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"ABSTRAK Latar belakang: Kolesistektomi merupakan tindakan abdomen tersering dan saat inikolesistektomi laparoskopi (KL) merupakan baku emas dan telah dilakukan pada 90% kasuskolesistitis simtomatik. Tujuan penelitian ini adalah untuk mengetahui hasil KL di RSCM,Jakarta. Metode: Penelitian retrospektif observasional ini menggunakan data dari departemen bedahdivisi digestif RSCM dari bulan Januari hingga Desember 2014. Partisipan penelitian iniadalah pria atau wanita yang berusia 23-66 tahun yang menjalani KL. Tindakan bedahdilakukan baik berupa perawatan 1 hari (one day care (ODC)) maupun elektif. Data yangdikaji adalah temuan preoperatif dan intraoperatif, durasi operasi, lama rawat inap, dan angkakonversi ke tindakan kolesistektomi terbuka (open). Kemudian kami menganalisis faktoryang mempengaruhi angka konversi. Hasil: Jumlah pasien yang masuk inklusi adalah 90 orang. Usia rata-rata 43,9 tahun (SE=1,26tahun) dengan jumlah pasien wanita 61 orang (67,8%). Median durasi operasi adalah 90±36,9menit dimana pasien yang konversi membutuhkan operasi lebih dari 2 jam lebih banyak(12% vs 1,5%), namun tidak bermakna secara statistik (p= 0,63). Median lama rawat inapadalah 9±27.2 hari dan meningkat bermakna pada kasus yag konversi (24±9 hari, p = 0.011).Median lama pre-operasi = 7±26,8 hari, dan pasca-operasi = 2±3.8 hari, dengan 13,3% pasiendilakukan endoscopic retrograde cholangio-pancreatography (ERCP) sebelum KL. Cederaduktus biliaris komunis (CBDK) ditemukan pada 3 kasus (3,33%). Konversi menjadilaparotomi dibutuhkan pada 4,44% kasus. Faktor yang mempengaruhi angka konversi hanyapada kasus adhesi (RR (95%IK) = 25,7 (2,4-273,5); p=0,007. Kesimpulan temuan: kolesistektomi laparoskopi menawarkan lama rawat inap yang lebihsingkat. Durasi operasi pendek dan prosedur ini standard, aman, dan efektif di institusi kami. ABSTRACT Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution."

"Latar Belakang: Penolakan cangkok akut pascatransplantasi hati anak dapat berakibat cangkok tidak berfungsi. Angka kejadian yang mencapai 31% di Rumah Sakit Cipto Mangunkusumo (RSCM) membutuhkan evaluasi faktor risiko untuk mengurangi morbiditas dan mortalitas. Metode: Rekam medis 44 resipien anak pascatransplantasi hati donor hidup dari tahun 2010-Januari 2020 dievaluasi, dan dianalisa menggunakan fisher test. Hasil: Sebelas subjek (25%) mengalami penolakan cangkok akut pascatransplantasi dengan median waktu 12 hari (jarak waktu 6-70 hari) pascatransplantasi. Total 44 subjek, 29 (65,9%) berusia > 1 tahun dan 30 (68,1%) bergizi kurang. Kejadian penolakan cangkok akut pada kelompok usia ≤1 tahun, adalah 5 (33%) dan pada usia >1 tahun, 6 (20%). Penolakan cangkok akut terjadi pada 6 subjek (20%) dengan gizi kurang, dan 5 subjek (35,7%) dengan gizi baik. Hasil analisa menunjukkan tidak ada hubungan antara usia (p= 0,468; 95% CI 0,47-0,77; OR 1,917) dan status gizi (p=0,287; 95% CI 0,11- 1,85; OR 0,450) terhadap reaksi penolakan cangkok akut pascatransplantasi hati donor hidup anak di RSCM. Hasil observasi tiga bulan pertama memperlihatkan rerata kadar tacrolimus darah 6-8 ng/mL pada hari 12-15, tidak mencapai target untuk mendapatkan efek imunosupresi yang adekuat. Kesimpulan: Pada penelitian ini status gizi kurang dan usia resipien saat transplantasi hati tidak signifikan sebagai faktor risiko independen reaksi penolakan cangkok akut, tetapi dapat dipikirkan bahwa kedua faktor ini mempengaruhi imunitas resipien, yang selanjutnya berperan dalam reaksi penolakan cangkok akut. Penggunaan imunosupresan yang adekuat juga harus diperhatikan dalam menekan reaksi penolakan cangkok pascatransplantasi hati.

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Background: Acute rejection post-liver transplant in children may result in graft failure. The incidence rate of up to 31% at Cipto Mangunkusumo Hospital (RSCM) needs further evaluation of risk factors to lower morbidity and mortality.

Methods: 44 medical records of post living donor liver transplant pediatric recipients between 2010 until January 2020 were evaluated and analyzed using Fisher’s test.

Results: Eleven subjects (25%) were found to experience acute rejection post-transplant with a median time of 12 days (range 6-70 days) after surgery. Of the 44 recipients, 29 subjects (65,9%) were >1 year old and 30 subjects (68,1%) were undernourished. Acute rejection occurred in 5 subjects (33%) ≤1 year-old and in 6 subjects (20%) that were >1 year old. Acute rejection of the transplant occurred in 6 subjects (20%) that were undernourished and in 5 subjects (35,7%) with good nutritional status. Analysis of the data found no relationship between age (p= 0,468; 95% CI 0,47-0,77; OR 1,917) and nutritional status (p=0,287; 95% CI 0,11-1,85; OR 0,450 to acute rejection in pediatric living donor liver transplant at RSCM. Observation in the first three months post-transplant reveal that mean levels of tacrolimus in the blood were 6-8 ng/mL on days 12-15, insufficient of reaching the target of obtaining an adequate immunosuppressive effect.

Conclusion: In this study, age and nutritional status of recipients during the time of transplant were found to be insignificant independent risk factors of liver transplant acute rejection. However, these two factors can be thought to effect recipients’ immune status, which plays a role in acute rejection post-transplant. The use of adequate immunosuppressant needs to be carefully monitored in suppressing rejection reactions post-liver transplant."

"Pendahuluan: Atresia bilier adalah kelainan pada saluran empedu yang merupakan penyebab kolestasis ekstrahepatik neonatal terbanyak dan menjadi indikasi transplantasi hati tersering (+ 50%) pada bayi dan anak. Keterlambatan diagnosis pada pasien atresia bilier di Indonesia menyebabkan angka THDH (transplantasi hati donor hidup) primer pada atresia bilier lebih tinggi dibandingkan dengan pusat transplantasi lain di dunia. Penelitian ini bertujuan untuk menilai luaran THDH primer pada pasien atresia bilier di RSCMdan faktor-faktor yang memengaruhinya.Metode: Penelitian ini merupakan penelitian kohort retrospektif dengan menggunakan data pasien anak dengan atresia bilier yang dilakukan THDH primer sejak Desember 2010 hingga Desember 2019. Luaran pasien dalam satu tahun pascaoperasi berupa morbiditas (komplikasi, lama rawat, relaparotomi) dan mortalitas dianalisis terhadap faktor prognostik praoperasi dan intraoperasi.Hasil: Telah dilakukan 58 operasi transplantasi hati di RSCM dengan 85% (34 subjek) merupakan THDH primer pada anak dengan atresia bilier. Mayoritas adalah laki-laki dengan median usia 14 bulan. Sebagian besar subjek mengalami gizi kurang (64,5%). Rerata skor PELD adalah 17,09, rerata GRWR sebesar 3,11. Rerata perdarahan intraoperasi sebesar 670,4 mL dengan median lama operasi 690 menit, median CIT adalah 57 menit dan rerata WIT adalah 54,9 menit. Komplikasi terjadi pada 96,7% subjek, dengan infeksi (77,4%) sebagai komplikasi tertinggi. Relaparotomi dilakukan pada 54,8% subjek. Median lama rawat 41 hari dengan rentang 18-117 hari. Mortalitas dalam satu tahun pascatransplantasi sebesar 9,3%. Hubungan bermakna didapatkan antara gizi kurang terhadap komplikasi infeksi (p = 0,033), GRWR terhadap lama perawatan pascaprosedur THDH primer (p = 0,00) dan WIT terhadap kejadian relaparotomi (p = 0,007).Simpulan: Dengan karakteristik pasien atresia bilier yang ada di Indonesia (mayoritas gizi kurang dan rerata skor PELD tinggi) didapatkan angka mortalitas satu tahun cukup kecil dan sebanding dengan pusat transplantasi di dunia. Kejadian relaparotomi dan komplikasi infeksi masih menjadi masalah utama dan perlu dilakukan penelitian lebih lanjut untuk mengevaluasi intervensi baik pembedahan maupun medikamentosa dalam memeperkecil kejadian morbiditas dan mortalitas.Kata Kunci : Atresia bilier, THDH primer, luaran, morbiditas, mortalitas

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Introduction: Biliary atresia is a disorder of the bile duct that the most common cause neonatal extrahepatic cholestasis and the most common indication for liver transplantation (+ 50%) in infants and children. Delayed in diagnosis patients with biliary atresia in Indonesia causes the primary LDLT (living donor liver transplantation) rate to be higher than other transplant centers in the world. This study aimed to assess the primary LDLT outcome patients with biliary atresia in RSCM and influencing factors.Methods: This study was a retrospective cohort study using data on pediatric patients with biliary atresia who were undergoing primary LDLT from December 2010 to December 2019 in RSCM. Patient outcomes within one year postoperatively in the form of morbidity (complications, length of stay, relaparotomy) and mortality were analyzed for preoperative and intraoperative prognostic factors.Results: There have been 58 liver transplantions in RSCM with 85% (34 subjects) being primary LDLT in children with biliary atresia. The majority were men with median age 14 months. Most of the subjects experienced malnutrition (64.5%). The average PELD score was 17.09, the average GRWR was 3.11. The mean intraoperative bleeding was 670.4 mL with median operating time 690 minutes, median CIT was 57 minutes and the mean WIT was 54.9 minutes. Complications occurred in 96.7% subjects with infection (77.4%) as the highest complication. Relaparotomy was performed in 54.8% subjects. The median length of stay was 41 days with a range of 18-117 days. One year post transplantation mortality was 9.3%. There were statistically significant found between malnutrition and infection complications (p = 0.033), GRWR with length of stay after primary LDLT (p = 0.00) and WIT with incidence of relaparotomy (p = 0.007).Conclusion: With the characteristics of biliary atresia patients in Indonesia (majority was malnutrition and the average PELD score is high) the one-year mortality rate is quite small and comparable to transplantation centers in the world. The incidence of relaparotomy and infectious complications are still major problems and further research is needed to evaluate both surgical and medical interventions in minimizing the incidence of morbidity and mortality.Key words: Biliary atresia, primary LDLT, outcome, morbidity, mortality"

"ABSTRAKLaparoscopic Living Donor Nephrectomy LLDN menjadi prosedur standar donor ginjal hidup di beberapa negara, termasuk Indonesia, khususnya di RSUPN Cipto Mangunkusumo Jakarta. Pada LLDN digunakan drain sebagai alat monitoring pasca operasi. Penelitian Randomized Controlled Trial ini dilaksanakan pada 40 pasien donor ginjal di Rumah Sakit Cipto Mangunkusumo Jakarta yang dibagi ke dalam dua grup; grup tanpa drain dan yang menggunakan drain grup kontrol , untuk membandingkan lama rawatan, skala nyeri, kondisi luka operasi, dan keluhan saluran cerna pasca operasi pada kedua grup. Tidak didapatkan perbedaan pada semua parameter antara LLDN menggunakan drain dan tanpa menggunakan drain.

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ABSTRACTLaparoscopic Living Donor Nephrectomy LLDN has become the standard procedure for living kidney donor in several countries, including Indonesia, especially in Cipto Mangunkusumo General Hospital Jakarta. Drainage tube in LLDN is intended as a tool of postoperative monitoring. This randomized controlled trial was performed in 40 LLDN patients in Cipto Mangunkusumo Hospital Jakarta, divided into two groups without drainage tube and using drainage tube control group , in order to compare postoperative length of stay, pain scale, surgical wound condition and gastrointestinal tract complaints. There were no differences found in all evaluated parameters within the two groups."

"Latar Belakang: Donasi organ merupakan isu etis, moral, dan medis yang kompleks. Donor organ berpotensi mengalami masalah psikososial pascadonasi, seperti depresi, cemas, stres, dan kekhawatiran akan kondisi kesehatannya. Donasi organ juga sering dikaitkan dengan isu perdagangan organ yang masih marak di Indonesia. Hingga saat ini, belum ada kesepakatan resmi mengenai domain konstruk pemeriksaan yang mendasari penulisan laporan kelaikan donor organ dalam bidang psikiatri. Hal ini dapat menyebabkan ketidakseragaman penulisan yang berpotensi mengakibatkan terlewatnya aspek psikososial yang penting untuk diidentifikasi dan meningkatkan risiko terjadinya masalah hukum. Oleh karena itu, identifikasi domain konstruk dari laporan pemeriksaan diperlukan untuk menetapkan panduan yang selanjutnya dapat dijadikan dasar pengembangan instrumen pemeriksaan kelaikan donor organ hidup di Indonesia. Metode: Penelitian menggunakan desain mixed method. Pendekatan kualitatif ditujukan untuk mengidentifikasi domain konstruk pemeriksaan menggunakan metode diskusi kelompok terpumpun (DKT) dengan 2 orang pakar. Data kualitatif dianalisis menggunakan conventional content analysis dengan tipologi thematic survey. Pendekatan kuantitatif ditujukan untuk menentukan proporsi kesesuaian penulisan laporan dengan domain konstruk pemeriksaan dan kontribusi tiap domain terhadap simpulan kecakapan yang diambil oleh pakar pada 404 laporan kelaikan donor ginjal dan hati dalam bidang psikiatri di RSCM yang diambil menggunakan metode total sampling. Analisis kuantitatif menggunakan uji Chi-square dan regresi logistik. Hasil: Analisis data kualitatif menghasilkan 9 kategori, yaitu sosiodemografi, motivasi, relasi dengan resipien, pemahaman, perasaan terhadap keputusan menjadi donor, resiliensi, isu psikiatri, penggunaan zat psikoaktif, dan isu legal. Didapatkan ketidakseragaman penulisan domain konstruk pada laporan, dengan proporsi penulisan terkecil pada domain penggunaan zat psikoaktif (5,45%) dan motivasi (82,18%). Faktor-faktor yang berperan memprediksi simpulan kecakapan calon donor adalah aspek pendidikan, motivasi, relasi dengan resipien, pemahaman, perasaan terhadap keputusan menjadi donor, resiliensi, isu psikiatri, dan isu legal dengan R2 sebesar 0,649. Simpulan: Terdapat 9 domain yang menyusun konstruk pemeriksaan kelaikan donor organ hidup dalam bidang psikiatri di RSCM. Domain yang paling memprediksi simpulan kecakapan adalah pemahaman dan resiliensi.

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Background: Organ donation is a complex ethical, moral, and medical issue. Organ donors are at risk for post-donation psychosocial problems, such as depression, anxiety, stress, and worries about their health condition. Organ donation is also associated to illegal organ-trafficking which is still a problem in Indonesia. To date, there has been no official agreement on the domains of psychiatric assessment that underlies the construct of living donor eligibility report. This can lead to the diverseness of reports which can potentially result in undetected important psychosocial aspects and increased legal risks. This research was conducted to identify domains on the psychiatric assessment of living organ donor eligibility report, which can then be used as the basic data for developing psychiatric living donor assessment instrument in Indonesia. 

Methods: This study used a mixed-method approach. A qualitative approach aimed at identifying domains of the psychiatric assessment using focus group discussion (FGD) with 2 experts. The qualitative data were analyzed using conventional content analysis with thematic survey typology. A quantitative approach aimed at determining the conformity of the reports and the contribution of each domains towards donor’s suitability concluded by experts on 404 living donor eligibility reports taken using total sampling method. The quantitative data were analyzed using Chi-square and logistic regression test. 

Results: The qualitative approach resulted in 9 categories: sociodemography, motivation, relationship with recipient, understanding, feelings toward the decision to become donor, resilience, psychiatric issues, use of psychoactive substances, and legal issues. There was inconsistency on the domains written in the reports, with the least written domains are use of psychoactive substances (5,45%) and motivation (82,18%). Based on the multivariate analysis, the domains that played a role in predicting donor’s suitability were education, motivation, relationship with recipient, understanding, feelings toward the decision to become donor, resilience, psychiatric issues, and legal issues with an R2 of 0,649.

Conslusion: There are 9 domains that make up the construct of psychiatric assessment of living organ donor eligibility in RSCM. Domains that most predict the psychiatric eligibility conclusion are understanding and resilience of the donor candidate."