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"Background: Protein is one of the nutrients that teeth need during growth, maturation and, after eruption. Protein consists of plantprotein and animal protein. Plantprotein has the highest average percentage of daily protein consumption inIndonesia.Plantprotein is found in nuts, tofu, and tempeh. The content of food sources of plantprotein has many benefits that are good for oral health.At the age of 8-9 years permanent first molar teeth have erupted they can experience caries within 1-2 years after eruption because of their morphological and functional characteristics. In children, dental caries is one of the most frequent chronic infectious diseases occur and have close links with nutrition.While snacks may also contribute to oral health problems.Aim: To determine the relationship between the level of consumption of plant protein and cariogenic food with the occurrence of permanent dental first molar teeth in children aged 8-9 years in Central Jakarta. Methods: This study isa cross-sectional observational analytic study. The subjects of the study were 109 children aged 8-9 years who were studying State Primary School in Central Jakarta. Teeth examined for permanent first molar teeth that have been erupted. The measuring instrument used was a questionnaire and caries assessment using classification (ICDAS). Result:.The results of the study showed the frequency distribution of caries as follows; 1.8% caries free, 63.3% enamel caries, and 34.9% dentin-pulp caries. Meanwhile, consumption of vegetable protein with caries depth and consumption of snack foods with depth of caries both showed very weak correlation results (r = 0.00-0.199) and there was no statistically significant difference (P> 0.05).Conclusion: There is a very weak correlation between consumption of vegetable protein and snack food with the depth of caries in permanent first molars in children aged 8-9 years in Central Jakarta, and there is no statistically significant difference"

"Latar Belakang: Protein merupakan komponen utama yang berperan dalam pertumbuhan dan perkembangan jaringan tubuh. Protein terdiri dari protein hewani dan nabati. Protein hewani terdapat dalam ikan, daging, dan telur. Defisiensi protein hewani dapat menyebabkan karies akibat menurunnya sistem pertahanan tubuh, atropi kelenjar saliva, serta adanya risiko kelainan struktur email gigi. Gigi molar satu permanen merupakan gigi yang dapat digunakan untuk menilai status kesehatan gigi anak karena memiliki anatomi pit dan fissure yang dalam, dan gigi tersebut erupsi pada usia dimana anak sering mengkonsumsi makanan manis. Usia 8 – 9 tahun dipilih karena pada usia tersebut gigi molar satu permanen telah erupsi dan gigi tersebut telah terpapar selama 2- 3 tahun di dalam rongga mulut, serta pada usia tersebut membutuhkan asupan nutrisi yang baik untuk mendukung pertumbuhan.Tujuan: Menganalisis hubungan tingkat konsumsi protein hewani dengan karies gigi molar satu permanen pada anak usia 8 – 9 tahun di Jakarta Pusat. Metode: Desain studi cross sectional. Subjek penelitian berjumlah 109 orang, yang dipilih menggunakan purposive sampling. Variabel yang digunakan bertujuan untuk menganalisis korelasi antara frekuensi konsumsi protein hewani dengan karies gigi molar satu permanen. Kuesioner yang digunakan untuk mengukur frekuensi konsumsi protein hewani yaitu Food Frequency Questionnaire (FFQ) dan pemeriksaan klinis karies gigi molar satu permanen menggunakan skor International Caries Detection and Assesment System (ICDAS).Hasil: Hasil dari penelitian menunjukkan distribusi frekuensi karies pada gigi molar satu permanen anak usia 8-9 tahun adalah 1,8% bebas karies, 63,3% karies email, dan 34,9% karies dentin-pulpa. Hubungan frekuensi konsumsi protein hewani dengan karies menunjukkan hubungan tidak bermakna secara statistik (p>0,05). Kesimpulan : Terdapat hubungan tidak bermakna antara frekuensi konsumsi protein hewani dengan karies gigi molar satu permanen pada anak usia 8 – 9 tahun di Jakarta Pusat.

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Background : Protein is the main component that have a role in body tissue’s growth and development. Protein consists of animal protein and plant protein. Animal protein can be found in fish, meat and egg. Protein deficiency can increase caries risk because of decreased immune system, salivary gland atrophy, and abnormalities of enamel structure. First permanent molar is a teeth that can be used to assess children’s oral health because it is more susceptible to caries than any other teeth. This tooth is susceptible to caries because it has deep pit & fissure anatomy and erupts at the age where children consume sweet food more often. Children aged 8 – 9 years is chosen because the first permanent is exposed long enough to oral environment and needed good nutrition for growth.

Aim: To analyze the correlation between animal protein consumption frequency and first permanent molar caries on children aged 8 – 9 years in Central Jakarta.

Method: This study design is cross sectional. Total research subject is 109 people that is chosen by purposive sampling method. The variables that are used in this research aim to analyze the correlation between animal protein consumption frequency and first permanent molar caries. Questionnaire that is used to assess the consumption frequency is Food Frequency Questionnaire (FFQ) and clinical examination to assess severity of first permanent molar caries uses International Caries Detection and Assessment System (ICDAS) score.

Result: This research shows first permanent molar caries frequency as follows; 1,8% free caries, 63,3% enamel caries, and 34,9% dentin-pulp caries. The correlation between animal protein consumption frequency and caries does not show any significant correlation (p>0,05).

Conclusion: There is no significant correlation between animal protein consumption frequency and first permanent molar caries in children aged 8 – 9 tahun in Central Jakarta."

"Latar Belakang: Asupan makanan merupakan salah satu faktor penyebab karies gigi dengan prevalensi yang sangat tinggi di Indonesia terutama pada anak usia sekolah. Tingkat konsumsi sayur dan buah pada anak di Indonesia masih cukup rendah, padahal jenis makanan ini dikenal dapat merangsang aliran dan meningkatkan kemampuan makan anak. self-cleansing saliva yang penting dalam pencegahan karies. Tujuan: Menganalisis hubungan antara frekuensi konsumsi sayur dan buah dengan kejadian karies pada gigi geraham pertama permanen pada anak usia 8 sampai 9 tahun di Jakarta Pusat. Metode: Penelitian ini merupakan penelitian potong lintang dengan menggunakan kuesioner frekuensi makanan dan pemeriksaan klinis anak usia 8 sampai 9 tahun di Jakarta Pusat. 109 anak di Jakarta Pusat diperiksa karies dengan klasifikasi ICDAS. Hasil: Penelitian ini menemukan nilai median frekuensi konsumsi sayur per hari pada anak adalah 1,6 (0-8,14) dan 1,4 (0-5). Sebanyak 98,2% anak mengalami karies gigi dan 63,3% anak mengalami karies terbatas pada email. Hubungan antara frekuensi konsumsi sayur dan buah dengan karies ditemukan sangat lemah dan tidak signifikan. Kesimpulan: Tingkat frekuensi konsumsi sayur dan buah pada anak di Jakarta Pusat masih rendah, dan prevalensi karies cukup tinggi. Hubungan yang lemah dan tidak signifikan antara frekuensi konsumsi sayur dan buah dengan karies menunjukkan bahwa ada faktor lain penyebab karies yang harus dikendalikan.

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Background: Food intake is one of the factors causing dental caries with a very high prevalence in Indonesia, especially in school-age children. The level of consumption of vegetables and fruit in children in Indonesia is still quite low, even though this type of food is known to stimulate flow and improve children's eating abilities. self-cleansing saliva which is important in caries prevention. Objective: To analyze the relationship between the frequency of consumption of vegetables and fruit with the incidence of caries in the permanent first molars in children aged 8 to 9 years in Central Jakarta. Methods: This study was a cross-sectional study using a food frequency questionnaire and clinical examination of children aged 8 to 9 years in Central Jakarta. 109 children in Central Jakarta were examined for caries with the ICDAS classification. Results: This study found the median frequency of vegetable consumption per day in children was 1.6 (0-8.14) and 1.4 (0-5). A total of 98.2% of children had dental caries and 63.3% of children had caries limited to enamel. The relationship between the frequency of consumption of vegetables and fruits with caries was found to be very weak and insignificant. Conclusion: The frequency of consumption of vegetables and fruit in children in Central Jakarta is still low, and the prevalence of caries is quite high. The weak and insignificant relationship between the frequency of consumption of vegetables and fruits with caries indicates that there are other factors that cause caries that must be controlled."

"Tujuan: Penelitian ini bertujuan untuk menguji reliabilitas kuesioner frekuensi konsumsi makanan kariogenik, mengetahui status karies gigi, dan hubungan frekuensi konsumsi makanan kariogenik dengan status karies gigi pada anak usia 15-16 tahun di DKI Jakarta. Metode: Survei epidemiologi dilakukan dengan desain penelitian cross sectional. Pemeriksaan karies gigi dilakukan oleh satu pemeriksa, menggunakan indeks DMFT. Indeks DMFT digunakan untuk mencatat prevalensi karies gigi berdasarkan kriteria WHO. Selain itu juga memberikan FFQ/ Food Frequency Quetionare yang dijawab oleh subjek untuk mendapatkan informasi mengenai frekuensi konsumsi makanan kariogenik, karakteristik anak, dan keadaan sosiodemografi. Data kemudian dianalisis dengan analitik komparatif. Hasil: Total sampel sebanyak 471 anak, dengan prevalensi yang mengalami karies gigi sebesar 75,4% dengan rata-rata 2,72. Kesimpulan: Status karies gigi pada anak usia 15-16 tahun di DKI Jakarta tergolong moderate, dengan rata-rata 2,72. Kedua kuesioner yang digunakan dalam penelitian ini adalah reliabel. Karies gigi berhubungan signifikan dengan jenis kelamin, pendidikan ibu dan item makanan yogurt, perment mint, kripik, dan minuman bersoda.

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Objective: This study aimed to examine the reliability of the questionnaire frequency of cariogenic food consumption, determine the dental caries status, and the relationship between the frequency of cariogenic food consumption and dental caries status in children aged 15-16 years in DKI Jakarta. Method: Epidemiology surveys were conducted with cross sectional study design. Dental caries was examined by one examiner, using DMFT index. DMFT index is used to record the prevalence of dental caries based on WHO criteria. FFQ / Food Frequency Quetionare answered by the subject to get information about the frequency of consumption of cariogenic foods, children's characteristics, and sociodemographic conditions. Data were analyzed with comparative analytic. Results: A total sample of 471 children, with a prevalence of dental caries of 75.4% with an average of 2.72. Conclusion: Dental caries status in children aged 15-16 years in DKI Jakarta is classified as moderate, with an average of 2.72. Both of questionnaires used in this study are reliable. Dental caries is significantly associated with gender, maternal education and food items such as yogurt, mint, mint, and carbonated drinks."

"Tujuan: Mengetahui perbedaan persepsi antara ortodontis dengan masyarakat awam serta pria dengan wanita dalam menilai hasil perawatan hipodonsia insisif lateral rahang atas bilateral. Metode penelitian: Bentuk, warna, dan tepi gingiva gigi insisif lateral rahang atas bilateral dimodifikasi secara digital sebagai simulasi hasil perawatan hipodonsia insisif lateral rahang atas bilateral. Ketiga foto hasil modifikasi dilampirkan pada kuesioner berbasis digital lalu dinilai oleh 100 ortodontis dan 100 masyarakat awam, terdiri dari 100 pria dan 100 wanita. Penilaian dilakukan dengan metode Visual Analogue Scale (VAS) dan uji statistik dilakukan dengan uji-t tidak berpasangan. Hasil: Perbedaan bermakna secara statistik ditemukan pada persepsi ortodontis dan masyarakat awam terhadap foto perawatan dengan substitusi kaninus tanpa rekonturing dan foto perawatan dengan protesa. Kesimpulan: Ortodontis dan masyarakat awam memiliki persepsi yang berbeda terhadap hasil perawatan hipodonsia insisif lateral rahang atas bilateral, sedangkan jenis kelamin tidak mempengaruhi persepsi terhadap hasil perawatan hipodonsia insisif lateral rahang atas bilateral.

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Objectives: This study aimed to compare the perception of Indonesian orthodontists and laypeople as well as men and women to the treatment of bilateral upper lateral incisor hypodontia. Methods: Shape, color, and gingival margin of bilateral upper lateral incisor were digitally modified as a simulation of bilateral upper lateral incisor hypodontia treatment result. Three modified photos were presented in a digital-based questionnaire and assessed by 100 orthodontists and 100 laypeople, consisting of 100 men and 100 women. The assessment was done using Visual Analogue Scale (VAS) and unpaired t-test was used to process the data. Results: Statistically significant differences were found between the perception of orthodontists and laypeople to the treatment utilizing canine substitution without recontouring, along with the treatment using prosthesis. Conclusions: Orthodontists and laypeople have different perceptions to the treatment results of bilateral upper lateral incisor hypodontia, while gender does not affect the perception to the treatment results.

"

"Tujuan: Menganalisis perbandingan informasi self-perceived dengan diagnosis klinis status karies gigi anak usia 12-15 tahun. Metode: Penelitian dengan desain cross sectional menggunakan kuesioner untuk mendapatkan informasi self-perceived dan pemeriksaan indeks DMFT dan PUFA dilakukan pada 494 anak di enam SMP Negeri di Jakarta. Hasil: Hasil sensitivitas paling tinggi untuk indeks DMFT gold standard adalah dari pertanyaan kebutuhan perawatan, yaitu 0.86 dengan spesifisitas 0.23. Hasil spesifisitas paling tinggi adalah dari pertanyaan mengenai sakit gigi 0.89 dengan sensitivitas 0.26. Untuk indeks PUFA gold standard , sensitivitas tertinggi adalah pertanyaan pendapat keadaan gigi 0.92 dengan spesifisitas 0.57. Spesifisitas paling tinggi adalah pertanyaan mengenai sakit gigi 0.82 dengan sensitivitas 0.40. Prevalensi dan skor rata-rata DMFT dan PUFA berurutan adalah 68.4 dan 2.4; 17.6 dan 0.2. Kesimpulan: Kuesioner lebih sensitif terhadap indeks PUFA sebagai gold standard dibandingkan dengan indeks DMFT. Informasi self-perceived yang didapat dari kuesioner tidak dapat dengan baik mengevaluasi status klinis karies gigi karena kurangnya persepsi anak terhadap sehat dan sakit.

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Objective: To analyze the comparison of self perceived information and clinically diagnosed dental health status among children aged 12 15 years.

Methods: A cross sectional study using questionnaire to obtain self perceived information and clinical examination using DMFT and PUFA indices was performed on 494 children in six junior high school in Jakarta.

Results: The highest sensitivity for DMFT index as the gold standard was found in question about treatment need, 0.86 with specificity of 0.23. The highest specificity was found in question about dental pain 0.89 with specificity of 0.26. When using the PUFA index as the gold standard, the highest sensitivity was found in question about opinion regarding dental health, 0.92 with specificity of 0.57. The highest specificity was found in question about dental pain 0.82 with sensitivity of 0.40. The prevalence and mean DMFT and PUFA index was 68.4 and 2.4 17.6 and 0.2, respectively.

Conclusion: Questionnaire was more sensitive using the PUFA index as the gold standard than the DMFT index. Self perceived information obtained from the questionnaire were of low value in evaluating dental health status due to the lack of children rsquo s health and disease perception."

"Latar belakang: Karies gigi merupakan penyakit gigi multifaktorial yang dipengaruhi oleh banyak faktor. Salah satunya adalah peran genetik. Banyak penelitian mengenai hubungan antara peran genetik kerentanan karies gigi telah dilakukan, terutama polimorfisme gen pada gen gigi tertentu.Tujuan: Untuk memperkirakan kemungkinan asosiasi gen amelogenin (AMELX) dan non-amelogenin (ENAM dan AMBN) terhadap kerentanan karies gigi berdasarkan populasi. Metode: Enam database elektronik, terdiri dari: PubMed, Scopus, EBSCO, Cochrane Library, ScienceDirect, dan Wiley Online Library dilakukan secara rumit sebagai pencarian data lanjutan untuk tanggal publikasi hingga Februari 2019. Proses menyeluruh dalam studi ulasan ini dilakukan dengan menggunakan Preferred Item pelaporan untuk pedoman Tinjauan Sistematik dan Meta-analisis (PRISMA). Bagian meta-analisis diimplementasikan dengan menggunakan dua perangkat lunak: Review Manager 5.4 dan Comprehensive Meta-analysis 2.0. Hasil: Empat belas studi termasuk dalam analisis kualitatif (tinjauan sistematis) dan kuantitatif (meta-analisis). Hasil analisis kuantitatif menyimpulkan bahwa ENAM rs3796704 berhubungan sebagai faktor protektif terhadap kerentanan karies gigi, terutama pada alel A (OR=0,7; p-value=0,009), genotipe AG (OR=0,7; p-value=0,03), dan genotipe AA (dominan) (OR=0.7; p-value=0.02). ENAM rs3796704 juga memiliki faktor protektif yang signifikan terhadap karies gigi pada etnis Kaukasia dan kelompok usia anak-anak. Namun, tidak ada hubungan bermakna antara AMELX rs946252, AMELX rs17878486, AMELX rs6639060, AMELX rs2106416, ENAM rs1264848, ENAM rs3796703, AMBN rs4694075, dan AMBN rs34538475 terhadap kerentanan karies gigi.Kesimpulan: ENAM rs3796704 memiliki hubungan yang signifikan terhadap kerentanan gigi karies.

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Background: Dental caries is a multifactorial dental disease that is influenced by many factors. One of them is genetic role. Many studies regarding the association between genetic roles dental caries susceptibility have been conducted, especially gene polymorphisms in certain dental genes.

Aim: estimate the possible association of amelogenin (AMELX) and non-amelogenin (ENAM and AMBN) genes to dental caries susceptibility in population-based.

Methods: Six electronic databases, consist of: PubMed, Scopus, EBSCO, Cochrane Library, ScienceDirect, and Wiley Online Library are carried out intricately as data advanced searches for publication date until February 2019. The thorough process in this review study is carried by using the Preferred Reporting items for Systematic Reviews and Meta-analyses (PRISMA) guideline. The meta-analysis part is implemented by using two softwares: Review Manager 5.4 and Comprehensive Meta-analysis 2.0.

Results: Fourteen studies are included in both qualitative (systematic review) and quantitative (meta-analysis) analyses. The result of the quantitative analysis concluded that ENAM rs3796704 is associated as protective factor to dental caries susceptibility, especially in allele A (OR=0.7; p-value=0.009), genotype AG (OR=0.7; p-value=0.03), and genotype AA (dominant) (OR=0.7; p-value=0.02). ENAM rs3796704 also has a significant protective factor to dental caries in caucasian ethnicity and children age group. However, there was no significant association of AMELX rs946252, AMELX rs17878486, AMELX rs6639060, AMELX rs2106416, ENAM rs1264848, ENAM rs3796703, AMBN rs4694075, and AMBN rs34538475 to dental caries susceptibility.

Conclusion: ENAM rs3796704 plays a significant association to dental caries susceptibility."

"Latar belakang: Suatu biomarker imunologis diperlukan untuk kasus yang berbatasan antara periodontitis kronis dan periodontitis agresif. Matrix Metalloproteinase-8 (MMP-8) merupakan suatu biomarker penentu risiko dan derajat keparahan penyakit periodonal serta evaluasi hasil perawatan periodontal. Tujuan: Menganalisis kadar MMP-8 pada cairan krevikular gingiva penderita periodontitis kronis dan periodontitis agresif. Metode: Penelitian ini mencakup 12 pasien periodontitis agresif, 17 pasien periodontitis kronis dan 6 subjek sehat. Kadar MMP-8 diukur dengan teknik ELISA. Hasil: Kadar MMP-8 pada periodonitits kronis tidak berbeda bermakna dengan periodontitis agresif (p>0,05). Kesimpulan: MMP-8 tidak dapat digunakan sebagai acuan diagnosis.

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Background: An immunologic biomarker is needed to distinguish between borderline cases between chronic periodontitis and agressive periodontitis. Matrix Metalloproteinase-8 (MMP-8) can be a risk profile of periodontal disease, disease progression and evaluation of periodontal treatment.

Aim: Analyze MMP-8 levels in gingival crevicular fluid of chronic and aggressive periodontitis patients.

Method: Sampel was collected from 6 healthy subjects, 12 subjects aggressive periodontitis and 17 chronic periodontitis subjects. MMP-8 levels were measured with ELISA.

Result:MMP-8 levels in chronic periodontitis did not show any difference to the MMP-8levels in aggressive periodonitits (p>0,05).

Conclusion: MMP-8 can not serve as a diagnostic parameter."

"Ibu memiliki peran penting dalam keluarga, terutama dalam pembentukan perilaku kesehatan gigi dan mulut anaknya karena ibu merupakan pengasuh utama dalam keluarga. Molar permanen pertama rentan terhadap karies karena gigi ini merupakan gigi permanen yang pertama kali tumbuh dan banyak tidak mengetahui keberadaan gigi ini. Penelitian ini bertujuan untuk melihat hubungan perilaku kesehatan gigi-mulut ibu dengan angka karies molar permanen pertama pada anak. Disain penelitian adalah analitik deskriptif potong lintang. Variabel yang dihubungkan adalah perilaku kesehatan gigi-mulut ibu dengan angka karies molar permanen pertama. Kuisioner untuk menilai perilaku kesehatan gigi-mulut ibu melalui model Knowledge, Attiude, and Practice (KAP) dan pemeriksaan karies dilakukan secara klinis mengikuti WHO. Perilaku kesehatan gigi-mulut ibu dinilai dari pengetahuan, sikap dan tindakan kesehatan gigi-mulut ibu. Analisa statistic dengan uji komparasi Mann-Whitney dan Kruskal-Wallis, serta uji korelasi menggunakan uji korelasi Spearman. Uji komparasi antara karakteristik ibu dengan angka karies molar permanen pertama pada anak memperlihatkan ada perbedaan tidak bermakna (p ³ 0,05). Uji korelasi antara perilaku kesehatan gigi-mulut ibu dengan angka karies molar permanen pertama menunjukkan korelasi kuat (r ³ 0, 66) dan bermakna (p £ 0,05). Uji korelasi antara perilaku kesehatan gigi-mulut ibu dengan pengetahuan, sikap, dan tindakan kesehatan gigi-mulut anak yang karies dan tidak karies ditemukan korelasi kuat (r ³ 0,66) dan bermakna (p £ 0,05). Kesimpulan tidak ada hubungan antara usia ibu, tingkat pendidikan dan status pekerjaan ibu dengan angka karies molar permanen satu anak. Ada hubungan bermakna antara perilaku kesehatan gigi-mulut ibu dengan angka karies molar permanen pertama pada anak. Ada hubungan antara perilaku kesehatan gigi-mulut ibu dengan pengetahuan, sikap, dan tindakan kesehatan gigi-mulut ibu.

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A mother has a very important role in the family, especially in shaping the oral health behavior of the child because mother is the main caregiver in the family. First permanent molar is susceptible to caries because these teeth were the first permanent teeth that erupt and many people not knowing the location of these teeth. The objective of the study is to analyze the relation between mother?s oral behaviors with the caries rate of child?s first permanent molar. The study design was analytic descriptive cross-sectional. The variables to correlate were the mother?s oral health behaviors with the caries rate of child?s first permanent molar. The questioner to assess the oral health behavior of the mother was through Knowledge, Attiude, and Practice (KAP) survey and the caries assessment was done according to WHO. Oral health behavior of the mother was asses from oral health knowledge, attitude and practice of the mother. Statistic analysis with Mann-Whitney dan Kruskal-Walliscomparison test, as well as Spearman correlation test was used. Comparison test between the mother?s and child?s characteristic with caries rate of first permanent molars showed there was no significant difference (p ³ 0,05). Correlation test between oral health behavior with caries rate of first permanent molar showed strong (r ³ 0, 66) and significant(p £ 0,05) correlation. Correlation test between mother?s oral health behavior and oral health knowledge, attitude and practice of the mother showed strong (r ³ 0,66) and significant (p £ 0,05) correlation.It can be concluded that there was a significant correlation between oral health behavior of the mother and caries rate of child?s first permanent molar. It also concluded that there was no correlation between mother?s age, educational level, and employment status of the mother with first permanent molar caries rate of the children. There is a significant correlation between the mother?s behavior and the first permanent molar caries rate of the child. There is a correlation between oral health behavior of the mother and the oral health knowledge, attitude, and practice of the mother."

"Sjogrens syndrome merupakan gangguan autoimun yang menyerang kelenjar eksokrin seperti kelenjar saliva dan kelenjar konjungtiva dengan gejala umum berupa penurunan produksi saliva dan produksi cairan konjungtiva yang menyebabkan sensasi kering pada rongga mulut dan mata yang dapat berkembang menjadi karies gigi, infeksi rongga mulut, sensai terbakar pada mata hingga kerusakan kornea. Gejala yang ditimbulkan Sjogrens syndrome sering kali menyerupai manifestasi gangguan kesehatan lain, seperti infeksi. Sejauh ini terdapat beberapa agen infeksius yang memiliki manifestasi menyerupai gejala umum pada Sjogrens syndrome, antara lain infeksi yang disebabkan virus Hepatitis C, virus Epstein-Barr, cytomegalovirus, human T lymphotropic virus1 HTLV-1, dan kemungkinan infeksi bakteri Heliobacter pylori yang memiliki kemampuan untuk terdisposisi pada jaringan epitel gastrik pasca infeksi pertama dan menyebabkan inflamasi persisten serta kemampuan untuk mempengaruhi produksi anti SSA/SSB. Beberapa penelitian menyatakan bahwa infeksi persisten mampu memicu gangguan autoimun yang disebabkan oleh aktivasi sel T dan sel B secara terus menerus sebagai upaya eradikasi sel terinfeksi yang memicu reaksi autoimun dan peningkatan kadar sel imun autoreaktif berupa kerusakan sel sehat di sekitarnya. Pada hasil kajian kepustakaan ini menemukan bahwa infeksi persisten bukan faktor satu satunya yang memicu kejadian Sjogrens syndrome namun terdapat faktor lain yang memicu infeksi dapat berkembang menjadi Sjogrens syndrome.

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Sjogrens syndrome is an exocrine glands autoimmune disease, causing decreasing liquids production on salivary gland and conjunctiva with the common symtomps including dry eyes and dry mouth and later causing burn sensations on eyes, cornea destruction, dental caries and oral cavity infections. The symptoms often resemble general health problem, such as infection manifestation. This far, there are several infectious agents in which possibly caused similar diseases manifestation as Sjogrens syndrome, including infections of Hepatitis C virus, Epstein Barr virus, cytomegalovirus, human T lymphotropic virus-1 HTLV-1, which have the ability to caused persistent infection on salivary glands after the first infection and possibly Heliobacter pylori infection based on the increasing anti Ro/SSA and anti-La/SSB on infected individuals. Some research states, persistent infection could trigger autoimmune disorders caused by continous T cells and B cells activation in an attempt to eradicate infected cells that is, but also triggered autoimmune response and increasing autoreactive cells consentration causing damage to healthy cells around the infected cells. However, the results in this literature study found persistent infection is not the only triggering factor of Sjogrens syndrome but there are other unknown factors that trigger infection can develop into Sjogrens syndrome."