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"ABSTRACTPurpose: Postoperative pneumonia affects the length of stay and mortality after surgery in elderly patients with colorectal cancer (CRC). We aimed to determine the risk factors of postoperative pneumonia in elderly patients with CRC, and to evaluate the impact of laparoscopic surgery on elderly patients with CRC.Methods: We retrospectively investigated 1473 patients ≥ 80 years of age who underwent surgery for stage 0-III CRC between 2003 and 2007. Using a multivariate analysis, we determined the risk factors for pneumonia occurrence from each baseline characteristic.Results: Among all included patients, 26 (1.8%) experienced postoperative pneumonia, and restrictive respiratory impairment, obstructive respiratory impairment, history of cerebrovascular events, and open surgery were determined as risk factors (odds ratio [95% confidence interval], 2.78 [1.22-6.20], 2.71 [1.22-6.30], 3.60 [1.37-8.55], and 3.57 [1.22-15.2], respectively). Furthermore, postoperative pneumonia was more frequently accompanied by increasing cumulative numbers of these risk factors (area under the receiver operating characteristic curve = 0.763).Conclusions: Laparoscopic surgery may be safely performed in elderly CRC patients, even those with respiratory impairment and a history of cerebrovascular events."

"It has been proposed that minor oral surgery can be performed safely in patients taking antithrombotic therapy without interrupting treatment; however, there is little evidence-based guidance about how to manage postoperative hemorrhage in patients taking antithrombotics, and few randomized trials that help to inform the risk–benefit ratio of continuing or suspending antithrombotic therapy. The aim of this study was to identify risk factors for postoperative hemorrhage to create a protocol for patients undergoing minor oral surgery with antithrombotic therapy. One hundred and two patients were enrolled, who subsequently underwent 142 minor oral surgical procedures while taking antithrombotic therapy. Demographic details including age and sex, laboratory coagulation investigations, and episodes of postoperative hemorrhage were recorded. The prothrombin time-international normalized ratio (PT-INR) of participants taking warfarin was <3.0 in all cases (mean 1.89 ± standard deviation 0.52; range 1.11–2.82). The activated partial thromboplastin time (APTT) was significantly associated with postoperative hemorrhage, which was significantly increased in patients taking warfarin alone or in combination with an antiplatelet agent compared with an antiplatelet agent alone. In 7 cases, postoperative hemorrhage continued for 4 days and more, requiring additional local hemostatic management. Our findings suggest that minor oral surgery can be performed under antithrombotic therapy without the need of discontinuing the antithrombotic agents. Local hemostatic materials did not suppress postoperative hemorrhage. APTT is a possible prediction factor for postoperative hemorrhage in such patients and, therefore, should be determined prior to minor oral surgery in addition to PT-INR value."

"Latar belakang. Jumlah pasien keganasan anak di Indonesia tertinggi di Asia Tenggara dan pneumonia merupakan komplikasi infeksi tersering serta memiliki luaran yang lebih berat. Namun, hingga saat ini belum ada penelitian mengenai prevalens, karakteristik, dan faktor risiko kejadian pneumonia pada pasien keganasan anak di IndonesiaTujuan. Mengetahui prevalens, karakteristik, dan faktor-faktor yang memengaruhi kejadian pneumonia pada pasien keganasan anak di RSCM.Metode. Penelitian ini merupakan studi deskriptif analitik dengan metode potong lintang retrospektif menggunakan data rekam medis pasien. Subjek yang diteliti ialah seluruh pasien keganasan berusia 1 bulan-18 tahun yang dirawat inap di IGD, PICU, dan bangsal anak RSCM dari Januari 2021 sampai Desember 2023. Faktor risiko yang dianalisis, antara lain usia, jenis keganasan, status imunisasi, status gizi, tipe terapi keganasan, neutropenia, dan riwayat rawat inap ≥ 14 hari.Hasil. Terdapat 162 subjek yang memenuhi kriteria inklusi dan eksklusi dalam penelitian. Prevalens pneumonia pada pasien keganasan anak di RSCM sebesar 43,2% (70/162) subjek, terdiri dari 78,5% (55/70) kasus pneumonia terkait RS dan 21,4% (15/70) kasus pneumonia komunitas. Karakteristik subjek dengan pneumonia, antara lain median usia 5,3 tahun (min-mak 0,2-17,5 tahun), median usia awitan keganasan 4,7 tahun (min-mak 0-17,3 tahun), jenis kelamin lelaki 57,1% subjek, pengidap leukemia 55,7% subjek, imunisasi tidak lengkap 38,6% subjek, status gizi kurang/buruk 54,3% subjek, terapi keganasan berupa kemoterapi 61,4% subjek, neutropenia 65,7% subjek, dan riwayat rawat inap ≥14 hari 34,3% subjek. Profil klinis dan pemeriksaan penunjang pada subjek dengan pneumonia, yakni 37,1% subjek mengalami pneumonia sangat berat, terapi oksigen dengan kecepatan  >6 lpm 40% subjek, 52,8% subjek tidak terdapat leukositosis, kadar CRP meningkat pada 80% subjek, kadar PCT meningkat pada 71,4% subjek, dan rontgen dada kesan sugestif pneumonia pada 82,9% subjek. Hasil analisis multivariat faktor yang memengaruhi kejadian pneumonia dan pneumonia terkait RS adalah status gizi kurang/buruk (AOR 3,24; IK 95% 1,49-7,05; p=0,003 dan AOR 2,98; IK 95% 1,24-7,17; p=0,015), neutropenia (AOR 4,15; IK 95% 1,94-8,84; p<0,001 dan AOR 4,59; IK 95% 1,94-10,86; p<0,001), serta riwayat rawat inap (AOR 8,48; IK 95% 2,63-27,31; p<0,001 dan AOR 12,34; IK 95% 3,71-41,09; p<0,001).Simpulan.Faktor yang memengaruhi kejadian pneumonia, khususnya pneumonia terkait RS pada pasien keganasan anak adalah status gizi kurang/buruk, neutropenia, dan riwayat rawat inap ≥ 14 hari.

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Background. The number of pediatric malignancies in Indonesia is the highest in Southeast Asia. Pneumonia is the most common infection in childhood cancer and also has more severe outcomes than normal children. However, there has been no research regarding the prevalence, characteristics, and risk factors influencing pneumonia in pediatric patients with malignancy in Indonesia

Objectives. To determine the prevalence, characteristics, and risk factors influencing pneumonia in pediatric patients with malignancy at RSCM.

Method. This research was a descriptive-analytical study with a retrospective cross-sectional design using medical records. The subjects studied were all malignancy patients aged 1 month-18 years who were hospitalized in the ER, PICU, and RSCM pediatric wards from January 2021 to December 2023. The risk factors which studied were age, type of malignancy, immunization status, nutritional status, type of malignancy therapy, neutropenia, and a history of hospitalization ≥ 14 days.

Result. 162 subjects met the inclusion and exclusion criteria in the study. The prevalence of pneumonia in pediatric malignancy patients at RSCM was 43,2% (70/162) subjects, consisting of 78,5% (55/70) cases of hospital-acquired pneumonia and 21,4% (15/70) cases of community-acquired pneumonia. Basic characteristics of the subjects, including median age 5,3 years (min-max 0,2-17,5 years), median age of malignancy onset 4,7 years (min-max 0-17,3 years), male 57,1% subjects, leukemia 55,7% subjects, incomplete immunization 38,6% subjects, malnutrition 54,3% subjects, chemotherapy in 61,4% subjects, neutropenia in 65,7% subjects, and history of hospitalization ≥ 14 days in 34,3% subjects. The clinical profiles and laboratory examinations in subjects with pneumonia, including 37,1% subjects had very severe pneumonia, 40% subjects had oxygen therapy >6 lpm, 52,8% subjects had no leukocytosis, CRP level increased in 80% subjects, PCT level increased in 71,4% subjects, and chest x-ray impression suggestive of pneumonia in 82,9% subjects. Multivariate analyses result of risk factors influencing pneumonia and hospital-acquired pneumonia are moderate/severe malnutrition (AOR 3,24; 95% CI 1,49-7,05; p = 0,003 and AOR 2,98; 95% CI 1,24-7,17; p = 0,015), neutropenia (AOR 4,15; 95% CI 1,94-8,84; p <0,001 and AOR 4,59; 95% CI 1,94-10,86; p <0,001) and history of hospitalization (AOR 8,48; 95% CI 2,63-27,31; p <0,001 and AOR 12,34; 95% CI 3,71-41,09; p <0,001).

Conclusion. Moderate/severe malnutrition, neutropenia, and a history of hospitalization ≥14 days are risk factors for pneumonia, especially hospital-acquired pneumonia in pediatric patients with malignancy."

"Background: multidrug-resistant organisms (MDRO) caused pneumonia has become a crucial case. MDRO infection has been a problem concern to community-acquired pneumonia (CAP). A lot of factors play roles in CAP with MDRO infection. This study aimed to analyze MDRO as the etiology of hospitalized patients with CAP along with its risk factors in Dr. Soetomo Hospital as one of the top referral hospitals in east Indonesia. Methods: this retrospective cohort study was conducted from January 2016 to December 2018. Data were collected from patients' medical records. Automatic Rapid Diagnosis (Phoenix TM) was used as a standard method for culture and susceptibility test. Various risk factors were analyzed for MDRO infection. Results: five most common pathogens in hospitalized patients with CAP were Acinetobacter baumannii 244/1364 (17.9%), Klebsiella pneumoniae 134/1364 (9.8%), Pseudomonas aeruginosa 91/1364 (6.7%), Escherichia coli 58/1364 (4.3%), and Enterobacter cloacae 45/1364 (3.3%). There were 294/1364 (21.5%) MDROs isolated from patients with CAP. MDRO infection was linked to previous hospitalization, malignancy, cardiovascular disease, and structural lung disease with p values of 0.002, <0.001, 0.024, and <0.001, respectively. Conclusion: the incidence of MDRO in CAP is high (21.5%). The risk factors related were previous hospitalization, malignancy, cardiovascular disease, and structural lung disease."

"ABSTRACTWe conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathogenic mutation of mismatch repair genes (MLH1, MSH2, and MSH6) from the nationwide Japanese retrospective multicenter study. Cox proportional hazards modeling was used to investigate the factors correlating with early-onset CRC diagnosis, using clinical data such as gender, tobacco use, alcohol consumption, body mass index, gene mutation (MLH1, MSH2 vs MSH6), and family cancer history. Alcohol was significantly correlated with an increased risk of early-onset CRC [HR 2.44, 95% CI 1.13-5.16 (p = 0.02)], but tobacco use was not [HR 0.8, 95%CI 0.38-1.62 (p = 0.53)]. These findings suggest that alcohol consumption is correlated with an earlier onset of CRC in Japanese patients with LS."

"Background: autoimmune patients can be more susceptible to infection. Proper knowledge, perception, and practices towards COVID-19 are essential for these patients during pandemic. This study aimed to know their knowledge, perception, and practices regarding COVID-19. Methods: cross sectional study using online survey was conducted from April to May 2020. Patients with autoimmune disease were asked about demographic characteristics, diagnosis, history of treatment, knowledge, perception, and practice regarding COVID-19. Results: there were 685 respondents. Most of them were female and had systemic lupus erythematosus with median age of 37 years old. Almost all respondents had good knowledge regarding transmission of COVID-19 and did proper prevention practices. Adequacy of information and steroid or mycophenolate mofetil/mycophenolic acid (MMF/MPA) use were related to perception of the effect of pandemic to their own health. Visiting private clinic and receiving hydroxychloroquine/chloroquine sulfate or sulfasalazine were related to perception that autoimmune conditions would make them more prone to COVID-19. Work from home was related to perception that when contracting COVID-19, the symptoms would be more severe. Living in Sumatra region and getting hydroxychloroquine/ chloroquine sulfate or MMF/MPA were related to perception that autoimmune medications could reduce risk of getting COVID-19. Adequate information, university education, private clinic visit, and hydroxychloroquine/ chloroquine sulfate use were related to perception that COVID-19 pandemic would cause difficulties in getting medications. Conclusion: almost all respondents had good knowledge and practices regarding COVID-19. Adequacy of information, autoimmune treatment, work from home, educational background, area of living, and health care facilities contributed to perception regarding COVID-19 pandemic."

"Mencegah terjadinya massa tulang puncak rendah merupakan salah satu dari sekian banyak strategi pencegahan osteoporosis. Suatu penelitian yang melibatkan 25 kasus dengan massa tulang puncak rendah dan 25 kontrol telah dilakukan untuk meneliti faktor risiko yang memengaruhi kejadian tersebut. Kelompok kasus memiliki indeks riwayat kalsium (IRK) yang lebih rendah dibanding kontrol (median 160 (1−2361) vs 965 (19−3185), p =0,001). Seseorang dengan nilai IRK<1000 memiliki risiko lebih tinggi mengalami massa tulang puncak rendah dibanding IRK lebih tinggi (odds ratio10,61, 95% CI: 2,05; 54,95). Riwayat konsumsi teh atau kopi, serta data komposisi tubuh dan aktivitas fisik saat penelitian bukan merupakan faktor risiko. Sehingga, penghitungan IRK dengan nilai batas 300 dan 1000 dapat digunakan untuk mengidentifikasi perempuan yang lebih berisiko dan modifikasi kebiasaan hidup dapat disarankan lebih dini.

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Preventing the occurrence of low peak bone mass is one of the many strategies of osteoporosis prevention. A study involving 25 cases with low peak bone mass and 25 controls was conducted to examine the risk factors of low peak bone mass. The cases had a lower historical calcium index (HCI) compared to controls (median of 160 (1-2361) vs. 965 (19-3185), p =0.001). Someone with HCI <1000 had risk of having low peak bone mass compared to those with higher HCI (odds ratio 10.61, 95% CI: 2.05; 54.95), and some with HCI <300 had a higher risk. History of tea or coffee consumption, as well as body composition and physical activity acquired during the study were not known as risk factors. Therefore, HCI calculations with cut-off of 300 and 1000 can be used to identify those at risk and earlier lifestyle modifications should be recommended."

"Latar belakang: Epilepsi merupakan salah satu penyebab terbanyak morbiditas di bidang saraf anak, yang menimbulkan berbagai permasalahan gangguan tumbuhkembang, dan kualitas hidup anak dengan insidens terbanyak di bawah usia 1 tahun. Faktor-faktor risiko terjadinya epilepsi di bawah usia 1 tahun seperti herediter, prenatal, perinatal dan pascanatal perlu diketahui sehingga dapat menjadi prediktor kejadian epilepsi dan dapat menatalaksana epilepsi sejak dini.Tujuan: (1) Mengidentifikasi faktor risiko epilepsi pada anak dengan awitan usia di bawah 1 tahun. (2) Menganalisis besar risiko faktor herediter. (3) Menganalisis besar risiko faktor perinatal (asfiksia, BBLR, prematur). (4) Menganalisis besar risiko faktor pascanatal (kejang demam, mikrosefali, keterlambatan perkembangan, tidak ASI eksklusif). (5) Memberikan gambaran probabilitas timbulnya epilepsi berdasarkan skoring prediktor terhadap faktor risiko.Metode: Penelitian kasus kontrol dilakukan pada pasien yang terdiagnosis epilepsi dengan awitan usia di bawah 1 tahun yang datang ke Poliklinik Neurologi Departemen Ilmu Kesehatan Anak FKUI/RSCM dari bulan Januari 2011 hingga Desember 2015. Pengambilan data dilakukan dengan melihat data rekam medis dan wawancara kepada orangtua. Faktor-faktor risiko yang dianggap berpengaruh dianalisis secara multivariat.Hasil: Insidens epilepsi di bawah usia 1 tahun selama 2011-2015 167 pasien. Pada analisis multivariat didapatkan faktor-faktor risiko yang bermakna berupa riwayat keluarga dengan epilepsi (p<0,001 dan OR 9,098; IK 95% 2,002-41,344), mikrosefali (p<0,001 dan OR 20,772; IK 95% 6,041-71,751), kejang demam (p<0,001 dan OR 13,408; IK 95% 3,855-46,636), tidak diberikannya ASI eksklusif (p<0,001 dan OR 9,667; IK 95% 4,607-20,283) serta keterlambatan perkembangan (p<0,001 dan OR 16,042; IK 95% 6,204-41,478). Probabilitas terjadinya epilepsi di bawah usia 1 tahun bila memiliki 1 faktor risiko yaitu 39%, 2 faktor risiko yaitu 86% dan 3-4 faktor risiko menjadi 98%.Simpulan: Faktor-faktor risiko yang bermakna berupa riwayat keluarga dengan epilepsi, mikrosefali, kejang demam, keterlambatan perkembangan serta tidak ASI eksklusif.

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Background: Epilepsy is the most common cause of morbidity in pediatric neurology, which results in delayed developmental problems and decreased quality of life during infancy. Risk factors of epilepsy in infancy such as hereditary, prenatal, perinatal and postnatal should be detected to be able to find the predictors of the incidence and to promptly manage epilepsy.Aim: (1) To identify the risk factors of epilepsy in infants. (2) To analyze hereditary factors. (3) To analyze perinatal risk factors (asphyxia, low birth weight, prematurity). (4) To analyze postnatal risk factors (febrile seizure, microcephaly, delayed development, no exclusive breastfeeding). (5) To find the probability of epilepsy based on the predictor score of risk factors.Method: A case control study for patients diagnosed with epilepsy during infancy who comes to Neurology outpatient clinic Department of Child Health, Faculty of Medicine, University of Indonesia from January 2011 to December 2015. Data was collected from medical records and parent interviews. The risk factors that are considered important are then analyzed multivariately.Result: The incidence of epilepsy in infant from 2011-2015 is 167 patients. In the multivariate analysis, the significant risk factors are family history with epilepsy (p<0.001 and OR 9.098l 95%; CI 2.002-41.344), microcephaly (p<0.001 and OR 20.772; 95% CI 6.041-71.751), febrile seizure (p<0.001 and OR 13.408; 95% CI 3.855-46.636), no exclusive breastfeeding (p<0.001 and OR 9.667; 95% CI 4.607-20.283) and delayed development (p<0.001 and OR 16.042; 95% CI 6.204-41.478). The probability of epilepsy in infants with more than 1 risk factor is 39%, with 2 risk factors is 86% and with 3-4 risk factors is 98%.Conclusion: The significant risk factors are family history with epilepsy, microcephaly, febrile seizure, delayed development and no exclusive breastfeeding."

"Latar belakang. Terdapat 5 domain keterampilan yang harus dicapai sesuai dengan kelompok usia anak. Apabila tidak dicapai hingga melebihi batasan usia yang seharusnya, anak dikatakan mengalami keterlambatan perkembangan. Keterampilan motorik kasar merupakan domain perkembangan dengan tingkat perhatian orang tua tertinggi, sebab keterampilan motorik kasar merupakan penentu otonomi seorang anak. Penelitian mengenai faktor risiko dibuat untuk menyusun strategi intervensi pencegahan keterlambatan perkembangan. Tujuan. (1) Mengetahui faktor risiko yang signifikan terhadap keterlambatan motorik kasar pada anak usia 6-24 bulan. (2) Mengetahui pengaruh antar masing-masing faktor risiko. Metode penelitian. Desain penelitian menggunakan kasus dan kontrol. Data diperoleh melalui data primer hasil penilaian keterampilan motorik kasar yang divalidasi oleh pembimbing dan wawancara orang tua pasien yang ada di Poli Kiara RSUPN Cipto Mangunkusumo dan Pondok Pinang. Anak dengan keterampilan motorik kasar terlambat dimasukkan dalam kelompok kasus dan dilakukan matching usia untuk memperoleh kelompok kontrol. Pengambilan data dilakukan dari bulan Februari sampai Juli 2018. Faktor-faktor risiko dianalisis secara bivariat dan multivariat. Hasil penelitian. Dilakukan analisis terhadap 63 anak dengan motorik kasar terlambat dan 63 anak dengan motorik kasar normal. Faktor risiko yang memiliki hubungan bermakna dengan keterlambatan motorik kasar pada anak, yaitu asfiksia perinatal (P=0,004 ; OR=5,714 ; IK 95%=1,553-21,026), prematuritas (P=0,009 ; OR=3,949 ; IK 95%=1,347-11,574), berat badan lahir rendah (P=0,011 ; OR=3,511 ; IK 95%=1,281-9,625), dan mikrosefali (P<0,001 ; OR=5,128 ; IK 95%=2,332-11,280). Setelah dilakukan analisis multivariat, mikrosefali (aOR=4,613 ; IK 95%=2,023-10,521) dan prematuritas (aOR=3,668 ; IK 95%=1,153-11,673) merupakan faktor yang paling berpengaruh terhadap keterlambatan motorik kasar pada anak. Kesimpulan. Mikrosefali dan prematuritas (usia gestasi < 37 minggu) merupakan faktor prediktor keterlambatan motorik kasar pada anak usia 6-24 bulan.

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Introduction. There are 5 domains of development that has to be accomplished by a child. If a child fails to master a skill according to his age group, he is said to have a delayed development. Gross motor is one of the domain with the highest parental concern as mastering gross motor is an important factor that determine the autonomy of a child. This study is made to arrange a strategic intervention on the prevention of delayed development.

Objectives. (1) To determine the significant risk factors for gross motor delay in children age 6-24 months old. (2) To determine the association between risk factors.

Methods. Case control study design was used. Data was obtained from direct assessment of gross motor skill (validated by supervisor) and parents’ interview in Cipto Mangunkusumo National Hospital and Pondok Pinang. Children with gross motor delay were categorized as the case group and age matching from this group was used to obtain the control group. Data was collected from February until July 2018. Bivariate and multivariate analysis on risk factors were done to find the significant risk factors and predictor factors for gross motor delay.

Results. 63 children with gross motor delay and 63 children with normal gross motor development were being analyzed. Significant risk factors for gross motor delay were perinatal asphyxia (P=0.004 ; OR=5.714 ; CI 95%=1.553-21.026), prematurity (P=0.009 ; OR=3.949 ; CI 95%=1.347-11.574), low birth weight (P=0.011 ; OR=3.511 ; CI 95%=1.281-9.625), and microcephaly (P<0.001 ; OR=5.128 ; CI 95%=2.332-11.280). After multivariate analysis, microcephaly (aOR=4.613 ; CI 95%=2.023-10.521) and prematurity (aOR=3.668 ; CI 95%=1.153-11.673) were the predictor factors for gross motor delay.

Conclusion. Microcephaly and prematurity (gestation age < 37 weeks) are the predictor factors for gross motor delay in children age 6-24 months old."

"Latar Belakang: Keterlambatan bicara adalah salah satu bentuk keterlambatan perkembangan pada anak. Untuk meminimalisir dampak negatif keterlambatan bicara, faktor risiko dibutuhkan untuk membantu mendiagnosis pasien, agar intervensi dini dapat dimulai.Tujuan: Identifikasi asosiasi antara jenis kelamin, usia kehamilan, berat lahir, lingkar kepala, penutupan anterior fontanel, perkembangan motorik kasar, periode ASI eksklusif, pengasuh sehari-hari, jumlah saudara kandung, paparan media, interaksi sosial dengan pasien, dan keterlambatan bicara pada anak usia 1 sampai 2 tahun.Metode: Penelitian kasus kontrol pada anak usia 1 sampai 2 tahun di Rumah Sakit Pusat Nasional (RSUPN) Cipto Mangunkusumo dan Klinik Anakku, Pondok Pinang di Jakarta, Indonesia, dari Januari 2018 sampai Maret 2018. Data dikumpulkan dari wawancara orang tua. Data yang diperoleh diolah dengan SPSS Statistics for Mac, dengan uji Chi-Square dan metode logistic regression. Hasil: Jumlah subjek pada studi ini adalah 126 anak, dengan 63 anak dengan keterlambatan bicara, dan 63 anak lainnya dengan perkembangan bicara yang normal. Pada uji multivariat, variabel yang signifikan adalah keterlambatan perkembangan motorik kasar (p < 0.001; OR = 9.607; 95% CI = 3.403-27.122), periode ASI eksklusif kurang dari 6 bulan (p = 0.016; OR = 3.278; 95% CI = 1.244-8.637), dan paparan gadget dan televisi selama lebih dari 2 jam sehari (p < 0.001; OR = 8.286; 95% CI = 2.555-26.871). Kontak sosial yang buruk (p = 0.998) adalah confounding factor pada studi ini.Kesimpulan: Keterlambatan perkembangan motorik kasar, periode ASI eksklusif kurang dari 6 bulan, paparan media selama lebih dari 2 jam, dan kontak yang buruk adalah faktor risiko keterlambatan bicara pada anak.

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Background: Speech delay is one of the most common developmental delay in children. To minimize the negative outcomes of speech delay, risk factors should be explored to help in patient diagnosis, so an early intervention can be initiated. Aim: Identify the association between gender, age, birth weight, asphyxia during birth, head circumference, closure of anterior fontanel, gross motor development, period of

breastfeeding, caregiver, number of siblings, media exposure, social interaction with subject and delayed speech in children between 1 to 2 years old. Method: A case-control study for children between 1 to 2 years old in Rumah Sakit Umum Pusat Nasional (RSUPN) Cipto Mangunkusumo and Klinik Anakku, Pondok Pinang in Jakarta, Indonesia, from January 2018 to March 2018. Data was collected from parent interviews. The data obtained was processed with SPSS Statistics for Mac, with Chi-Square test and logistic regression method.

Result: The total number of subjects in this study was 126, with 63 children with speech delay and 63 children with normal speech development. In the multivariate analysis, the significant risk factors were delayed gross motor development (p < 0.001; OR = 9.607; 95% CI = 3.403-27.122), period of exclusive breastfeeding of less than 6 months (p = 0.016; OR = 3.278; 95% CI = 1.244-8.637), and exposure to gadgets and television for more than 2 hours (p < 0.001; OR = 8.286; 95% CI = 2.555-26.871). Poor social interaction (p = 0.998) was found to be the confounding factor. Conclusion: Delayed gross motor development, period of exclusive breastfeeding of less than 6 months, media exposure for more than 2 hours, and poor are risk factors of

delayed speech development in children."