat didapatkan faktor risiko yang bermakna yaitu habitual snoring p=0,022 dan PR 8,85; IK 1,37-57 dan hipertrofi adenoid p=0,006 dan PR 12,93; IK 2,09-79 . Simpulan: Prevalens OSA pada anak sindrom Down sebesar 61,9 . Faktor risiko yang bermakna yaitu habitual snoring dan hipertrofi adenoid.

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Background Down syndrome DS is the most common chromosomal disorder. Children with DS have predisposing factors to OSA with prevalence 30 60 , compared with 0.7 2 in the general child population. Until now there is no data about OSA in DS children in Indonesia. Objective To identify the prevalence of OSA in DS and to analyze the effect of habitual snoring, obesity, airways allergic diseases, tonsillar hypertrophy, and adenoid hypertrophy as risk factor for OSA. Method This is a cross sectional study, held in Respirology Clinic of IKA FKUI RSCM Jakarta from July 2016 to July 2017. Subjects in this study were DS children aged 3 18 years who are members of the Foundation POTADS Parents Association of Children with Down Syndrome . OSA was diagnosed by polygraphy examination with cutoff AHI ge 3. The risk factors that are considered important are then analyzed multivariately. Results OSA prevalance among 42 subject are 61,9 . Degree of OSA are 42.9 mild, 14.3 moderate, and 4.8 severe. In the multivariate analysis, the significant risk factor are habitual snoring p 0,022 and PR 8,85 CI 1,37 57 and adenoid hypertrophy p 0,006 and PR 12,93 CI 2,09 79 . Conclusion Prevalence of OSA in DS children is 61,9 . The significant risk factor are habitual snoring and adenoid hypertrophy."

"Selama beberapa tahun terakhir, jumlah penderita hipertensi di Indonesia telah meningkat pesat. Penelitian sebelumnya telah menunjukan bahwa OSA secara independen merupakan faktor risiko penting dalam perkembangan hipertensi. Tujuan dari penelitian ini adalah untuk mengetahui hubungan OSA dan tekanan darah pada penderita hipertensi. Desain penelitian ini adalahdeskriptif korelasi dengan pendekatan potong-lintang pada 96 pasien hipertensi di salah satu Puskesmas Kota Depok, yang direkrut dengan consecutive sampling. OSA diidentifikasi dengan menggunakan kuesioner Berlin, tekanan darah dengan menggunakan aneroid spigmomanometer serta pengukuran antropometri menggunakan timbangan berat badan dan stature meter. Penelitian ini menunjukan bahwa 57,3% responden berisiko tinggi OSA. Hasil analisis dengan menggunakan uji Mann-Whitney menunjukan bahwa OSA berhubungan dengan tekanan darah sistolik (p= 0,028; 95%CI= 0,000-0,066), tetapi tidak berhubungan dengan tekanan darah diastolik (p= 0,231; 95%CI= 0,229-0,416). Studi ini membuktikan bahwa OSA berkaitan dengan peningkatan morbiditas hipertensi karena dampaknya terhadap peningkatan tekanan darah. Pengkajian terhadap OSA dalam pelayanan kesehatan perlu dilakukan untuk meningkatkan kualitas hidup pasien terutama pada penderita hipertensi.

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Over the past few years, the number of patient of hypertension in Indonesia have increased rapidly. Previous studies have investigated that the OSA independently is important risk factor of hypertension. The objective of this study was to know the relation of OSA to blood pressure on hypertensive patients. This study design was descriptive correlation with cross-sectional approach on 96 hypertensive patients at one of the community health center in Depok city, who were selected with consecutive sampling technique. The OSA was assessed by using the Berlin questionnaire, blood pressure was assessed by aneroid sphygmomanometer, and anthropometric measurements was assessed by weight scale and stature meter.

This study showed that 57,3% subjects had the high risk for OSA. The result of analysis by using the Mann-Whitney test showed that OSA related to systolic blood pressure (p= 0.028; CI95%= 0.000;0.066) but was not related to diastolic blood pressure (p= 0.231; CI95%=0.229-0.416). This study showed that OSA related to increasing morbidity of hypertension because its effect on elevated blood pressure.The assessment of OSA needs to be implemented in providing health care, in order to increase the quality of life for patients especially on hypertensive patients."

"Latar belakang: Profesi pengemudi taksi merupakan profesi yang unik, lingkungan kerja luas, jam kerja panjang, sistem pcnggajian yang fluktuatif, dan risiko kecelakaan di jalan raya. Pada PT X 60% kccelakaan dikarenakan mengantuk. Salah satu penyebab kondisi mengantuk adalah adanya kemungkinan obstructive sleep apnea (OSA). Bcbcrapa faktor risiko kemungkinan OSA seperti kegemukan dan hipertensi dijumpai pada pengemudi PT X. Metode: Penelitian ini menggunakan desain cross sectional pada pengemudi taksi X Mampang Jakana Selatan, pada bulan November»Desember 2008. Pengumpulan dilakukan dengan pengisian Kuesioner Berlin, dan pemeriksaan fisik (tekanan darah, bcrat, badan, tinggi badan, dan lingkar leher) pada 280 orang pengemudi. Hasil: Jumlah responden sebanyak 280 orang, didapatkan 70 orang (25%) kemungkinan OSA. Kemungkinan OSA pada pengemudi dipcngaruhi olch bcbcrapa faktor yaitu: IMT 325 (acyusred OR 4.29, p <0.001, 95% Cl 2.04 - 9.05) riwayat keluarga mendengkur (aafiusled OR 2,34, p <0.00l, 95% Cl 1.45 - 3.78), lingkar leher 3 40 cm (afyusred OR 3.37, p 0.002, 95% Cl 1.58 - 7.19), umur 3 36 tahun (argusted OR 2.47, p 0.027, 95% CI I.ll - 5.48) dan jadwal keija tinggi (ac§usted OR 3.07, p 0.0l6, 95% Cl L23 - 7.66). Kesimpulan: Didapat prevalensi kemungkinan OSA pada pengemudi Taksi X sebesar 25%. Kemungkinan OSA pada pcngcmudi Taksi X dipengaruhi oleh faktor indeks massa tubuh 325, riwayat keluarga mendengkur, Iingkar leher 540 cm, umur 336 tahun serta jadwal kerjatinggi.

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Background: Taxi Driver is an unique profession because of the wide environment, the long hours working duration, the fluctuation wages, and the accidental risks. About 60% taxi's accidents in Company X were caused by sleepy conditions. Sleepy conditions may be caused by obstructive sleep apnea (OSA). Some factors that increase the prevalence of suspected OSA, like obesity and hypertension were founded among the taxi drivers in this company.

Method: This study was conducted with cross sectional design. The data was collected from November until December 2008 in Mampang, Jakarta Selatan. Data collection used Berlin's Questionnaire and Physical examinations (blood pressure, weight, height, neck circumference) to 280 drivers.

Result: This research showed that there are 25%, it?s mean 70 respondents from 280 respondents have OSA prevalence. Prevalence of OSA among taxi?s drivers is caused by several factors. The factors are Body Mass index (BMI) 3 25 (adjusted OR 4.29, p < 0.00l, 95% Cl 2.04 - 9.05), snoring historical in family (adjusted OR 2.34, p < 0.001 , 95% CI 1.45 - 3.78), neck circumference 3 40 cm (adjusted OR 3.37, p 0.002, 95% CI 1.58 - 7.l9), age 2 36 years old (adjusted OR 2.47, p 0.027, 95% Cl 1.ll - 5.48) and high work schedule (adjusted OR 3.07, p 0.0l6, 95% Cl 1.23 - 7.66).

Conclusion: This research has founded that there are 25%, it?s mean 70 respondents from 280 respondents have suspected OSA. Prevalence of suspected OSA among taxi?s drivers is caused by BMI 2 25, snoring historical in family, neck circumference 5 40 cm, age 3 36 years old and high work schedule."

"Latar Belakang. Apnea tidur obstruktif (ATO) banyak tidak disadari oleh klinisi dan prevalensinya di Indonesia cukup tinggi. Stroke merupakan penyebab kematian ke-2 di dunia dan Indonesia. ATO meningkatkan risiko kejadian stroke. Karakteristik klinis pasien ATO dengan stroke masih belum banyak diteliti. Tujuan. Mengetahui karakteristik klinis pasien kecurigaan tinggi ATO dengan stroke di RSCM. Metode. Penelitian potong lintang dengan metode consecutive dilakukan pada bulan Maret - Juni 2019 di RSCM (dari Poliklinik Neurologi dan data pencatatan pasien ATO Divisi Respirologi dan Penyakit Kritis Departemen Ilmu Penyakit Dalam). Kecurigaan tinggi ATO ditegakkan berdasarkan kuesioner Berlin-ID. Pasien dibedakan menjadi stroke dan bukan stroke. Pasien yang tidak kooperatif atau menolak penelitian dieksklusi dari penelitian. Usia, jenis kelamin, Indeks Massa Tubuh (IMT), tekanan darah, kadar HbA1c, dan lingkar leher dinilai pada setiap pasien. Ketebalan tunika intima media arteri karotis (CIMT) dinilai pada 23 subyek. Analisis data dilakukan dengan SPSS 24. Hasil Utama. Sebanyak 103 pasien kecurigaan tinggi ATO diikutsertakan dalam penelitian (34 dengan stroke dan 69 bukan stroke). Proporsi pasien kecurigaan tinggi ATO dengan stroke di RSCM adalah 33%. Pasien kecurigaan tinggi ATO dengan stroke dan bukan stroke di RSCM memiliki rerata usia 58,5 dan 57 tahun, 82,4% dan 94,2% mengalami gangguan mendengkur, 61,8% dan 36,2% laki-laki, 20,6% dan 10,1% overweight, 61,8% dan 63,8% obese, 58,8% dan 49,3% hipertensi (80% dan 85,3% tidak terkontrol), rerata CIMT kanan-kiri 0,66-0,71 mm dan 0,59-0,66 mm, 26,5% dan 34,8% diabetes melitus/DM (77,8% dan 64,7% memiliki HbA1c terkontrol), dan median lingkar leher 35,5 dan 34 cm (laki-laki 38 dan 39 cm, perempuan 33,5 dan 35 cm). Simpulan. Proporsi pasien stroke pada kecurigaan tinggi ATO di RSCM adalah 33%. Dibandingkan dengan bukan stroke, pasien kecurigaan tinggi ATO dengan stroke di RSCM memiliki rerata usia yang lebih tinggi, proporsi overweight lebih tinggi, proporsi hipertensi lebih tinggi, rerata CIMT lebih tinggi, proporsi DM dalam terapi dengan HbA1c terkontrol lebih tinggi, dan median lingkar leher lebih tinggi.

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Background. Obstructive sleep apnea (OSA) is not recognized by clinicians and its prevalence in Indonesia is quite high. Stroke is the second leading cause of death in the world and Indonesia. OSA increases the risk of stroke events. The clinical characteristics of OSA patients with stroke have not been widely studied. Objective. To know the clinical characteristics of high suspicious OSA patients with stroke in RSCM.. Method. A cross-sectional study using the consecutive method was carried out in March - June 2019 at RSCM (from Neurology Polyclinic and OSA patient record data of Respirology and Critical Illness Division of Internal Medicine Department). High suspicious OSA was diagnosed based on Berlin-ID questionnaire. Subjects were divided into stroke and not stroke. Subjects who were not cooperative or refuse the study were excluded. Age, gender, Body Mass Index, blood pressure, HbA1c levels, and neck circumference were assessed in each patient. The thickness of the carotid artery tunica intima (CIMT) was assessed in 23 subjects. Data analysis was performed with SPSS 24. Result. A total of 103 high suspicious OSA patients were included in the study (34 with stroke, 69 not stroke). The proportion of high suspicious OSA patients with stroke is 33%. Patients with high suspicious OSA with stroke and non-stroke in RSCM had an average age of 58.5 and 57 years, 82.4% and 94.2% experienced snoring disorders, 61.8% and 36.2% men, 20.6 % and 10.1% overweight, 61.8% and 63.8% obese, 58.8% and 49.3% hypertension (80% and 85.3% uncontrolled), mean right-left CIMT 0.66- 0.71 mm and 0.59-0.66 mm, 26.5% and 34.8% diabetes mellitus/DM (77.8% and 64.7% had controlled HbA1c), and the median neck circumferences were 35.5 and 34 cm (males 38 and 39 cm, females 33.5 and 35 cm). Conclusion. The proportion of stroke in high suspicious OSA patients is 33%. Compared with non-stroke, high suspicious OSA patients with stroke in RSCM had a higher mean age, higher overweight proportion, higher hypertension proportion, higher CIMT mean, higher DM in therapy with controlled HbA1c proportion, and higher median neck circumference."