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"ABSTRAKAn increase in lipid peroxidation and a decrease in antioxidant activity have been reported in patients with cancer in comparison with normal subjects. Objective: To estimate the status of serum and saliva by assessing the serum and salivary vitamin E levels in patients with oral potentially malignant disorders and oral cancer. Methods: A total of 90 participants were enrolled in this study. 30 subjects with oral potentially malignant disorders, 30 subjects with oral cancer, and 30 healthy subjects (controls). Serum and saliva samples were collected and vitamin E levels were assessed. The data were analyzed using ANOVA for between group comparison. Post hoc Tukey analysis was used for comparing the two study groups with the control group. Pearson correlation coeffcient was used to determine concordance between the groups. Results: Mean vitamin E levels in serum and saliva were signifcantly decreased in oral potentially malignant disorders and oral cancer compared with controls. Conclusion: As signifcant reduction in vitamin E levels was observed in saliva, it was evident that salivary vitamin E levels potentially be used as a reliable, non invasive biomarker for diagnosing and managing oral potentially malignant disorders and oral cancer. "

"Peningkatan stres oksidatif selama penuaan, dianggap sebagai kontributor utama pada proses neuro-degenerasi dan kehilangan neuron, dan merupakan faktor utama dalam patologi penyakit Alzheimer dan penurunan kognitif terkait usia. Vitamin E merupakan antioksidan potensial yang menjadi fokus utama penelitian gangguan fungsi kognitif dan penyakit Alzheimer. Penelitian potong lintang pada populasi lansia sehat di Kelurahan Cikoko ini dilakukan pada bulan Desember 2014 untuk menilai hubungan antara kadar vitamin E serum dengan fungsi kognitif. Selain itu juga menilai asupan vitamin C dan E dengan metode FFQ. Penilaian fungsi kognitif dengan instrumen MoCA-Ina. Pemeriksaan laboratorium untuk mengetahui kadar vitamin E menggunakan metode HPLC. Data dianalisis dengan uji Mann-Whitney dan Chi-square. Sebagian besar subyek (75,9%) adalah perempuan dengan usia rata-rata 65 tahun. Sementara, kadar rata-rata vitamin E adekuat, yaitu 21,6 μmol/L. Hasil penelitian ini menunjukkan bahwa tidak ada hubungan signifikan antara kadar vitamin E serum dengan fungsi kognitif yang dinilai dengan skor MoCA-Ina. Meskipun berat badan normal hingga obes I menunjukkan hubungan signifikan dengan skor kognitif (r = 0,17 p = 0,026), tetapi tidak ada hubungan signifikan antara asupan vitamin C dengan fungsi kognitif (r = 0,19 p = 0,15) atau antara asupan vitamin E dengan fungsi kognitif (r = 0,04, p = 0.72) pada penelitian ini. Kesimpulan, tidak terdapat hubungan antara kadar vitamin E serum dengan fungsi kognitif.

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Oxidative stress increases during ageing, is considered as a major contributor to neuro-degeneration and neuronal loss, and is a primary factor in the pathology of both Alzheimer’s disease and age-related cognitive decline. Vitamin E has been the main focus of investigation in studies of cognitive impairment and alzheimer’s disease during aging as a potent antioxidant.

A cross-sectional study of an elderly population in Cikoko Regency in December 2014 was conducted to evaluate the association between serum vitamin E levels and cognitive function in elderly. Correlation between intakes of vitamin C and E as well as Body Mass Index to the MoCA-Ina scores were also investigated. Fifty four elderly were included in the study and interviewed for their vitamins intake using a Food Frequency Questionnaires (FFQ). Cognitive function was examined by Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Levels of vitamin E serum were assessed by high performance liquid chromatography. Data were analyzed by using the Mann-Whitney and Chi-square test. The majority of the subjects were female (75.9%) with median age 65 years old. While, the median levels of vitamin E was 21.55 μmol/L.

The result of this study showed that there was no association between vitamin E level and MoCA-Ina scores. Although normal weight to obese I was significantly associated with cognitive scores (r = 0,17 p = 0.026), no significant correlation between vitamin C intake and cognitive function scores (r = 0.19 p = 0.15) or between vitamin E intake and MoCA-Ina scores were found in this study (r = 0.04, p = 0.72). In conclusion, there is no association between vitamin E serum and cognitive function."

"Preeklampsia merupakan gangguan kehamilan yang mengancam kesehatan ibu dan bayi Penelitian ini merupakan studi potong melintang yang bertujuan untuk mengetahui perbedaan kadar vitamin E dan MDA pada 48 subyek preeklampsia dan non preeklampsia di RS Tarakan Jakarta Penilaian mencakup wawancara sosio demografi riwayat obstetri asupan vitamin E dengan FFQ semikuantitatif LILA kadar vitamin E dan MDA serum Kategori usia usia kehamilan dan kadar MDA lebih tinggi pada preeklampsia Edukasi untuk perempuan usia reproduktif tentang pentingnya asupan makanan vitamin E yang cukup diperlukan untuk mencapai keberhasilan kehamilan.

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Preeclampsia is a disorder of pregnancy that deteriorate mother and baby rsquo s health This study was a cross sectional study aiming to investigate differences in the levels of vitamin E and MDA of 48 subjects with preeclampsia and non preeclampsia in Tarakan Hospital Jakarta Assessment included interviews of socio demographic obstetric history vitamin E intake with semiquantitative FFQ MUAC serum vitamin E and MDA concentrations Categories of age gestational age and MDA levels were higher among preeclamptics Education for reproductive age women about the importance of sufficient intake of vitamin E foods is necessary to achieve successful pregnancy."

"Indonesian Journal of Dentistry 2006; Edisi Khusus KPPIKG XIV: 22-24Lichen planus is relatively common inflamatory disorder which may have cutaneous and/or mucosal manifestation. The maglinant potential of oral lichen planus is still debatable. Some authors are sceptical about the premaglinant nature of the disease, while other investigators have reporterd that maglinant transformation occur in 1-10% of the cases. The aim of this study is to report a case of erosive oral lichen planus which shows maglinant transformation on histopatologic examination. A man of 39 years old visited the Dental Departement of Kariadi's Hospital with pain symptom of palatum, buccal and gingival mucosa both side for 6 months. On the physical examination shows the white lesions with striae configuration and pain, red erosive area inside on the palatum extends to the buccal mucosa and the gingival. The suspect dignose is erosive lichen planus, but the histopathologic examination shows epidermoid carcinoma. lt is concluded that erosive oral lichen planus has the potential to transform into epidermoid carcinoma."

"Mengelahui efek pemberian suplementasi vitamin C dan E terhadap kadarmalondialdehida plasma pada perokok kretek filter selama empat minggu di Jakarta.Penelitian ini merupakan uji klinis paralel, acalg tersamar tunggal antara kelompokyang inendapat suplementasi vitamin C dan E (P) dengan kelompok yang mendapatplasebo (K). Sebanyak 40 orang perokok kretek filterr di rumah makan, Jakarta Utaramemenuhi ln-iteria dan diikutkan dalam penelitian Dilakukan randomisasi blolc untukmenentukan kclompok perlakuan dan kontrol. Kelompok perlakuan mendapatkansuplementasi vitamin C 500 mg dan E 400 IU/hari selama empat minggu, dankclompok kontrol mendapat plasebo. Data yang dikumpulkan meliputi data demograti(usia, konsumsi rokok, indeks Brinkman, tekanan dan lg kadar glukosa darah puasa,kadar kolesterol tétal), IMT, analisis asupan zat gizi, kadar malondialdehida plasma.Analisis data menggunakan uji t tidak berpasangan atau uji Mann Whimsy denganbatas kemaknaan p <0,05.Karakteristik demografi subyek pada awal penelitian meliputi usia, konsumsi rokok,indeks Brinkman, tel-canan damh, Radar glukosa darah puasa, kadar kolesterol total,IMT , analisis asupan zat gizi, kadar malondialdchida plasma antara kelompokperlakuan dan kontrol homogen. Rerata kadar MDA plasma awal pada kelompokperlakuan dan pada kelompok kontrol 1,39i0,19 vs 1,34=b=0,09 nmol/mL. Pada akhirperlakuan, rerata kadar MDA plasma sabesar 1,18=l=0,22 pada kelompok perlakuan dan1,3 1=k0,13 nmol/mL kelompok kontrol, berbeda bermakna (p <0,03‘7).Setelah suplementasi vitamin C 500 mg dan E 400 IU/hari selama empat minggutcrdapat perbedaan bermakna renta kadar MDA plasma antara kedua kelompok.

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AbstractTo investigate the effects of vitamin C and E supplementation on plasmamalondialdehycle in clove cigarettes smokers during four weeks in JakartaThis is a parallel randomized single-blind clinical study between interventionalgroup with vitamin C and E supplementation (P) and control group with hasplacebo (K). Forty clove cigarettes smokers in Rmtaurant, Jakarta had fulfilledthe criteria and recruited in the research. Subjects were allocated by blockrandomization into intervention and control group. Intervention group treatedwith vitamin C 500 mg and vitamin E 400 IU daily for 4 weeks, while controlgroup treated with placebo. Data collection includes demographic characteristic(age, smoking habits, Brinkman index, blood pressure, blood glucose, totalcholesterol), body mass index (BMI), daily nutrient analysis, plasma MDA.Statistical analysis using unpairod t-test or Mann Whitney test with significantlevel at p < 0,05.Demographic characteristic (age, smoking habits, Brinlcman index, bloodpressure, blood glucose, total cholesterol), body mass index (BMI), dailynutrient analysis, plasma MDA between both groups were homogen. Initialplasma MDA in the intervention group. and control were l,39=|=0,l9 vsl,34=l=0,09 nmol/tnL. After intervention plasma MDA were l,l8=k0,22 in theintervention group and 1,3l£),13 nmol/mL in control group (p <0,03'7).After supplementation of vitamin C 500 mg/day and vitamin E 400 IU/dayduring 4 weeks, showed significantly differences average of plasma MDAbetween two groups."

"Pendahuluan: Profil Kesehatan Mulut dan Saliva pada Pasien Geriatri di Rumah Sakit Cipto Mangunkusumo. Pasien geriatri meningkat sejalan dengan peningkatan populasi Lansia. Permasalahan kesehatan umum dan gigi-mulut akan mempengaruhi kualitas hidup mereka. Tujuan: Studi ini bertujuan untuk mendeskripsikan kesehatan gigi dan mulut secara menyeluruh pada pasien geriatri di poliklinik geriatri di Rumah Sakit Cipto Mangunkusumo. Bahan dan Cara: penelitian ini adalah studi deskriptif. Kuesioner digunakan untuk mendapatkan data demografik. Pemeriksaan klinis intreoral dilakukan berdasarkan standar Fakultas Kedokteran Gigi Universitas Indonesia. Hasil: Jumlah sampel adalah 75 pasien geriatri dengan usia 60-86 tahun. Rata-rata skor DMF-T adalah 4.68±2.89, OHI-S 2.79±1.10, PBI 0.78±0.59. Rata-rata skor unstimulated salivary pH 6.62±0.54 dan stimulated buffer capacity saliva 7.46±2.83. Ratarata laju aliran saliva adalah 0,24 mL/menit dan hiposalivasi ditemukan pada 39 orang. 93 variasi normal dan 117 lesipatologis ditemukan pada studi ini. Kesimpulan: Ditemukannya status kesehatan gigi dan mulut yang rendah pada sampel penelitian ini menunjukkan adanya kemungkinan penyebabnya adalah rendahnya laju alur saliva, pH saliva, dan kemampuan buffer saliva. Pemeriksaan kesehatan gigi dan mulut secara sistematik dan rutin pada Lansia merupakan hal yang penting dan seyogyanya dilakukan secara holistik dengan kolaborasi antara dokter dan dokter gigi.

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Introduction: Population of geriatric patients would increase in line with that of elderly population. Health problems related to this group of people would have impact on general and oral health maintenance aiming for good quality of life. Objectives: This study aimed to determine the profile of oral health, saliva, and oral mucosa on geriatric patients at Geriatric Policlinic in Cipto Mangunkusumo Hospital. Materials and Methods: This research was a descriptive crosssectionalstudy, which data was taken using questionnaire containing basic demographical information and oral clinical examination using standard form used by Faculty of Dentistry Universitas Indonesia. Results: The study included 75 geriatric patients, ranging from 60 to 86 of age. The mean of DMF-T score of 69 geriatric patients was 4.68 ±2.893, OHI-S 2.790 ±1.102, PBI 0.779±0.585. The mean of unstimulated salivary pH score was 6.618 ± 0.54 and stimulatedbuffer capacity of saliva was 7.46±2.827. Mean of salivary flow rate is 0.24mL/min and 39 people had hiposalivation. 93 normal variations and 117 pathological oral lesion was found. Conclusion: This study showed that poor oral health status and pathological oral lesion found in this study elderly population could be caused from poor salivary flow, pH saliva, and buffer capacity of saliva. Systematic oral examination of the elderly is of considerable importance and oughtbe carried out regularly by a dentist in collaboration with the physician; making holistic management of the elderly properly performed."

"Serat asbes yang terinhalasi masuk ke dalam alveolus menyebabkan terjadinya peningkatan produksi reactive oxigen spesies (ROS) yang dapat memicu terjadinya reaksi inflamasi. Interleukin 6 merupakan penanda reaksi inflamasi akibat pajanan serat asbes. Vitamin C dan E merupakan antioksidan yang bekerja sebagai scavenger ROS. Vitamin C juga dapat menghambat aktivitas faktor transkripsi NFқB. Vitamin E selain dapat menghambat aktivitas faktor transkripsi JAK/STAT3 dan NFқB, juga dapat menghambat aktivitas COX2 dan LOX5. Penelitian potong lintang di sekretariat serikat buruh pabrik asbes X Kabupaten Karawang bulan Oktober 2014 dilakukan untuk menilai korelasi asupan vitamin C, E dengan kadar interleukin 6 pada pekerja pabrik asbes. Lima puluh dua pekerja pabrik asbes berhasil menyelesaikan protokol penelitian. Hasilnya menunjukkan tidak terdapat korelasi bermakna (p >0,05) antara asupan vitamin C dengan kadar IL-6 dan antara asupan vitamin E dengan kadar IL-6. Terdapat korelasi positif antara kadar vitamin C dengan kadar IL-6 (r = 0,31) dengan p <0,05, namun tidak terdapat korelasi antara kadar vitamin E dengan kadar IL-6.

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Asbestos fibers that are inhaled into the alveoli cause increased production of reactive oxygen species (ROS) which may trigger inflammation reaction. Interleukin 6 (IL-6) is a marker of inflammation reaction caused by asbestos fibers exposure. Vitamin C and vitamin E are antioxidants acting as ROS scavengers. Vitamin C can also inhibit the activity of transcription factor NFқB. Vitamin E can inhibit the activities of transcription factors JAK/STAT3 and NFқB as well as the activities of COX2 and LOX5.

A cross-sectional sudy at a labor union secretariat in Karawang Regency in October 2014 was conducted to evaluate the correlations between intakes and levels of vitamin C and vitamin E and level of IL-6 in asbestos factory workers. Fifty two asbestos factory workers finished the study. The result showed no significant correlation between vitamin C intake and IL-6 level or between vitamin E intake and IL-6 level. There was a moderate positive correlation between vitamin C level and IL-6 level (r = 0.31, p <0.05), but there was no correlation between vitamin E level and IL-6 level."

"Kadar CRP serum dapat digunakan sebagai prediktor penurunan berat badan dan indikator prognostik inflamasi. Penelitian ini dilakukan untuk mengetahui korelasi kadar CRP serum dengan penurunan berat badan dan mukositis oral pada pasien kanker kepala leher yang menjalani radioterapi. Penelitian ini adalah penelitian observasional dengan desain potong lintang pada pasien kanker kepala leher yang telah menjalani terapi radiasi minimal 25 kali di Departeman Radioterapi RSUPNCM Jakarta dengan usia ge;18 ndash;65 tahun. Hasil penelitian menunjukkan bahwa sebagian besar subyek 71,2 memiliki kadar CRP serum normal, mengalami penurunan berat badan ge;5 dalam waktu sebulan 76,9 dengan rerata penurunan berat badan -9,42 7,76 , dan juga mengalami mukositis oral 65,4 dengan persentase terbanyak yaitu derajat 1 59,6 . Tidak terdapat mukositis oral derajat 3 dan 4. Tidak terdapat korelasi antara kadar CRP serum dengan penurunan berat r=0,166; p=0,239 , dan mukositis oral r=0,137; p=0,331 . Kesimpulan adalah kadar CRP serum saat radioterapi tidak memengaruhi penurunan berat badan dan mukositis oral. Sebagian besar subyek tetap mengalami penurunan berat badan selama menjalani radioterapi sehingga pemasangan NGT yang lebih awal yaitu sebelum terapi radiasi dimulai NGT profilaksis perlu dilakukan, namun hal ini membutuhkan penelitian lebih lanjut.

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Serum CRP levels can be used as a predictor of weight loss and prognostic indicator of inflammation. This study was conducted to determine the correlation of serum CRP levels with weight loss and oral mucositis in patients with head and neck cancer undergoing radiotherapy. This study was an observational study in the head and neck cancer patients who have undergone radiation therapy at least 25 times at the Department of Radiotherapy RSUPNCM Jakarta with aged ge 18 ndash 65 years old. Our study results showed that most of the subjects 71,2 had normal serum CRP levels, weight loss of ge 5 in one month 76,9 , and also experienced oral mucositis 65,4 . Mostly had grade 1 oral mucositis 59,6 . There were no grade 3 and 4 oral mucositis.There were no correlation between serum CRP levels with weight loss r 0,166 p 0,239 , and oral mucositis r 0,137 p 0.331 . In conclusion, serum CRP levels did not influence weight loss and oral mucositis in patients with head and neck cancer undergoing radiotherapy. Most of the subjects still experienced weight loss during radiotherapy. Therefore, NGT prophylaxis is needed, but this requires further study."

"Many diseases can have an impact upon oral health and/​or the safe delivery of dental care. Consequently, oral health care providers need to be comfortable with assessing the risk of providing dental care to their patients with systemic disease as well as the evaluation of oral conditions that may represent manifestations or consequences of systemic disease. Risk Assessment and Oral Diagnostics in Clinical Dentistry aims to enable the dental practitioner to comfortably and capably assess when medical conditions may impact dental care and diagnose oral conditions using routine testing."