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"ABSTRACTPurposeGeriatric surgery poses specific challenges due to patient vulnerability in relation to aging. We analyzed perioperative challenges concerning super-elderly patients with breast cancer.MethodsBetween 2013 and 2018, 908 patients with breast cancer were treated surgically. Of these, two patient groups were compared: Group A (≥ 85 years old, n = 34, 3,7%) and Group B (75-84 years old, n = 136, 15%).ResultsIn Groups A and B, 26,4% and 36,8% of patients lived alone, respectively. Group A patients had higher rates of psychiatric and cardiovascular disease (32,4% and 41,2%) than Group B (8,8% and 16,2%) (p = 0,0009 and p = 0,0031, respectively). There was no marked difference in the type of surgery or length of hospital stay between groups, and most complications involved surgical site disorders. Postoperatively, Group A had a higher rate of delirium (29,4%) than Group B (3,7%) (p < 0,0001). The 30-day postoperative mortality rate was 0, and 76,5% of Group A and 45,6% of Group B patients received no adjuvant therapy (p = 0,0024).ConclusionsAge alone does not constitute a contraindication for appropriate surgery, although there are some challenges necessary to consider for super-elderly patients."

"Latar Belakang: MnSOD adalah antioxidant yang paling umum untuk melindungi sel-sel dari stres radical oksidatif Endogenous dan exogenous radical bebas superoksida . Sel punca kanker diketahui untuk bertahan dalam keadaan hipoksia dan kelangsungan hidup sel punca kanker dipengerahi oleh level ekspresi MnSOD. Namun, efek hipoksia terhadap ekspresi gen MnSOD SOD2 masih belum diketahui.Tujuan: Penelitian ini dilakukan untuk menginvestigasi tingkat ekspresi MnSOD dalam berbagai interval waktu hipoksia dalam induksi hipoksia kepada CD24-/44 sel punca kanker payudara. Metode: Sampel kanker payudara diperoleh dalam klinik dan dipisahkan dengan Magnetic cell Sorting MACs . Sampel berikut di induksi hipoksia dalam interval 0 jam, 30 menit, 4 jam, 6 jam dan 24 jam di dalam ruangan hipoksia. Kemudian, mRNA diisolasi dan dipotimasi untuk primer annealing. C t value Cycle threshold diperoleh dari qRT-PCR dan dilakukan kalkulasi untuk mengetahui ekspresi relatif MnSOD terhadap ekspresi gen 18s. Hasil PCR akan dilakukan elektroforesis untuk mengkonfirmasi amplifikasi MnSOD. Hasil: Tingkat ekspresi MnSOD menurun di setiap interval hipoksia. Ekspresi MnSOD diturunkan paling rendah setelah 4 jam setelah diinduksi hipoksia. Kesimpulan: Semua sel punca kanker payudara CD44 /CD24- yang telah diinduksi dalam interval hipoksia yang berbeda-beda telah berdiferensiasi, hasil ditunjukan dengan penurunan dalam ekspresi MnSOD."

"Latar Belakang: Plasenta akreta merupakan suatu kondisi dimana seluruh atau sebagian dari plasenta menginvasi atau melekat pada dinding uterus. Seiring dengan meningkatnya jumlah tindakan seksio sesaria, kejadian plasenta akreta juga meningkat. Suatu studi yang dilakukan di Rumah Sakit Cipto Mangunkusumo (RSCM) pada tahun 2017, didapatkan bahwa kejadian plasenta akreta sebesar 1 per 9000 kelahiran. Persalinan seksio sesarea pada plasenta akreta memiliki berbagai komplikasi mulai dari perdarahan, cedera organ, perawatan ICU yang lebih lama, relaparatomi hingga kematian. Penting untuk mengetahui berbagai faktor risiko yang dapat mempengaruhi terjadinya komplikasi ini.Tujuan: Untuk mengetahui berbagai faktor risiko yang mempengaruhi terjadinya komplikasi pada persalinan seksio sesarea pada berbagai rumah sakit di Jakarta. Metode: Penelitian ini merupakan penelitian deskriptif, menggunakan desain case control yang dilaksanakan pada Mei-Agustus 2019. Data diambil dari rekam medis dari pasien yang melakukan persalinan seksio sesarea dengan indikasi plasenta akreta pada tahun 2014-2018 dari 3 rumah sakit umum pusat di Jakarta yaitu RSCM, RSP dan RSF.  Dilakukan pengambilan data berbagai komplikasi pada persalinan seksio sesarea dan faktor-faktor risiko yang mempengaruhinya.Hasil: Didapatkan 133 subyek yang memenuhi kriteria inklusi dan eksklusi. Dari analisis bivariat didapatkan kadar Hb preoperatif kurang dari 10 g/dL serta jenis operasi seksio sesarea yang dilanjutkan dengan reseksi uterus dibandingkan dengan SC yang dilanjutkan dengan histerektomi total secara statistik mempengaruhi terjadinya komplikasi perdarahan (p=0,042; 95%CI=1,02-9,59, OR 3,01) dan (OR 0,20, p=0,005; CI 95%=0,07-0,55). Usia kehamilan saat persalinan kurang dari 36 minggu dan kedalaman plasenta sesuai dengan akreta saat intraoperatif dibandingkan dengan perkreta (p=0,03; 95%CI=0,14-0,94, OR 0,37) dan (p=0,001; 95%CI=1,49-191,5, OR 8,74) secara statistik mempengaruhi terjadinya komplikasi cedera organ. Hasil ini berbeda dengan penelitian sebelumnya bahwa plasenta perkreta lebih berisiko terjadinya cedera organ dibandingkan akreta. Perbedaan ini dapat dipengaruhi oleh faktor lainnya seperti letak plasenta dan luas invasi plasenta.Kesimpulan: Terdapat hubungan antara kadar Hb preoperatif, jenis operasi, usia kehamilan saat persalinan serta kedalaman plasenta terhadap terjadinya komplikasi pada persalinan seksio sesarea dengan plasenta akreta.

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Background: Placenta accreta is a condition in which all or part of the placenta invades or attaches to the uterine wall. As the number of cesarean section increases, the incidence of placenta accreta also increases. A study conducted at Cipto Mangunkusumo Hospital (RSCM) in 2017 found that the incidence of placenta accreta was 1 per 9000 births. Delivery of cesarean section on placenta accreta has various complications such as bleeding, organ injury, prolonged ICU admission, relaparatomy, and death. It is important to know risk factors that can influence the occurrence of this complication.

Objective: To determine the risk factors that influence the occurrence of complications in cesarean delivery at several hospitals in Jakarta.

Method: This study is a descriptive study, using a case control design in May-August 2019. Data was taken from medical records of patients who delivered cesarean section with an indication of placenta accreta in 2014-2018 from 3 tertiary public hospitals in Jakarta, which are  RSCM, RSP and RSF. Data were collected on complications in cesarean section delivery and risk factors that influenced.

Results: There were 133 subjects who met the inclusion and exclusion criteria. From the bivariate analysis, preoperative Hb levels of less than 10 g/dL and type of cesarean section surgery followed by uterine resection compared with SC followed by total hysterectomy statistically influenced the occurrence of bleeding complications (p = 0.042; 95% CI = 1.02-9.59, OR 3.01) and (OR 0.20, p = 0.005; 95% CI = 0.07-0.55). The gestational age at delivery was less than 36 weeks and the depth of the placenta was in accordance with the intraoperative accreta compared to the percreta (p = 0.03; 95% CI = 0.14-0.94, OR 0.37) and (p = 0.001; 95 % CI = 1.49-191.5, OR 8.74) statistically affects the occurrence of organ injury. These results different from previous studies that the placenta percreta is more at risk of organ injury than accreta. This difference can be influenced by other factors such as the location of the placenta and the size of invasion.

Conclusion: There is a relationship between preoperative hemoglobin levels, type of surgery, gestational age at delivery and placental depth to the complications of cesarean delivery with  placenta accreta."

"Angiografi Koroner dan Intervensi Koroner Perkutan Transradial adalah salah satunya pengobatan penyakit jantung koroner. Penggunaan akses transradial ini bisa menimbulkan beberapa komplikasi. Penelitian ini bertujuan untuk mengetahui gambarannya komplikasi akses radial pada angiografi pasca koroner dan/atau pasien Intervensi Koroner Perkutan di salah satu rumah sakit rujukan nasional. Penelitian dilakukan secara retrospektif menggunakan desain penampang berurutan pengambilan sampel melibatkan 111 responden. Hasil penelitian menunjukkan kejadian itu Komplikasi akses radial terjadi pada 33 (29,7%) responden dengan jenis komplikasi ini bervariasi yaitu obstruksi arteri radial (5,4%), spasme arteri radial (8,1%), perdarahanarea insersi (8,1%), hematoma area insersi (10,8%) dan ekimosis (23,4%). Studi ini merekomendasikan perlunya peran perawat, terutama dalam asesmen dan pemantauan pasien untuk mendeteksi komplikasi setelah angiografi Intervensi Koroner dan/atau Perkutan.

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Coronary Angiography and Transradial Percutaneous Coronary Intervention is one of the treatments for coronary heart disease. The use of transradial access can cause several complications. This study aims to describe the complications of radial access in post-coronary angiography and/or Percutaneous Coronary Intervention patients at one of the national referral hospitals. The study was conducted retrospectively using a sequential cross-sectional design. Sampling involved 111 respondents. The results showed that the incidence of radial access complications occurred in 33 (29.7%) respondents with varied types of complications, namely radial artery obstruction (5.4%), radial artery spasm (8.1%), bleeding. insertion area (8.1%), insertion area hematoma (10.8%) and ecchymosis (23.4%). This study recommends the need for a nurse role, especially in the assessment and monitoring of patients to detect complications after coronary and/or percutaneous interventional angiography."

"The volume is authored by a colorectal surgeon with long-standing clinical and scientific experience and is devoted to the management of complications following surgery of the anorectum and the pelvic floor. It is aimed not only at general surgeons, perineologists and, of course, proctologists, but also at gastroenterologists, endoscopists, radiologists and physiotherapists, i.e. those who may be involved in both diagnosis and cure whenever an adverse event, either unpredictable or potentially preventable, causes an intra- or postoperative, early or late, mild or life-threatening complication. Severe bleeding, dehiscence, perforation, anorectal stricture, fecal incontinence, and even caval vein thrombosis, fatal Fournier gangrene and pneumomediastinum may occur after anal surgery. The incidence, pathogenesis prevention and treatment of such events are discussed in detail in 10 chapters with 30 tables, 200 illustrations and more than 1000 references. Both conventional procedures and recent innovations are reported. “Unforgettable clinical cases (complications with litigation)” and “Tips and Tricks” are sections increasing the appeal of this book. The approach is “evidence-based” and holistic, focusing on anorectal problems while taking into consideration whole body-mental unity—showing, for example, that a non-healing perineal wound may be due to hypo-pituitarism, and failure after a re-intervention may be related to psychological distress."

"The increasing prevalence of obesity in many countries means that it should now be considered a pandemic. It is widely recognized that obesity increases the risk of a variety of life-threatening conditions, including heart disease, diabetes, and hypertension. Bariatric surgery is often the most effective way to treat such morbid obesity. Nevertheless, while various bariatric procedures have been proposed, to date standards have been lacking. In this book, leading experts from around the world discuss all aspects of bariatric surgery and present their own favored versions of surgical procedures with the aid of informative illustrations. Technical nuances are carefully described, and detailed attention is devoted to potential complications and how to avoid them. "