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Caroline Gladys Puspita
"ABSTRAK
Kejadian inkontinensia alvi pasca salin di Asia lebih rendah dibandingkan di Afrika
maupun Eropa. Primipara diketahui lebih sulit menghadapi gangguan ini sehingga
ikatan Ibu dengan bayi berkurang, kesejahteraan bayi baru lahir menurun hingga terjadi
pembatasan interaksi sosial dan depresi. Faktor-faktor yang mempengaruhi
inkontinensia alvi pasca salin multifaktorial dan bersifat kontroversial, antara lain;
indeks massa tubuh, cara persalinan, durasi kala dua, berat lahir bayi, episiotomi, dan
cedera sfingter ani. Akan tetapi, data maupun faktor-faktor yang mempengaruhi
inkontinensia alvi pasca salin belum terekam dengan baik di Indonesia. Tujuan
penelitian ini adalah untuk mengetahui insidens inkontinensia alvi pada primipara dan
faktor-faktor yang mempengaruhi saat persalinan serta menentukan kemungkinan
terjadinya inkontinensia alvi pasca salin. Penelitian kohort prospektif ini dilakukan di
rumah sakit dr. Cipto Mangunkusumo, Jakarta pada primipara yang bersalin sejak
Januari hingga Desember 2017. Sebanyak 279 perempuan dengan kehamilan tunggal
dan cukup bulan diikuti dan dinilai kejadian inkontinensia alvi menggunakan kuesioner
Wexner pada enam minggu dan tiga bulan pasca salin. Insidens inkontinensia alvi
sebesar 4.3 persen pada enam minggu dan menurun menjadi 2.5 persen pada tiga bulan pasca
salin. Berat lahir ≥ 3.097,5 gram (p=0,033; RR=6,5, IK95 persen 1,19-19,76), persalinan
dengan alat (p= 0,01; RR=6,5; IK95 persen 1,96-24,99), dan cedera sfingter ani (p kurang dari 0,001;
RR=58,50; IK95 persen 10,6-322,48) memiliki peran terhadap inkontinensia alvi pasca salin.
Sebaliknya, indeks massa tubuh, episiotomi dandurasi kala dua tidak mempengaruhi.
Kemungkinan terjadinya inkotinensia alvi pasca salin dibagi menjadi rendah (0,67 persen-4,44 persen), sedang (20,15 persen-26,12 persen) dan tinggi (65,77 persen-92,97 persen) bergantung dari tiga
variabel yang berperan tersebut. Inkontinensia alvi pasca salin pada primipara sebesar
4.3 persen akan menurun pada tiga bulan pasca salin. Cedera sfingter ani, persalinan
pervagina, dengan alat dan berat lahir lebih dari 3097,5 gram merupakan faktor yang
dapat digunakan untuk menentukan kemungkinan terjadinya inkontinensia alvi."
Fakultas Kedokteran Universitas Indonesia, 2018
S70368
UI - Skripsi Membership  Universitas Indonesia Library
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Elisia
"ABSTRAK
Latar belakang: Tesis ini bertujuan untuk mengetahui insidens retensio urin
pasca rekonstruksi POP dan faktor-faktor yang berhubungan.Retensio urin
merupakan komplikasi akut tindakan rekonstruksi dan banyak dijumpai pada
prosedur operasi, termasuk operasi POP (POP). Untuk menghindari morbiditas
lebih lanjut, penelitian ini bertujuan untuk mengetahui insidens rertensio urin
pasca rekonstruksi POP faktor-faktor risiko yang berhubungan.
Metode: Penelitian ini adalah penelitian kohort prospektif yang dilaksanakan di
RS Cipto Mangunkusumo dan RS Fatmawati dengan mengikutsertakan wanita
yang hendak mengalami rekonstruksi POP dalam rentang waktu April 2013
hingga April 2015. Kriteria inklusi dan eksklusi subjek meliputi wanita dengan
POP derajat 2,3 dan 4 tanpa riwayat retensio urin sebelumnya, konsumsi obatobatan
yang
dapat menyebabkan retensio urin dan tanpa cedera kandung kemih.
Pasca rekonstruksi, subjek dilakukan pemasangan kateter urin selama 24 jam.
Kemudian, enam jam pasca pelesapan kateter, dilakukan pengukuran residu urin
pada kandung kemih. Retensio urin didefinisikan dengan didapatkannya residu
urin >100 ml.
Hasil: Dari 200 subjek, ditemukan 59 subjek (29,5%) mengalami retensio urin.
Tidak ada hubungan antara faktor risiko umur, Indeks Massa Tubuh (IMT),
derajat POP, derajat sistokel, kejadian infeksi saluran kemih, dan durasi operasi
terhadap retensio urin. Jenis prosedur total vagina hysterectomy + kolporafi
anterior + kolpoperineorafi + sacrospinous fixation dan durasi operasi > 130
menit berhubungan dengan retensio urin dengan RR 3,66 95% IK 2,91-4,60
p<0,001 dan 1,66 95%IK 1,07-2,59 p=0,02, berturut-turut
Kesimpulan: Insidens retensio urin cukup tinggi pasca rekonstruksi POP. Jenis
tindakan rekonstruksi tertentu dan semakin lamanya durasi rekonstruksi
berhubungan dengan kejadian retensio urin.ABSTRACT
Background: The objective of this study was to know the incidence of post
operativeurinaryretention after pelvic organ prolapse surgery and associated
factors.Post operative urinary retention (POUR) is considered as an acute
complication after a surgey in many operative procedures, including pelvic organ
prolpase (POP) surgery. To avoid further morbidity, this study aimed to know the
incidence of POUR after POP surgery and its risk factors.
Methods: This is a prospective cohort study conducted in Cipto Mangunkusumo
hospital and Fatmawati Hospital from April 2013 to April 2015. Subjects were
women who wanted to undergo POP surgery with two to four degree of POP.
Subjects with history of urinary retention, drugs consumption that tend to cause
urinary retention or bladder unjury were excluded. After the reconstruction,
urinary catheter was placed for 24 hours. Then, after six hours, catheter was
removed and residual urine was measured. Urinary retention was defined as
residual urine more than 100 ml.
Results: Of 200 subjects recruited, 59 (29.5%) had POUR. There were no
association between age, body mass index, degree of uterine POPe, degree of
cystocele, urinary tract infectionand POUR. Duration of surgery > 130 minute and
Total vagina hysterectomy +anterior colporraphy + colpoperineorraphy +
sacrospinous fixation procedure and duration of surgery > 130 minute were
associated with POUR (RR 3.66, 2.91-4.60 95% CI, p<0.001 and 1.66 , 072.5995%CI,
p=0.02;
respectively)
Conclusion: POUR incidence after POP surgery was quite high. Type of the
procedure and duration of surgery were associated with POUR.
;Background: The objective of this study was to know the incidence of post
operativeurinaryretention after pelvic organ prolapse surgery and associated
factors.Post operative urinary retention (POUR) is considered as an acute
complication after a surgey in many operative procedures, including pelvic organ
prolpase (POP) surgery. To avoid further morbidity, this study aimed to know the
incidence of POUR after POP surgery and its risk factors.
Methods: This is a prospective cohort study conducted in Cipto Mangunkusumo
hospital and Fatmawati Hospital from April 2013 to April 2015. Subjects were
women who wanted to undergo POP surgery with two to four degree of POP.
Subjects with history of urinary retention, drugs consumption that tend to cause
urinary retention or bladder unjury were excluded. After the reconstruction,
urinary catheter was placed for 24 hours. Then, after six hours, catheter was
removed and residual urine was measured. Urinary retention was defined as
residual urine more than 100 ml.
Results: Of 200 subjects recruited, 59 (29.5%) had POUR. There were no
association between age, body mass index, degree of uterine POPe, degree of
cystocele, urinary tract infectionand POUR. Duration of surgery > 130 minute and
Total vagina hysterectomy +anterior colporraphy + colpoperineorraphy +
sacrospinous fixation procedure and duration of surgery > 130 minute were
associated with POUR (RR 3.66, 2.91-4.60 95% CI, p<0.001 and 1.66 , 072.5995%CI,
p=0.02;
respectively)
Conclusion: POUR incidence after POP surgery was quite high. Type of the
procedure and duration of surgery were associated with POUR.
;Background: The objective of this study was to know the incidence of post
operativeurinaryretention after pelvic organ prolapse surgery and associated
factors.Post operative urinary retention (POUR) is considered as an acute
complication after a surgey in many operative procedures, including pelvic organ
prolpase (POP) surgery. To avoid further morbidity, this study aimed to know the
incidence of POUR after POP surgery and its risk factors.
Methods: This is a prospective cohort study conducted in Cipto Mangunkusumo
hospital and Fatmawati Hospital from April 2013 to April 2015. Subjects were
women who wanted to undergo POP surgery with two to four degree of POP.
Subjects with history of urinary retention, drugs consumption that tend to cause
urinary retention or bladder unjury were excluded. After the reconstruction,
urinary catheter was placed for 24 hours. Then, after six hours, catheter was
removed and residual urine was measured. Urinary retention was defined as
residual urine more than 100 ml.
Results: Of 200 subjects recruited, 59 (29.5%) had POUR. There were no
association between age, body mass index, degree of uterine POPe, degree of
cystocele, urinary tract infectionand POUR. Duration of surgery > 130 minute and
Total vagina hysterectomy +anterior colporraphy + colpoperineorraphy +
sacrospinous fixation procedure and duration of surgery > 130 minute were
associated with POUR (RR 3.66, 2.91-4.60 95% CI, p<0.001 and 1.66 , 072.5995%CI,
p=0.02;
respectively)
Conclusion: POUR incidence after POP surgery was quite high. Type of the
procedure and duration of surgery were associated with POUR.
"
Fakultas Kedokteran Universitas Indonesia, 2015
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Napitupulu, Laresi Indah Sonata BR
"Latar belakang: Salah satu masalah perempuan dengan epilepsi (PDE) saat ini adalah infertilitas. Prevalensinya sendiri mencapai sepertiga dari PDE. Penelitian ini bertujuan untuk mengentahui faktor-faktor apa saja yang memengaruhi kejadian infertilitas, khususnya pada populasi PDE di RS Cipto Manungkusumo (RSCM).
Metode Penelitian: Studi potong lintang pada pasien PDE rawat jalan di poli epilepsi, dilakukan telusur rekam mendis dan pengisian kuesioner. Analisis bivariat menggunakan uji Chi Square dan Mann Whitney, dilanjutkan dengan analisis multivariat regresi logistik.
Hasil: Prevalensi PDE yang mengalami infertilitas di RSCM ada 51,1% dengan usia rata-rata 35,57 ± 5,53 tahun. Disfungsi seksual (p=0,020), gangguan orgasme (p=0,042) dan gangguan nyeri seksual (p=0,005) berhubungan dengan kejadian infertilitas pada PDE. Pada analisis multivariat regresi logistik, tidak didapatkan adanya faktor independen yang memengaruhi kejadian infertilitas pada PDE.
Kesimpulan: Prevalensi infertilitas pada PDE di RSCM cukup besar yakni 51,1%. Faktor yang memengaruhinya adalah disfungsi seksual, gangguan orgasme dan nyeri seksual. Oleh karena itu, penting bagi klinis untuk mendeteksi dini faktor-faktor tersebut pada PDE untuk mencegah dampak lebih lanjut yang dapat ditimbulkan.

Background: Infertility is one of the issues facing women with epilepsy (WWE) today. Its prevalence alone reaches one-third of WWE. The purpose of this study is ti determine what variables affect the prevalence of infertility, particularly in the group of WWE at Cipto Mangunkusumo Hospital (RSCM)
Method: Outpatient WWE at epilepsy clinic were the subject of this cross-sectional study. A questionnaire was completed and medical records were searched. Chi square and Mann Whitney tests were employed in bivariate analysis before multivariate logistic regression analysis.
Results: In our study, the prevalence of WWE with infertility is 51,1%, and their average age is 35,57 ± 5,53 years old. Sexual dysfunction, orgasmic disorders and sexual pain disorders are associated with infertility in WWE. There were no independent factors affecting the infertility in WWE in multivariate logistic regression study.
Conclusion: 51,1% of WWE at RSCM are infertile, which is a significant prevalence. Sexual dysfunction, orgasmic disorders, and sexual pain are all factors that might affect it. In order to limit any negative effects such as infertility, it is crucial for clinicians to detect these factors early in WWE.
"
Depok: Fakultas Kedokteran Universitas Indonesia, 2023
T-pdf
UI - Tesis Membership  Universitas Indonesia Library
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Fenny D`Silva
"Latar belakang. Transplantasi hati merupakan terapi definitif untuk penyakit hati tahap akhir baik pada dewasa maupun anak. Beberapa dekade terakhir, kemajuan dalam teknik bedah, perservasi, terapi imunosupresif, pemantauan dan pengobatan infeksi telah meningkatkan keberhasilan transplantasi hati. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang memengaruhi kesintasan satu tahun pasien dan graft pasca-transplantasi di Rumah Sakit Cipto Mangunkusumo.
Metode. Penelitian ini merupakan studi kohort retrospektif yang mengkarakterisasi pasien <18 tahun yang menjalani transplantasi hati selama periode tahun 2010 dan 2022. Sumber data melalui penelusuran rekam medis. Kurva Kaplan-Meier digunakan untuk menggambarkan kesintasan pasien dan graft. Analisis statistik bivariat dan multivariat dilakukan dengan menggunakan uji log-rank dan Cox’s proportional hazards. Nilai p <0,05 dianggap signifikan pada analisis multivariat.
Hasil. Sebanyak 55 pasien anak yang menjalani transplantasi hati; 50,9% adalah lelaki dengan rerata usia 16 bulan. Atresia bilier merupakan penyebab terbanyak dari penyakit hati kronis tahap akhir yang menjalani transplantasi hati. Kesintasan satu tahun secara keseluruhan adalah 85,5%. Berdasarkan hasil analisis multivariat, skor pediatric end-stage liver disease (PELD) ≥20 (p = 0,011) dan durasi operasi ≥16 jam (p = 0,002) merupakan faktor yang berhubungan dengan kesintasan pasien dan graft yang lebih rendah.
Kesimpulan. Pemantauan khusus direkomendasikan pada pasien anak dengan skor PELD tinggi yang menjalani transplantasi hati dan durasi operasi yang lebih lama untuk meningkatkan kesintasan pasien dan graft. Diperlukan penelitian lebih lanjut dengan ukuran sampel yang lebih besar untuk mendapatkan hasil yang signifikan terhadap kesintasan pasien dan graft.

Background. Liver transplantation is the treatment of choice for end-stage liver in both adults and children. The last few decades, progress in terms of surgical techniques, preservation, immunosuppressive therapy, monitoring and treatment of infection have improved survival of liver transplantation. This study aims to identify factors that influence one-year post-transplant patient and graft survival at Cipto Mangunkusumo General Hospital.
Methods. This is a retrospective cohort analysis characterizing patients transplanted between 2010 and 2022 included all recipients <18 years of age undergoing pediatric liver transplantation. Data sources included hospital medical records. Outcomes measures were overall patient and graft survival. Kaplan-Meier Curve is used to describe patient and graft survival. Bivariate and multivariate statistical analysis was undertaken using log-rank test and Cox’s proportional hazards model. A p value <0.05 was considered significant at the multivariate level.
Results. A total of 55 pediatric patients underwent liver transplantation; 50,9% were boys and median age was 16 months. Biliary atresia were the most common causes of liver disease. Overall 1-year survival rates were 85.5%. According to multivariate analysis, pediatric end-stage liver disease (PELD) score ≥20 (p = 0.011) and operative duration ≥16 hours (p = 0,002) were factors associated with worse patient and graft survival.
Conclusion. Greater caution is recommended in pediatric patients with high PELD score undergoing liver transplantation and longer operative duration to improve patient and graft survival. Further research is needed with larger sample size to obtain a significant impact on patient and graft survival.
"
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2022
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library
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Megawati
"Transplantasi ginjal TG merupakan salah satu terapi pilihan utama pada pasien Gagal Ginjal Terminal GGT . TG dapat meningkatkan kualitas hidup pasien GGT. Kualitas hidup dapat dipengaruhi oleh berbagai faktor, seperti faktor fisik, psikologis dan mental.
Tujuan penelitian ini adalah untuk mengetahui faktor- faktor yang mempengaruhi kualitas hidup pasien TG. Desain Penelitian menggunakan Cross Sectional Study, Sampel dalam penelitian ini berjumlah 110 pasien TG dengan tehnik pengambilan sampel menggunakan metode purposive sampling. Instrumen penelitan menggunakan kuesioner kualitas hidup WHOQoL ndash; BREF, yaitu kuesioner yang telah banyak digunakan dalam mengukur kualitas hidup di dunia dan secara validitas dan reabilitas merupakan kuesioner yang valid dan reliabel. Analisi data menggunakan: proporsi, chi- square dan regresi logistik ganda.
Hasil penelitian menunjukkan bahwa kualitas hidup pasien TG di RSUPN Dr. Cipto Mangunkusumo adalah baik 71, 8 . Faktor yang mempengaruhi kualitas hidup pasien adalah: usia p = 0,002 , pendidikan p = 0,001 pekerjaan p = 0,010 , dukungan keluarga p = 0,024 , dan kepatuhan pasien dalam mengkonsumsi obat immunosupressant p = 0,009 , faktor yang dominan mempengaruhi kualitas hidup adalah: pendidikan OR= 11, 490 dan kepatuhan dalam mengkonsumsi obat immunosuppressant OR= 10, 530.
Kesimpulan: Kualitas hidup pasien TG dipengaruhi oleh, usia, pendidikan, pekerjaan, dukungan keluarga dan kepatuhan pasien dalam mengkonsumsi obat immunosupressant Rekomendasi: Penelitian lebih lanjut terkait dimensi kualitas hidup: dimensi fisik, psikologis, hubungan sosial dan lingkungan dan pemberian intervensi keperawatan berupa edukasi sebelum dan sesudah TG.

Kidney transplantation KT is one of the major therapies in terminal renal failure. KT can increase Quality of Life QoL of the patients with terminal renal failure. QoL can be affected by several factors, such as physical, psychological and mental factors.
The aim of this research is to identify the factors that affects QoL of KT patients. The research design used Cross Sectional Study, with purposive sampling. The samples of study is 110 KT patients. The research instrument uses WHOQoL ndash BREF, instrument WHOQoL ndash BREF has been widely used in measuring the QoL in the world and the validity and reliability is a valid and reliable questionnaire. Data analysis uses proportion, chi square and multiple logistic regression.
The results of this research showed that the QoL of KT patients at General Hospital Cipto Mangunkusumo is good 71, 8 . The Factors influencing of the QoL of the patients were age, p 0,002, education p 0,001 occupation p 0,010 , family p 0,024 , and patient adherence to taking immunosuppressant drugs p 0,009.
Conclusions The QoL of patients affected by age, education, occupation, family and patient adherence to taking immunosuppressant drugs. Recommendations Further research related to the dimensions of the Qol with are physical, psychological, social and environmental dimensions and Intervention of Nursing through prre and post opertif education of KT."
Depok: Fakultas Ilmu Kperawatan Universitas Indonesia, 2018
T51501
UI - Tesis Membership  Universitas Indonesia Library
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Achmad Fahron
"Latar Belakang: Meningkatnva populasi usia laniut. masalah kesehatan pada kelompok usia tersebut juga meningkat. Salah satu masalah kesehatan vane sering dijumpai adalah inkontinensia urin tine sires (IUS). Beberapa nenelitian telah dilakukan untuk melihat faktor- faktor risiko terjadinva IUS, tetapi hasilnva tidak konsisten.
Tuiuan: Mengetahui hubungan antara usia, riwayat cara persalinan, jumlah persalinan lama menopause dan IMT dengan IUS pada perempuan usia laniut di RSCM Jakarta.
Metodologi: Disain penelitian potong-lintang. Subyek pada perempuan >60 tahun yang memenuhi kriteria inklusi. Inkontinensia Urin tine Sires dinilai dari anamnesis, pemeriksaan fisik serta pemeriksaan kontraksi vagina dengan nerineometri.
Hasil: Didapatkan hasil 35 kasus dan 47 kontrol. Subyek penelitian dengan usia >75 tahun didapatkan 8 (53.3%) IUS riwayat cara persalinan mengalami tindakan didapatkan 18 150.0%) IUS. jumlah persalinan lebih dari 2 kali didapatkan 30 (43,5%) IUS lama menopause lebih dari 7 tahun didapatkan 35 (45,5%) IUS, IMT ~ 26 didapatkan 14 (58.3%) IUS. Dilakukan analisis bivariat didapatkan hasil antara usia dan IUS dengan OR 1.69 (IK 95% 0.55 - 5.22).. antara riwavat cara persalinan dan IUS dengan OR 1,71 (TTY 95% 0.70 ? 4.14) antara iumlah persalinan dan MS dengan OR 1.23 (IK 95% 0.37 - 4.15). antara IMT > 26 dan IUS dengan OR 2.47 (IK 95% 0,93 - 6.52). Lama menopause tidak dapat dianalisis karena tidak didapatkan lama menopause < 7 tahun harus mengalami IUS. Seluruh variabel hasil analisis bivariat vane memiliki p mendekati 0.25 diikutsertakan dalam analisis multivariat. Setelah dilakukan analisis multivariat dengan regresi logistik didapatkan hanva IMT vane tampaknva berhubunsan denaan IUS (OR 2.9911K 95% 1.07-8.361)
Simpulan: Indeks massa tubuh merunakan faktor risiko teriadinva IUS.

Background: The increase of elderly nonulation leads to the increase of health problems among those who belongs to this population. Stress urinary incontinence (SUI) is one of many problems which is frequently found. Several studies have been carried out to detect risk factors for SUI. but the results were still inconsistent.
Objective: To assess the relationship between age. types of delivery. Parity, menopausal period, and BM1 with SU1 in elderly women at Cipto Mangunkusumo Hospital, Jakarta.
Method: A cross-sectional study of elderly women > 60 years who met the inclusion criteria. SUI was evaluated from interviews. physical examinations and vaginal contractions measured with a perineometer.
Results: This study comprised 35 cases and 47 controls. SUI were detected in 8 (53.3%) of subjects who were > 75 years, in 18 (50.0%) of those who had intervention during delivery. in 30 (43,5%) of those who had parity > 2. in 35 (45.5%) of those who had had menopause > 7 years. and in 14 (58.3%) of those with BMI > 26. Bivariate analyses were performed and the results are OR 1,69 (95% CI 0.55-5.22) between age and SUL _ OR 1.71 (95% CI 0.70 - 4.14) between tunes of delivery and SUL OR L23 (95% CI 0,37 - 4.15) between parity > 2 and SU1. OR 2.47 (95% CI 0,93 - 6.521 between BM1 > 26 and Slll, Menopausal period could not be analyzed because no subjects who had less than 7 year - period of menopause was found to have SUI. Variables which had p close to 0.25 in bivariate analyses were measured in multivariate analyses with logistic regression. Those variables were types of delivery and BMI. As a result BMI was the only variable which was related to SUI (OR 2.99[95% CI 1,07-8,36 ).
Conclusion: BM1 is a risk factor for SUI"
Depok: Universitas Indonesia, 2005
T21444
UI - Tesis Membership  Universitas Indonesia Library
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Dipdo Petrus Widjaya
"Latar Belakang : Pneumotoraks merupakan kasus kegawat daruratan yang harus ditatalaksana segera. Penilaian berbagai penyakit paru dan faktor-faktor penyebab secara tepat sangat penting diketahui sebagai panduan dalam kerjasama antardisiplin ilmu dan untuk meningkatkan penatalaksanaan pneumotoraks secara menyeluruh. Faktor risiko yang mempengaruhi kesintasan pasien pneumotoraks adalah usia dan infeksi HIV, namun data di Indonesia masih belum ada.
Tujuan : Untuk mengetahui karakteristik pasien pneumotoraks dan faktor-faktor yang mempengaruhi kesintasannya selama perawatan di RSCM.
Metode : Penelitian desain kohort retrospektif, dilakukan terhadap pasien pneumotoraks yang dirawat inap di RSCM pada kurun waktu Januari 2000 sampai Desember 2011. Kesintasan kumulatif selama 8 hari perawatan dan faktor yang mempengaruhi dianalisis secara bivariat dengan metode Kaplan Meier dan uji Log-rank serta analisis multivariat dengan Cox proportional hazard regression model untuk menghitung hazard ratio (HR) dan interval kepercayaan 95%.
Hasil : Seratus empat pasien pneumotoraks yang memenuhi kriteria penelitian ditemukan lebih banyak pada laki-laki 78(73,1%) dengan rerata usia 39,7(simpang baku[SB],16,2) tahun. Keluhan respirasi terbanyak berupa sesak napas 103(99%) dan kelainan pada pemeriksaan fisik hipersonor 101(97,1%). Foto polos toraks menunjukkan hiperlusen avaskular 95(91,4%). Faktor penyebab kejadian yang didapatkan adalah merokok 43(41,3%), pneumonia 42(40,3%), tuberkulosis 37(35,5%), trauma dada 13(12,5%), kejadian iatrogenik 6(5,7%), keganasan paru 6(5,7%), PPOK 5(4,8%), asma bronkiale 5(4,8%) dan artritis reumatoid 1(1%). Jenis pneumotoraks terbanyak adalah pneumotoraks spontan sekunder 49(47,1%). Tatalaksana sebagian besar dengan pemasangan WSD 98(94,2%). Keluaran pasien pneumotoraks hidup 69(66,3%), meninggal 35(33,7%). Penyebab kematian terbanyak pada pasien pneumotoraks saat perawatan adalah gagal napas 16(45,8%). Faktor-faktor yang memperburuk kesintasan pasien pneumotoraks adalah trauma dada (HR=3,49 (IK 95% 1,52;8,04)) dan tuberkulosis paru (HR=3,33 (IK 95% 1,39;7,99)).
Kesimpulan : Adanya tuberkulosis paru dan trauma dada memperburuk kesintasan pasien pneumotoraks selama perawatan di RSCM.

Background : Pneumothorax is an emergency case should be managed immediately. Assessment of lung diseases and the factors that cause pneumothorax is very important to know the proper guidelines in cooperation an interdisciplinary medical science and to improve the overall management of pneumothorax. Risk factors affecting the survival rate of pneumothorax patients are age and HIV infection, but there is no data in Indonesia.
Objective : The purpose of this study was to determine the characteristics of pneumothorax patients and factors affecting survival during hospitalization in RSCM.
Methods : Retrospective cohort study design conducted on pneumothorax patients who were admitted in RSCM in the period January 2000 to December 2011. Cumulative survival rate for 8 days of hospitalization and the factors affecting analyzed by bivariate with Kaplan Meier method and log-rank test and multivariate analysis by cox proportional hazard regression model to calculate hazard ratio (HR) and 95% confidence intervals.
Results : A total of 104 pneumothorax patients were reviewed. Their mean age was 39.7 years (SD ± 16.2 years) with a male to female ratio of 3:1. Commonest symtoms was shortness of breath 103(99%) and abnormalities on physical examination was hypersonor 101(97.1%). Plain chest X-ray showed hyperlucent avascular 95(91.4%).
Etiologic factors for the incidence of secondary pneumothorax were smoking 43(41.3%), pneumonia 42(40.3%), tuberculosis 37(35.5%), chest trauma 13(12.5%), iatrogenic 6(5.7%), lung malignancy 6(5.7%), COPD 5(4.8%), asthma 5(4.8%) and rheumatoid arthritis 1(1%). Commonest type of pneumothorax was secondary spontaneous pneumothorax 49(47.1%). Most of pneumothorax patients were successfully managed by chest thoracoscopy 98(94.2%). Outcome of pneumothorax patients were live 69(66.3%), died 35(33.7%). Causes of death in pneumothorax patients was respiratory failure 16(45.8%). Factors that worsen the survival rate of pneumothorax patients were chest trauma (HR = 3.49 (95% CI 1.52 to 8.04)) and pulmonary tuberculosis (HR = 3.33 (95% CI 1.39 to 7.99 )).
Conclusions : Factors that worsen the survival rate of pneumothorax patients were pulmonary tuberculosis and chest trauma that hospitalized in RSCM.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2013
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Glenda Angeline T.
"Latar belakang : Insiden sindrom pascakolesistektomi SPK di RS dr.Cipto Mangunkusumo RSCM pada tahun 2012 sebesar 54.29 , lebih tinggi daripada penelitian di negara lain.
Tujuan : Studi ini bertujuan mencari faktor risiko SPK untuk mengupayakan turunnya insiden SPK.
Metode : Dilakukan suatu studi cross-sectional terhadap subjek yang menjalani kolesistektomi pada periode Januari - Desember 2015.
Hasil : Total 112 pasien menjalani laparoskopik kolesistektomi. Insiden SPK didapatkan sebesar 45,5 . Pada analisis bivariat didapatkan hubungan signifikan antara SPK dengan lama keluhan praoperasi p=0,033, OR=2,29 , flatulens praoperasi p=0,000, OR=16,48 , gejala non-spesifik praoperasi p=0,000, OR=6,93 , persepsi pasien p=0,000, OR=5,723 . Pada analisis regresi logistik didapatkan flatulens praoperasi p=0,000, OR=17,152 , gejala non-spesifik praoperasi p=0,012, OR=3,984 dan persepsi pasien praoperasi p=0,003, OR=5,907 merupakan faktor risiko untuk SPK. Rerata lama observasi pascaoperasi adalah 14,95 bulan.
Kesimpulan : Tingginya angka SPK di RSCM akibat jumlah subjek dengan gejala praoperasi non-spesifik yang lebih tinggi, persepsi praoperasi yang buruk, dan perbedaan lama observasi pascaoperasi.

Background: Incidence of postcholecystectomy syndrome in Cipto Mangunkusumo Hospital at 2012 is 54.29 , higher than ever reported.
Objective: The objective of the study was to identify risk factors of PCS and decrease its incidence.
Method: A cross sectional study was performed enroll all subjects that underwent cholecystectomy from January to December 2015.
Result: All 112 subjects underwent laparoscopic cholecystectomy. We found the incidence for PCS to be 45.5 . Bivariate analysis showed there were significant correlation between PCS and preoperative symptom duration p 0.033, OR 2.29 , preoperative flatulence p 0.000, OR 16.48 , non specific preoperative symptoms p 0.000, OR 6.93 , poor preoperative perception p 0.000, OR 5.723 . Multivariate logistic regression analysis showed that only preoperative flatulence p 0.000, OR 17.152 , non specific preoperative symptoms p 0.012, OR 3.984 , and poor preoperative perception p 0.003, OR 5.907 were independent predictive factors for PCS. Mean of postoperative observation was 14.95 months.
Conclusion: High incidence of PCS in RSCM was influenced by larger number of subject with non specific preoperative symptoms, poor preoperative perception and the difference in duration for postoperative observation.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2017
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Budhi Arifin Noor
"Latar belakang: Chronic limb threatening ischemia (CLTI) merupakan bentuk terparah peripheral arterial disease. Pasien kaki diabetik dengan CLTI memiliki risiko amputasi mayor dan mortalitas paska revaskularisasi dan dipengaruhi beberapa faktor seperti usia lanjut, gagal ginjal kronik, komorbid penyakit jantung dan hipertensi. Indonesia belum memiliki data amputasi mayor dan mortalitas kaki diabetik dengan CLTI setelah revaskularisasi dan faktor-faktor yang berpengaruh. Penelitian ini bertujuan mengetahui angka amputasi mayor dan mortalitas satu tahun pasca revaskularisasi beserta faktor-faktor yang memengaruhi di Rumah Sakit Cipto Mangunkusumo (RSCM).
Metode: Kohort retrospektif pasien kaki diabetik dengan CLTI setelah revaskularisasi di RSCM Januari 2010 – Desember 2020. Pengambilan data rekam medis. Luaran utama amputasi mayor dan mortalitas satu tahun setelah revaskularisasi. Dilakukan analisis bivariat dengan uji Kai Kuadrat, jika persyaratan tidak terpenuhi maka menggunakan Fischer-exact, variabel bermakna diuji lebih lanjut dengan regresi logistik.
Hasil: Penelitian melibatkan 150 subjek. Amputasi mayor dan mortalitas satu tahun setelah revaskularisasi sebesar 27,3% dan 24,7%. Tidak didapatkan hubungan yang bermakna antara faktor-faktor yang diteliti dengan amputasi mayor dan mortalitas satu tahun.
Kesimpulan: Didapatkan angka amputasi mayor dan mortalitas 1 tahun pasca revaskularisasi. Usia lanjut, gagal ginjal kronik, komorbid penyakit jantung dan hipertensi bukan merupakan faktor yang memengaruhi angka amputasi dan mortalitas satu tahun.

Background: Chronic limb threatening ischemia (CLTI) is the most severe form of peripheral arterial disease. Diabetic foot patients with CLTI have major amputation and mortality risk after revascularization and affected by factors such as elderly, chronic kidney disease (CKD), cardiac morbidity and hypertension. In Indonesia there are no data regarding diabetic foot major amputation and mortality with CLTI after revacularization and influencing factors. Study aims to determine one year major amputation and mortality and factors that can affect diabetic foot pastients with CLTI after revascularization.
Methods: Retrospective cohort study on diabetic foot patients with CLTI undergoing revascularization at Cipto Mangunkusumo National Hospital from January 2010 to December 2020. The primary outcome was one-year major amputation and mortality after revascularization. Factors included were age, CKD, cardiac comorbidity and hypertension. We conducted bivariate analysis using Chi Square or Fisher-exact test. Variables were further tested using multivariate test.
Result: 150 subjects were enrolled. One-year major amputation and mortality was 27.3% and 24.7%. There are not significant correlations between factors with major amputation and mortality.
Conclusion: Major amputation and mortality rate one year after revascularization at RSCM are gained. Elderly, CKD, cardiac comorbidity and hypertension are not factors affecting one-year major amputation and mortality.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2021
UI - Tugas Akhir  Universitas Indonesia Library
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Siagian, Ira Handayani
"Latar belakang: Necrotizing enterocolitis / enterokolitis nekrotikan (NEC/EKN) adalah masalah serius yang sering terjadi pada neonatus, dengan tingkat insiden dan mortalitas yang tinggi, terutama pada bayi berat lahir yang rendah. Beberapa faktor telah diidentifikasi sebagai berpotensi meningkatkan risiko dan derajat keparahan EKN. Meskipun penelitian sebelumnya telah dilakukan di berbagai negara, belum ada penelitian serupa EKN dilakukan di Indonesia untuk memahami faktor-faktor yang berhubungan dengan EKN.
Metode: Penelitian ini memiliki desain penelitian kohort retrospektif dan dilakukan di Unit Penelitian Kesehatan Neonatologi FKUI-RSCM dengan pengambilan sampel pada periode tahun 2016-2021 dan penulisan hasil penelitian pada Mei 2022-Desember 2023. Populasi target melibatkan neonatus dengan EKN, dengan populasi terjangkau merupakan pasien neonatus dengan derajat EKN I dan II yang diambil pada periode penelitian. Pasien dengan kelainan kongenital saluran cerna atau menjalani operasi lainnya selain tata laksana EKN dieksklusi dari penelitian. Variabel yang dinilai dalam penelitian ini adalah usia kehamilan, jenis kelamin, jenis kelahiran, skor APGAR, berat lahir rendah, sindrom gawat napas, sepsis, kadar C- reactive protein (CRP), pemberian antibiotik, jenis antibiotik, dan penggunaan ventilator.
Hasil: Hasil penelitian menunjukkan bahwa tidak ada hubungan yang signifikan antara faktor-faktor seperti usia kehamilan, jenis kelahiran, skor APGAR, berat lahir rendah, sindrom gawat napas, sepsis, kadar CRP, pemberian antibiotik, jenis antibiotik, penggunaan ventilator, dan jenis kelamin dengan insiden peningkatan derajat keparahan EKN (p > 0,05) maupun waktu peningkatan derajat keparahan EKN (p > 0,05).
Kesimpulan: Berdasarkan penelitian ini, dapat disimpulkan bahwa dalam populasi pasien neonatus dengan EKN derajat I dan II di RSCM, faktor-faktor internal dan eksternal yang diteliti tidak berhubungan secara signifikan dengan insiden maupun waktu peningkatan derajat keparahan EKN.

Background: Necrotizing enterocolitis (NEC) is a serious problem that often occurs in neonates, with a high incidence and mortality rate, especially in neonates with very low birth weight. Several factors have been identified as potentially increasing the risk and severity of NEC. Although previous research has been conducted in various countries, there has been no similar study conducted in Indonesia to understand the factors associated with NEC.
Methods: This study has a retrospective cohort study design and was conducted in the Neonatology Research Center Unit, RSCM-FKUI with subject recruitment during the period of 2016 to 2021 and research report written during the period of May 2022 to December 2023. The target population included neonates with NEC, with the accessible population consisting of neonates with NEC I and II. Patients with congenital gastrointestinal tract disorders or those undergoing surgeries other than NEC management were excluded from the study. Variables assessed in this study included gestational age, sex, type of birth, APGAR score, very low birth weight, respiratory distress syndrome, sepsis, C-reactive protein (CRP) levels, antibiotic use, type of antibiotics, and ventilator use.
Results: The study results showed no significant relationship between factors such as gestational age, type of birth, APGAR score, very low birth weight, respiratory distress syndrome, sepsis, CRP levels, antibiotic use, type of antibiotics, ventilator use, and gender with the incidence of an increase in the severity of NEC (p > 0.05) or the time of the increase in the severity of NEC (p > 0.05).
Conclusion: Based on this study, it can be concluded that in the population of neonatal patients with NEC I and II at RSCM, the examined internal and external factors are not significantly associated with the incidence or time of the increase in the severity of NEC.
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Depok: Fakultas Kedokteran Universitas Indonesia, 2024
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