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"ABSTRAKLatar belakang : Keberhasilan gigi tiruan dukungan implan sangat ditentukan oleh stabilitas awal (primary stability) pada saat pemasangan, sehingga terjadiosseointegrasi. Stabilitas tersebut dipengaruhi oleh beban oklusal yang diterima melalui restorasi sementara. Beban oklusal yang diterima implant pada , dapat secara langsung pada saat implantasi (immediateloading) atau setelah terjadi osseointegrasi (delayed loading). Masih banyak kontroversi mengenai pengaruh besar beban pada stabilitas implan. Oleh karena itu, perlu dilakukan penelitian seberapa besar pengaruh kontak oklusal pada restorasi terhadap stabilitas implan yang dipasang secara immediate loading.Metode : Pada tiga ekor Macacafascicularis, dilakukan pemasangan Sembilan implant gigi. Segera setelah implant ditanam pada tulang, restorasi sementara dipasang pada implant dengan kontak ingan, normal dan tanpa kontak. Nilai stabilitas implant diukur menggunakan Ostell ISQ segera setelah pemasangan implan, bulan pertama dankedua setelah pemasangan implan.Hasil : Terdapat perbedaan bermakna dari nilaistabilitas implan (p<0,05) antara kelompok kontak oklusal normal dengan tanpakontak; dan kontak oklusal normal dengan kontak ringan. Namun tidak ditemukan perbedaan bermakna (p>0,05)pada kenaikan nilai stabilitas implan yang terjadi antara periode baseline, bulan pertama dan bulan kedua pada seluruh kelompok kontak oklusal.Simpulan: Terdapat pengaruh kontak oklusal restorasi sementara pada implan yang dipasang secara immediateloading terhadap stabilitas implan dan kontak oklusal yang menghasilkan nilai stabilitas paling besar setelah pemasangan implan adalah restorasi tanpa kontak.

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ABSTRACT

Introduction: successful of dental implant were determined by primary stability when placement. The stability were influnced by occlusal loading thriugh provisional restoration. There are two types of loading protocol that usually used, immediate and delayed loading. But there are still controversies about the influence of occlusal loading on implant's stability. Therefore, it was necessary to study the influence of immediate loading to implant's stability.

Method: Nine dental implants were placed on the mandibular of three Macacafascicularis. Provisional restorations with various occlusal contacts (no contact, light, and normal contact) were placed to the implant. Implant stability was measured using the Ostell ISQ three times, immediately (baseline), first month and second month after implant placement.

Result: Implant stability between implant with no occlusal contact and normal contact and also light occlusal and normal occlusal contact were found significantly different (p<0,05). However, there was no significant increased (p>0,05) found on implant stability measured at baseline, first and second month after implant placement for all occlusal contact groups.

Conclusion: There were influence of immediate loading to implant's stability and provisional restoration of implant without occlusal contact showed highest implant good stability result."

"Because of its high predictability of success, implant therapy is a reliable treatment for replacement of missing teeth. The concept of immediate implant loading has been widely accepted in terms of early esthetic and functional recovery. However, there is little biological evidence to support this concept. The objective of this study was to examine the interactive effects of mechanical loading and surface roughness of immediately loaded titanium implants on bone formation in rats. Screw-shaped anodized titanium implants were either untreated (smooth) or acid-etched. Two implants were inserted parallel to each other in the tibiae of rats, and a closed coil spring (2.0 N) was immediately applied. Trabecular and cortical bone around both implants was analyzed using microtomographic images, and a removal torque test was performed at weeks 1, 2, and 4. Immediate loading of acid-etched implants resulted in significant decreases in bone mineral density, contact surface area, and cortical bone thickness. These effects were not observed after immediate loading of smooth implants. Conversely, loading did not influence acid-etched implant fixation; however, smooth implant fixation at week 1 was significantly reduced. These results imply that surface roughness regulates bone response to mechanical stress and that immediate loading might not inhibit osseointegration for smooth and rough implants in the late healing stages."

"ABSTRACTThis study aimed to examine the dynamic change in bone metabolism by immediate loading in several sites around implants using high-resolution Na18F-PET scan. Two titanium implants ( 1.2 mm) were inserted parallel to each other in the right tibiae of Wistar rats (n = 4). The left tibia was set as control side. One day after insertion, closed coil springs of 4.0 N were attached to the expose superior portions of the implants to apply a continuous mechanical stress. The rats with fluorine-18 (18F) ion (5 mCi/rat) intravenously injected were scanned by PET scanner at 4, 7, 14, 28 days after load application. Round region of interests (ROIs) were set around the distal implant of the right tibia (loaded side) and same site (control) of the left tibia. Furthermore, four rectangular ROIs were set at the superior and inferior parts of traction side (mesial) and opposite side (distal) of the distal implant. Longitudinal dynamic changes in bone metabolism were evaluated by examination of the accumulation count of 18F ion at each ROI. The uptake values of ROIs (loaded side) initially increased until 7 days, and they gradually decreased from the peak level to the pre-loading level despite a static force being applied to the implants. In cancellous bone, the uptake values at the superior part of traction side and inferior part of opposite side showed significantly high value compared with those at other parts. In conclusion, immediate loading to the implant initially enhanced bone metabolism around it, especially at the part with compressive stress. Peri-implant bone metabolism varies according to different loading conditions."

"Latar belakang Kanker payudara merupakan salah satu kanker paling banyak dialami oleh perempuan di dunia. Data yang didapatkan di RSUPN Cipto Mangunkusumo Jakarta menunjukkan bahwa sebagian besar pasien datang pada stadium lanjut lokal. Penanganan kanker payudara pada tahap lanjut lokal meliputi pemberian kemoterapi neoadjuvan, mastektomi, serta rekonstruksi. Waktu pelaksanaan rekonstruksi payudara pascamastektomi terbaik masih mejadi perdebatan pada klinisi. Studi ini bertujuan untuk membandingkan luaran antara rekonstruksi payudara secara immediate dan delayed pada pasien kanker payudara lanjut lokal yang dilakukan mastektomi dan pemberian kemoterapi neoadjuvan.Metode Penelitian ini merupakan sebuah studi tinjauan sistematik dengan pencarian literatur dari basis data elektronik Cochrane, Pubmed, dan ScienceDirect, tanpa membatasi waktu dan bahasa. Telaah kritis dilakukan dengan menggunakan panduan Critical Appraisal Skills Programme (CASP). Luaran yang dinilai dalam penelitian ini adalah mortalitas, rekurensi, komplikasi, dan kualitas hidup.Hasil Ditemukan sebanyak empat artikel tentang perbandingan antara luaran rekonstruksi immediate dan delayed pada rekonstruksi kanker payudara stadium lanjut lokal pascakemoterapi neoadjuvan yang kemudian disaring hingga diperoleh dua artikel yang dinilai layak dikaji. Dari hasil kajian ini diketahui bahwa tidak terdapat perbedaan mortalitas dan rekurensi antar kelompok, didapatkan tingkat komplikasi yang lebih tinggi pada kelompok dengan rekonstruksi immediate, serta tidak didapatkan data mengenai kualitas hidup pada kedua kelompok.Kesimpulan Didapatkan tingkat komplikasi yang lebih tinggi secara signifikan pada rekonstruksi payudara secara immediate, namun tidak didapatkan perbedaan luaran pada parameter lainnya antar kelompok

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Background Breast cancer is one of the most common cancers among women in the world. Data from Cipto Mangunkusumo National General Hospital showed that most of the patients were in locally-advanced stage. The treatment of locally advanced breast cancer includes administration of neoadjuvant chemotherapy, mastectomy, and reconstruction. The ideal timing of post-mastectomy breast reconstruction is still a matter of debate for clinicians. This study aimed to compare the outcome between immediate and delayed breast reconstruction in locally advanced breast cancer after mastectomy and neoadjuvant chemotherapy.

Method This systematic review utilized Cochrane, Pubmed, and ScienceDirect as the databases. There was no limitation on the timing of publication, nor the language. The critical analysis was conducted using the Critical Appraisal Skills Program (CASP) guide. The outcomes assessed in this study were mortality, recurrences, complications, and quality of life.

Result There were four articles comparing immediate and delayed reconstruction outcomes in locally advanced breast cancer, after mastectomy and neoadjuvant chemotherapy. The articles were further screened to obtain two articles deemed suitable for this study. This study showed that there was no difference in mortality and recurrence between groups. However, there was a significant higher complication rate in the immediate reconstruction group. There was no data regarding the quality of life in the two groups.

Conclusion There was significantly higher rate of complications with immediate breast reconstruction, but there was no difference in outcome in other parameters between groups"