Hasil Pencarian  ::  Simpan CSV :: Kembali

"ABSTRACTTo evaluate the degree of periodontal tissue destruction, aspartate aminotransferase (AST) levels in the gingival crevicular fluid (GCF) are utilized as a predictor of periodontal therapy. We have previously shown that the usefulness of AST activities [periodontal tissue monitor (PTM) values] using a PTM-kit to evaluate the effects of initial periodontal therapy and periodontal regeneration therapy by enamel matrix derivative (EMD). This prospective, longitudinal study was conducted using 38 healthy and 80 periodontitis sites with probing depth (PD) of 5 - 10 mm for guided tissue regeneration (GTR) and EMD from 36 patients. GCF samples were used to evaluate PTM values at base line (BL) and after 6 months of surgeries (re-evaluation: RE), and periodontal examinations were performed concurrently. PTM values at BL were statistically improved at RE, accompanied by the improvement of periodontal parameters in both groups. PTM values and PD, and the clinical attachment level (CAL) showed high correlations. PD, CAL and bleeding on probing (BOP) were highly correlated with PTM values in both groups, whereas only PD showed a significant correlation with PTM values at RE in the GTR group. Change in the amounts of PD, CAL and BOP between BL and RE in both groups showed no correlation with PTM values. In the negative PTM value sites at BL in EMD group, the mean PD was significantly reduced at RE compared with positive PTM sites at BL. PTM values are able to be utilized as the biochemical predictor of prognosis after periodontal regeneration therapy."

"Efek pergerakan gigi pada perawatan ortodonti pada aktivitas aspartat aminotransferase saliva. Aspartat aminotransferase merupakan salah satu indikator biologis yang dilepaskan ke dalam cairan celah gusi. Aplikasi gaya ortodonti pada gigi dapat meningkatkan aktivitas aspartat aminotransferase dalam cairan celah gusi. namun peningkatan aktivitas aspartat aminotransferase dalam cairan saliva akibat gaya ortodonti belum diketahui. Tujuan: (1) mengevaluasi durasi pemberian gaya ortodonti terhadap aktivitas aspartat aminotransferase di dalam saliva berdasarkan durasi pemberian gaya. (2) mengevaluasi korelasi jarak pergerakan gigi dengan aktivitas aspartat aminotransferase. Metode: Pengumpulan 20 sampel saliva subjek dilakukan sebelum pencabutan gigi premolar pertama, sebelum dan sesudah pemberian gaya untuk penarikan kaninus ke distal. Penarikan kaninus menggunakan gaya interrupted (module chain) sebesar 100g selama 30 hari. Pengambilan saliva dan pengukuran jarak pergerakan gigi kaninus dilakukan 1 hari, 7 hari, 14 hari, 21 hari, dan 28 hari setelah pemberian gaya. Pengukuran aktivitas aspartat aminotransferase dalam saliva menggunakan alat spektrofotometer. Hasil: hasil penelitian menunjukkan pemberian gaya ortodonti dapat mempengaruhi aktivitas aspartat aminotransferase dalam saliva (F=25,290, p=0,000). Jarak pergerakan gigi berkorelasi dengan aktivitas aspartat aminotransferase (F=0,429, p=0,000). Simpulan: Aktivitas aspartat aminotransferase dapat digunakan sebagai indikator jarak pergerakan gigi berdasarkan durasi pemberian gaya.

---

Aspartate aminotransferase is one of biological indicator in gingival crevicular fluid (CFG). Force orthodontic application could increase activity of aspartate aminotransferase in CFG. However, the increase activity of aspartate aminotransferase in saliva due to orthodontic force and its correlation between aspartate aminotransferase activity and tooth movement remains unclear. Objectives: To evaluate application orthodontic force on the aspartate aminotransferase activity in saliva based on the duration of force and finding correlation between tooth movement and aspartate aminotransferase activity. Methods: Twenty saliva samples collected before extraction of first premolar, at the time of force application for canine retraction and after force application. The canines retraction used 100grams of interrupted force (module chain) for thirty days. The collection of saliva and the measurement of tooth movement were carried out 1 day, 7 days, 14 days, 21 days, and 28 days after force application. The measurement of aspartate aminotransferase activity in saliva was done using spectrophotometer. Results: Application of orthodontic force influences the salivary aspartate aminotransferase activity (F=25.290, p=0.000). Furthermore, tooth movement correlated with aspartate aminotransferase activity (F=0.429, p=0.000). Conclusion: Aspartate aminotransferase activity could be used as tooth movement indicator that related to the duration of force application."

"Aktifitas aspartat amino transferase setelah berkumur dengan teh hijau dan klorheksidin glukonat. Perawatan ortodontik dapat meningkatkan akumulasi plak gigi. Plak dapat menyebabkan peradangan pada gingiva. peradangan dapat dinilai dari kadar aspartat aminotransferase (AST) dalam cairan krevicular gingiva (CKG). bat kumur bermanfaat untuk mengurangi akumulasi plak gigi selama perawatan ortodontik. Klorheksidin glukonat sering digunakan sebagai obat kumur. Teh hijau adalah salah satu bahan alam yang dapat digunakan untuk obat kumur yang dianggap dapat mengurangi akumulasi plak. Tujuan: Membandingkan efek antara teh hijau dan klorheksidin glukonat aktivitas AST di GCF pada pasien yang menjalani perawatan ortodontik dengan molar band. Metode: Studi eksperimental dilakukan terhadap 40 subjek dewasa. Subjek dibagi secara acak menjadi dua kelompok: teh hijau (n=20) dan klorheksidin glukonat (n=20). Aktivitas AST diukur sebelum pemasangan band , 7 dan 30 hari setelah pemasangan band. Uji ANOVA digunakan untuk menganalisis data. Hasil: Terdapat perbedaan signifikan antara kadar AST sebelum, 7 dan 30 hari setelah pemasangan band pada kelompok teh hijau (p<0,05). Tidak ada perbedaan yang signifikan antara kadar AST sebelum pemasangan band, 7 dan 30 hari setelah pemasangan band pada kelompok klorheksidin glukonat (p<0,049). Tidak ada perbedaan antara masing-masing kelompok (p<0,05). Simpulan: Obat kumur teh hijau memiliki efektivitas yang sama dengan klorheksidin glukonat dalam mengurangi tingkat AST pada pasien ortodontik.

---

Patients undergoing fixed orthodontic treatment are susceptible to dental plaque accumulation. Plaque can cause inflammation in gingiva. It could be assessed by aspartat aminotransferase (AST) in gingival crevicular fluid (GCF). Mouth rinse could be useful to reduce dental plaque accumulation during orthodontic treatment. Chlorhexidine gluconate is often used as mouth rinse in dental practice. n the other hand, green tea is one of natural ingredient that can be used for mouth rinse which is assumed could reduce plaque accumulation. Objectives: To compare the effect between green tea and chlorhexidine gluconate on AST activity in GCF in patient undergoing orthodontic treatment with molar band. Methods: An experimental study was conducted included forty adult subjects. They were randomized into two groups: green tea (n=20) and chlorhexidine gluconate (n=20). AST activity was measured before band insertion, 7 and 30 days after band insertion. One way and two-ways ANOVA were used to analyze the data. Results: The results showed significant difference of AST levels between before, 7 and 30 days after band insertion in the green tea groups (p<0.05). In contrast, there was no significant differences of AST levels between before band insertion, 7 and 30 days after band insertion in the chlorhexidine gluconate groups (p=0.049). There were no difference between each groups with two way ANOVA (p<0.05). Conclusions: Gargle effect of green tea was as effective as chlorhexidine gluconate in reducing AST levels related to banded first molars in adolescents undergoing orthodontic treatment."

"ABSTRAKBackground : The BODE index is generally used for predicting mortality risk of COPDpatients. The BODE index included the body mass index, degree of airflow obstruction (FEV1),dyspnea (MMRC questionnaire), and exercise capacity (6-minute walk test). Exacerbation ofCOPD associated with decreased health related quality of life (HRQoL). HRQoL has become animportant outcome in respiratory patients as proved by St.George’s Respiratory Questionnaire(SGRQ). We hypothesized that the greater BODE score the more frequent occurrence ofexacerbation and increase SGRQ total score.Methods : Prospective cohort study of COPD patients in Persahabatan Hospital assessed forBODE index (baseline) and followed at 3, 6, 9 and 12 months. Patient were also examined withSGRQ (baseline) and followed at 6 and 12 months. We monitored the occurrence of exacerbationby telephone, visiting to COPD’s clinic or emergency unit every month for one year.Results : Eighty five patient were examined at baseline with mean of BODE index 4.29 andSGRQ total score 41.42%. After one year monitored 52 patients have completed examination, 29patient have not complete examination and four patient died. Using t-test analysis the correlationof BODE index between single and frequent exacerbation is significant (p<0.05), the correlationof SGRQ between single and frequent exacerbation is significant (p<0.05) and correlationbetween BODE and SGRQ is significant (p=0.045).

---

ABSTRACTLatar belakang : Indeks BODE dapat memprediksi mortalitas pada PPOK. Indeks BODEterdiri dari indeks masa tubuh, VEP1, skala sesak MMRC dan Uji jalan 6 menit. KuesionerSGRQ digunakan untuk menilai kualitas hidup pasien PPOK. Menurunnya kualitas hidup pasienPPOK dapat disebabkan oleh eksaserbasi. Hipotesis penelitian ini adalah semakin tinggi indeksBODE maka semakin sering eksaserbasi dan meningkatkan nilai SGRQ.Metode : Menggunakan disain kohort prospektif, indeks BODE pasien PPOK dinilai pada awalkunjungan (0bulan) bulan ke-3,6,9 dan 12. Pasien mengisi lembar kerja penelitian dan mengisikuesioner SGRQ pada awal kunjungan, bulan ke-6 dan 12. Peneliti memonitor terjadinyaeksaserbasi setiap bulannya melalui telepon, saat kunjungan ke poli asma PPOK atau instalasigawat darurat selama setahunHasil : Didapat 85 pasien pada kunjungan awal dengan rerata indeks BODE 4.29 dan rerataSGRQ skor total 41.41%. Setelah 12 bulan pemantauan didapatkan 52 pasien yang melengkapipemeriksaan, 29 pasien keluar dan 4 pasien meninggal dunia karena PPOK atau komplikasi.Analisis statistik t-test didapatkan perbedaan bermakna antara indeks BODE kelompok sekalieksaserbasi dengan kelompok sering eksaserbasi (p<0.05). Terdapat perbedaan bermakna SGRQskor total pada kelompok sekali eksaserbasi dengan kelompok sering ekaserbasi (p<0.05) sertahubungan bermakna antara indeks BODE dengan SGRQ skor total (p=0.0457).Kesimpulan : Indeks BODE dapat digunakan untuk memprediksi eksaserbasi dan kualitas hiduppasien PPOK."

"Background: Hepatitis B is endemic in Indonesia and treatment response need to be monitored during and after antiviral therapy. Liver stiffness measurement and alanine aminotransferase to platelet ratio index (APRI) are noninvasive method to detect liver fibrosis available in Indonesia. However, little is known about their ability to evaluate treatment response in chronic hepatitis B (CHB) patients in Indonesia. This study aimed to investigate liver stiffness changes by transient elastography (TE) and APRI before and after one year oral antiviral treatment in CHB patients and the correlation between TE and APRI.Methods: this study was retrospective cohort on CHB patients in CiptoMangunkusumo Hospital, Jakarta who uderwent treatment between January 2012 and December 2014. Patients received oral antiviral treatment with newer nucleoside analogues (entecavir or telbivudine) for at least one year. TE and APRI were obtained before and after treatment. TE and APRI reductions were analyzed statistically with Spearmans test.Results: a total of 41 patients were enrolled in this study. Median liver stiffness value was significantly reduced from 10.8 to 5.9 kPa after oral antiviral treatment (p<0.001, Wilcoxons test). Median APRI was also significantly reduced from 1.13 to 0.43 after treatment (p<0.001, Wilcoxons test). The correlation between liver stiffness and APRI before treatment was weak (r=0.40), but it was strong after treatment (r=0.73).Conclusion: the liver stiffness measured with transient elastography and APRI significantly decreased after one year of antiviral treatment in chronic HBV patients. There was a significant correlation between TE and APRI after one year of treatment.

---

Latar belakang: prevalensi Hepatitis B di Indonesia masih tinggi dan pengobatan dengan obat antivirus memerlukan pamantauan untuk menilai respons terapi. Salah satu metode pemantauan respons terapi yang non-infasif dan mudah dilakukan di Indonesia adalah dengan pengukuran derajat kekerasan hati atau transient elatography (TE)dan alanine aminotransferase-to-platelet ratio index (APRI) yang merupakan metode alternatif untuk mendeteksi fibrosis hati. Meskipun demikian, akurasinya dalam mengevaluasi respon terapi pada pasien hepatitis B kronik di Indonesia masih belum diketahui. Penelitian ini bertujuan untuk mengetahui perubahan derajat kekerasan hati dengan menggunakan transient elastography (TE) dan APRI sebelum dan setelah terapi antiviral per oral selama satu tahun pada pasien hepatitis B kronik dan korelasi antara TE dan APRI.

Metode: desain penelitian yang digunakan adalah studi kohort retrospektif pada pasien hepatitis B kronik di Rumah Sakit Cipto Mangunkusumo Jakarta yang diberikan terapi selama bulan Januari 2012 hingga Desember 2014. Pasien diberikan antiviral dengan analog nukleosida terbaru (entecavir atau telbivudine) selama minimal satu tahun. TE dan APRI diperiksakan sebelum dan setelah terapi. Reduksi TE dan APRI diuji secara statistik menggunakan korelasi Spearman.

Hasil: penelitian ini mengikutsertakan 41 pasien dan mendapatkan nilai median kekerasan hati berkurang secara signifikan dari 10,8 menjadi 5,9 kPa setelah terapi antiviral per oral (p<0,001, Uji Wilcoxon). Nilai median APRI juga berkurang secara signifikan dari 1,13 menjadi 0,43 setelah terapi (p<0,001, Uji Wilcoxon). Sebelum terapi dimulai nilai korelasi antara derajat kekerasan hati dan APRI menunjukkan hasil 0.40 dan nilai korelasi setelah terapi antiviral menjadi 0,73.

Kesimpulan: derajat kekerasan hati yang diukur menggunakan TE dan APRI berkurang secara signifikan setelah terapi antiviral selama satu tahun pada pasien hepatitis B kronik.Terdapat korelasi yang signifikan antara TE dan APRI."

"Latar Belakang: Periodontitis merupakan salah satu kondisi periodontal yang dapat menyebabkan poket periodontal. Terdapat berbagai metode perawatan poket periodontal, salah satunya adalah Guided Tissue Regeneration. Penelitian mengenai persepsi dan preferensi Dokter Gigi Spesialis Periodonsia di Indonesia mengenai penggunaan membran GTRpada terapi regeneratif jaringan periodontal belum pernah dilakukan di Indonesia. Tujuan: Mendapatkan persepsi dan preferensi dokter gigi spesialis periodonsia di Indonesia mengenai penggunaan membran GTR. Metode: Penelitian deskriptif dengan pendekatan potong lintang menggunakan kuesioner kepada dokter gigi spesialis periodonsia di Indonesia. Hasil: 93 responden melakukan bedah regeneratif GTR dengan mayoritas 1-3 bedah setiap bulan dengan indikasi 2-3 wall defect. GTR dilakukan menggunakan membran resorbable collagen karena memberikan hasil perawatan yang lebih baik dengan parameter keberhasilan pertumbuhan tulang secara radiografi dan persentase kesuksesan sebesar 75%. Alasan responden tidak melakukan GTR karena biaya cukup tinggi. Responden puas dan percaya diri dengan teknik GTR dan setuju penggunaan material dari hewan, manusia dan sintetis. Jumlah bedah regeneratif periodontal GTR oleh dokter gigi spesialis periodonsia di Indonesia dipengaruhi oleh lama praktik dan tidak dipengaruhi oleh domisili daerah praktik. Kesimpulan: Terdapat perbedaan persepsi dan preferensi dokter gigi spesialis periodonsia di Indonesia dalam penggunaan teknik GTR pada terapi jaringan periodontal regeneratif dan terdapat perbedaan signifikan antara jumlah bedah regeneratif periodontal GTR oleh dokter gigi spesialis periodonsia dan lama praktik.

---

Background: Periodontitis is one of the periodontal conditions that can cause periodontal pockets. There are various methods of treating periodontal pockets, one of which is Guided Tissue Regeneration. Research on the perceptions and preferences of Periodontists in Indonesia regarding the use of GTR membranes in periodontal tissue regenerative therapy has never been conducted in Indonesia.

Objective: Obtain the perceptions and preferences of periodontists in Indonesia regarding the use of GTR membranes.

Methods: Descriptive study with a cross-sectional approach using a questionnaire to periodontists in Indonesia.

Results: 93 periodontists in Indonesia performed GTR with the majority of surgeries performed 1-3 times a month and indications of 2-3 wall defects. GTR is performed using a resorbable collagen membrane because it provides better treatment results with radiographic parameters of bone growth success and a treatment success rate of 75%. The reason respondents did not do the GTR was because the cost was quite high. Respondents were satisfied and confident with the GTR technique and agreed to use animal, human and synthetic materials. The number of GTR periodontal regenerative surgeries by periodontists in Indonesia is influenced by length of practice and not by domicile in the practice area.

Conclusion: There are differences in the perceptions and preferences of periodontists in Indonesia regarding the use of the GTR technique in regenerative periodontal tissue therapy and there are significant differences between the number of GTR regenerative periodontal surgeries by periodontists and the length of practice.

"

"Growth factor is a general term used to denote a class of naturally occuring proteins that function in the body to promote mitogenesis, directed migration and metabolic activity of cells. Growth factor to mediate repair and regeneration the periodontium. A combination of growth factor may more effectively stimulate these diverse processes of regeneration than single growth factor. Combination PDGF and IGF-I, significant amounts of newly formed bone and new cementum. PDGF and TGF beta are known to be abundant in the alfa granules of platelets. Currently the use of Palatelet Rich Plasma (PRP) into a bone graft combination showed a significant gain in periodontal regeneration. It is probable that it's used to promote periodontal regeneration."