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"Latar Belakang. Walaupun pasien HIV mendapat terapi antiretroviral yang efektif, penurunan fungsi fisik sering ditemukan lebih awal dan menimbulkan masalah baru berupa penuaan dan frailty.Tujuan. Mengetahui proporsi dan faktor-faktor yang berhubungan dengan prefrail dan frail pada pasien HIV dalam terapi antiretroviral.Metode. Desain studi potong lintang pada pasien HIV usia ≥30 tahun dalam terapi ARV minimal 6 bulan. Pasien yang memenuhi inklusi dilakukan pencatatan demografis, penyakit komorbid, faktor terkait HIV seperti lama terdiagnosis, lama ARV, dan CD4, pengukuran antropometri seperti indeks massa tubuh, penilaian depresi dengan Indo BDI-II, dan penilaian frailty dengan kriteria Fried. Pasien dengan riwayat infeksi otak, kanker, dan oportunistik aktif dieksklusi. Analisis bivariat dan multivariat dilakukan pada faktor-faktor tersebut.Hasil. Terdapat 164 pasien yang dianalisis. Proporsi prefrail sebanyak 51,2% (84 pasien) dan frail 3,7% (6 pasien), dengan komponen dominan pada kelemahan genggam. Pasien laki-laki sebanyak 72% dengan median usia (IQR) 40,5 (36-47) tahun, dan median CD4 nadir (IQR) 53 (21-147) sel/mm3, median CD4 awal (IQR) 77 (32 - 206) sel/mm3. Hepatitis C menjadi faktor komorbid terbanyak. Depresi berhubungan dengan prefrail dan frail dengan OR 2,14 (IK95%: 1,034-4,439) dan p = 0,036. Tidak terdapat hubungan faktor usia ≥50 tahun, ≥2 penyakit komorbid, lama terdiagnosis HIV ≥5 tahun, lama ARV ≥5 tahun, CD4 <200 sel/mm3, indeks massa tubuh ≥25 kg/m2, dan pendapatan rendah dengan prefrail dan frail.Kesimpulan. Terdapat proporsi prefrail sebanyak 51,2% dan frail 3,7%. Depresi merupakan salah satu faktor yang terbukti berhubungan terhadap prefrail dan frail pada pasien HIV dalam terapi ARV.

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Background. Although HIV patients receive effective antiretroviral therapy, decrease in physical function is often found earlier and creates new problems in the form of aging and frailty

Aim. to determine the proportion and factors associated with prefrail and frail in HIV patients on antiretroviral therapy.

Method. A cross-sectional study design in HIV patients aged ≥30 years who were on ARV therapy for at least 6 months. Patients who fulfilled the inclusion were recorded demographically, comorbid diseases, HIV-related factors such as length of diagnosis, duration of ARV, CD4, anthropometric measurements such as body mass index, depression assessment with Indo BDI-II, and frailty assessment with Fried criteria. Patients with a history of brain infection, cancer, and active opportunists were excluded. Bivariate and multivariate analysis was carried out on these factors.

Results. There were 164 patients analyzed. The proportions of prefrail and frail were 51.2% and 3.7% respectively, with the dominant component in muscle weakness. Male patients were 72% with median age (IQR) 40.5 (36-47) years, median baseline CD4 (IQR) 77 (32 - 206) cell/mm3, and median nadir CD4 (IQR) 53 (21-147) cells/mm3. Hepatitis C is the most comorbid factor. Depression is related to prefrail and frail with OR 2.14 (95%CI: 1,034-4,439) and p = 0,036. There was no correlation between factors such as age ≥50 years, ≥2 comorbid diseases, length of diagnosis of HIV ≥5 years, duration of ARV ≥5 years, CD4 cell count <200 cells/mm3, body mass index ≥25 kg/m2, and low income with prefrail and frail.

Conclusion. The proportions of prefrail and frail are 51.2% and 3.7% respectively. Depression is one of the factors that is proven to be related to prefrail and frail in HIV patients in ARV therapy."

"Latar belakang : Seiring dengan semakin efektifnya terapi Antiretroviral (ARV) pasien HIV memiliki harapan hidup lebih lama, morbiditas dan mortalitas penyakit HIV yang tidak berhubungan dengan Acquired Immunodeficiency Syndrome semakin meningkat. Non-alcoholic Fatty Liver Disease (NAFLD) telah dikenali sebagai penyakit hati tersering yang mempengaruhi lebih dari seperempat jumlah populasi global dan jumlahnya semakin meningkat di Indonesia. Pasien yang terinfeksi HIV memiliki risiko lebih tinggi untuk terkena NAFLD. Penelitian ini bertujuan untuk mendapatkan informasi tentang prevalensi dan faktor yang berhubungan dengan NAFLD pada pasien HIV dalam pengobatan antiretroviral (ARV) tanpa hepatitis viral kronis. Metode: Penelitian ini merupakan studi potong lintang yang melibatkan pasien HIV dalam pengobatan ARV tanpa koinfeksi virus hepatitis yang berobat di poliklinik Kelompok Studi Khusus (POKDISUS) Rumah Sakit Cipto Mangunkusumo Jakarta. NAFLD didefinisikan sebagai perlemakan di jaringan hati yang dibuktikan oleh pemeriksaan imaging transient elastography dengan Controlled Attenuation Parameter (CAP) setidaknya 238 dB/m. Perkiraan faktor-faktor yang berhubungan dengan NAFLD dianalisis dengan regresi logistik bivariat dan multivariat. Hasil: Pada penelitian ini secara keseluruhan didapatkan 105 subyek pasien HIV yang direkrut secara konsekutif. Prevalensi NAFLD didapatkan 52,4% (95% CI ±9,55). Faktor-faktor yang berhubungan dengan NAFLD pada populasi ini adalah hipertensi (PR = 3,755; 95% CI 1,218-11,575; p = 0,021) dan Index Massa Tubuh (IMT) (PR = 1,212 95% CI 1,051-1,396; p = 0,008). Faktor terkait HIV seperti CD4+ nadir, lama mendapat terapi ARV didapatkan tidak terkait NAFLD. Kesimpulan: Prevalensi NAFLD pada pasien HIV di Indonesia tinggi. NAFLD didapatkan berkaitan dengan hipertensi dan IMT, namun tidak dengan faktor-faktor terkait HIV. Penapisan non invasif untuk NAFLD sebaiknya diimplementasikan pada populasi ini untuk intervensi awal dan pencegahan komplikasi.

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Background: As HIV-infected persons experience longer life expectancies, other cause of morbidity and mortality among this group are increasingly being identified. Non-alcoholic fatty liver disease (NAFLD) has been recognized as the most common liver disease affecting more than a quarter of global population and increasing number in Indonesia. HIV-infected persons are at an increased risk of having NAFLD. This study aimed to inform prevalence and factors associated with NAFLD in HIV-infected patients without chronic viral hepatitis on antiretroviral therapy (ARV). Methods: A cross sectional study of HIV-infected person on ARV without hepatitis co-infection was done in HIV Integrated Clinic Cipto Mangunkusumo Hospital, Jakarta. NAFLD was defined as having at least 238 dB/m in transient elastography with associated Controlled Attenuation Parameter (CAP) examination. Bivariate and multivariate logistic regression analysis were applied to estimate factors associated with NAFLD Results: A total of 105 consecutive HIV infected person were included in the study analyzed. The prevalence of NAFLD was 52.4% (95% CI ±9.55). Factors related to NAFLD in this population were hypertension (PR = 3.755; 95% CI 1.218-11.575; p = 0.021) and Body Mass Index (BMI) (PR = 1.212 95% CI 1.051-1.396; p = 0.008). HIV specific variables such as nadir CD4, duration of ARV were not associated with NAFLD. Conclusion : There was a high prevalence of NAFLD among Indonesian person infected with HIV. NAFLD was associated with BMI and hypertension, but not with HIV related factors. Non-invasive screening for NAFLD should be implemented in this populaton to establish early intervention and prevent complication"

"Latar Belakang. Walaupun pasien HIV mendapat terapi antiretroviral yang efektif, penurunan fungsi fisik sering ditemukan lebih awal dan menimbulkan masalah baru berupa penuaan dan frailty.Tujuan. Mengetahui proporsi dan faktor-faktor yang berhubungan dengan prefrail dan frail pada pasien HIV dalam terapi antiretroviral.Metode. Desain studi potong lintang pada pasien HIV usia ≥30 tahun dalam terapi ARV minimal 6 bulan. Pasien yang memenuhi inklusi dilakukan pencatatan demografis, penyakit komorbid, faktor terkait HIV seperti lama terdiagnosis, lama ARV, dan CD4, pengukuran antropometri seperti indeks massa tubuh, penilaian depresi dengan Indo BDI-II, dan penilaian frailty dengan kriteria Fried. Pasien dengan riwayat infeksi otak, kanker, dan oportunistik aktif dieksklusi. Analisis bivariat dan multivariat dilakukan pada faktor-faktor tersebut.Hasil. Terdapat 164 pasien yang dianalisis. Proporsi prefrail sebanyak 51,2% (84 pasien) dan frail 3,7% (6 pasien), dengan komponen dominan pada kelemahan genggam. Pasien laki-laki sebanyak 72% dengan median usia (IQR) 40,5 (36-47) tahun, dan median CD4 nadir (IQR) 53 (21–147) sel/mm3, median CD4 awal (IQR) 77 (32 – 206) sel/mm3. Hepatitis C menjadi faktor komorbid terbanyak. Depresi berhubungan dengan prefrail dan frail dengan OR 2,14 (IK95%: 1,034–4,439) dan p = 0,036. Tidak terdapat hubungan faktor usia ≥50 tahun, ≥2 penyakit komorbid, lama terdiagnosis HIV ≥5 tahun, lama ARV ≥5 tahun, CD4 <200 sel/mm3, indeks massa tubuh ≥25 kg/m2, dan pendapatan rendah dengan prefrail dan frail.Kesimpulan. Terdapat proporsi prefrail sebanyak 51,2% dan frail 3,7%. Depresi merupakan salah satu faktor yang terbukti berhubungan terhadap prefrail dan frail pada pasien HIV dalam terapi ARV.

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Background. Although HIV patients receive effective antiretroviral therapy, decrease in physical function is often found earlier and creates new problems in the form of aging and frailty

Aim. to determine the proportion and factors associated with prefrail and frail in HIV patients on antiretroviral therapy.

Method. A cross-sectional study design in HIV patients aged ≥30 years who were on ARV therapy for at least 6 months. Patients who fulfilled the inclusion were recorded demographically, comorbid diseases, HIV-related factors such as length of diagnosis, duration of ARV, CD4, anthropometric measurements such as body mass index, depression assessment with Indo BDI-II, and frailty assessment with Fried criteria. Patients with a history of brain infection, cancer, and active opportunists were excluded. Bivariate and multivariate analysis was carried out on these factors.

Results. There were 164 patients analyzed. The proportions of prefrail and frail were 51.2% and 3.7% respectively, with the dominant component in muscle weakness. Male patients were 72% with median age (IQR) 40.5 (36-47) years, median baseline CD4 (IQR) 77 (32 - 206) cell/mm3, and median nadir CD4 (IQR) 53 (21–147) cells/mm3. Hepatitis C is the most comorbid factor. Depression is related to prefrail and frail with OR 2.14 (95%CI: 1,034-4,439) and p = 0,036. There was no correlation between factors such as age ≥50 years, ≥2 comorbid diseases, length of diagnosis of HIV ≥5 years, duration of ARV ≥5 years, CD4 cell count <200 cells/mm3, body mass index ≥25 kg/m2, and low income with prefrail and frail.

Conclusion. The proportions of prefrail and frail are 51.2% and 3.7% respectively. Depression is one of the factors that is proven to be related to prefrail and frail in HIV patients in ARV therapy."

"ABSTRAK Latar Belakang: Hingga saat ini belum ada panduan mengenai paduan terapiantiretroviral (antiretroviral therapy/ART) terpilih pada pasien HIV dewasadengan riwayat interupsi tidak terencana. Kondisi pasien pada saat reintroduksiART perlu dievaluasi sebagai dasar pemilihan paduan ART Tujuan: Mengetahui proporsi keberhasilan virologis pada reintroduksi ART linipertama pasca interupsi tidak terencana. Mengetahui hubungan antara berbagaifaktor klinis dan laboratoris dengan keberhasilan virologis pada reintroduksi tersebut. Metode: Penelitian kohort retrospektif dilakukan pada pasien HIV yangmendapatkan reintroduksi ART lini pertama pasca interupsi tidak terencanaselama minimal 1 bulan. Data didapatkan dari rekam medis RS dr. CiptoMangunkusumo di Jakarta. Viral load (VL) dinilai 6-18 bulan setelah reintroduksiART lini pertama, dinyatakan berhasil bila VL <400 kopi/ml. Dilakukan analisisterhadap faktor yang berhubungan dengan keberhasilan virologis tersebut.Hasil: Selama periode Januari 2005 s.d. Desember 2014 terdapat 100 subjek yangmendapatkan reintroduksi ART lini pertama dan memiliki data viral load 6-18bulan pasca reintroduksi. Pasca reintroduksi ART didapatkan keberhasilanvirologis pada 55 (55%) subjek. Pada analisis didapatkan dua faktor yangberhubungan dengan keberhasilan virologis pada reintroduksi ART lini pertama,yaitu frekuensi interupsi satu kali (adjusted OR/aOR 5,51; IK95% 1,82-16,68;p=0,003), nilai CD4 saat reintroduksi ≥200 sel/mmxi 3 (aOR 4,33; IK95% 1,1416,39,p=0,031).Simpulan:Proporsi keberhasilan virologis pada reintroduksi ART lini pertamapasca interupsi tidak terencana adalah 55%. Pasien dengan frekuensi interupsi 1kali dan pasien dengan nilai CD4 saat reintroduksi ≥200 sel/mm3 memiliki kecenderungan untuk mencapai keberhasilan virologis pada reintroduksi ART.ABSTRACT There is no guideline concerning antiretroviral therapy (ART) ofchoice for adult HIV patients after unplanned interruption. Hence, patients?conditions at time of ART reintroduction need to be evaluated as a basis forselecting ART regiment. Objectives: To know the proportion of virological success of first line ARTreintroduction after unplanned interruption. To know the association betweeneither clinical or laboratory factors and virological success in reintroduction. Methods: We conducted a retrospective cohort study in HIV patients that werereintroduced to first line ART after having unplanned interruption for at least onemonth period. The data were collected from medical records of Dr. CiptoMangunkusumo Hospital in Jakarta. Viral load (VL) was evaluated at 6-18months after first line ART reintroduction, declared as a success if VL <400copies/mL. Analysis was done to factors associated with such virological success.Results: Between January 2005 and December 2014, 100 subjects werereintroduced to first line ART and having VL data in 6 to 18 months after thereintroduction. Virological success was achieved in 55 (55%) subjects. In theanalysis we found that virological success was associated with interrupted once(adjusted OR/aOR 5.51%, 95%CI 1.82-16.68, p=0.003) and CD4 ≥200 cell/mmxii Universitas Indonesia 3at the time of reintroduction (aOR 4.33, 95%CI 1.14-16.39, p=0.031).Conclusions: Proportion of virological success on first line ART reintroductionafter unplanned interruption was 55%. Patients who were having interrupted onceand patients with CD4 ≥200 cell/mm3 at the time of reintroduction would havehigher odds of virological success on first line ART reintroduction.;Background: There is no guideline concerning antiretroviral therapy (ART) ofchoice for adult HIV patients after unplanned interruption. Hence, patients?conditions at time of ART reintroduction need to be evaluated as a basis forselecting ART regiment. Objectives: To know the proportion of virological success of first line ARTreintroduction after unplanned interruption. To know the association betweeneither clinical or laboratory factors and virological success in reintroduction. Methods: We conducted a retrospective cohort study in HIV patients that werereintroduced to first line ART after having unplanned interruption for at least onemonth period. The data were collected from medical records of Dr. CiptoMangunkusumo Hospital in Jakarta. Viral load (VL) was evaluated at 6-18months after first line ART reintroduction, declared as a success if VL <400copies/mL. Analysis was done to factors associated with such virological success.Results: Between January 2005 and December 2014, 100 subjects werereintroduced to first line ART and having VL data in 6 to 18 months after thereintroduction. Virological success was achieved in 55 (55%) subjects. In theanalysis we found that virological success was associated with interrupted once(adjusted OR/aOR 5.51%, 95%CI 1.82-16.68, p=0.003) and CD4 ≥200 cell/mmxii Universitas Indonesia 3at the time of reintroduction (aOR 4.33, 95%CI 1.14-16.39, p=0.031).Conclusions: Proportion of virological success on first line ART reintroductionafter unplanned interruption was 55%. Patients who were having interrupted onceand patients with CD4 ≥200 cell/mm3 at the time of reintroduction would havehigher odds of virological success on first line ART reintroduction.;Background: There is no guideline concerning antiretroviral therapy (ART) ofchoice for adult HIV patients after unplanned interruption. Hence, patients?conditions at time of ART reintroduction need to be evaluated as a basis forselecting ART regiment. Objectives: To know the proportion of virological success of first line ARTreintroduction after unplanned interruption. To know the association betweeneither clinical or laboratory factors and virological success in reintroduction. Methods: We conducted a retrospective cohort study in HIV patients that werereintroduced to first line ART after having unplanned interruption for at least onemonth period. The data were collected from medical records of Dr. CiptoMangunkusumo Hospital in Jakarta. Viral load (VL) was evaluated at 6-18months after first line ART reintroduction, declared as a success if VL <400copies/mL. Analysis was done to factors associated with such virological success.Results: Between January 2005 and December 2014, 100 subjects werereintroduced to first line ART and having VL data in 6 to 18 months after thereintroduction. Virological success was achieved in 55 (55%) subjects. In theanalysis we found that virological success was associated with interrupted once(adjusted OR/aOR 5.51%, 95%CI 1.82-16.68, p=0.003) and CD4 ≥200 cell/mmxii Universitas Indonesia 3at the time of reintroduction (aOR 4.33, 95%CI 1.14-16.39, p=0.031).Conclusions: Proportion of virological success on first line ART reintroductionafter unplanned interruption was 55%. Patients who were having interrupted onceand patients with CD4 ≥200 cell/mm3 at the time of reintroduction would havehigher odds of virological success on first line ART reintroduction.;Background: There is no guideline concerning antiretroviral therapy (ART) ofchoice for adult HIV patients after unplanned interruption. Hence, patients?conditions at time of ART reintroduction need to be evaluated as a basis forselecting ART regiment. Objectives: To know the proportion of virological success of first line ARTreintroduction after unplanned interruption. To know the association betweeneither clinical or laboratory factors and virological success in reintroduction. Methods: We conducted a retrospective cohort study in HIV patients that werereintroduced to first line ART after having unplanned interruption for at least onemonth period. The data were collected from medical records of Dr. CiptoMangunkusumo Hospital in Jakarta. Viral load (VL) was evaluated at 6-18months after first line ART reintroduction, declared as a success if VL <400copies/mL. Analysis was done to factors associated with such virological success.Results: Between January 2005 and December 2014, 100 subjects werereintroduced to first line ART and having VL data in 6 to 18 months after thereintroduction. Virological success was achieved in 55 (55%) subjects. In theanalysis we found that virological success was associated with interrupted once(adjusted OR/aOR 5.51%, 95%CI 1.82-16.68, p=0.003) and CD4 ≥200 cell/mmxii Universitas Indonesia 3at the time of reintroduction (aOR 4.33, 95%CI 1.14-16.39, p=0.031).Conclusions: Proportion of virological success on first line ART reintroductionafter unplanned interruption was 55%. Patients who were having interrupted onceand patients with CD4 ≥200 cell/mm3 at the time of reintroduction would havehigher odds of virological success on first line ART reintroduction."

"ABSTRAKLatar Belakang: Neuropati perifer merupakan komplikasi neurologis tersering pada pasien HIV. Stavudin, yang dikaitkan dengan risiko neuropati perifer, mulai ditinggalkan sebagai pilihan pertama terapi antiretroviral. Penelitian ini bertujuan untuk mengetahui angka kejadian neuropati pada pasien HIV dalam terapi antiretroviral non stavudin menggunakan multimodalitas pemeriksaan, dan faktor risiko yang berhubungan.Metode Penelitian: Penelitian berdesain potong lintang menggunakan data sekunder dari penelitian JakCCANDO ditambah dengan data primer dari pasien HIV dalam terapi antiretroviral non stavudin minimal 12 bulan yang berobat di Unit Pelayanan Tepadu (UPT) HIV Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo (RSUPNCM). Anamnesis dan penelusuran data faktor risiko, skrining klinis Brief Peripheral Neuropathy Screen (BPNS), elektroneurografi, dan Stimulated Skin Wrinkling (SSW) dengan krim lidokain:prilokain 5% dilakukan pada setiap subjek penelitian. Data dianalisis dengan SPSS 17.0.Hasil: Angka kejadian polineuropati simetris distal (PSD) pada 68 subjek penelitian berdasarkan BPNS, elektroneurografi, SSW, dan kombinasi ketiga modalitas ialah 16,2%, 25%, 29,4%, dan 52,9%. Subjek dengan CD4 nadir kurang dari 50 sel/l memiliki risiko PSD sebesar 2,85 kali lebih tinggi dibandingkan kelompok subjek dengan CD4 nadir yang lebih tinggi (IK 95% 1,99-8,29). Subjek yang memiliki tinggi badan lebih dari sama dengan 170 cm (p<0,03) dan viral load lebih dari sama dengan 35.000 kopi/ml (p<0,05) memiliki rerata kecepatan hantar saraf sensorik tungkai bawah lebih rendah dibandingkan subjek dengan tinggi badan dan viral load yang lebih rendah.Kesimpulan: Angka kejadian neuropati perifer pada pasien HIV masih cukup tinggi yaitu 52,9% dari subjek penelitian, meskipun stavudin tidak lagi digunakan. Penggunaan multimodalitas pemeriksaan memberikan kemampuan deteksi neuropati lebih banyak dibandingkan modalitas pemeriksaan tunggal. Subjek dengan CD4 nadir kurang dari 50 sel/l, 2,85 kali lebih berisiko mengalami PSD. Penelitian ini juga menunjukkan adanya hubungan antara tinggi badan lebih dari sama dengan 170 cm dan viral load lebih dari sama 35.000 kopi/ml terhadap abnormalitas parameter elektroneurografi saraf sensorik tungkai bawah.

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ABSTRACT

Background: Peripheral neuropathy was a common neurologic complications in HIV patients. Stavudine, which was often associated with neuropathy risk, is no longer used as first line HAART. This study was aimed to determine prevalence of neuropathy in HIV patients receving HAART without stavudine using multi modalities examination, and associated risk factors.

Materials and Method: A cross-sectional study was undertaken using secondary data from JakCCANDO study subjects and primary data from HIV patients receiving antiretroviral therapy without stavudine for minimum 12 months in Integrated HIV Outpatient Clinics of Cipto Mangunkusumo General Hospital. All subjects were performed history taking, Brief Peripheral Neuropathy Screen (BPNS), electroneurography, and Stimulated Skin Wrinkling (SSW) using lidocaine:prilocaine 5% cream. Data analysis was done using SPSS 17.0.

Results:Prevalence of symmetric distal polyneuropathy (DSP) from 68 study subjects based on BPNS, electroneurography, SSW, and combination of three modalities were 16,2%, 25%, 29,4%, and 52,9%. Subjects with nadir CD4 less than 50 cells/l were at increased risk of DSP 2,85 times larger than subjects with higher nadir CD4 (CI 95% 1,99-8,29). Subjects with a height of equal or more than 170 cm (p<0,03) and viral load of equal or more than 35.000 copies/ml (p<0,05) had significantly decrease mean of lower extremities sensory nerve conduction velocities based on electroneurography compared to subjects with lower height and viral load.

Conclusions: Peripheral neuropathy remained a numerous neurological complication, as much as 52,9% of study subjects, even when stavudine was no longer used. Multiple diagnostic tools used in this study gave higher neuropathy number compared to single diagnostic modality. Subjects with nadir CD4 less than 50 cells/l had 2,85 times higher risk of having DSP. There were also correlation between height equal or more than 170 cm and viral load equal or more than 35.000 copies/ml with electroneurographic parameter abnormalities of sensory nerve in lower extremities."

"ABSTRAKLatar Belakang. Efavirenz adalah salah satu obat antiretroviral lini pertama dalam tatalaksana infeksi HIV. Namun, penelitian dari beberapa negara menunjukkan sekitar 50% pengguna efavirenz mengalami efek samping psikiatrik, seperti gangguan tidur, mimpi buruk, insomnia, cemas, depresi sampai gangguan kognitif. Penelitian ini bertujuan untuk mengetahui prevalensi psikopatologi pada ODHA yang mendapatkan terapi efavirenz, serta faktor yang berhubungan, seperti faktor demografik, mekanisme koping, dan stigma.Metode. Studi potong lintang ini menggunakan kuesioner yang diberikan pada pasien HIV di UPT HIV RSUPN Cipto Mangunkusumo yang menggunakan efavirenz. Psikopatologi diukur menggunakan SCL-90, mekanisme koping dengan Brief COPE, dan stigma dengan Berger HIV Stigma Scale. Selain itu, faktor demografik seperti usia, jeniskelamin, riwayat gangguan jiwa, riwayat penggunaan narkotika, dan stadium HIV.Hasil. Prevalensi psikopatologi pada pasien HIV yang diterapi dengan EFV sebesar 50 dari 112 subjek penelitian (44,6 %). Gejala psikopatologi terbanyak yang didapatkan adalah depresi 25.0% diikuti oleh gejala obsesif kompulsif 17.9%. Faktor yang menunjukkan hubungan signifikan dengan adanya psikopatologi adalah usia (p=0,01), stigma (p=0,01), dan riwayat penggunaan alkohol/zat psikoaktif lainnya (p=0,02).Kesimpulan. Depresi merupakan psikopatologi yang paling banyak didapatkan pada penelitian ini. Faktor usia, stigma, dan riwayat penggunaan alkohol/zat psikoaktif lainnya mempunyai hubungan yang bermakna terhadap munculnya gejala psikopatologi pada pasien yang mendapatkan terapi EFV.

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ABSTRACTBackground. Efavirenz is one of the first-line antiretroviral drugs in the management of HIV infection. However, research from several countries shows that about 50% of efavirenz users experience psychiatric side effects, such as sleep disorders, nightmares, insomnia, anxiety, depression to cognitive disorders. This study aims to determine theprevalence of psychopathology in HIV patients who received efavirenz therapy, as well as related factors, such as demographic factors, coping mechanisms, and stigma.Method. This cross-sectional design used a questionnaire given to HIV patients at UPT HIV Cipto Mangunkusumo General Hospital who used efavirenz. Psychopathology was measured using SCL-90, coping mechanism with COPE Brief, and stigma with Berger HIV Stigma Scale. In addition, demographic factors such as age, sex, history of mentaldisorders, history of drug use, and stage of HIV.Results. The prevalence of psychopathology in HIV patients treated with EFV was 50 out of 112 study subjects (44.6%). The most common psychopathological symptom was depression 25.0% followed by obsessive compulsive symptoms 17.9%. Factors that showed a significant correlation with the prevalence of psychopathology were age (p = 0.01), stigma (p = 0.01), and history of alcohol / other psychoactive substance use (p = 0.02).Conclusion. Depression is the most commonly obtained psychopathology in this study. Age, stigma, and history of using alcohol / other psychoactive substance use have a significant significant correlation with the prevalence of psychopathological symptoms in patients receiving EFV therapy."

"Latar belakang HIV / AIDS adalah penyakit kronis dengan spektrum klinis luas yang membutuhkan perawatan seumur hidup, dan dapat menurunkan kualitas hidup. Belum ada alat sederhana untuk mengevaluasi gejala infeksi HIV dan efek samping pengobatan yang dapat digunakan dalam pengaturan rawat jalan. Pengukuran gejala objektif penting karena berkorelasi dengan kepatuhan pengobatan dan progresifitas penyakit.Objektif. Untuk menilai keandalan Indeks Gejala HIV versi Indonesia untuk mengukur gejala pasien HIV / AIDS, dan mengetahui profil gejala / pola pasien HIV / AIDS di Indonesia menggunakan Indeks Gejala HIV.Metode. Ini adalah studi cross sectional pada subyek HIV / AIDS rawat jalan. Subjek direkrut secara acak di klinik HIV Rumah Sakit Cipto Mangunkusumo dari September hingga November 2018. Penilaian reliabilitas onaire Questi dilakukan pada 20 subjek, dan evaluasi gejala dilakukan pada 87 subjek. Adaptasi bahasa dari versi bahasa Inggris asli ke bahasa Indonesia dilakukan dengan metode Beaton dan Guillemin. Realibility dari versi Indonesia Indeks Gejala HIV diuji dengan alpha cronbach adalah analisis koefisien, dan validitas internal itu diuji dengan multitrait analisis skala. Indeks Gejala HIV versi Indonesia yang valid dan andal kemudian digunakan untuk membuat profil pola gejala pasien HIV / AIDS di Rumah Sakit Cipto Mangunkusumo .Hasil. Indeks Gejala HIV versi Indonesia dapat diandalkan ( cronbach alpha 0,76) dan valid ( korelasi multitrait > 0,4) untuk mengukur gejala pasien HIV / AIDS. Gejala yang paling umum adalah kelelahan (55,7%), diikuti oleh insomnia (43,3%), pusing dan pusing (42,3%), masalah kulit (42,3%), dan nyeri, mati rasa, atau kesemutan di tangan atau kaki (39,2%). Keluhan paling jarang adalah demam (15,5%), batuk (20,6%), mual atau muntah (20,6%), diare (21,6%), dan kehilangan nafsu makan (23,7%).Kesimpulan. Indeks gejala HIV versi Indonesia dapat diandalkan dan valid untuk mengukur gejala pasien HIV / AIDS secara objektif. Gejala yang paling sering adalah kelelahan atau kelemahan, pusing atau sakit kepala ringan, susah tidur, masalah kulit, dan nyeri, mati rasa, atau kesemutan di tangan atau kaki.

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Backgrounds. HIV/AIDS is a chronic disease with a wide clinical spectrum which needs a long life treatment, and could decrease quality of life. There is yet a simple tool to evaluate symptoms of HIV infection and treatment s side effect that can be used in outpatient setting. Objective symptoms measurement is important because it is correlated to treatment adherence and progressivity of the disease.

Objective. To assess reliability of Indonesian version of HIV Symptom Index for measuring symptoms of HIV/AIDS patients, and knowing the symptom profile/pattern of HIV/AIDS patients in Indonesia using HIV Symptom Index.

Method. It is a cross sectional study in outpatient HIV/AIDS subjects. Subjects are recruited randomly in Cipto Mangunkusumo Hospital s HIV clinic from September until November 2018. Questionaire reliability assessment was done on 20 subjects, and symptom evaluation is done on 87 subjects. Language adaptation from the original english version into Indonesian was done with Beaton and Guillemin method. Realibility of Indonesian version of HIV Symptom Index was tested by alpha cronbach s a coefficient analysis, and the internal validity was tested with multitrait scaling analysis. The Valid and reliable Indonesian version of HIV Symptom Index is then used to profile the symptom pattern of HIV/AIDS patients in Cipto Mangunkusumo Hospital.

Result. Indonesian version of HIV Symptom Index is reliable (cronbach alpha 0,76) and valid (multitrait correlation >0,4) to measure symptoms of HIV/AIDS patients. The most common symptom is fatigue (55,7%), followed by insomnia (43,3%), dizziness and lightheaded (42.3%), skin problems (42,3%), and pain, numbness, or tingling in the hands or feet (39,2%). The rarest symptoms are fever (15,5%), cough (20,6%), nausea or vomiting (20,6%), diarrhea (21,6%), and lost of appetite (23,7%).

Conclusion. Indonesian version of HIV symptom Index is reliable and valid to measure symptoms of HIV/AIDS patiens objectively. Most frequent symotoms are fatigue or weakness, dizzines or lightheaded, insomnia, skin problems, and pain, numbness, or tingling in the hands or feet."

"[ABSTRAKLatar Belakang. Penderita HIV/AIDS di Indonesia semakin meningkat, sedangkan infeksi HIV/AIDS maupun terapi ARV dapat menyebabkan penurunan kadar testosteron yang sangat memengaruhi kualitas hidup penyandang HIV/AIDS. Gejala dan tanda penurunan kadar testosteron pada pria dengan HIV sangat tidak spesifik, sedangkan pemeriksaan laboratorium sangat mahal, sehingga perlu diketahui faktor-faktor pada pasien yang dapat memprediksi penurunan kadar testosteron.Tujuan. Mengetahui apakah jumlah CD4 awal, lamanya terapi ARV, jenis ARV, lipodistrofi dan besarnya lingkar pinggang memengaruhi kadar testosteron bebas pada pria dengan HIV yang mendapat ARV.Metode. Penelitian potong lintang dilakukan pada bulan Maret 2015 di Unit Pelayanan HIV Terpadu RSCM, Jakarta. Subjek adalah pria dengan HIV berusia 18-40 tahun, mendapat ARV teratur sekurangnya dalam 1 tahun terakhir. Pemeriksaan meliputi anamnesis, pengukuran lingkar pinggang dan lipodistrofi, pemeriksaan kadar testosteron total, SHBG dan testosteron bebas (Free Testosteron Index: FTi). Uji regresi linier digunakan untuk menilai faktor-faktor yang berhubungan dengan kadar testosteron bebas pada penelitian ini.Hasil. Dari 54 subjek, didapatkan median usia 35,11 tahun (21-40), median lamanya ARV 59 bulan (16-129), median CD4 awal 57/mm3 (3-443), rerata lingkar pinggang 82,4cm (SB 10,33). Subjek yang mengalami lipodistrofi sebanyak 17 orang (32%). Subjek yang menggunakan ARV lini pertama 48 orang. Median kadar testosteron bebas 30,87% (9,78-85,64) dan subjek yang memiliki kadar testosteron bebas rendah sebanyak 32 orang(59%). Terdapatnya lipodistrofi (p=0,003, OR= -12,25) dan lamanya menggunakan ARV (p=0,002, OR=-0,182) berhubungan dengan kadar testosteron bebas pada penelitian ini.Simpulan : Pada pria dengan HIV yang mendapat terapi ARV, adanya lipodistrofi dan lamanya terapi ARV berhubungan dengan kadar testosteron bebas. Kadar CD4 awal, jenis ARV dan lingkar pinggang tidak berhubungan dengan kadar testosteron bebas.

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ABSTRACTBackground. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.;Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels., Background. There are increasing numbers of people living with HIV/AIDS in Indonesia. HIV/AIDS infection could cause a decrease in testosterone level which affect patients? quality of life. Symptoms of decreasing testosterone level in HIV infected male are very unspecific, while laboratory tests are costly. Therefore it is important to know factors that could predict a decrease in HIV patient?s testosterone level.Purpose. To know the correlation between initial CD4 count, duration and type of ARV, lipodystrophy, size of waist circumference with free testosterone level of HIV infected male on ARV.Method. A cross-sectional study was conducted March 2015 in HIV Integrated Clinic, RSCM, Jakarta. The subjects were 18-40 years old, got regular ARV therapy for at least 1 year. Examination includes measuring waist circumference, presence of lipodystrophy, examination of total testosterone, SHBG and free testosterone level (Free Testosterone Index:FTi). Linear regression used to analyze factors associated with free testosterone level in this study.Results. Of 54 subjects examined, the median age was 35.11 years (21-40), median duration of antiretroviral therapy was 59 months (16-129), mean of waist circumference was 82.4 cm (SB 10.33), median of initial CD4 level was 57/mm3 (3-443). Total subjects with lipodystrophy were 17 subjects (32%), subjects who used first-line combination were 48 and 6 subjects used a second line combination. Median level of free testosterone levels was 30.87% (9.78-85.64) and there were 32 subjects with a low free testosterone level (59%). The presence of lipodystrophy (p=0,003, OR=-12,225) and duration of antiretroviral therapy (p=0,002, OR=-0,182) are associated with free testosterone level.Conclusions. Among HIV infected male who receiving antiretroviral therapy, the presence of lipodystrophy and duration of antiretroviral therapy are associated with free testosterone levels. There were no association between initial CD4 count, type of antiretroviral therapy and waist circumference with free testosterone levels.]"

"Kepatuhan terapi ARV adalah hal terpenting bagi penderita HIV agar keberhasilan manajemen terapi dapat tercapai, dimana dapat dipengaruhi beberapa faktor diantaranya sosiodemografi (usia, jenis kelamin, tingkat pendidikan, dan pekerjaan), tingkat pengetahuan HIV, dan pengetahuan ARV. Penelitian ini bertujuan untuk mengetahui faktor yang berpengaruh terhadap kepatuhan terapi ARV pada penderita HIV/AIDS. Menggunakan cross sectional, analisa data menggunakan uji chi-square, pada 90 responden penderita HIV yang mengkonsumsi ARV di Kota Depok.Hasil penelitian ini menunjukkan faktor-faktor yang berhubungan dengan kepatuhan terapi ARV diantaranya Usia (p: 0,000 , α: 0,05), Tingkat pendidikan (p: 0,000 , α: 0,05), Pengetahuan HIV (p: 0,000 , α: 0,05), dan Pengetahuan ARV (p: 0,006 , α: 0,05). Sementara jenis kelamin (p: 0,729 , α: 0,05),dan Pekerjaan (p: 0,119 , α: 0,05) tidak berhubungan.

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The adherence towards ARV therapy plays the most important role for HIV infected patients in order to achieve successful management of therapy, which various factors are presumed to affect such as sociodemographic factors (age, sex, education, and occupation), knowledge HIV and ARV. This research is conducted to find out the factors, which are affecting the obedience of the HIV infected people toward ARV therapy. The criss sectional design is used in the research, to analyze data , the author uses chi-square consecutive sampling and total samples from 90 correspondents, HIV infected patients who are currently consuming ARV in Depok.

The result of the research condusted in this thesis shows factors associated with adherence toward ARV therapy among age (p: 0,000 , α: 0,05), education (p: 0,000 , α: 0,05), knowledge HIV (p: 0,000 , α: 0,05), and knowledge ARV (p: 0,006 , α: 0,05). While sex (p: 0,729 , α: 0,05), and occupation (p: 0,119 , α: 0,05) are not associated."

"Latar belakang: Terapi kombinasi antiretroviral (ARV) telah meningkatkan angka harapan hidup pasien HIV. Koinfeksi HCV kemudian menjadi penyebab utama morbiditas dan mortalitas terkait hati pada pasien HIV dalam terapi ARV. Aktivasi imun residual dipikirkan berperan penting dalam kondisi ini. Beta-2 mikroglobulin sebagai penanda aktivasi imun kronik dan hubungannya dengan CD4, derajat fibrosis, dan kadar RNA VHC masih harus dieksplorasi pada kelompok pasien HIV-VHC. Metode: Sebanyak 64 pasien yang telah mengalami supresi HIV diikutsertakan pada penelitian ini: 37 pasien koinfeksi HIV-VHC dan 27 pasien HIV. Seluruh pasien koinfeksi belum mendapat terapi VHC. Kadar β2M plasma dianalisis dengan teknik ELISA. Derajat fibrosis diperiksa menggunakan transient elastography. Kadar CD4 dan RNA VHC diperoleh dari rekam medis dalam enam bulan terakhir. Perbedaan rerata β2M dianalisis dengan uji t independen. Korelasi β2M dengan CD4, RNA VHC, dan derajat fibrosis dinilai dengan uji Pearson atau Spearman. Hasil: Kadar plasma β2M didapatkan lebih tinggi pada pasien koinfeksi HIV-VHC (2,75 ± 0,8 mg/L) dibandingkan dengan monoinfeksi HIV (1,93 ± 0,95 mg/L, p <0,001 dan IK95% 0, 37-1,25). Tidak ditemukan korelasi signifikan antara β2M dengan kadar CD4, derajat fibrosis, dan RNA VHC. Kesimpulan: Pasien koinfeksi HIV-VHC dalam terapi ARV menunjukkan derajat aktivasi imun residual yang lebih tinggi dibandingkan HIV monoinfeksi.

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Background: Introduction of combined antiretroviral therapy (cART) has improved life expectancy of HIV infected individuals. HCV coinfection then becomes the main cause of liver-related morbidity and mortality. Residual immune activation may play an important role. The level of beta-2 microglobulin as an immune activation marker and its associations with CD4, fibrosis stage, and HCV RNA remain to be explored in HIV/HCV coinfection. Methods: A total of 64 patients having supressed HIV viral load were included: 37 patients with HIV/HCV coinfection and 27 HIV patients. All coinfected patients were naïve to HCV treatment. Plasma levels of β2M were analyzed using ELISA. The fibrosis stage was determined using transient elastography. CD4, HCV RNA levels were obtained from medical records within the last six months. The mean difference of β2M was analyzed using independent t-test. β2M correlations with CD4, HCV RNA, and fibrosis degree were assessed by Pearson or Spearman test. Results: The levels of plasma β2M were higher in HIV/HCV coinfected patients (2.75 ± 0.8 mg/L) compared to HIV monoinfection (1.93 ± 0.95 mg/L, p < 0.001 and 95CI 0.37-1.25). There were no significant correlations of β2M with CD4 level, fibrosis stage, and HCV RNA. Conclusion: HIV/HCV coinfected patients on ART show a higher level of residual immune activation compared to HIV patients."