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"Latar Belakang: Penyakit kardiovaskular terutama penyakit jantung koroner (PJK) merupakan penyebab utama kematian pasien dengan penyakit perlemakan hati non-alkoholik (PPHNA). Pengukuran controlled attenuation parameter (CAP) menilai derajat steatosis hati secara non-invasif dan terukur, sementara skor SYNTAX dapat menggambarkan derajat aterosklerosis koroner dan membantu pemilihan modalitas revaskularisasi koroner (PCI atau CABG). Hingga saat ini, belum diketahui korelasi antara nilai CAP dengan skor SYNTAX pada pasien PJK signifikan. Tujuan: Mengetahui korelasi antara nilai CAP steatosis hati dengan skor SYNTAX lesi koroner pada pasien PJK signifikan. Metode: Studi potong lintang dengan populasi terjangkau adalah pasien dewasa yang menjalani tindakan angiografi koroner di ruang cathlab Rumah Sakit Cipto Mangunkusumo pada bulan Juli hingga Oktober 2023 dan terbukti menderita PJK signifikan. Selanjutnya dilakukan anamnesis, pemeriksaan fisik, pemeriksaan darah, penilaian CAP dengan elastografi transien, dan penghitungan skor SYNTAX. Analisis data dilakukan untuk mencari koefisien korelasi antara nilai CAP dengan skor SYNTAX. Hasil: Didapatkan 124 subjek penelitian dengan dengan rasio laki-laki berbanding perempuan 5:1 dan rerata usia 59,8 ± 11,1 tahun. Rerata IMT 25,6 ± 3,5 kg/m2, dengan 54,8% subjek tergolong obesitas. Sebanyak 94,4% dan 55,6% subjek menderita hipertensi dan DM, dengan tekanan darah dan parameter glikemik relatif terkontrol. Rerata HDL 38,8 ± 10,8 mg/dL dengan 55,6% subjek memiliki HDL rendah, dan median LDL 109,5 mg/dL dengan 89,5% subjek belum mencapai target LDL. Rerata nilai CAP 256,5 ± 47,3 dB/m, dengan 52,5% subjek (IK 95%: 43,3% - 61,5%) menderita steatosis signifikan (nilai CAP ≥ 248 dB/m), Median skor SYNTAX 22. Uji korelasi Spearman menunjukkan korelasi positif dan signifikan antara nilai CAP dengan skor SYNTAX (r = 0,245, p < 0,0001). Kesimpulan: Diantara pasien dengan PJK signifikan, 52,5% diantaranya memiliki steatosis hati non-alkoholik signifikan. Terdapat korelasi positif dan bermakna antara nilai CAP dengan skor SYNTAX pada pasien PJK signifika.

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Background: Cardiovascular diseases, particularly coronary artery disease (CAD), is the leading cause of death in patients with non-alcoholic fatty liver disease (NAFLD). The controlled attenuation parameter (CAP) measurement assesses the degree of liver steatosis in a non-invasive and measurable manner, while the SYNTAX score depicts the degree of coronary atherosclerosis and aids in the selection of coronary revascularization modalities (PCI or CABG). To date, the correlation between CAP values and SYNTAX scores in patients with significant CAD remains unknown. Objective: To determine the correlation between controlled attenuation parameter (CAP) value of liver steatosis and SYNTAX score of coronary lesions in patients with significant CAD. Methods: This cross-sectional study was conducted on an accessible population of adult patients who underwent coronary angiography at Cipto Mangunkusumo Hospital catheterization laboratory from July to October 2023, and were proven to have significant CAD. Anamnesis, physical examination, blood tests, CAP assessment with transient elastography, and SYNTAX score calculation were performed. Data analysis was conducted to find the correlation coefficient between CAP values and SYNTAX scores. Results: A total of 124 patients were included in this study, with a mean age of 59.8 ± 11.1 years and 5:1 of male to female ratio. The mean BMI was 25.6 ± 3.5 kg/m2, with 54.8% subjects classified as obese. A total of 94.4% and 55.6% subjects were hypertensive and diabetic with relatively controlled blood pressure and glycemic parameters. The mean HDL was 38.8 ± 10.8 mg/dL with 55.6% of the subjects having low HDL, and a median LDL of 109.5 mg/dL, with 89.5% of the subjects yet to achieve the optimal LDL target. The mean CAP value was 256.5 ± 47.3 dB/m, with 52.5% of the subjects having significant steatosis (CAP value ≥ 248 dB/m). The median SYNTAX score was 22. The Spearman correlation test showed a positive and significant correlation between CAP values and SYNTAX score (r = 0.245, p < 0.0001). Conclusion: Among patients with significant CAD, 52.5% have significant non-alcoholic hepatic steatosis. There is a positive and significant correlation between CAP values and SYNTAX scores in patients with significant CAD."

"Latar belakang: Psoriasis adalah suatu penyakit inflamasi kulit yang kronik, ditandai oleh plak eritematosa dan skuama kasar berlapis. Psoriasis dihubungkan dengan berbagai penyakit penyerta. Penyakit perlemakan hati nonalkoholik (PPHNA) merupakan salah satu penyakit penyerta yang sering ditemukan dan dapat memengaruhi derajat keparahan psoriasis, begitu pula sebaliknya. Penelitian untuk mengetahui korelasi derajat keparahan psoriasis dan perlemakan hati nonalkoholik (PHNA) belum pernah dilakukan. Tujuan: Mengetahui korelasi derajat keparahan psoriasis dan derajat PHNA. Metode: Studi potong lintang ini dilakukan terhadap pasien psoriasis dewasa di Poliklinik Ilmu Kesehatan Kulit dan Kelamin Rumah Sakit dr. Cipto Mangunkusumo pada bulan Desember 2017-Februari 2018. Dilakukan anamnesis dan pemeriksaan fisis untuk mendapatkan nilai derajat keparahan psoriasis (psoriasis area and severity index; PASI) dan dicatat pula nilai body surface area (BSA). Penelitian dilanjutkan dengan pemeriksaan derajat PHNA pada semua pasien dengan menggunakan controlled attenuation parameter (CAP). Hasil: Didapatkan total 36 subjek dengan rerata umur 49,08 tahun (+15,52 tahun). Proporsi psoriasis derajat ringan, sedang, dan berat berturut-turut adalah 50%, 27,8%, dan 22,2%. Median PASI 6,1 (2-38,4) dan median BSA 7,5 (2-93). Proporsi PPHNA berdasarkan CAP adalah 77,8%. Rerata skor CAP 250,03+45,64. Tidak terdapat korelasi yang bermakna secara statistik antara derajat keparahan psoriasis berdasarkan PASI dengan derajat PHNA berdasarkan CAP (r=0,258; p=0,128). Namun bila digunakan BSA pada penilaian derajat keparahan psoriasis, didapatkan hasil korelasi yang bermakna (r=0,382; p=0,021). Ditemukan bahwa indeks massa tubuh (IMT) dan lingkar perut berkorelasi positif secara bermakna dengan skor CAP (berturut-turut r=0,448, p=0,006 dan r=0,485, p=0,003). Kesimpulan: Tidak ditemukan korelasi yang bermakna secara statistik antara derajat keparahan psoriasis berdasarkan PASI dengan derajat PHNA. Namun ditemukan korelasi yang bermakna antara derajat keparahan psoriasis berdasarkan BSA dengan derajat PHNA. Luas lesi kulit psoriasis berpengaruh terhadap derajat PHNA. Selain itu terdapat beberapa faktor, misalnya IMT dan lingkar perut, yang dapat memengaruhi derajat keparahan PHNA pada pasien psoriasis.

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Background: Psoriasis is a chronic inflammatory skin disease, characterized by erythematous plaques and thick scales. Psoriasis is associated with various comorbidities. Nonalcoholic fatty liver disease (NAFLD) is one of the most common comorbidities that can affect the severity of psoriasis, vice versa. Research regarding the correlation of the severity of psoriasis and nonalcoholic fatty liver (NAFL) has never been done. Objective: To measure the correlation of the severity of psoriasis and the degree of NAFL. Methods: A cross-sectional study of adult patients with psoriasis was conducted in Dermatovenereology outpatient clinic of Cipto Mangunkusumo Hospital from December 2017 through February 2018. Psoriasis severity (psoriasis area and severity index; PASI) and body surface area (BSA) were recorded and compared with NAFL severity by controlled attenuation parameter (CAP). Results: A total of 36 subjects were enrolled with an average age of 49.08 years (+15.52 years). The proportions of mild, moderate, and severe psoriasis were 50%, 27.8%, and 22.2%, respectively. Median PASI was 6.1 (2-38.4) and BSA was 7.5 (2-93). The proportion of NAFLD was 77.8%. The mean of CAP score was 250.03+45.64. There was no statistically significant correlation between the severity of psoriasis based on PASI and CAP score (r = 0.258; p = 0.128). However, based on BSA, we found significant correlation (r = 0.382; p = 0,021). The body mass index (BMI) and abdominal circumference were significantly correlated with CAP score (r = 0.448, p = 0.006 and r = 0.485, p = 0.003, respectively). Conclusion: There was no statistically significant correlation between the severity of psoriasis based on PASI and nonalcoholic fatty liver degree, but a statistically significant correlation was found when using BSA in measuring the severity of psoriasis. In psoriasis, the extent of skin lesions may be influential to the degree of nonalcoholic fatty liver. In addition there are several factors, such as BMI and abdominal circumference, which may affect the severity of nonalcoholic fatty liver in psoriasis patients."

"Latar Belakang. Keluarga derajat pertama (first degree relatives/FDR) dari Diabetes Melitus tipe 2 (DMT2) memiliki kecenderungan untuk memiliki gangguan metabolik dan vaskular lebih dini tanpa melaui resistensi insulin (RI) sebagai perantaranya seperti lebih tebalnya tunika intima media karotis. Penyakit perlemakan hati non-alkoholik (non-alcoholic fatty liver disease/NAFLD) adalah penyakit hati kronik yang banyak ditemukan pada pasien DMT2 yang dependen terhadap RI. Studi tentang hubungan FDR DMT2 dengan NAFLD masih sangat terbatas dan inkonklusif. Hubungan tersebut masih belum jelas apakah kejadian NAFLD pada FDR DMT2 dependen terhadap RI atau karena kerentanan genetik FDR DMT2. Tujuan. Untuk mengetahui hubungan antara FDR DMT2 dengan NAFLD. Metode. Sebanyak 118 dewasa muda (19-39 tahun) dengan toleransi glukosa normal (59 subjek FDR DMT2 dan 59 subjek non-FDR dengan matching usia dan jenis kelamin) diikutsertakan dalam penelitian potong lintang ini. Pengukuran antropometri (tinggi, berat badan, indeks massa tubuh (IMT) dan lingkar perut) dan analisis laboratorium (glukosa darah puasa, HbA1c, profil lipid, serum glutamic pyruvic transaminase (SGPT)), serum glutamic oxaloacetic transaminase (SGOT)) diperiksa pada penelitian ini. Perlemakan hati didiagnosis dengan ultrasonografi (USG) menggunakan kriteria standar. Hasil Penelitian. Dua puluh enam subjek (22,03%) dengan NAFLD terdeteksi dengan USG dalam penelitian ini dengan proporsi yang sama pada kedua kelompok. Pada kelompok FDR DMT2 didapatkan jumlah subjek dengan angka HDL rendah dan sindrom metabolik lebih tinggi dibandingkan dengan kelompok tanpa FDR. Kesimpulan. Pada penelitian ini tidak didapatkan hubungan antara FDR DMT2 dengan NAFLD.

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Background. First degree relatives (FDR) of type 2 diabetes mellitus (T2DM) predisposes individuals to have earlier metabolic and vascular disorders independent of insulin resistance (IR) such as thicker carotid intima media thickness than that of non-FDR. Non-alcoholic fatty liver disease (NAFLD) is the most commonly found chronic liver disease in T2DM which is IR dependent. Studies about NAFLD in FDR of T2DM populations are very limited and inconclusive. It is unclear whether the occurrence of NAFLD in FDR of T2DM is IR dependent or due to genetic vulnerability.

Aim. to determine the association between NAFLD and FDR of T2DM.

Method. A total of 118 young adults (19-39 years old) with normal glucose tolerance (59 FDR of T2DM and age-sex matched 59 non-FDR subjects) were included in this cross-sectional study. Anthropometric measurement (height, weight, BMI and waist circumference) and routine laboratory analysis (fasting blood glucose, HbA1c, lipid profile, alanine aminotransferase (ALT), aspartate transaminase (AST)) were examined. Fatty liver was diagnosed by ultrasonography (US) using standard criteria.

Result. Twenty-six (22,03%) subjects with NAFLD were detected by US with similar proportion for each group. Low HDL level and metabolic syndrome were found higher in FDR group.

Conclusion. we couldn`t prove the association between FDR of T2DM and NAFLD in this research."

"Obesitas merupakan masalah utama pada kesehatan masyarakat dunia yang diketahui juga sebagai salah satu faktor risiko penyakit perlemakan hati non alkoholik(NAFLD). Sistem penilaian untuk mendeteksi NAFLD telah dikembangkan dan divalidasi di Indonesia. Namun, pola makan orang obesitas yang mungkin memberikan pengaruh terhadap NAFLD masih belum diketahui. Penelitian ini mengevaluasi asupan sukrosa pada obesitas dewasa di Jakarta dan hubungannya dengan skor NAFLD. Ini adalah studi potong lintang berbasis komunitas di antara orang dewasa dengan indeks massa tubuh (BMI)>25 kg/m2 antara September dan Oktober 2018 di Jakarta, Indonesia. Asupan sukrosa dinilai menggunakan food recal l2x24 jam, dihitung berdasarkan tabel komposisi makanan Indonesia dan Amerika dengan menggunakan Nutrisurvey 2007.Skor NAFLD terdiri dari enam faktor risiko, yaitu BMI>25 kg/m2, jenis kelamin laki-laki, usia>35 tahun, trigliserida>150 mg/dL, kadar kolesterol lipoprotein kepadatan tinggi<40 mg/dL untuk pria atau <50 mg/dL untuk wanita, dan kadar alanin aminotrans feraseserum >35 U/L. Dari 102 subjek yang terdaftar, 75 orang(73,5%) adalah wanita. Median dari total skor NAFLD adalah 6,7 dengan rentang dari 3,6 hingga 10,2. Median asupan karbohidrat total adalah 179,6 (54,1-476,8) g/hari, dan median total asupan sukrosa adalah 47,0 (13,7-220,5) g/hari. Asupan sukrosa lebih tinggi signifikan pada responden dengan skor NAFLD >6,7 dibandingkan <6,7. (47,8 vs. 45,3 g; p=0,042; Mann-Whitney U test). Analisis multivariat mengonfirmasi adanya hubungan asupan sukrosa dan skor tinggi perlemakan hati non alkoholik.Kesimpulan: Asupan sukrosa tidak memiliki hubungan bermakna dengan skor NAFLD pada penyandang obesitas dewasa, namun bermakna jika dikaitkan dengan skor tinggi perlemakan hati non alkoholik. Dibutuhkan penelitian lebih lanjut untuk pengembangan variabel tambahan pada skor NAFLD.

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Obesity is a major problem in a world public health which is also known as one of the risk factors of non-alcoholic fatty liver disease (NAFLD). An assessment system for detecting NAFLD has been developed and validated in Indonesia. However, the diet pattern of obese people who might have an effect on NALFD is still unknown. This study evaluated sucrose intake among obese adults in Jakarta and ints association with NAFLD score. This was a community-based cross sectional study among adults with body mass index (BMI) >25 kg/m2 between September and Oktober 2018 in Jakarta, Indonesia. Sucrose intake was assessed using 2x24-hour food recall, calculated based on the Indonesian and American food composition tables using dietary software Nutrisurvey. The NAFLD score consists of six risk factors, i.e. BMI >25 kg/m2, male sex, age >35 years, triglycerides >150 mg/dL, high density lipoprotein cholesterol levels <40 mg/dL for men or <50 mg/dL for women, and serum alanine aminotransferase levels >35 U/L. A total of 102 subjects were recruited; 75 (73.5%) of them were women. The median of total NAFLD scores was 6.7, ranging from 3.6 to 10.2. Median total carbohydrate intake was 179.6 (54.1-476.8) g/day, while the median total sucrose intake was 47.0 (13.7-220.5) g/day. Sucrose intake was significantly higher in patients with NAFLD score >6.7 than <6.7 (47.8 vs. 45.3 g; p=0.042; Mann-Whitney U test). Multivariate analysis confirmed the association of sucrose intake and higher total NAFLD score.

Conclusions: Sucrose intake and NAFLD score have no significant association among obese adults. Further research is needed to develop additional variables on NAFLD score.

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"ABSTRACTBackground: non alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders. Recent studies suggested the role of uric acid in NAFLD through oxidative stress and inflammatory process. This study is aimed to evaluate the association between serum uric acid and NAFLD. Methods: a systematic literature review was conducted using Pubmed and Cochrane library. The quality of all studies was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). All data were analyzed using REVIEW MANAGER 5.3. Results: eleven studies from America and Asia involving 100,275 subjects were included. The pooled adjusted OR for NAFLD was 1.92 (95% CI: 1.66-2.23; p<0.00001). Subgroup analyses were done based on study design, gender, non-diabetic subjects, non-obese subjects. All subgroup analyses showed statistically significant adjusted OR and most of which having low to moderate heterogeneity. Two studies revealed relationship between increased serum uric acid levels and severity of NAFLD. No publication bias was observed. Conclusion: our study demonstrated association between serum uric acid level and NAFLD. This finding brings a new insight of uric acid in clinical practice. Increased in serum uric acid levels might serve as a trigger for physician to screen for NAFLD."

"ABSTRACTLaju filtrasi glomerulus menjadi salah satu indikator keseluruhan tingkat fungsi ginjal. Selain pemeriksaan laju filtrasi glomerulus terdapat pula pemeriksaan lainnya yang juga dinilai dapat menggambarkan kondisi tersebut, yaitu pemeriksaan kadar asam urat. Namun selama ini belum adanya kepastian korelasi dan ukuran kadar asam urat yang sesuai untuk menentukan stadium penyakit ginjal kronik. Tujuan dari penelitian ini adalah mengetahui apakah terdapat korelasi antara Kadar asam urat dalam darah dan laju filtrasi glomerulus pada penderita penyakit ginjal kronik. Penelitian menggunakan desain potong lintang pada 75 orang pasien penyakit ginjal kronik yang melakukan pemeriksaan asam urat dan laju filtrasi glomerulus pada Laboratorium RSCM data sekunder. Analisis data dilakukan menggunakan uji korelasi Spearmans. Hasil penelitian ini, terdapat hubungan yang signifikan antara kadar asam urat darah dengan kadar laju filtrasi glomerulus p: 0,005; r: -0,362. Kesimpulannya, terdapat korelasi lemah negatif antara kadar asam urat darah dengan kadar laju filtrasi glomerulus pada pasien penyakit ginjal kronik. Kondisi ini kemungkinan dapat terjadi karena adanya faktor-faktor lain yang lebih berkontribusi terhadap kadar asam urat dan kadar laju filtrasi glomerulus.

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ABSTRACTGlomerular filtration rate is an indicator of kidney function. Beside of glomerular filtration rate, uric acid measurement in blood is also kidney function indicator. However, correlation between uric acid level and chronic kidney disease stadium has not been established. This research aims to find the correlation between those two variables. This research was done from laboratory result of 75 chronic kidney disease patients who underwent uric acid and glomerular filtration rate examination in RSCM laboratory. Sparmann rsquo s correlation test was done and showed significant correlation between blood uric acid level p 0.005 r 0.362 . Therefore, there is weak negative correlation between blood uric acid level and glomerular filtration rate in chronic kidney disease patients. It can be caused by other more contributing factors to blood uric acid level and glomerular filtration rate. "

"ABSTRACTLatar Belakang: Defisiensi vitamin B12 belum diketahui secara jelas insidensi dan prevalensinya di seluruh dunia dan hanya terdapat penelitian di daerah-daerah tertentu. Terdapat indikasi defisiensi asam folat dan vitamin B12 menjadi masalah kesehatan masyarakat dalam beberapa negara. Dalam beberapa penelitian, ditemukan bahwa kadar vitamin B12 yang rendah berhubungan dengan terjadinya perlemakan hati. Kondisi perlemakan hati memiliki spektrum yang luas, dari perlemakan hati sederhana, steatohepatitis, fibrosis, hingga sirosis hati. Tujuan: Penelitian ini bertujuan untuk mengetahui perubahan gambaran histopatologi perlemakan hati pada tikus dengan diet restriksi vitamin B12 dalam durasi waktu tertentu. Metode: Penelitian dilakukan dengan 18 ekor tikus Sprague-Dawley yang terbagi dalam 3 kelompok: (1) kelompok kontrol dengan diet normal selama 16 minggu; (2) kelompok perlakuan dengan diet restriksi vitamin B12 selama 8 minggu; dan (3) kelompok perlakuan dengan diet restriksi vitamin B12 selama 16 minggu. Setelah masa perlakuan selesai, hewan coba didekapitasi dan diambil jaringan hati dan dilakukan pemeriksaan histopatologi dengan pewarnaan Hematoxylin-Eosin untuk diamati perlemakan hati yang terjadi.Hasil: Ditemukan steatosis mikrovesikular pada ketiga kelompok. Hanya sedikit ditemukan steatosis markovesikular, inflamasi lobular, dan pembengkakan hepatiosit pada kelompok perlakuan. Pemberian diet restriksi vitamin B12 menunjukkan perbedaan yang bermakna ketika dilihat melalui persentase pelemakan hati yang terjadi (p=0,001). Analisis post-hoc dilakukan dan didapatkan hasil yaitu terdapat perbedaan perlemakan hati yang bermakna pada kelompok kontrol dibandingkan kelompok perlakuan 8 minggu dan pada kelompok kontrol dibandingkan kelompok perlakuan 16 minggu. Kesimpulan: Diet restriksi vitamin B12 menunjukkan adanya perbedaan gambaran perlemakan hati yang bermakna yang terlihat pada gambaran histologi jaringan hati setelah perlakuan 8 dan 16 minggu.

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ABSTRACTIntroduction: Vitamin B12 deficiencys incidence and prevalence throughout the world are still unknown  and studies only found in certain areas. There is an indication that folate and vitamin B12 deficiency will be global health problem in some countries. In some research, it was found that low level of serum vitamin B12 was associated with non-alcoholic fatty liver disease (NAFLD). NAFLD has a broad spectrum, from simple steatosis, steatohepatitis, fibrosis, until cirrhosis. Objective: This research aimed to investigate the histopathological changes of steatosis in rats induced with vitamin B12 restriction diet within observation period. Method: This experimental study was conducted with 18 Sprague-Dawley rats that were divided equally in 3 groups: (1) control group with normal diet for 16 weeks; (2) treatment group with vitamin B12 restriction diet for 8 weeks; and (3) treatment group with vitamin B12 restriction diet for 16 weeks. After observation period was finished, decapitation was performed to obtain rats liver tissue. Liver tissue then stained with Hematoxylin-Eosin to observe the steatosis percentage. Result: Microvesicular steatosis was observed in all groups. There were a little macrovesicular steatosis, lobular inflammation, and hepatic ballooning in treatment group. Steatosis percentage showed significant result when all groups were compared (p=0,001). Post-hoc analysis then performed; there was significant difference of steatosis percentage of control group compared with 8 weeks treatment group and control group compared with 16 weeks treatment group. Conclusion: Vitamin B12 restriction diet showed significant difference of steatosis showed in liver tissue after 8 and 16 weeks of treatment."

"Latar Belakang dan Tujuan: Korelasi antara kadar asam urat dan penyakit kardiovaskular sudah lama diketahui dan terdapat sejumlah penelitian epidemiologi melaporkan korelasi antara kadar asam urat dan berbagai kondisi penyakit kardiovaskular. Kami meneliti korelasi antara kadar asam urat terhadap kompleksitas stenosis arteri koroner pada pasien sindrom koroner akut berdasarkan skor SYNTAX.Metode Penelitian: Penelitian ini adalah studi analisis korelasi dengan desain potong lintang pada total 60 pasien sindrom koroner akut yang menjalani angiografi koroner dari data rekam medik. Penelitian dilakukan di RSCM pada bulan November 2012 dengan sampel data rekam medik ICCU RSCM Januari 2012-Oktober 2012, menggunakan teknik sampling konsekutif. Analisis korelasi pearson digunakan untuk melihat korelasi kadar asam urat dengan kompleksitas stenosis arteri koroner pada pasien sindrom koroner akut, dan analisis multivariat regresi linier.Hasil: Analisis korelasi Pearson pada kadar asam urat terdapat korelasi positif lemah yang bermakna terhadap skor SYNTAX (r=0.3, p=0.02). Kadar asam urat memiliki pengaruh 8 % terhadap kompleksitas stenosis arteri koroner. Analisis multivariat regresi linier menunjukkan asam urat (?; 0.3, p<0.018) merupakan faktor independen terhadap skor SYNTAX.Kesimpulan: Pada penelitian kami, kadar asam urat memiliki korelasi lemah dengan kompleksitas stenosis arteri koroner arteri koroner pada pasien sindrom koroner akut. Penelitian selanjutnya dianjurkan apakah pemberian inhibitor xanthine oxidase dapat mencegah progresifitas penyakit arteri koroner.

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Background and Objectives: Serum uric acid has been associated with increased cardiovascular risk in general population recently in many studies. We hypothesized that serum uric acid would be correlated with severity of coronary artery disease. We therefore investigated the link between serum uric acid level and the extend of coronary artery disease (CAD) assessed by SYNTAX score (SS).

Materials and Methods: Subjects’ data were collected through medical record consecutively. A cross sectional study performed in 60 acute coronary syndrome patients who underwent coronary angiography in ICCU, Cipto Mangunkusumo Hospital, Jakarta, from January 2012 untill October 2012. We analyzed the correlation serum levels of uric acid and angiographic severity of CAD. SS was used for assessing the severity of coronary artery disease.

Result: Serum level of uric acid positively weak correlated with SS (r=0.3, p=0.02). Multivariate regression analysis showed that serum level uric acid (?;0.3, p<0.018) were the independent for SS.

Conclution: Serum level of uric acid is independenly correlated with the severity and complexity of CAD evaluated by SS in patient acute coronary syndrome. "

"Latar belakang. Studi sebelumnya menunjukkan bahwa hiperurisemia mengambil bagian dalam berkontribusi dalam berkontribusi pada proses sindrom metabolik dua arah. Hiperurisemia merupakan kelainan metabolisme asam urat yang menghasilkan kondisi SUA yang berlebihan dalam plasma darah sebagai akibat dari degradasi metabolisme purin. Namun, masih ada penelitian SUA dan sindrom metabolik yang langka pada subjek dewasa muda dan tidak ada penelitian yang pernah dilakukan pada FDR dewasa muda dari subjek T2DM sejauh ini secara lokal dan internasional. Untuk mengetahui perbedaan kadar asam urat serum (SUA) antara derajat-kerabat pertama (FDR) diabetes melitus tipe 2 (T2DM) dan non-FDR T2DM, serta korelasinya dengan resistensi insulin pada FDR T2DM.Metode. Sebanyak 126 (62 FDR dan 64 non-FDR, berusia 25-39 tahun) mata pelajaran terdaftar. Indeks massa tubuh, lingkar pinggang, tekanan darah, glukosa plasma puasa, profil lipid dan kadar SUA diukur. Subjek dengan gangguan toleransi glukosa dan hipertensi tidak termasuk. Hiperurisemia didefinisikan oleh American College of Rheumatology (≥ 7,0 mg/dL untuk pria dan ≥ 6,5 mg/dL untuk wanita), resistensi insulin didefinisikan oleh Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Sebanyak 126 subjek yang memenuhi kriteria inklusi. Kami tidak menemukan perbedaan yang signifikan dalam karakteristik dasar kelompok FDR dan non FDR dari kelompok T2DM. Tingkat SUA tidak berbeda antara FDR dan non-FDR T2DM (5,75 1,41 mg/dL dan 5,54 1,80 mg/dL, p = 0,287). Tidak ada korelasi antara SUA dan resistensi insulin pada FDR T2DM (r = 0,208, p = 0,105).Kesimpulan. Tingkat SUA dalam normoglikemia dan normotensi FDR T2DM tidak berbeda dibandingkan dengan non-FDR T2DM. Tidak ada korelasi antara SUA dan resistensi insulin pada orang dewasa muda yang sehat dari FDR T2DM.

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Background. Previous studies showed that hyperuricemia takes part in contributing the process of metabolic syndrome bidirectionally. Hyperuricemia is an abnormality of uric acid metabolism which produce a condition of excessive SUA in blood plasma as a result of degradation from purine metabolism. However, there is still scarce research of SUA and metabolic syndrome on young adult subjects and no study has ever done in young adult FDR of T2DM subjects so far locally and internationally. To determine difference of serum uric acid (SUA) level between first degree-relatives (FDR) of type 2 diabetes mellitus (T2DM) and non-FDR of T2DM, and its correlation with insulin resistance in FDR of T2DM.

Methods. A total of 126 (62 FDR and 64 non-FDR, aged 25-39 years) subjects were enrolled. Body mass index, waist circumference, blood pressure, fasting plasma glucose, lipid profile and SUA levels were measured. Subjects with impaired glucose tolerance and hypertension were excluded. Hyperuricemia was defined by American College of Rheumatology (≥ 7.0 mg/dL for males and ≥ 6.5 mg/dL for females), insulin resistance was defined by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).

Results. There were 126 subject met inclusion criteria. We discovered no significant differences in basic characteristics of both FDR and non FDR of T2DM groups. SUA level was not different between FDR and non-FDR of T2DM (5.75+1.41 mg/dL and 5.54+1.80 mg/dL, p = 0.287). There was no correlation between SUA and insulin resistance in FDR of T2DM (r = 0.208, p = 0.105).

Conclusions.  SUA level in normoglycemia and normotensive FDR of T2DM was not different compared to non-FDR of T2DM. There was no correlation between SUA and insulin resistance in healthy young adults of FDR of T2DM."