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"ABSTRAKThe objective of this study was to determine whether total serum IgE levels are elevated in workers with trimellitic anhydride-induced asthma as compared with anhydride-exposed workers without an occupational immunologic syndrome. Sera from 12 highly exposed workers with trimellic anhydride-induced asthma, and from 31 similarly exposed workers without occupational immunologic disease, were assayed for total immunoglobulin E (IgE) levels by Total IgE FAST analysis. The mean total IgE levels were 176.74 ng/mL and 34.55 ng/mL respectively. The difference between the two groups was statistically significant, but considerable overlap of IgE levels between groups was seen. In conclusion, although mean total IgE levels are significantly different between TMA-exposed workers with or without occupational asthma, the significant amount of overlap and poor sensitivity of the test preclude the use of this assay in the individual evaluation of these workers."

"This second edition of the well-regarded Multiple Choice Questions and Revision Aid in Occupational Medicine continues as a comprehensive revision and study resource for those preparing for professional examinations in occupational health, occupational medicine and occupational health & safety.The content has been extensively revised and updated to cover relevant and current issues. There are three sections organized by question type – MCQ, MEQ, and OSPE. Each question is accompanied by the correct answer along with a brief justification explanation. The subject topics cover typical occupational health/medicine syllabuses associated with professional examinations including the use of the ‘best of many’ MCQ format. The book is essential reading for medical and non-medical practitioners studying for these examinations and will also be useful to those already in the multi-disciplinary field or those intending to enter it."

"This study aimed to demonstrate class switch recombination (CSR) in heavy chain expressing immunoglobulin G (IgG) and IgE in human B cells (CD20+CD27-) were cultured with crude P. falciparum antigen (cPfAg) and anti-CD40. on day 4 post-exposure, total RNA from B cells was prepared and the occurance of CSR from IgM to IgG and/or IgE was investigated by reverse transciption-polymerase chain reaction. Molecular markers to detect active CSR included enzyme activation-induced cytidine deaminase mRNA, y and e-germline transcripts (y,e-GLT), circle transcript (CT) and mature transcript (y and e-mRNA) expression. On day 7 and day 14 after exposure, levels of Igs in the culture supernatant were determined by enzyme-linked immunosorbent assay. Our findings showed that we could demonstrate cPfAg-stimulated B cells undergoing CSR by use of the expressed CSR markers and the increase in spesific IgG and IgE indicating the potential of this approach in the study of CSR in P. falciparum stimulated B cells. "