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"This book explains the anatomy and physiology of cartilage tissue in an integrated way. The emphasis is on how cartilage tissue functions and maintains homeostasis in a challenging mechanical environment. Supported by hundreds of references, the book posts new hypotheses explaining how cartilage adapts and achieves homeostasis in vivo, and tests them against available data. This exploratory approach creates a sense of discovery that the reader can join, or perhaps test themselves through their own research. The main benefit will be obtained by research students and professors looking to understand the deeper concepts that will further their own research, or clinicians (including health professionals and surgeons) who want to gain a deeper physiological understanding of cartilage tissue, which can then serve as a basis for more rational clinical decision-making they need to make on a daily basis. To help bridge the gap between basic science and clinically relevant joint disease, applications and interpretations of key physiological concepts are discussed in the context of osteoarthritis at the end of most chapters."

"This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented.The book focusses especially on:1. Basic physiology, molecular biology, microstructural and material properties of the skin.2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches.3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing).4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology."

"This book (vol. 2) presents the proceedings of the IUPESM World Congress on Biomedical Engineering and Medical Physics, a triennially organized joint meeting of medical physicists, biomedical engineers and adjoining health care professionals. Besides the purely scientific and technological topics, the 2018 Congress will also focus on other aspects of professional involvement in health care, such as education and training, accreditation and certification, health technology assessment and patient safety. The IUPESM meeting is an important forum for medical physicists and biomedical engineers in medicine and healthcare learn and share knowledge, and discuss the latest research outcomes and technological advancements as well as new ideas in both medical physics and biomedical engineering field."

"This book (vol. 3) presents the proceedings of the IUPESM World Congress on Biomedical Engineering and Medical Physics, a triennially organized joint meeting of medical physicists, biomedical engineers and adjoining health care professionals. Besides the purely scientific and technological topics, the 2018 Congress will also focus on other aspects of professional involvement in health care, such as education and training, accreditation and certification, health technology assessment and patient safety. The IUPESM meeting is an important forum for medical physicists and biomedical engineers in medicine and healthcare learn and share knowledge, and discuss the latest research outcomes and technological advancements as well as new ideas in both medical physics and biomedical engineering field."

"This book reviews current knowledge on the diagnosis and treatment (surgical and non-surgical) of cartilage defects at the knee joint. In the discussion of diagnosis, the focus is primarily on imaging findings, particularly those obtained with MRI. The remainder of the book is devoted to the full range of current conservative and surgical treatments, with attention to both treatment indications and results as reported in the recent literature. In reviewing non-surgical treatment, oral and intra-articular medical management is evaluated and rehabilitation and physical therapy are also considered. The three main types of surgical technique, microfracture surgery and similar procedures, mosaicplasty and related techniques, and autologous chondrocyte transplantation, are then extensively discussed in a series of highly informative chapters. "

"Presents the proceedings of the IUPESM World Congress on Biomedical Engineering and Medical Physics, a triennially organized joint meeting of medical physicists, biomedical engineers and adjoining health care professionals"

"This book presents novel and advanced technologies for medical sciences in order to solidify knowledge in the related fields and define their key stakeholders. The fifteen papers included in this book were written by invited experts of international stature and address important technologies for medical sciences, including : computational modeling and simulation, image processing and analysis, medical imaging, human motion and posture, tissue engineering, design and development medical devices, and mechanic biology.Different applications are treated in such diverse fields as biomechanical studies, prosthesis and orthosis, medical diagnosis, sport, and virtual reality. "

"Latar belakang: Osteoartritis (OA) adalah kelainan sendi lutut degeneratif tersering, jumlah pasien OA semakin bertambah dengan bertambahnya harapan hidup. Artroplasti distraksi adalah sebuah alternatif yang relatif lebih tidak invasif untuk tatalaksana OA dengan menghilangkan stres mekanis dan mempertahankan tekanan intermiten cairan sendi, sehingga menghentikan siklus kerusakan pada OA. Penelitian ini bertujuan mempelajari perubahan anatomi dan histopatologi setelah artroplasti distraksi pada model hewan osteoartritis.Metode: Penelitian dilakukan pada 32 lutut kambing (16 kambing) yang terlebih dahulu diinduksi secara mekanis menjadi OA dengan menisektomi lateral. Selama masa penelitian, 6 kambing mati. Artroplasti distraksi dilaksanakan menggunakan fiksasi eksterna pada 10 lutut selama 4 minggu, dan 10 lutut kontralateral dibiarkan, kemudian diperiksa secara anatomis dan histopatologis untuk diperbandingkan mengunakan staging International Cartilage Repair Society (ICRS) dan skoring Osteoarthritis Research Society International (OARSI). Perbedaan anatomis dan histopatologis diuji kemaknaannya menggunakan uji Wilcoxon.Hasil: Terdapat perburukan secara anatomi dan histopatologi pada lutut yang diberikan perlakuan. Nilai median perbandingan secara makroskopis dengan staging ICRS berbeda bermakna (1,5 vs 2,5; p < 0,002). Perbandingan secara histopatologi dengan skoring OARSI berbeda bermakna (6 vs 10; p < 0,002).Kesimpulan: Arthroplasti distraksi pada model OA kambing dalam penelitian ini, tidak memberikan perbaikan, melainkan memperburuk OA. Penelitian lebih lanjut diperlukan untuk memberikan dasar biologis yang kuat dari artroplasti distraksi sebagai terapi alternatif untuk OA.

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Background: Osteoarthritis (OA) is the most common knee degenerative disease, the number of OA patients increases along with the increase of life expectancy. Distraction arthroplasty is a less invasive alternatif for OA management by releaving mechanical stress while maintaining intermitten joint fluid pressure changes, thus halting the OA destructive cycle and inducing repair. This study aims to evaluate the anatomical and histopathological changes after distraction arthroplasty on osteoarthritic animal models.

Methods: The study was performed on 32 goat stiffle joint (16 goats) with mechanically induced OA by lateral meniscectomy. During the study 6 goats were decreased. Distraction arthroplasty was performed using external fixation on 10 knees for 4 weeks, and the contralateral knees left untreated. The knees were anatomically and histopathologically examined using International Cartilage Repair Society (ICRS) staging and Osteoarthritis Research Society International (OARSI) scoring. The differences of the anatomical and histopathological changes are tested for significance using the Wilcoxon test.

Results: There was anatomical and histopathological worsening of the OA on treated knees. The anatomical difference assessed using ICRS stage gave median values of 1.5 and 2.5 respectively (p < 0.002). The histopathological difference assessed using OARSI scoring was significant (6 vs 10; p < 0.002).

Conclusion: Distraction arthroplasty in OA goat models in this study, worsens the OA instead of inducing repair. Further studies are required to find out a convincing biological basis of distraction arthroplasty as an alternative treatment for OA."

""Biomedical Informatics: Computer Applications in Health Care and Biomedicine meets the growing demand of practitioners, researchers, educators, and students for a comprehensive introduction to key topics in the field and the underlying scientific issues that sit at the intersection of biomedical science, patient care, public health, and information technology (IT). This 4th edition reflects the remarkable changes in both computing and health care that continue to occur and the exploding interest in the role that IT must play in care coordination and the melding of genomics with innovations in clinical practice and treatment. New chapters have been introduced on the health information infrastructure, consumer health informatics, telemedicine, translational bioinformatics, clinical research informatics, and health IT policy, while the others have all undergone extensive revisions, in many cases with new authors. The organization and philosophy are unchanged, focusing on the science of information and knowledge management and the role of computers and communications in modern biomedical research, health, and health care. Emphasizing the conceptual basis of the field rather than technical details, it provides an introduction and extensive bibliography so that readers can comprehend, assess, and utilize biomedical informatics and health IT. The volume focuses on easy-to-understand examples, a guide to additional literature, chapter summaries, and a comprehensive glossary with concise definitions of recurring terms for self-study or classroom use."--Back cover."