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"extracted from Lumbricus rubellus, with fibrinogenolytic, fibrinolytic and anti-aggregation activities reported in an in vitro study. Plasma half-life is an important parameter to calculate its dose. This study was conducted to evaluate the biological half-life of DLBS1033 by measuring serial plasmin-antiplasmin (PAP) complex. PAP complex is a stable and inactive compound as a result of fibrinolysis process. Methods: this was an open-label clinical trial in healthy adult subjects. Subjects were divided into two groups to receive single dose drugs (received 3 x 490 mg) or repeated administration until steady state conditions (3 x 490 mg/day for 3 days). Blood samples for PAP complex measurement were collected at time 0 (before drug administration for single dose group), then at 0.5, 1, 1.5, 2, 3, 6, 8, 10, 12, and 24 hours after drug administration. Safety parameters used in this study were creatinine, prothrombin time (PT), activated partial thromboplastin time (aPTT), SGOT, and SGPT. Results: the biological half-life of DLBS1033 was calculated based on the mean of PAP complex concentration on each time sampling. In single dose group, the highest mean of PAP complex concentration was reached before drug administration. Our result showed that the activity of DLBS1033 could not be determined after single dose administration. In steady state condition, the PAP complex concentration increase in 2 hours after last drug administration. The biological half-life of DLBS1033 was 8.6 hours. There were no significant safety findings on all laboratory parameters and no serious adverse events. Conclusion: it is concluded that the fibrinolytic effects of DLBS1033 can be measured in steady state condition. The biological half-life of DLBS1033 in steady state condition was 8.6 hours. There were no serious adverse events on two groups of subjects.

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Latar belakang: DLBS1033 adalah fraksi protein bioaktif yang diekstraksi dari Lumbricus rubellus, dan dari studi in vitro diketahui memiliki aktivitas fibrinogenolitik, fibrinolitik dan antiagregasi. Waktu paruh obat dalam plasma merupakan parameter yang penting dalam menghitung dosis obat. Studi ini dilakukan untuk mengevaluasi waktu paruh biologis DLBS1033 melalui pengukuran kadar plasmin-antiplasmin complex (PAP complex). PAP complex adalah senyawa hasil proses fibrinolisis yang stabil dan inaktif. Metode: desain studi ini adalah uji klinik terbuka pada subyek dewasa sehat. Subyek dibagi menjadi dua kelompok, kelompok yang mendapatkan dosis tunggal (diberi obat 3 x 490 mg) dan kelompok yang mendapatkan dosis berulang hingga mencapai steady state (diberi obat 3 x 490 mg/hari selama 3 hari). Sampel darah untuk pemeriksaan konsentrasi PAP complex diambil pada jam ke-0 (sebelum pemberian obat pada kelompok dosis tunggal), jam ke-0,5, 1, 1,5, 2, 3, 4, 6, 8, 10, 12, dan 24. Parameter keamanan yang diperiksa pada penelitian ini adalah kreatinin, prothrombin time (PT), activated partial thromboplastin time (aPTT), SGOT, dan SGPT. Hasil: waktu paruh biologis DLBS1033 dihitung berdasarkan rerata kadar PAP complex pada tiap waktu pengambilan sampel darah di tiap kelompok. Pada kelompok dosis tunggal, rerata tertinggi konsentrasi PAP complex tercapai sebelum pemberian obat. Hasil ini menunjukkan bahwa aktivitas DLBS1033 tidak bermakna ketika diberikan sebagai dosis tunggal. Pada keadaan steady state, konsentrasi PAP complex meningkat dalam 2 jam setelah pemberian obat terakhir. Waktu paruh biologis DLBS1033 adalah 8,6 jam. Pada penelitian ini tidak didapatkan hasil laboratorium yang bermakna dan kejadian tidak diinginkan yang serius. Kesimpulan: pada penelitian ini disimpulkan bahwa efek fibrinolitik DLBS1033 dapat diukur pada keadaan steady state. Waktu paruh biologis DLBS1033 pada kelompok steady state adalah 8,6 jam. Tidak ditemukan kejadian tidak diinginkan yang serius pada kedua kelompok subyek."

"ABSTRAKProses pengomposan di UPS Merdeka dilakukan dengan metode open windrow dengan menggunakan sampah rumah tangga dan sampah daun. Penelitian ini bertujuan untuk mengetahui keterkaitan kandungan logam berat dalam kompos, perbandingan potensi pengurangan kandungan logam berat, dan standar kualitas kompos sesuai SNI 19-7030-2004. Kompos dibagi menjadi 2 tumpukan dimana pada hari ke-100 kompos A diberikan cacing Lumbricus rubellus dan menjadi vermikompos. Massa logam berat Pb lebih banyak mengalami kehilangan massa pada kompos A sebesar 95,61% dan 95,53% untuk kompos B. Untuk massa logam berat Cu pada kompos A dan kompos B lebih banyak terdapat di kompos hari ke-105 dengan persentase sebesar 96,88% untuk kompos A dan 96,02% untuk kompos B. Massa logam berat dalam jaringan cacing pada kompos A sebesar 0,01% untuk kedua jenis logam. Pengurangan kandungan logam berat terlihat dalam vermikompos dimana peningkatan kandungan logam Pb dan Cu dalam jaringan cacing sebesar 194,3% dan 25,2%. Parameter kadar air, temperatur, pH, logam Pb, C/N, bau, warna, serta tekstur memenuhi standar kualitas kompos. Sedangkan parameter logam Cu tidak memenuhi standar kualitas kompos.

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ABSTRACTThe composting process conducted by UPS Merdeka with open windrow method using household waste and leaf litter. This study aims to know the relevance of heavy metal content in compost, ratio comparison of heavy metal potential reduction, and compost standard quality is SNI 19-7030-2004. Compost was divided into two piles when in 100th day, Lumbricus rubellus was given to compost A and became vermicompost. Pb mass was much more reduced (95.61%) than compost B (95.53%). Cu mass in two compost pileswere increasing by the 105th day, with 96.88% in compost A and in 96.02% compost B. Heavy metal mass in worm tissue in compost A was 0.01% for the both metals. The reducing of heavy metal content were seen in vermicompost where the increasing of metal Pb and Cu content in worm tissue are 194.3% and 25.2%. Water content parameters, temperature, pH, Pb, C/N, odor, color, and texture meet the quality standards, while the parameters of Cu do not meet the compost quality standards."

"Based on Puhn's twenty years of experience as a clinical nutrition specialist, The 5 Vital Secrets for a Healthy Life offers a time-tested healing program of complementary therapies that will help you attain and maintain a strong, healthy body and a sharp, confident mind. Adele Puhn begins by stressing the importance of the health links that can connect your symptoms to underlying conditions - some of them obvious, some of them startlingly subtle. She guides you, step-by-step, to becoming your own health detective - as you discover the solution to the "mystery" your body is trying to tell you. Puhn shows you how to find the real clues your body is telling you to help you on your way to good health. And to ensure that health, she also includes her own unique mix of herbal remedies, food regimens, nutritional supplements, and inspiring advice. To help you visualize how apparently unconnected conditions can wreak havoc on your health, Puhn has created a remarkable device: the Body Bank. When you make deposits - in the form of supplements, specific foods, or a good night's sleep - your account grows, building a wealth of health. When you make withdrawals - some as obvious as eating too much fatty foods and some you might not even be aware of doing! - you're depleting your system and beginning to "run in the red". But even if you find yourself with a full-fledged bankruptcy condition, don't despair. Puhn gives you simple, easy-to-implement solutions to bolster your entire system"

"Penelitian ini dilakukan untuk mengetahui apakah bioavailabilitas formulasi ibuprofen suppositoria 125 mg yang diproduksi oleh PT Kalbe Farma,Tbk. (Ibukal®) bioekivalen dengan produk yang sama dari komparatornya (Proris®). Parameter farmakokinetik yang dinilai dalam studi ini ialah luas daerah di bawah kurva kadar - waktu selama 10 jam (AUC0-t), luas daerah di bawah kurva kadar - waktu sampai waktu tak terhingga (AUC0-inf), kadar puncak (Cmax), dan waktu untuk mencapai kadar puncak (tmax). Penelitian ini menggunakan rancangan menyilang acak, tersamar tunggal yang mengikutsertakan 12 sukarelawan dewasa sehat. Sukarelawan dipuasakan semalam dan keesokan harinya diberi 1 suppositoria obat uji (produk PT.Kalbe-Farma) atau 1 suppositoria obat pembanding (produk komparatornya). Contoh darah diambil pada jam ke 0 (kontrol), 20 min; 40 min; 1; 1,5; 2; 2,5; 3; 4; 6; 8; dan 10 jam setelah pemberian obat. Setelah 1 minggu periode washout, prosedur ini diulang dengan memberikan obat pembandingnya. Kadar obat ditentukan dengan kromatografi cair kinerja tinggi dengan detektor ultraviolet. Pada penelitian bioavailabilitas ini, rerata (SD) AUC0-t, AUC0-inf, Cmax dan tmax dari obat uji masing-masing adalah 28,59(3,37) µg.jam.mL-1, 30,47(3,56) µg.jam.mL-1,8,24(1,44)µg/mL, dan 1,33(0,44) jam. Rerata (SD) AUC0-t, AUC0-inf, Cmax dan tmax dari obat pembanding masing-masing adalah 28,13(8,14) µg.jam.mL-1, 30,56(8,05) µg.jam.mL-1, 8,27(2,88) µg/mL, dan 1,79(0,33) jam. Rasio rerata geometrik obat uji terhadap obat pembandingnya ialah 104,38% untuk AUC0-t, 101,97% untuk AUC0-inf, dan 104,02% untuk Cmax, Nilai 90% confidence intervals(CI) nya ialah 90,38-120,54% untuk AUC0-t, 89,51-116,16% untuk AUC0-inf, dan 85,73-126,16% untuk Cmax. Tidak ada efek samping yang dijumpai dalam penelitian ini. Dari hasil penelitian ini disimpulkan bahwa Ibuprofen suppositoria 125 mg produksi PT. Kalbe Farma,Tbk. (Ibukal®) bioekuivalen dengan produk yang sama dari komparatornya (Proris®). (Med J Indones 2007; 16:181-6).

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This study was aimed to investigate the bioequivalence of ibuprofen 125 mg suppository formulation (Ibukal®, test formulation from PT. Kalbe Farma, Tbk., Jakarta) and the ibuprofen suppository comparative formulation (Proris®, from PT. Pharos Indonesia, Jakarta) in 12 healthy volunteers. The pharmacokinetic parameters used in this study were the area under the concentration-time curve from time zero to hour 10 (AUC0-t), the area under the concentration-time curve from time zero to infinite (AUC0-inf), the maximum concentration (Cmax), and the time needed to reach the maximum concentration (tmax). The study was designed as a random cross-over fashion, single-blinded which included 12 healthy adult volunteers. The volunteers were fasted overnight and in the morning they received a suppository of the test drug (Ibukal®) or a suppository of the comparative drug (Proris®). Blood samples were withdrawn on hour 0 (control), 20 min; 40 min; 1; 1,5; 2; 2,5; 3; 4; 6; 8; and 10 time points after the administration of the drug. Following a wash-out period of 1 week, this procedure was repeated using the other drug. The serum concentration of the drug was determined by means of high-performance liquid chromatography with ultraviolet detection. The results of the study showed that, the mean (SD) of AUC0-t, AUC0-inf, Cmax and tmax of the test drug were, respectively, 28.59(3.37) µg.h.mL-1, 30.47(3.56) µg.h.mL-1, 8.24(1.44) µg/mL, and 1.33(0.44) h. The mean (SD) of AUC0-t, AUC0-inf, Cmax and tmax of the comparative drug were, respectively, 28.13(8.14) µg.h.mL-1, 30.56(8.05) µg.h.mL-1, 8.27(2.88) µg/mL, and 1.79(0.33) h. The geometric means ratio of the test to the comparative drug were 104.38% (CI 90%: 90.38-120.54%) for AUC0-t, 101.97% (CI 90%: 89.51-116.16%) for AUC0-inf, and 104.02% (CI 90%: 85.73-126.16%) for Cmax. There was no side effect of the drug detected in this study. From the results we can conclude that the 125 mg of ibuprofen suppository of PT Kalbe Farma, Tbk. (Ibukal®) is bioequivalent to that of the comparative drug (Proris®). (Med J Indones 2007; 16:181-6)"

"Pemberian kombinasi ekstrak phaseolus vulgaris dosis 1500 mg dan akar bose dosis 50 mg menghasilkan penurunan kadar glukosa posprandial yang tidak bermakna jika dibandingkan pemberian 50 mg akarbose saja."

"Tujuan Penelitian ini bertujuan untuk mengukur besarnya efek kombinasi ekstrak Phaseolus vulgaris dan akarbose dibandingkan dengan akarbose saja dalam menurunkan kadar glukosa posprandial pada sukarelawan sehat setelah makan nasi. Metode Sampel darah diambil pada waktuwaktu tertentu sampai tiga jam setelah makan nasi. Parameter kadar glukosa posprandial adalah luas area di bawah kurva kadar glukosa terhadap waktu selama tiga jam setelah makan nasi. Hasil Setelah pemberian kombinasi ini terjadi penurunan luas area di bawah kurva sebesar 21.6%, sedangkan pada pemberian akarbose terjadi penurunan sebesar 22.9%. Simpulan Pemberian kom binasi ekstrak Phaseolus vulgaris dosis 1500 mg dan akarbose dosis 50 mg menghasilkan penurunan kadar glukosa posprandial yang tidak bermakna jika dibandingkan pemberian 50 mg akarbose saja.

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AbstractAim: This study was aimed to measure the effects of combination Phaseolus vulgaris extract and acarbose compared to acarbose alone on postprandial glucose concentration in healthy volunteers after cooked rice intake. Methods: Blood sample were obtained at several time points up to three hours after cooked rice intake. The parameter for postprandial glucose concentration is the area under the curve (AUC) of glucose concentration vs.time for three hours after cooked rice intake. Results: After taking this combination, postprandial glucose concentration was reduced by 21.6%, while the reduction by acarbose alone was 22.9%. Conclusions: The reduction of postprandial glucose concentration after administration of this combination was not significantly different compared to that after administration of acarbose alone. Keywords: Phaseolus vulgaris extract, acarbose, postprandial glucose concentration."

"In this trial adolescent girls with body dissatisfaction (N=481; M age=17) were randomized to an eating disorder prevention program involving dissonance-inducing activities that reduce thin-ideal internalization, a prevention program promoting healthy weight management, an expressive writing control condition, or an assessment-only control condition. Dissonance participants showed significantly greater reductions in eating disorder risk factors and bulimic symptoms than healthy weight, expressive writing, and assessment-only participants and healthy weight participants showed significantly greater reductions in risk factors and symptoms than expressive writing and assessment-only participants from pretest to posttest. Although these effects faded over 6-month and 12-month follow-up, dissonance and healthy weight participants showed significantly lower binge eating and obesity onset and reduced service utilization through 12-month follow-up, suggesting both interventions have public health potential."