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"This volume presents information on stem cells and cancer stem cells, therapeutic applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this volume. Specific stem cells discussed are, human embryonic stem cells, hematopoietic stem cells, cord blood stem cells, human pluripotent stem cells, gliosarcoma stem cells, induced pluripotent stem cells, intestinal stem cells, human thyroid cancer stem cells, tumor stem cells, menstrual stem-like cells, neural stem cells, breast cancer stem cells, allogeneic mesenchymal stem cells, fetal membrane-derived mesemchynmal stem cells, and omental stem cells. The method for isolating bone marrow stromal cells is explained. Method for generating marmoset-induced pluripotent stem cells, using transcription factors, is also explained. Use of stem cell lines in therapeutic applications is discussed. Programming of stem cells is described. Methods for transplantation of stem cells are presented. Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier’s disease, and neurogenerative diseases in general, is explained. For example, generation of human cardiac muscle cells from adipose-derived stem cells is included. Another example is repairing bone defects using mesenchymal stem cells and mesenchymal-derived endothelial cells. Differentiation of new neurons from neural stem cells is described. Method for repairing retina condition using human embryonic stem cells is explained; these cells can induce neural differentiation. Treatment of graft-versus-host disease resulting from hematopoietic stem cell transplantation is elaborated."

"IPRs have never been economically and politically more important or controversial than they are today. There are continuing debates over the pricing of essential drugs for ill and afficted and their avaibility....."

"Studi sebelumnya telah membuktikan bahwa kanker kepaladan leher telah menjadi masalah penting di negara Asia termasuk Indonesia. Terdapat faktor resiko yang mendukung terjadinya insidens kanker tersebut dibagi menjadi faktor yang dapat dan yang tidak dapat dimodifikasi. Faktor-Faktor tersebut memiliki implikasi penting dalam mempelajari faktor resiko yang paling berpengaruh dalam insidens kanker nasofaring di Indonesia. Studi ini ditujukan untuk menentukan perbandingan antara tingkat pendidikan dan konsumsi alkohol pada pasien dengan kanker nasofaring dan kanker oral pada pasien yang datang ke klinik gigi RSCM pada tahun 2006-2009. Data dalam studi ini berdasar pada rekam medis pasien yang datang ke klinik gigi RSCM pada tahun 2006-2009. Data dianalisa menggunakan SPSS versi 20. Signifikansi di tes menggunakan Smirnof-Kolmogorov Z test. Pasien yang mengaku mengkonsumsi alkohol sebagian besar merupakan pasien dengan kanker nasofaring. Sementara, untuk tingkat pendidikan, sebagian besar pasien pada kanker nasofaring merupakan pasien dengan tingkat pendidikan yang rendah. Tidak terdapat asosiasi yang signifikan antara tingkat pendidikan dengan pasien kanker (P=0.995). Begitu pula dengan konsumsi alkohol, tidak terdapat asosiasi yang signifikan antara penggunaan alkohol pada pasien kanker nasofaring. Dapat disimpulkan bahwa tidak terdapat asosiasi antara tingkat pendidikan dan penggunaan alkohol dengan kanker nasofaring.

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As many of the previous studies has proven, head and neck cancer has been a major problem in many of Southeast Asian countries, including Indonesia. The contributing risk factors to incidence of HNC are divided into modifiable and unmodifiable risk factors. Those risk factors has very important implications in understanding the most influencing risk factors of HNC among Indonesia populationThis study aim to determine the comparison of educational level and alcohol consumption in patients with nasopharyngeal cancer and oral cancer who came to dental clinic RSCM Jakarta between 2006-2009. The data was obtained from medical record of patients diagnosed with head and neck cancer who visited oral medicine clinic of RSCM Jakarta from 2006-2009. The data then was analyzed using SPSS version 20..The significance association were tested using Kolmogorof-Smirnov Z. The result showed that patient with the presence of alcohol use were mostly diagnosed with nasopharyngeal cancer. However, after compared between nasopharyngeal and non-npc group, there were no significant association found between the two groups (P=1.000). The level of formal education also did not significantly associated with the nasopharyngeal and nonnpc (P=0.995). In conclusion, there was no significant association found between educational level and alcohol use in nasopharyngeal cancer patients."

"Natural recovery from disease and damage in the adult mammalian central nervous system (CNS) is limited compared with that in lower vertebrate species, including fish and salamanders. Species-specific differences in the plasticity of the CNS reflect these differences in regenerative capacity. Despite numer- ous extensive studies in the field of CNS regeneration, our understanding of the molecular mechanisms determining the regenerative capacity of the CNS is still relatively poor. The discovery of adult neural stem cells (aNSCs) in mammals, including humans, in the early 1990s has opened up new possibilities for the treatment of CNS disorders via self-regeneration through the mobilization of these cells. How- ever, we now know that aNSCs in mammals are not plastic enough to induce significant regeneration. In contrast, aNSCs in some regenerative species have been found to be as highly plastic as early embry- onic neural stem cells (NSCs). We must expand our knowledge of NSCs and of regenerative processes in lower vertebrates in an effort to develop effective regenerative treatments for damaged CNS in humans. "

"Colon polyp is a term used for abnormality from bulging tissue above surrounding colonic mucosal layer. Adenoma polyp was the commonly found polyp that progress to colorectal cancer. Most of those patients was asymptomatic. Undetected and unmanaged polyp was a risk factors of colorectal cancer even."

"Difference between tissue specific stem cells and embryonic stem cells is explained. The advantages of the latter are included. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissue/organ regeneration is detailed. Role of neural cancer stem cells in brain tumors, including their role in brain tumor therapy and the role of CD133 stem cell antigen in glioma patients, is emphasized. Therapeutic role of bone marrow-derived stem cells in myocardial infarction and the role of mesenchymal stem cells in orthopedics are explained. Transplantation of umbilical cord hematopoietic stem cells and allogeneic hematopoietic stem cell transplantation followed by graft-versus-host disease are presented. Role of cancer stem cells specifically in glioblastoma and medulloblastoma is included. It is also emphasized that CD133 is an appropriate stem cell marker for gliomas. Targeting of cancer cells is also explained."

"It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Because of the pluripotency of embryonic stem cells, this volume discusses various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological uses. The role of these cells in cell differentiation is also included. The role of cancer stem cells of breast, colon, and melanoma tumors in response to antitumor therapy is detailed. The role of cancer stem cells, specifically in the deadliest brain cancer, glioblastoma multiforme, is explained. Transplantation of bone marrow-derived stem cells for myocardial infarcation and use of mesenchymal stem cells in orthopedics are described."

"The difference among pluripotent stem cells, multipotent stem cells, and unipotent stem cells is pointed out. Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: human embryonic stem cells, human mesenchymal stem cells, germ cell-derived pluripotent stem cells, induced pluripotent stem cells, human umbilical cord blood-derived stem cells, breast tumor stem cells,and hematopoietic stem cells. Because of the potential of human embryonic stem cells to produce unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential. Because of their pluripotency, these cells have been used in various applications such as tissue engineering, regenerative medicine, pharmacological and toxicological studies, and fundamental studies of cell differentiation. The formation of embryoid bodies, which are three-dimensional aggregates of embryonic stem cells, is explained as this is the first step in cell differentiation. Such embryoid body culture has been widely used as a trigger for the in vitro differentiation of embryonic stem cells. The basic capacity of self-renewal of human embryogenic stem cells is explained. The role of TGF-beta in the propagation of human embryonic stem cells is discussed. The differentiation of human embryonic stem cells into neurons, hepatocytes, cardiomyocytes, and retinal cells is fully explained. Donor policies for hematopoietic stem cells are also explained. "