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"ABSTRAKIn this paper, five contemporary scalable systems to support medical research teams are presented. Their functionalities extend from heterogeneous unstructured data acquisition through large scale data storing, to on the fly analyzing by using robust methods. Such kinds of systems can be useful in the development of new medical procedures and recommendation rules for decision support systems. A short description of each of them is provided. Further, a set of the most important features is selected, and a comparison based on it is performed. The need for high performance computing is emphasized. A general discussion how to improve the existing solutions or develop new ones in the future is also presented."

"The LNCS journal Transactions on Large-Scale Data- and Knowledge-Centered Systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between Grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the fifth issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems, contains nine selected full-length papers, focusing on the topics of query processing, information extraction, management of dataspaces and contents, and mobile applications."

"The LNCS journal Transactions on large-scale data- and knowledge-centered systems focuses on data management, knowledge discovery, and knowledge processing, which are core and hot topics in computer science. Since the 1990s, the Internet has become the main driving force behind application development in all domains. An increase in the demand for resource sharing across different sites connected through networks has led to an evolution of data- and knowledge-management systems from centralized systems to decentralized systems enabling large-scale distributed applications providing high scalability. Current decentralized systems still focus on data and knowledge as their main resource. Feasibility of these systems relies basically on P2P (peer-to-peer) techniques and the support of agent systems with scaling and decentralized control. Synergy between grids, P2P systems, and agent technologies is the key to data- and knowledge-centered systems in large-scale environments. This, the seventh issue of transactions on large-scale data- and knowledge-centered systems, contains five revised selected regular papers on the following topics: data management, data streams, service-oriented computing, abstract algebraic frameworks, RDF and ontologies, and conceptual model frameworks."

"This book presents a language integrated query framework for big data. The continuous, rapid growth of data information to volumes of up to terabytes (1,024 gigabytes) or petabytes (1,048,576 gigabytes) means that the need for a system to manage and query information from large scale data sources is becoming more urgent. Currently available frameworks and methodologies are limited in terms of efficiency and querying compatibility between data sources due to the differences in information storage structures. For this research, the authors designed and programmed a framework based on the fundamentals of language integrated query to query existing data sources without the process of data restructuring. A web portal for the framework was also built to enable users to query protein data from the Protein Data Bank (PDB) and implement it on Microsoft Azure, a cloud computing environment known for its reliability, vast computing resources and cost-effectiveness."

"Mathematical models are used to simulate, and sometimes control, the behavior of physical and artificial processes such as the weather and very large-scale integration (VLSI) circuits. The increasing need for accuracy has led to the development of highly complex models. However, in the presence of limited computational, accuracy, and storage capabilities, model reduction (system approximation) is often necessary. Approximation of Large-Scale Dynamical Systems provides a comprehensive picture of model reduction, combining system theory with numerical linear algebra and computational considerations. It addresses the issue of model reduction and the resulting trade-offs between accuracy and complexity. Special attention is given to numerical aspects, simulation questions, and practical applications."

"Topics covered include skyline queries, probabilistic logics and reasoning, theory of conceptual modeling, prediction in networks of moving objects, validation of XML integrity constraints, management of loosely structured multi-dimensional data, data discovery in the presence of annotations, and quality ranking for Web articles."