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"ABSTRACTPurpose: Laparoscopic splenectomy (LS) has become the standard operative approach for splenectomy. Portal or splenic vein thrombosis (PSVT) is a serious and common complication after LS, and lethal complications of PSVT can occur when the portal vein is completely occluded by portal vein thrombosis (PVT). We aimed to clarify the predictors of PSVT after LS and to determine which of them were also predictors of PVT.Methods: A total of 56 consecutive patients who underwent elective LS were enrolled in this study. The patients were divided into two groups based on the presence or absence of PSVT after LS. In addition, patients with PSVT were divided into two groups: a PVT group and a non-PVT group. The preoperative and intraoperative clinical data were compared among the groups.Results: Thirty (53.6%) patients developed PSVT. The splenic vein diameter was the most useful predictor for the development of PSVT, and 10 mm was an accurate splenic vein diameter cut-off value for use as a predictive factor for PSVT. In addition, the splenic vein diameter was the most useful predictor of the development of PVT from splenic vein thrombosis (SVT), and 14 mm was found to be an accurate cut-off value.Conclusion: PSVT is a common postoperative complication that is identified on enhanced computed tomography. The splenic vein diameter is not only a predictor of PSVT but also of the development of PVT from SVT."

"Based on its relation to the liver sinusoid, increased pressure of portal vein can occur at three levels: presinusoid, sinusoid ,and postsinusoid. Obstruction of the presinusoid veins can be caused by extra-hepatic condition such as venous thrombosis.

We reported a case of portal hypertension with esophageal varices bleeding was a result of obstruction due to thrombosis of the splenic vein and portal vein under hypercoagulant conditions due to thrombocyto-sis. The management of esophageal varices was sclerotherapy while for overcome the thrombosis the patient was given hydroxy urea."

"Pendahuluan dan tujuan: Pembedahan laparoskopi telah diakui dapat mengurangi tingkat morbiditas sehingga meningkatkan keselamatan pasien. Saat tindakan LLDN, komplikasi yang paling sering adalah cedera pembuluh darah ginjal, yang sering membutuhkan transfusi darah. Selain perlunya transfusi darah, pendarahan berat yang disebabkan oleh cedera pembuluh ginjal membutuhkan konversi dan perbaikan terbuka. Dengan demikian, penelitian ini ingin mendeskripsikan dan menganalisis kebutuhan transfusi darah dalam operasi laparoscopic living donor nephrectomy di pusat kami.Bahan dan metode:  Studi kohort retrospektif ini dilakukan di Departemen Urologi di Rumah Sakit Nasional Cipto Mangunkusumo. Rekam medis semua pasien donor ginjal yang menjalani prosedur LLDN di institusi kami dari November 2011 hingga Oktober 2017 ditinjau. Data termasuk usia donor, kadar hemoglobin sebelum operasi, kadar hemoglobin pasca operasi, jumlah pendarahan intraoperatif, jumlah arteri renalis, jumlah vena renalis, sisi donor, konversi ke operasi terbuka, durasi operasi, dan BMI donor dikumpulkan dan dianalisis. Data-data ini selanjutnya dikorelasikan dengan tingkat transfusi.Hasil: Terdapat 500 pasien yang menjalani tindakan laparoscopic living donor nephrectomy di institusi kami. Semua pasien menjalani prosedur LLDN dengan pendekatan transperitoneal. Perbedaan proporsi tingkat transfusi darah antara pasien pria 0,9% dibandingkan dengan 0,6% pada pasien wanita tidaklah signifikan (p=0,782). Tidak ada perbedaan yang signifikan dalam proporsi tingkat transfusi darah dengan sisi ginjal (p=0,494), jumlah arteri (p=0,362), usia (p=0,978), BMI (p=0,569), dan kadar hemoglobin sebelum operasi (p=0,766). Median perkiraan jumlah pendarahan pada pasien yang menerima transfusi darah intraoperatif secara signifikan lebih besar daripada pasien yang tidak menerima transfusi darah (p <0,001).Kesimpulan: Berdasarkan penelitian ini, kami menyarankan bahwa di institusi kami, penggunaan produk darah pra operasi tidak selalu diperlukan. Kurva pembelajaran dan teknik ahli bedah memiliki peran penting dalam mencegah komplikasi intraoperatif dan kehilangan darah.

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Introduction and objectives: Laparoscopic surgery has been acknowledged to reduce the morbidity rate thus improving patient safety. During the LLDN, the most frequent complication is renal vessels injuries, which often requires a blood transfusion. Besides the need for a blood transfusion, major bleeding caused by renal vessels injuries require open conversion and repair. Thus, this study would like to descript and analyze the need for blood transfusion in laparoscopic living donor nephrectomy surgery in our center.Materials and methods: We performed a retrospective cohort study in the Department of Urology at Cipto Mangunkusumo National Hospital. The records of all kidney transplantation donor patients who underwent LLDN procedures carried out at our institution from November 2011 to October 2017 were reviewed. Data including donor age, preoperative hemoglobin level, postoperative hemoglobin level, intraoperative bleeding, number of artery(ies), number of vein(s), donor side, conversion to open surgery, surgery duration, and donor BMI were collected and analyzed. These data were further correlated with transfusion rate.Results: There were 500 patients underwent laparoscopic living donor nephrectomy procedure at our institution. All of the patients had LLDN with a transperitoneal approach. The difference in blood transfusion rate proportion between male patients with 0.9% compared to 0.6% in female patients was not significant (p=0.782). There are no significant difference in blood transfusion rate proportion regarding to renal side (p=0.494), number of artery (p=0.362), age (p=0.978), BMI (p=0.569), and preoperative hemoglobin (p=0.766). Median estimated blood loss in patients who received intraoperative blood transfusion was significantly much greater than in patients who did not receive a blood transfusion (p<0.001).Conclusion: Based on this study, we suggest that in our institution, preoperative blood products are not necessarily needed. The surgeon's learning curve and technique play a significant role in preventing intraoperative complications and blood loss."

"Latar belakang : Konduit vena lebih rentan mengalami trombosis dini dalam satu tahun pertama pasca bedah pintas arteri koroner sehingga meningkatkan risiko morbiditas maupun mortalitas. Penelitian ini bertujuan untuk meneliti ada tidaknya perbedaan kejadian trombosis dini konduit vena pascabedah pintas arteri koroner (BPAK) dengan teknik on-pump dan off-pump pada pasien non-resisten aspirin.Metode : Dilakukan suatu studi kohort prospektif pada pasien yang menjalani operasi BPAK elektif di Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita dari bulan September 2019 hingga September 2020. Penelitan ini membandingkan kejadian trombosis pada satu bulan pascabedah pada kelompok on-pump dan off-pump dengan menggunakan pemeriksaan MSCT, serta membandingkan nilai MGF dan PI pada kedua kelompok tersebut.Hasil : Sebanyak 60 konduit vena dari 28 pasien yang menjalani BPAK dilibatkan dalam penelitian ini. Sebanyak masing-masing 30 konduit pada kelompok off-pump dan on-pump. Hasil penelitian ini menunjukan tidak ada perbedaan bermakna pada kejadian trombosis dini antara kedua kelompok. Kejadian trombosis dini pada BPAK on-pump sebanyak 13,3% dan pada BPAK off-pump 13,3% (p=1). Evaluasi nilai MGF dan PI juga menunjukan hasil tidak berbeda bermakna antara kedua teknik operasi maupun pada kelompok konduit yang paten atau oklusi.Simpulan : Tidak ada perbedaan bermakna pada kejadian trombosis dini antara BPAK baik secara on pump maupun off pump

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Introduction : Early thrombosis is more common in vein grafts and may occur within the first year after coronary artery bypass graft surgery and can increase morbidity and mortality rate. This study aims to establish whether there is a difference of the incidence of early thrombosis after on-pump and off-pump CABG in non-aspirin resistant patient population.

Method : Patients who undergone elective CABG surgery from September 2019 to September 2020 in single center was included in this prospective cohort study. This study compares the incidence of vein graft thrombosis at one month postoperative in both groups on pump and off pump using MSCT, and compares MGF and PI value of in on pump and off pump group also in patent and occluded vein grafts.

Results : A total of 60 vein grafts (30 on-pump and 30 off-pump) from 28 patients were analyzed in this study. There was no significant difference on the incidence of early vein graft thrombosis between two groups (13,3% in on pump vs 13,3% in off pump, p:1). MGF and PI value showed no difference in both techniques also no difference in patent group and occluded group

Conclusion : There is no significant difference in early vein graft thrombosis after on-pump or off-pump CABG."

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Latar belakang : Konduit vena lebih rentan mengalami trombosis dini dalam satu tahun pertama pasca bedah pintas arteri koroner sehingga meningkatkan risiko morbiditas maupun mortalitas. Penelitian ini bertujuan untuk meneliti ada tidaknya perbedaan kejadian trombosis dini konduit vena pascabedah pintas arteri koroner (BPAK) dengan teknik on-pump dan off-pump pada pasien non-resisten aspirin.

Metode : Dilakukan suatu studi kohort prospektif pada pasien yang menjalani operasi BPAK elektif di Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita dari bulan September 2019 hingga September 2020. Penelitan ini membandingkan kejadian trombosis pada satu bulan pascabedah pada kelompok on-pump dan off-pump dengan menggunakan pemeriksaan MSCT, serta membandingkan nilai MGF dan PI pada kedua kelompok tersebut.

Hasil : Sebanyak 60 konduit vena dari 28 pasien yang menjalani BPAK dilibatkan dalam penelitian ini. Sebanyak masing-masing 30 konduit pada kelompok off-pump dan on-pump.  Hasil penelitian ini menunjukan tidak ada perbedaan bermakna pada kejadian trombosis dini antara kedua kelompok. Kejadian trombosis dini pada BPAK on-pump sebanyak 13,3% dan pada BPAK off-pump 13,3% (p=1). Evaluasi nilai MGF dan PI juga menunjukan hasil tidak berbeda bermakna antara kedua teknik operasi maupun pada kelompok konduit yang paten atau oklusi.

Simpulan : Tidak ada perbedaan bermakna pada kejadian trombosis dini antara BPAK baik secara on pump maupun off pump.

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Introduction : Early thrombosis is more common in vein grafts and may occur within the first year after coronary artery bypass graft surgery and can increase morbidity and mortality rate. This study aims to establish whether there is a difference of the incidence of early thrombosis after on-pump and off-pump CABG in non-aspirin resistant patient population.

Method : Patients who undergone elective CABG surgery from September 2019 to September 2020 in single center was included in this prospective cohort study. This study compares the incidence of vein graft thrombosis at one month postoperative in both groups on pump and off pump using MSCT, and compares MGF and PI value of in on pump and off pump group also in patent and occluded vein grafts.

Results : A total of 60 vein grafts (30 on-pump and 30 off-pump) from 28 patients were analyzed in this study. There was no significant difference on the incidence of early vein graft thrombosis between two groups (13,3% in on pump vs 13,3% in off pump, p:1). MGF and PI value showed no difference in both techniques also no difference in patent group and occluded group

Conclusion : There is no significant difference in early vein graft thrombosis after on-pump or off-pump CABG.

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"ABSTRAK Latar belakang: Kolesistektomi merupakan tindakan abdomen tersering dan saat inikolesistektomi laparoskopi (KL) merupakan baku emas dan telah dilakukan pada 90% kasuskolesistitis simtomatik. Tujuan penelitian ini adalah untuk mengetahui hasil KL di RSCM,Jakarta. Metode: Penelitian retrospektif observasional ini menggunakan data dari departemen bedahdivisi digestif RSCM dari bulan Januari hingga Desember 2014. Partisipan penelitian iniadalah pria atau wanita yang berusia 23-66 tahun yang menjalani KL. Tindakan bedahdilakukan baik berupa perawatan 1 hari (one day care (ODC)) maupun elektif. Data yangdikaji adalah temuan preoperatif dan intraoperatif, durasi operasi, lama rawat inap, dan angkakonversi ke tindakan kolesistektomi terbuka (open). Kemudian kami menganalisis faktoryang mempengaruhi angka konversi. Hasil: Jumlah pasien yang masuk inklusi adalah 90 orang. Usia rata-rata 43,9 tahun (SE=1,26tahun) dengan jumlah pasien wanita 61 orang (67,8%). Median durasi operasi adalah 90±36,9menit dimana pasien yang konversi membutuhkan operasi lebih dari 2 jam lebih banyak(12% vs 1,5%), namun tidak bermakna secara statistik (p= 0,63). Median lama rawat inapadalah 9±27.2 hari dan meningkat bermakna pada kasus yag konversi (24±9 hari, p = 0.011).Median lama pre-operasi = 7±26,8 hari, dan pasca-operasi = 2±3.8 hari, dengan 13,3% pasiendilakukan endoscopic retrograde cholangio-pancreatography (ERCP) sebelum KL. Cederaduktus biliaris komunis (CBDK) ditemukan pada 3 kasus (3,33%). Konversi menjadilaparotomi dibutuhkan pada 4,44% kasus. Faktor yang mempengaruhi angka konversi hanyapada kasus adhesi (RR (95%IK) = 25,7 (2,4-273,5); p=0,007. Kesimpulan temuan: kolesistektomi laparoskopi menawarkan lama rawat inap yang lebihsingkat. Durasi operasi pendek dan prosedur ini standard, aman, dan efektif di institusi kami. ABSTRACT Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution.;Background: Cholecystectomy is the most frequently performed abdominal operation andcurrently laparoscopic cholecystectomy (LC) is considered gold standard being performed in90% cases of symptomatic gallstones. The aim of the study was to determine results obtainedwith LC at our hospital, RSCM, Jakarta. Methods: This retrospective observational study was conducted in digestive divison insurgery department of RSCM using data from January to December 2014. The studyparticipants were patients of both gender aged 23?66 years undergoing LC. Surgery wasperformed either in one day care (ODC) or elective schedule. Demographic variables,preoperative and intraoperative findings, mean operation time, hospital stay, and conversionrate were evaluated. Factors influencing rate of conversion were also studied. Results: A total of 90 patients were included. Mean age was 43.9 years (SE=1.26 years) witha female 61 (67.8%). Median operative time was 90±36.9 minutes which converted casespatient needed to operate in more than 2 hours (12% vs 1.5%), but not statistically significant(p= 0.63). Median hospital stay was 9±27.2 days that significantly increased in convertedcases (24±9 days, p-value= 0.011). Median of pre-operation = 7±26.8 days, and postoperation= 2±3.8 days, with 13.3% patients underwent endoscopic retrograde cholangiopancreatography(ERCP). Common bile duct injury (CBDI) was found in 3 cases (3.33%).Conversion to laparotomy was required in 4.44% cases. Factors that influenced the rate ofconversion included was only adhesion (RR (95%CI) = 25.7 (2.4-273.5), p=0.007. Findings: Laparoscopic cholecystectomy offers shorter hospital stay. The operative time isshort and procedure is standard, safe and effective in our institution."

"ABSTRACTPurposeLung transplantation is accepted as an effective modality for patients with end-stage pulmonary lymphangioleiomyomatosis (LAM). Generally, bilateral lung transplantation is preferred to single lung transplantation (SLT) for LAM because of native lung-related complications, such as pneumothorax and chylothorax. It remains controversial whether SLT is a suitable surgical option for LAM. The objective of this study was to evaluate the morbidity, mortality and outcome after SLT for LAM in a lung transplant center in Japan.MethodsWe reviewed the records of 29 patients who underwent SLT for LAM in our hospital between March, 2000 and November, 2017. The data collected included the pre-transplant demographics of recipients, surgical characteristics, complications, morbidity, mortality and survival after SLT for LAM.ResultsThe most common complication after SLT for LAM was contralateral pneumothorax (n = 7; 24.1%). Six of these recipients were treated successfully with chest-tube placement and none required surgery for the pneumothorax. The second-most common complication was chylous pleural effusion (n = 6; 20.7%) and these recipients were all successfully treated by pleurodesis. The 5-year survival rate after SLT for LAM was 79.5%.ConclusionLAM-related complications after SLT for this disease can be managed. SLT is a treatment option and may improve access to lung transplantation for patients with end-stage LAM."

"Pendahuluan: Deep Vein Thrombosis (DVT) memiliki kecenderungan terus meningkat dengan koinsidensi mortalitas jangka pendek dan morbiditas jangka panjang. COVID-19 dapat menyebabkan hypercoagulable state dan menjadi predisposisi terjadinya DVT. Penelitian ini bertujuan untuk menganalisis hubungan kadar fibrinogen, D-Dimer, dan dosis heparin teraupetik berdasarkan kadar APTT dengan adanya COVID-19 pada pasien DVT. Metode: Desain penelitian komparatif dan kohort prospektif digunakan untuk membandingkan kadar fibrinogen, D-Dimer, dan dosis heparin terapeutik antara pasien COVID-19 dan non COVID-19 yang menderita DVT di RSPN Cipto Mangunkusumo pada bulan Maret 2020 – Maret 2022. Penegakan diagnosis DVT dilakukan dengan pemeriksaan ultrasonografi dan/atau computed tomography angiography (CTA) fase vena. Data variabel utama dan lainnya diperoleh dari rekam medis pasien. Uji T independen atau Mann-Whitney digunakan untuk menganalisis perbedaan nilai variabel antara kedua kelompok. Hasil: Dari total 253 sampel, tidak terdapat perbedaan karakterisitik awal antara kelompok DVT COVID-19 (n=44) dan DVT non COVID-19 (n=209), kecuali pada parameter Wells Score. Kelompok DVT COVID-19 memiliki kadar Fibrinogen, D-Dimer, dan aPTT yang lebih tinggi daripada kelompok DVT non COVID-19, baik sebelum terapi maupun sesudah terapi heparanisasi (semua nilai p =0,000). Pada akhir pengamatan, didapatkan dosis heparin terapeutik pada kelompok DVT COVID-19 lebih tinggi dibanding pada kelompok DVT non COVID-19 (30,00 (20,00-40,00)x103 U vs. 25,00 (20,00-35,00)x103 U, p=0,000). Kesimpulan: Kadar fibriongen, D-Dimer, dan dosis heparin terapeutik pada pasien DVT yang menderita COVID-19 lebih tinggi dibandingkan pada pasien DVT yang tidak menderita COVID-19. Inisiasi pemberian dosis heparin terapeutik dosis tinggi dapat dipertimbangkan pada pasien DVT dengan komorbid COVID-19 dan dipandu oleh hasil pemeriksaan biomarker koagulasi darah.

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Introduction: Deep Vein Thrombosis (DVT) has an increasing trend with a coincidence of short-term mortality and long-term morbidity. COVID-19 can cause a hypercoagulable state and predispose to DVT. This study aims to analyze the relationship between fibrinogen levels, D-Dimer, and therapeutic heparin doses based on APTT levels in the presence of COVID-19 in DVT patients. Methods: A comparative study design and a prospective cohort were used to compare levels of fibrinogen, D-Dimer, and therapeutic heparin doses between COVID-19 and non-COVID-19 patients suffering from DVT at Cipto Mangunkusumo Hospital in March 2020 – March 2022. Diagnosis of DVT was performed by ultrasound examination and/or computed tomography angiography (CTA) venous phase. The primary variable data and others were obtained from the patient's medical record. An Independent T-test or Mann-Whitney was used to analyze the differences in variable values between the two groups. Results: Of 253 samples, there was no difference in initial characteristics between the DVT COVID-19 (n=44) and non-COVID-19 DVT groups (n=209), except for the Wells Score parameter. The COVID-19 DVT group had higher levels of fibrinogen, D-Dimer, and aPTT than the non-COVID-19 DVT group, both before and after heparinization therapy (all p-values = 0.000). At the end of the follow-up period, the therapeutic dose of heparin in the COVID-19 DVT group was higher than in the non-COVID-19 DVT group (30.00 (20.00-40.00)x103 U vs. 25.00 (20.00-35.00)x103 U, p-value=0.000). Conclusion: The levels of fibrinogen, D-Dimer, and therapeutic doses of heparin in DVT patients who have COVID-19 are higher than in DVT patients who do not have COVID-19. Initiation of a higher therapeutic dose of heparin can be considered in DVT patients with comorbid COVID-19 and guided by the results of blood coagulation biomarkers."

"ABSTRAKLatar belakang dan Tujuan : Varises esofagus merupakan komplikasi sirosis hati dengan mortalitas tertinggi. Pemeriksaan USG Doppler yang bersifat non invasif, tersedia luas dan relatif murah, dipertimbangkan sebagai metode skrining, namun belum ditemukan parameter Doppler splenoportal yang dapat digunakan sebagai indikator varises dengan akurat. Indeks volume aliran vena lienalis terhadap kecepatan aliran vena porta dipikirkan dapat menjadi parameter baru yang akurat.Metode : Studi observasional potong lintang dilakukan pada 28 pasien sirosis hati di Divisi Hepatologi Departemen Ilmu Penyakit Dalam Rumah Sakit Cipto Mangunkusumo dalam kurun waktu November 2015 hingga Februari 2016. Indeks dan parameter Doppler lainnya merupakan data primer. Subjek dibagi menjadi tiga kelompok, yakni kelompok non varises, varises kecil dan besar. Uji komparatif dilakukan untuk membandingkan indeks dan parameter Doppler lainnya diantara ketiga kelompok tersebut. Analisis kurva receiver operating characteristic (ROC) dilakukan pada parameter yang secara statistik bermakna untuk mendapatkan nilai sensitifitas dan spesifisitasnya.Hasil : Nilai tengah indeks pada kelompok non varises 9,60 (4,67 – 15,07), varises kecil 21,18 (8,92 – 25,24) dan varises besar 64,43 (46,67 – 145,88) dengan nilai p<0,001. Pada analisis kurva ROC didapatkan titik potong indeks 15,78 dengan sensitifitas 80% dan spesifisitas 100% untuk membedakan kelompok varises kecil dan non varises, serta titik potong 36,0 dengan sensitifitas dan spesifisitas 100% untuk membedakan kelompok varises besar dan kecil.Kesimpulan : Terdapat hubungan yang bermakna antara indeks volume aliran vena lienalis terhadap kecepatan aliran vena porta secara ultrasonografi dengan derajat varises esofagus secara endoskopi pada pasien sirosis hati dan indeks tersebut dapat digunakan sebagai indikator varises esofagus dengan akurasi tinggi.

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ABSTRACTBackground and Objective : Esophageal varices is a complication of liver cirrhosis with high mortality. Doppler ultrasound examination is non-invasive, widely available and relatively low cost to be considered as a screening method of varices. Unfortunately, there is still no splenoportal Doppler parameter that can be used as an indicator of varices with high accuracy. Index of splenic vein flow volume to portal vein flow velocity is thought to be a new, more accurate parameter.Methods : A cross-sectional observational study conducted in 28 patients with liver cirrhosis in the Division of Hepatology Department of Internal Medicine Cipto Mangunkusumo Hospital during November 2015 to February 2016. Index and other splenoportal Doppler parameters are the primary data. Subjects were divided into three groups : a group of non varices, small and large varices. The comparative test conducted to compare the mean index and other splenoportal Doppler parameters among the three groups. Analysis of receiver operating characteristic (ROC) curve was performed on parameters that are statistically significant to get the sensitivity and specificity value.Results : Median index in the group of non varices is 9,60 (4,67 – 15,07), 21,18 (8,92 – 25,24) in small varices and 64,43 (46,67 – 145,88) in large varices group with p<0.001. ROC curve analysis generated optimal cutting point index 15,78 which gives 80% sensitivity and 100% specificity to differentiate small and non varices group and the cutoff point of 36.0 which provides 100% sensitivity and specificity to differentiate among the large and small varices.Conclusions : There is a significant association between the index of splenic vein flow volume to portal vein flow velocity by ultrasound with the degree of esophageal varices by endoscopy in patients with liver cirrhosis and this index can be used as indicator of esophageal varices with high accuracy."

"Agenesis vena porta adalah kelainan yang jarang ditemukan dimana aliran darah vena dari limpa dan usus tidak melalui hepar tetapi mengalir ke aliran sistemik melalui berbagai pintasan. Dilaporkan satu kasus pasien wanita berusia 32 tahun dengan kelainan ini dimana pasien mengalami hematemesis dan melena berulang dan didapati adanya splenomegali dan hipersplenisme. Pada angiografi tidak ditemukan adanya vena porta. Dilakukan tindakan splenektomi untuk menurunkan tekanan pada vena-vena sekitar gaster dan mengkoreksi hipersplenisme. Enam bulan pasca operasi dilakukan endoskopi dengan hasil varises pada esofagus sudah menghilang sedangkan varises pada gaster sudah mengecil. (Med J Indones 2004; 14: 122-7)

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Congenital Absence of the Portal Vein (CAPV) is a rare anomaly in which the intestinal and splenic venous drainage bypasses the liver and drains into the systemic veins through various venous shunts. We present a case of a 32-year-old woman with this malformation, the patient experienced hematemesis and melena repetitively and had splenomegaly and hypersplenism. The angiography demonstrated absence of portal vein. Splenectomy was performed to reduce the pressure of the veins around stomach and to correct the hypersplenism. In endoscopy examination six months after surgery, the esophageal varices had disappear and the size of gastric varices had decrease. (Med J Indones 2004; 14: 122-7)"