Hasil Pencarian  ::  Simpan CSV :: Kembali

"Background. Metformin is the first-line oral antidiabetic agent used in the treatment of diabetes mellitus. One of the adverse reactions of the long term use of metformin is cobalamin malabsorption. Clinical and laboratory findings are important in the diagnosis of cobalamin deficiency.Objective. This study aimed to evaluate the risk of cobalamin deficiency symptoms related to long-term use of metformin in type 2 diabetes mellitus patients at Pasar Rebo General Hospital in Jakarta.Setting. This quantitative, observational study with retrospective cohort design was conducted in outpatient department Pasar Rebo General Hospital November 2015 until January 2016.Methods. 200 subjects were recruited and divided into two groups, patients who had been taking metformin for 1-3 years and patients who had been taking metformin for more than 3 years. Each patient was assessed for thepresence of cobalamin deficiency symptoms. Main outcome measure. Cobalamin deficiency symptoms evaluated were symptoms of neuropathy(measured by DN4 questionnaire) and hematologic abnormalities associated to cobalamin deficiency, i.e. macrocytic erythrocyte, hypersegmented neutrophils, and giant bands.Results. There are significant differences in the proportions of neuropathy symptoms (RR 2.36, 95%, p=0.000) and hematologic abnormalities (RR 1.5, 95%, p=0.007) between the two groups.Conclusions. Long-term use of metformin (≥3 years) may increase the risk of cobalamin deficiency symptoms in type 2 diabetes mellitus patients."

"[ABSTRAKLatar Belakang : Sindrom frailty berkaitan dengan angka morbiditas dankematian yang lebih tinggi, sehingga dipakai sebagai prediktor kesehatan padaorang usia lanjut (usila). Polifarmasi sebagai salah satu faktor risiko sindromfrailty, dapat berkaitan dengan obat PPI yang sering diberikan pada usila, atasindikasi adanya keluhan gangguan saluran cerna bagian atas. Sampai saat inibelum ada penelitian yang mempelajari hubungan PPI jangka panjang dansindrom frailty pada usila. Penelitian ini diharapkan dapat memberikan datamengenai penggunaan PPI jangka panjang (≥ 6 bulan) terhadap risiko sindromfrailty pada usila.Metode : Desain studi kasus kontrol dengan kriteria inklusi subjek penelitian 60tahun ke atas dan berstatus kognitif baik. Kriteria ekslusi adalah data yg tidaklengkap atau terdapat kontraindikasi PPI. Kasus adalah usila terdiagnosis Frailtymenurut FI-40 item dan kontrol adalah usila yang tidak frailty berdasarkaninstrumen yang sama. Pengambilan data primer termasuk status frailty telahdilakukan bulan Maret-Juni 2013 oleh Seto E dan Sumantri S. Pengambilan datasekunder yang digunakan pada penelitian ini dilakukan pada bulan Oktober-November 2014 dari data primer tersebut, ditambah dengan data dari rekam medispoliklinik Geriatri dan poliklinik diabetes RS Cipto Mangunkusumo.Hasil : Didapatkan 225 subjek (75 kasus:150 kontrol), 59,6% berjenis kelaminperempuan (rerata usia 72,14 tahun; simpang baku ± 6,4 tathun) dan 47,1%berpendidikan tinggi. Subjek yang berpendidikan rendah, berstatus cerai mati,berstatus nutrisi lebih buruk, tidak mandiri, memerlukan caregiver, hidup tidakberkecukupan dan kondisi kesehatan yang lebih buruk lebih banyak didapatkanpada kelompok frailty dibandingkan kelompok yang tidak frail. Proporsipengguna PPI Jangka Panjang sebesar 40,9%. Penggunaan PPI jangka panjangmeningkatkan risiko sindrom frailty (Crude OR 2,15; IK 95% 1,22-3,78; p<0,007)dengan adjusted OR 1,83 (IK 1,0-3,36) terhadap variabel nutrisi dan merokok.Kesimpulan : Penggunaan PPI jangka panjang (≥ 6 bulan) secara independenmeningkatkan salah satu risiko sindrom frailty pada usila.

---

ABSTRACTBackground: Frailty syndrome as being used as the newest elderly healthpredictor, associated with higher morbidity and mortality. PPI are often used inelderly due to presence of upper gastrointestinal complaints, and related withpolypharmacy as one of the risk factor for frailty syndrome. No study has studiedthe relationship of long term PPI and frailty syndrome in elderly. The objective ofthe study is to find whether long term use of PPI (≥ 6 months) would increase therisk of frailty syndrome in the elderly.Methods: A case control study includes subjects 60 years and above with goodcognitive status. All subject with history of hypersensitivity of PPI is excluded.Elderly diagnosed as frailty based in FI-40 item is defined as cases, whileindividuals that are not frailty are classified as the control. Primary data(included frailty status) was collected on March-June 2013 by Seto E andSumantri S, et al. Secondary data used in the current study was gathered onOctober-November 2014, from the primary data above and from the medicalrecord taken from geriatric and diabetic outpatient clinics Cipto MangunkusumoHospital.Result: There were 225 subjects collected (75 cases : 150 controls), 59,6% werefemale (mean age 72,14 years old, SD ± 6,4 years) and 47,1% with highereducation. Lower education, divorced, poor nutrition, dependent, neededcaregiver, economicaly insufficient, more comorbidity and poor health conditionare seen in frailty group.The proportion of long term PPI use were 40,9%. Longterm PPI medication increase the risk of frailty syndrome (Crude OR 2,154; CI95% 1,225-3,778; p<0,007) with adjusted OR 1,83 (CI 95% 1,02-3,37) afteradjusting to nutrition and smoking variables.Conclusion: Long term use of PPI significantly increase the risk of frailtysyndrome compared to the non-users.;Background: Frailty syndrome as being used as the newest elderly healthpredictor, associated with higher morbidity and mortality. PPI are often used inelderly due to presence of upper gastrointestinal complaints, and related withpolypharmacy as one of the risk factor for frailty syndrome. No study has studiedthe relationship of long term PPI and frailty syndrome in elderly. The objective ofthe study is to find whether long term use of PPI (≥ 6 months) would increase therisk of frailty syndrome in the elderly.Methods: A case control study includes subjects 60 years and above with goodcognitive status. All subject with history of hypersensitivity of PPI is excluded.Elderly diagnosed as frailty based in FI-40 item is defined as cases, whileindividuals that are not frailty are classified as the control. Primary data(included frailty status) was collected on March-June 2013 by Seto E andSumantri S, et al. Secondary data used in the current study was gathered onOctober-November 2014, from the primary data above and from the medicalrecord taken from geriatric and diabetic outpatient clinics Cipto MangunkusumoHospital.Result: There were 225 subjects collected (75 cases : 150 controls), 59,6% werefemale (mean age 72,14 years old, SD ± 6,4 years) and 47,1% with highereducation. Lower education, divorced, poor nutrition, dependent, neededcaregiver, economicaly insufficient, more comorbidity and poor health conditionare seen in frailty group.The proportion of long term PPI use were 40,9%. Longterm PPI medication increase the risk of frailty syndrome (Crude OR 2,154; CI95% 1,225-3,778; p<0,007) with adjusted OR 1,83 (CI 95% 1,02-3,37) afteradjusting to nutrition and smoking variables.Conclusion: Long term use of PPI significantly increase the risk of frailtysyndrome compared to the non-users., Background: Frailty syndrome as being used as the newest elderly healthpredictor, associated with higher morbidity and mortality. PPI are often used inelderly due to presence of upper gastrointestinal complaints, and related withpolypharmacy as one of the risk factor for frailty syndrome. No study has studiedthe relationship of long term PPI and frailty syndrome in elderly. The objective ofthe study is to find whether long term use of PPI (≥ 6 months) would increase therisk of frailty syndrome in the elderly.Methods: A case control study includes subjects 60 years and above with goodcognitive status. All subject with history of hypersensitivity of PPI is excluded.Elderly diagnosed as frailty based in FI-40 item is defined as cases, whileindividuals that are not frailty are classified as the control. Primary data(included frailty status) was collected on March-June 2013 by Seto E andSumantri S, et al. Secondary data used in the current study was gathered onOctober-November 2014, from the primary data above and from the medicalrecord taken from geriatric and diabetic outpatient clinics Cipto MangunkusumoHospital.Result: There were 225 subjects collected (75 cases : 150 controls), 59,6% werefemale (mean age 72,14 years old, SD ± 6,4 years) and 47,1% with highereducation. Lower education, divorced, poor nutrition, dependent, neededcaregiver, economicaly insufficient, more comorbidity and poor health conditionare seen in frailty group.The proportion of long term PPI use were 40,9%. Longterm PPI medication increase the risk of frailty syndrome (Crude OR 2,154; CI95% 1,225-3,778; p<0,007) with adjusted OR 1,83 (CI 95% 1,02-3,37) afteradjusting to nutrition and smoking variables.Conclusion: Long term use of PPI significantly increase the risk of frailtysyndrome compared to the non-users.]"

"The authors evaluated the effect of a brief tailored smoking control intervention delivered during basic military training on tobacco use in a population of military personnel (N = 33,215). Participants were randomized to either a tobacco use intervention (smoking cessation, smokeless tobacco use cessation, or prevention depending on tobacco use history) or a health education control condition. Results indicated that smokers who received intervention were 1.16 (95% confidence interval [CI] = 1.04, 1.30) times (7-day point prevalence) and 1.23 (95% CI = 1.07, 1.41) times (continuous abstinence) more likely to be abstinent than controls from smoking cigarettes at the 1-year follow-up (p < .01); the cessation rate difference was 1.60% (31.09% vs. 29.49%) and 1.73% (15.47% vs. 13.74%) for point prevalence and continuous abstinence, respectively. Additionally, smokeless tobacco users were 1.33 (95% CI = 1.08, 1.63) times more likely than controls (p < .01) continuously abstinent at follow-up, an overall cessation rate difference of 5.44% (33.72% vs. 28.28%). The smoking prevention program had no impact on smoking initiation. These results suggest potential for large-scale tobacco control efforts."

"ABSTRAKArmed conflicts create drastic socioeconomic shocks that lead to land use and land cover changes in ways that are not yet well understood. Several studies have used satellite imagery to detect such changes during periods of conflict. However, there has been an insufficient examination of older conflicts before the 1970s. By examining older conflicts, we can examine the effects of conflict on land use and land cover over a long time span. This study reveals land use and land cover changes during the Second Indochina War (1960-75) and the wars immediate and long-term effects on land use and land cover by combining an analysis of aerial and satellite photographs with fieldwork. This study concludes that the war created an abnormal situation in which a large number of people from a different ethnic group came to live amongst the original inhabitants of the research site. This led to a unique farming landscape and vast areas of forest destruction. The study also reveals that forest destruction during the war was a significant milestone in the history of the vegetation of the research site, and the vegetative landscape has still not recovered to its prewar condition. These findings, as well as the results of previous research, suggest that we need to be more conscious of the effects of war on forest degradation in Laos."

"Summary: Overview: Now in its 6th Edition, ASSISTING IN LONG-TERM CARE is the complete learning solution for Certified Nursing Assistants! The user-friendly book delivers all required content to prepare you for the certification exam while developing career skills for long-term care and sub-acute hospital settings. Topics include professional communication, daily CNA responsibilities, residents' rights, nutrition and hydration, restorative care, resident mobility, and maintaining a safe environment - all according to federal OBRA standards for nursing home care. ASSISTING IN LONG-TERM CARE, 6th Edition also walks you through more than one hundred clinical procedures, detailing your role as a CNA in each. Available in hard copy and e-book formats, ASSISTING IN LONG-TERM CARE, 6th Edition's helpful study features include review questions and self-tests, icons that point out key material, and a robust package of interactive, supplemental learning tools."

"Tuberkulosis dan diabetes melitus telah menjadi double bourden of disease, sehingga diperlukan prediktor sebagai dasar deteksi dini tuberkulosis pada pasien diabetes. Tujuan penelitian ini untuk mengetahui apakah faktor risiko penyakit imunodefisiensi, penggunaan steroid jangka panjang dan riwayat vaksinasi BCG dapat digunakan sebagai prediktor DM-TB. Penelitian ini merupakan survey cross-sectional yang dilakukan di enam Puskesmas dan Diabetes Centre di Ternate. Sebanyak 92 pasien DM diskrining untuk pemeriksaan TB dan 31 pasien didiagnosis DM-TB. Dalam uji statistik, risiko penyakit imunodefisiensi dan vaksinasi BCG tidak signifikan berhubungan dengan kejadian DM-TB (p=0,981 dan p=0,524). Penggunaan steroid jangka panjang memberikan hasil yang signifikan(p=0,01).

---

Tuberculosis (TB) and diabetes melitus (DM) have become the double burden of diseases. Therefore, there is a need for predictor for early detection of tuberculosis in diabetic patients. The purpose of this study was to determine whether immunodeficiency disease risk factors, long-term steroid use and BCG vaccination can be used as a predictor in combination of DM-TB. This cross-sectional study was conducted in six public health centers and Diabetes Center in Ternate. Ninety two diabetic patients were screened for TB examination and 31 patients diagnosed with DM-TB. The risk of immunodeficiency diseases and BCG vaccination was not significantly associated with the incidence of DM-TB (p=0.981 and p=0.524). However, long-term use of steroids was significantly related (p=0.01)."

"Latar Belakang : Pasien Penyakit Ginjal Kronik (PGK) stadium 5 memerlukan terapi pengganti ginjal seperti hemodialisis. Pemasangan akses vaskular untuk hemodialisis pada tahap awal adalah melalui catheter double lumen (CDL) vena sentral. Posisi ujung distal kateter hemodialisis jangka panjang menjadi hal yang penting untuk efisiensi dialisis jangka panjang. Penelitian mengenai pengaruh posisi ujung kateter CDL terhadap kejadian disfungsi CDL jangka panjang belum banyak dilakukan, terutama di Indonesia. Metode: Penelitian ini bersifat retrospektif kohort dan dilaksanakan di RSUP Nasional Dr. Cipto Mangunkusumo Jakarta dan RS Hermina Bekasi selama bulan September hingga November 2023. Hasil: Terdapat 36 subjek penelitian yang memenuhi kriteria. Pasien gagal ginjal tahap akhir di RSUP Cipto Mangunkusumo Jakarta dan RS Hermina Bekasi sebagian besar terdiri dari perempuan (52,8%), kelompok usia >60 tahun (33,3%), memiliki lama patensi kateter ≥3 bulan (52,8%), letak ujung kateter pada cavoatrial junction (38,9%) dan mengalami disfungsi akibat terbentuknya fibrin sheath (68,3%). Terdapat korelasi derajat sedang yang tidak signifikan secara statistik antara letak ujung kateter dengan lama patensi kateter CDL jangka panjang kurang atau lebih dari 3 bulan (p=0,202). Terdapat korelasi derajat sedang yang tidak signifikan secara statistik antara letak ujung kateter dengan penyebab terjadinya disfungsi kateter CDL yaitu fibrin sheath, trombosis, atau stenosis (p=0,209). Kesimpulan: Penelitian ini menemukan bahwa korelasi antara letak ujung kateter dengan lama patensi CDL jangka panjang atau penyebab terjadinya disfungsi kateter CDL jangka panjang tidak signifikan secara statistik.

---

Background: Chronic Kidney Disease (CKD) stage 5 patients require renal replacement therapy such as hemodialysis. The initial vascular access for hemodialysis is through a central venous double lumen (CDL) catheter. The distal tip position of the long-term hemodialysis catheter is important for long-term dialysis efficiency. Research on the effect of CDL catheter tip position on the incidence of long-term CDL dysfunction has not been widely conducted, especially in Indonesia. Method: This retrospective cohort study was conducted at Dr. Cipto Mangunkusumo National Hospital Jakarta and Hermina Hospital Bekasi from September to November 2023. Results: There were 36 research subjects who met the criteria. Patients with end-stage renal failure at Cipto Mangunkusumo National Hospital Jakarta and Hermina Bekasi Hospital were mostly female (52.8%), aged >60 years (33.3%), had catheter patency ≥3 months (52.8%), catheter tip location at cavoatrial junction (38.9%) and experienced dysfunction due to fibrin sheath formation (68.3%). There was a statistically insignificant moderate correlation between the location of the catheter tip and the duration of long-term CDL catheter patency of less or more than 3 months (p=0.202). There was a statistically insignificant moderate correlation between the location of the catheter tip and the causes of CDL catheter dysfunction, namely fibrin sheath, thrombosis, or stenosis (p=0.209). Conclusion: This study found that the correlation between catheter tip location and the length of long-term CDL patency or the cause of long-term CDL catheter dysfunction was not statistically significant.

"

"In this volume, leading field workers report on the history and infrastructure of their projects in Madagascar, Africa, Asia and South America. More importantly, they provide summaries of their long-term research efforts on primate behaviour, ecology and life history, highlighting insights that were only possible because of the long-term nature of the study. The chapters of this volume collectively outline the many scientific reasons for studying primate behaviour, ecology and demography over multiple generations. "