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"It is now widely accepted that there are important links between inactivity and chronic lifestyle-related diseases, and that exercise can bring tangible therapeutic benefits to people with chronic disease. Exercise and Chronic Disease: An Evidence-Based Approach offers the most up-to-date survey currently available of the scientific and clinical evidence underlying the effects of exercise in relation to functional outcomes, disease-specific health-related outcomes and quality of life in patients with chronic disease conditions."

"This textbook approaches the study of critical care with teaching in mind. In medicine teachable moments usually occur in clinical context, where the engagement in a real case exemplifies principles of diagnosis or therapy. In order to replicate the teaching method, selected cases are presented within each chapter offering the reader an opportunity to process and reflect on the components of the topic within a practical scenario. While medical practice attempts to be evidence-based, common approaches to diagnosis and management incorporate not only evidence but heuristics and biases which await either validation or repudiation. Hence, each chapter is divided into two segments: the Principles of Management section - the common approach to the care of patients having a given condition is presented - and the Evidence Contour section, in which each author discusses the aspects of diagnosis and management that are the subject of ongoing debate."

"Now in a completely updated second edition, An Evidence-based Approach to Dietary Phytochemicals and Other Dietary Factors is a trusted resource for all health professionals who need to interpret the explosion of information on the role of a plant-based diet in health and disease. It consolidates a wealth of scientifically accurate, peer-reviewed data on plant foods, dietary phytochemicals, and dietary supplements, and includes information on essential intake recommendations, dietary sources, nutrient and drug interactions, phytochemicals in disease prevention, possible adverse effects, and much more.Special features:All chapters revised and updated, with new sections on choline, coenzyme Q10, L-Carnitine, lipoic acid, and other dietary factorsLogically structured for quick access to information: begins with the evidence-based benefits of fruits and vegetables, legumes, nuts, whole grains, coffee, and tea; and goes on to the scientific and clinical data on individual dietary phytochemicals and classes of phytochemicals, including carotenoids, flavonoids, fiber, and moreSummaries at the end of each chapter for rapid reviewPeer-reviewed by experts in the field, ensuring that all material is accurate and up-to-dateThe well-constructed appendix includes not only a quick reference to diseases and foods and where to find them in the book, but also useful tables on phytochemical-drug interactions, phytochemical-nutrient interactions, and phytochemical-rich foods; a summary of the glycemic index of dietary carbohydrates; and a comprehensive glossary of term"

"Background: peripheral neuropathy is known as one of most common complication in diabetes mellitus type 2 patient. This complication is caused by uncontrolled condition of blood glucose level in long periode. Regular physical activity in moderate to high intensity is beneficial in management of diabetes mellitus. This report aimed to know the effectiveness of aerobic exercise in causing improved peripheral functions in type 2 diabetes mellitus.Methods: literature searching using several related keywords in Medline, Pubmed,, and Cochrane library, following inclusion and exclusion criteria. Result: Dixit et al suggested that a heart rate intensity of 40-60 percent aerobic exercise of 30-45 min duration per session for eight weeks suggest an important impact in controlling diabetic peripheral neuropathy. Kluding PM et al suggested that significantly improved selected measures of peripheral nerve function (worst, pain levels and MNSI score, glycemic control (HbA1c), and resting heart rate. Conclusion: the studies showed significant benefit of aerobic exercise, despite the short duration of exercise being used as intervention towards improvement in peripheral nerve function. However, further studies with large samples and longer duration of intervention are needed to confirm the finding.

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Latar belakang: neuropati perifer merupakan salah satu komplikasi yang sering dijumpai pada penderita diabetes mellitus tipe 2. Timbulnya komplikasi ini dilatarbelakangi oleh kondisi kadar gula darah tidak terkontrol dalam waktu yang lama. Aktivitas fisik rutin dengan intensitas sedang sampai tinggi bermanfaat dalam pengelolaan diabetes mellitus. Telaah ini bertujuan untuk mengetahui efektivitas latihan aerobik dalam memperbaiki fungsi perifer yang lebih baik pada diabetes melitus tipe 2.

Metode: pencarian literatur menggunakan beberapa kata kunci yang terkait di perpustakaan elektronik Medline®, Pubmed®, dan Cochrane library, mengikuti kriteria inklusi dan eksklusi.

Hasil: studi Dixit et al menunjukkan bahwa 40-60% intensitas denyut jantung latihan aerobik dengan durasi 30-45 menit per sesi selama delapan minggu menunjukkan adanya dampak penting dalam mengontrol diabetes neuropati perifer. Kluding PM et al menunjukkan perbaikan secara signifikan dari pengukuran terpilih fungsi nervus perifer (tingkat keparahan “terburuk” dan skor MNSI), kontrol glikemik (HbA1c), dan denyut jantung istirahat.

Kesimpulan: penelitian ini menunjukkan manfaat latihan aerobik yang signifikan, meski menggunakan latihan singkat sebagai intervensi terhadap perbaikan fungsi saraf perifer. Namun, diperlukan penelitian lebih lanjut dengan sampel besar dan durasi intervensi yang lebih lama untuk mengonfirmasi temuan tersebut."

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