Hasil Pencarian

Ditemukan 180414 dokumen yang sesuai dengan query

Kartika Widya Rukmi

Korelasi ekspresi androgen receptor dan ekspresi chromogranin a pada adenokarsinoma prostat di RSUPN. Dr. Cipto Mangunkusumo = Correlation of androgen receptor expression and chromogranin a expression in prostate adenocarcinoma at RSUPN Dr. Cipto Mangunkusumo

"ABSTRAK

Latar belakang : Insiden Adenokarsinoma di RSCM meningkat pada periode 2001-2006 dibanding periode sebelumnya 1995-2000 . Banyak penderita yang resisten terhadap pengobaan hormonal. Resistensi ini diduga akibat sel tumor mengalami transformasi Neuroendokrin. Akan dilakukan penelitian untuk melihat ekspresi Androgen Receptor AR dan Chromogranin A CgA pada adenokarsinoma prostat di RSCM tahun 2011-2015.Tujuan : Membuktikan korelasi ekspresi AR dan CgA dengan derajat keganasan.Metode : Studi potong lintang analitik terhadap 70 kasus adenokarsinoma prostat di departemen PA FKUI/RSCM tahun 2011-2015. Kasus dipulas imunohistokimia AR dan Cg A serta dilakukan interpretasi hasil. AR dinilai prosentase positivitasnya pada inti epitel dan stromal. CgA dinilai prosentase positivitasnya pada sitoplasma. Uji korelasi dilakukan untuk melihat kemaknaan dan kekuatan korelasi antar variabel terikat.Hasil : Karakteristik sampel usia 47,1 >70 tahun; diferensiasi histopatologik/skor gleason 42,9 buruk/>7, grade group 28,6 grade5 dan PSA 64,3 dalam rentang 11-100ng/ml. Ekspresi CgA berkorelasi negatif lemah dengan ekspresi AR epitel r=-0,288;p=0,016 . Ekspresi CgA tidak berkorelasi dengan ekspresi AR stromal p=0,886 . Terdapat hubungan bermakna ekspresi AR epitel dengan grade group p=0,003 . Tidak terdapat hubungan bermakna ekspresi AR epitel dengan usia, diferensiasi histopatologik/skor gleason dan PSA. Ekspresi CgA berhubungan bermakna dengan diferensiasi histopatologik/skor gleason dan grade group p=0,018;p=0,038 . Tidak terdapat hubungan bermakna ekspresi CgA dengan usia dan PSA. Ekspresi AR stromal tidak berhubungan bermakna dengan usia, diferensiasi histopatologik, grade group, skor gleason, maupun PSA.Kesimpulan : Terdapat korelasi yang lemah antara AR dan CgA sehingga pulasan AR dan CgA dapat dipakai untuk pemilihan terapi.

ABSTRACT

Background Prevalence of prostate adenocarcinoma doubled in 2001 2006 compared to 1995 2000 in RSCM. Many patients resistant to hormonal treatment. This resistance is thought to be due to tumor cells undergoing neuroendocrine transformation. Study will be conducted to analyze the expression of Androgen Receptor AR and Chromogranin A CgA in prostate adenocarcinoma at RSCM in 2011 2015. Objective To prove correlation of expression of AR and CgA with degree of malignancy. Methods A cross sectional study was carried out on 70 cases of prostate adenocarcinoma in department of Anatomic Pathology FKUI RSCM from 2011 2015. AR expressed in stromal and epithelial nuclei, CgA expressed in cytoplasm. Statistical tests used to discover significance and correlation between the dependent variables. Results Most samples are more than 70 years old 47,1 , has poor histologic gleason score 42.9 , are in clinical grade 5 28.6 , and has PSA score range between 11 100 ng ml. CgA expression negatively correlates to epithelial AR expression r 0,288 p 0.016 , while no correlation are found between CgA expression and stromal AR expression p 0.886 . There is significant difference between epithelial AR expression with grade group p 0.003 , but not with age, histopathologic differentiation Gleason score and PSA. There are significant difference between CgA expression and histopathologic differentiation grade group and Gleason score p 0.018 p 0.038 , but not with age and PSA. No significant difference observed between stromal AR expression with age, histopathologic differentiation gleason score, grade group or PSA. Conclusion There rsquo s a weak correlation between AR and CgA so that AR and CgA expression can be used for the selection of therapy. "

2017

T-Pdf

UI - Tesis Membership Universitas Indonesia Library

Feriandri Utomo

Analisis ekspresi transporter zink (ZnT-1) sebagai faktor prognosis adenokarsinoma prostat = Expression analysis of zinc transporter (ZnT-1) as prognostic factor of prostate adenocarcinoma

"[ABSTRAK

Pendahuluan: Penurunan kadar Zink (Zn) pada prostat berkorelasi dengan peningkatan skor Gleason adenokarsinoma prostat dan menyebabkan rendahnya Caspase-3 sebagai eksekutor apoptosis. Tingkat ekspresi transporter Zn pada sel tumor prostat berhubungan dengan tingkat keganasannya. ZnT-1 merupakan transporter Zn ke luar sel prostat, sedangkan ZIP-1 merupakan transporter Zn ke dalam sel prostat. Ekspresi ZIP-1 turun pada adenokarsinoma prostat. Korelasi ZnT-1, ZIP-1 dan Caspase-3 diduga berpengaruh dalam karsinogenesis prostat, sehingga berpotensi untuk menjadi faktor prognosis adenokarsinoma prostat. Tujuan: Mempelajari korelasi ekspresi ZnT-1 dan aktivasi Caspase-3 terhadap skor Gleason, menganalisis korelasi ekspresi ZIP-1, ZnT-1 dan aktivasi Caspase- 3, serta mengetahui profil ekspresi ZnT-1 pada jaringan adenokarsinoma prostat yang berbeda skor Gleason, dibandingkan dengan jaringan Benign Prostatic Hyperplasia (BPH),

Desain: Studi retrospektif analitik potong lintang. Metode: Sampel penelitian ini adalah 31 blok parafin prostat yang dikelompokkan menjadi BPH, adenokarsinoma prostat skor Gleason ≤ 7 dan skor Gleason > 7. Ekspresi ZnT-1 dinilai dengan pulasan imunohistokimia. Data ekspresi ZIP-1 dan Caspase-3 merupakan data sekunder dari penelitian Septiawan et al. Hasil: Ekspresi ZnT-1 berkorelasi dengan skor Gleason adenokarsinoma prostat. Ekspresi ZIP-1 berkorelasi dengan aktivasi Caspase-3 pada adenokarsinoma prostat dan adenokarsinoma prostat skor Gleason ≤ 7. Ekspresi ZnT-1 berkorelasi dengan ekspresi ZIP-1 pada adenokarsinoma prostat skor Gleason > 7. Ekspresi ZIP-1 berkorelasi kuat dengan aktivasi Caspase-3 pada adenokarsinoma prostat skor Gleason 8. Ekspresi ZnT-1 pada adenokarsinoma prostat skor Gleason > 7 lebih rendah dibandingkan pada skor Gleason ≤ 7, tetapi tidak dapat dianalisis kemaknaan perbedaannya dengan BPH karena hanya diperoleh 1 sampel BPH pada penelitian ini. Kesimpulan: Transporter Zn berpotensi untuk menjadi faktor prognosis adenokarsinoma prostat.

ABSTRACT

Background: Decreased levels of Zinc ( Zn ) in the prostate correlates with an increase in the grade Gleason score of prostate adenocarcinoma and decrease in Caspase-3 as apoptosis executor. Zn transporter expression levels in prostate tumor cells associates with the level of malignancy. The ZnT-1 is Zn exporter, while the ZIP-1 is Zn importer of prostate cells. ZIP-1 expression drops on adenocarcinoma prostate. Correlation ZnT-1, ZIP-1 and Caspase-3 allegedly influential in prostate carcinogenesis and potential to be prognostic factor of prostate adenocarcinoma.

Objective: To analyze the correlation ZnT-1 and Caspase-3 activation of the gleason score, to analyze the correlation of the expression of ZIP-1, ZnT-1 and Caspase-3 activation in adenocarcinoma prostate, and to study the profile expression of ZnT-1 in prostate adenocarcinoma with different grading of Gleason scores, compared with benign prostatic hyperplasia (BPH),

Design: A cross-sectional retrospective study analytic . Methodology: The sample is 31 paraffin blocks were grouped into BPH, prostate adenocarcinoma Gleason scored ≤ 7 and prostate adenocarcinoma Gleason scored > 7. Samples are analyzed expression of ZnT-1 by immunohistochemical staining. ZIP-1 and Caspase-3 expression is secondary data of Septiawan et al?s immunohistochemical staining. Results: ZnT-1 expression correlated with gleason score. ZIP-1 correlated with the activation of Caspase-3 in prostate adenocarcinoma and prostate adenocarcinoma Gleason score ≤ 7. ZnT-1 correlated with ZIP-1 in prostate adenocarcinoma Gleason score > 7. ZnT-1 expression in prostate adenocarcinoma Gleason scored > 7 was lower than prostate adenocarcinoma Gleason score ≤ 7, but could not be analyzed the difference significance with BPH because there was only 1 BPH sample in this research. Conclusion: Zn transporters have the potential to be a prognostic factor of prostate adenocarcinoma.;Background: Decreased levels of Zinc ( Zn ) in the prostate correlates with an increase in the grade Gleason score of prostate adenocarcinoma and decrease in Caspase-3 as apoptosis executor. Zn transporter expression levels in prostate tumor cells associates with the level of malignancy. The ZnT-1 is Zn exporter, while the ZIP-1 is Zn importer of prostate cells. ZIP-1 expression drops on adenocarcinoma prostate. Correlation ZnT-1, ZIP-1 and Caspase-3 allegedly influential in prostate carcinogenesis and potential to be prognostic factor of prostate adenocarcinoma.

Design: A cross-sectional retrospective study analytic . Methodology: The sample is 31 paraffin blocks were grouped into BPH, prostate adenocarcinoma Gleason scored ≤ 7 and prostate adenocarcinoma Gleason scored > 7. Samples are analyzed expression of ZnT-1 by immunohistochemical staining. ZIP-1 and Caspase-3 expression is secondary data of Septiawan et al’s immunohistochemical staining. Results: ZnT-1 expression correlated with gleason score. ZIP-1 correlated with the activation of Caspase-3 in prostate adenocarcinoma and prostate adenocarcinoma Gleason score ≤ 7. ZnT-1 correlated with ZIP-1 in prostate adenocarcinoma Gleason score > 7. ZnT-1 expression in prostate adenocarcinoma Gleason scored > 7 was lower than prostate adenocarcinoma Gleason score ≤ 7, but could not be analyzed the difference significance with BPH because there was only 1 BPH sample in this research. Conclusion: Zn transporters have the potential to be a prognostic factor of prostate adenocarcinoma.;Background: Decreased levels of Zinc ( Zn ) in the prostate correlates with an increase in the grade Gleason score of prostate adenocarcinoma and decrease in Caspase-3 as apoptosis executor. Zn transporter expression levels in prostate tumor cells associates with the level of malignancy. The ZnT-1 is Zn exporter, while the ZIP-1 is Zn importer of prostate cells. ZIP-1 expression drops on adenocarcinoma prostate. Correlation ZnT-1, ZIP-1 and Caspase-3 allegedly influential in prostate carcinogenesis and potential to be prognostic factor of prostate adenocarcinoma.

Design: A cross-sectional retrospective study analytic . Methodology: The sample is 31 paraffin blocks were grouped into BPH, prostate adenocarcinoma Gleason scored ≤ 7 and prostate adenocarcinoma Gleason scored > 7. Samples are analyzed expression of ZnT-1 by immunohistochemical staining. ZIP-1 and Caspase-3 expression is secondary data of Septiawan et al’s immunohistochemical staining. Results: ZnT-1 expression correlated with gleason score. ZIP-1 correlated with the activation of Caspase-3 in prostate adenocarcinoma and prostate adenocarcinoma Gleason score ≤ 7. ZnT-1 correlated with ZIP-1 in prostate adenocarcinoma Gleason score > 7. ZnT-1 expression in prostate adenocarcinoma Gleason scored > 7 was lower than prostate adenocarcinoma Gleason score ≤ 7, but could not be analyzed the difference significance with BPH because there was only 1 BPH sample in this research. Conclusion: Zn transporters have the potential to be a prognostic factor of prostate adenocarcinoma., Background: Decreased levels of Zinc ( Zn ) in the prostate correlates with an increase in the grade Gleason score of prostate adenocarcinoma and decrease in Caspase-3 as apoptosis executor. Zn transporter expression levels in prostate tumor cells associates with the level of malignancy. The ZnT-1 is Zn exporter, while the ZIP-1 is Zn importer of prostate cells. ZIP-1 expression drops on adenocarcinoma prostate. Correlation ZnT-1, ZIP-1 and Caspase-3 allegedly influential in prostate carcinogenesis and potential to be prognostic factor of prostate adenocarcinoma.

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2014

T58771

UI - Tesis Membership Universitas Indonesia Library

Aditya D. Septiawan

Analysis expression of ZIP1 and caspase-3 protein in adenocarsinoma of the prostate / Aditya D Septiawan, Ria Kodariah, Meilania Saraswati

"Objective: Carcinogenesis of adenocarcinoma of the prostate occurs due to dysregulation of zinc level within the cells.

Intracellular zinc molecules influx is regulated by a transporter protein ZIP1, whose non-presence is predicted to inhibit

apoptosis, thus leads to the development of prostate adenocarcinoma. Methods: This study was aimed to analyze the

correlation of ZIP1 and Caspase-3 expression in prostate adenocarcinoma on its grading as represented by Gleason

Score. This was a cross-sectional, retrospective analytical study on 31 formalin-fixed, paraffin-embedded tissue that

meets inclusion criteria. The specimen was stained using the immune-histochemistry technique for ZIP1 and Caspase-3.

Protein expression of each case was counted using ImageJ analysis. Gleason score was acquired as secondary data from

the cases’s reports. The correlation of their expression with respect to Gleason score was analyzed with Pearson’s

correlation using SPSS 11.5. Results: Mean expression level of ZIP1 and Caspase-3 in prostate adenocarcinoma were

35% and 33%, respectively. There was a significantly positive correlation between ZIP1 and Caspase-3 expression

(r = 0.379; p = 0.018). However, their correlation was stronger in intermediate-grade group (r = 0.73; p = 0.01) and the

correlation was much weaker in high-grade group (r = 0.04; p = 0.48). Conclusions: There was a positive correlation

between ZIP1 and Caspase-3 expression in prostate adenocarcinoma."

Fakultas Kedokteran Universitas Indonesia, 2016

PDF

Artikel Jurnal Universitas Indonesia Library

Mohamad Yanuar Amal

Perbedaan Rasio Apparent Diffusion Coefficient Tumor Prostat Terhadap Derajat Keganasan Adenokarsinoma Asinar Prostat Pada Pemeriksaan Magnetic Resonance Imaging 1,5 Tesla Menggunakan Body Coil = Differences Apparent Diffusion Coefficient Ratio in determining the Degree of Adenocarcinoma Acinar Prostate using 1.5 Tesla MRI Prostate Examination with Body Coil

"Latar Belakang:Kanker prostat merupakan keganasan ketiga yang paling sering ditemukan di Indonesia. Sekitar 90-95% kanker prostat adalah adenokarsinoma asinar. Prognosis kanker prostat dan strategi tatalaksana didasarkan pada derajat keganasan. Tujuan penelitian ini untuk evaluasi rasio ADC dalam menentukan agresivitas kanker prostat.

Metode:Sebanyak 32 sampel kanker prostat dari zona perifer yang terbukti dengan biopsi dan telah dilakukan pemeriksaan MRI 1,5T dengan body coil. Rasio ADC dihitung menggunakan nilai ADC tumor dengan urin di vesika urinaria, otot obturator, dan ramus pubis sebagai referensi. Analisis rasio ADC dengan hasil histopatologi grade group <2 dan >3 menggunakan student t. Kurva ROC digunakan untuk akurasi diagnostik rasio ADC dalam menentukan grade group.

Hasil:Terdapat 12 dan 20 sampel grade group <2 dan >3. Rasio ADC tumor-urin 0,24, tumor-obturator internus 0,64, dan tumor-ramus pubis 0,85, lebih rendah dan bermakna pada pasien dengan grade group >3 (p <0,005). AUC dihitung menggunakan rasio ADC tumor-urin menunjukkan hasil tertinggi (0,988) di antara rasio ADC tumor-obturator internus (0,887) dan tumor-ramus pubis (0,783).Kesimpulan:Ketiga rasio ADC berbeda bermakna dalam membedakan grade group<2 dan grade group>3, serta merupakan prediktor signifikan dari kanker prostatgrade group >3.

Background: Prostate cancer is the third most common malignancy in Indonesia. Approximately 90-95% of prostate cancers are adenocarcinoma acinar. Prostate cancer prognosis and treatment strategies are based on degree of malignancy. Objective of this study was to evaluate the ADC ratio in determining the aggressiveness of prostate cancer.
Method: Thirty two prostate cancer samples from peripheral zones were proven by biopsy and 1.5T MRI examination was performed with body coil. ADC ratio was calculated using ADC value of tumor with urine in bladder, obturator muscle, and pubic ramus as a reference. Analysis ADC ratio with grade group <2 and >3 using a student T-test. The ROC curve is used for the accuracy of ADC ratio in determining the grade group.
Results: Twelve and 20 samples of grade group <2 and >3. Three ADC ratio (0.24, 0.64, and 0.85, respecively) lower in grade group >3 (p <0.002). AUC was calculated, ratio ADC tumor-urine show the highest results (0.988) among tumor-internal obturator (0.887) and tumor-pubic ramus (0.783).
Conclusion: Three ADC ratio have differed significantly in distinguishing grade group <2 and >3, and were a significant predictor of grade group >3 prostate cancer."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018

T-Pdf

UI - Tesis Membership Universitas Indonesia Library

Eka Novita

Perbedaan ekspresi androgen receptor ar pada hiperplasia prostat dan adenokarsinoma prostat tipe asinar di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo = The Difference of immunohistochemical expression of androgen receptor ar in benign prostate hyperplasia and adenocarcinoma acinar of the prostate in Cipto Mangunkusumo hospital

"ABSTRAK

Latar Belakang: Beberapa studi menyebutkan bahwa penilaian kelainan yang terjadi pada prostat adalah dengan mengukur jumlah Androgen Receptor AR pada setiap kasus dan dipakai sebagai evaluasi terhadap keberhasilan terapi hormonal baik pada hiperplasia prostat/benign prostat hyperplasia BPH maupun adenokarsinoma prostat /adenocarcinoma prostate CaP . AR memerankan peran dalam proses pertumbuhan, differensiasi dan memelihara kondisi jaringan prostat tetap normal. Pada penelitian lain menyebutkan bahwa ekspresi AR positif berhubungan erat dengan gambaran derajat dan differensiasi tumor serta nilai skor Gleason. Tujuan penelitian ini untuk mengetahui perbedaan ekspresi AR pada hiperplasia prostat dan adenokarsinoma prostat.Bahan dan Metode: Penelitian ini menggunakan metode potong lintang. Sampel penelitian terdiri atas 20 kasus hiperplasia prostat dan 25 kasus adenokarsinoma prostat tipe asinar. Dilakukan pulasan imunohistokimia AR dan penilaian intensitas pulasan pada inti stromal dan inti epitel dengan menggunakan histoscore H-score . Hasil: Terdapat perbedaan bermakna kadar PSA antara hiperplasia prostat dan adenokarsinoma prostat p=0,004 . Ekspresi AR pada inti sel stromal pada hiperplasia prostat lebih tinggi dibandingkan pada adenokarsinoma prostat, dan mempunyai hasil statistik yang bermakna p=0,000 . Sedangkan ekspresi AR pada inti sel epitel menunjukkan hasil yang tidak bermakna pada kedua kelompok kasus p=0,152 . Intesitas ekspresi AR pada adenokarsinoma prostat dengan skor Gleason rendah le;7 lebih kuat dibandingkan adenokarsinoma prostat dengan skor Gleason tinggi >7 .Kesimpulan: Ekspresi AR pada inti sel stromal pada hiperplasia prostat lebih tinggi dibandingkan pada adenokarsinoma prostat. Peningkatan skor Gleason cenderung diikuti dengan penurunan intensitas ekspresi AR. Ekspresi AR pada hiperplasia prostat dan adenokarsinoma prostat dapat digunakan dalam prognosis dan prediksi serta evaluasi keberhasilan terapi hormonal.

ABSTRACT

"Background Previous studies suggested that Androgen Receptor AR expression could be used to evaluate the successful rate among patient with Benign prostate hyperplasia BPH or Adenocarcinoma acinar of the prostate CaP treated with hormonal therapy. AR plays role in prostate growth and differentiation, and maintains the normal state of the tissue. While in pathologic state, AR expression correlate with tumor grade and differentiation, and Gleason score GS . This study aimed to compare the expression of AR between BPH with CaP.Method This research use a cross sectional study conducted twenty cases of BPH and twenty five cases of CaP. Each tissue were stained using antibody against AR, and histologically reviewed. The captured photomicrographs were further analyze using histoscore H score .Result There was statistically signifinat levels PSA between BPH and CaP p 0,004 . The nucleus of stromal AR expression in BPH group compare to CaP group was statistically significant difference diagnose vs nucleus of stromal AR expression p 0,000 . Meanwhile, no significant difference is found between nucleus of epithelial AR expression between two group p 0,152 . The intensity expression AR in CaP with low Gleason score GS le 7 is higher than CaP with high Gleason score GS 7 Conclusion BPH expresess more nucleus of stromal AR than CaP. The higher Gleason score tends followed by declining intensity expression of AR. Thus suggest AR rsquo s role can use in prognosis, prediction and evaluation of hormonal theraphy of BPH or prostate malignancy."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2016

T58868

UI - Tesis Membership Universitas Indonesia Library

Jasmine Arini Putri

The correlation between gleason score and prostate specific antigen (PSA) in patients diagnosed with prostatic adenocarcinoma in Department of Anatomical Pathology Cipto Mangunkusumo Hospital = Korelasi antara skor gleason dengan prostate specific antigen (PSA) pada pasien adenokarsinoma prostat di Departemen Patologi Anatomik RSCM

"Latar belakang: Adenokarsinoma prostat adalah keganasan tersering kedua yang dialami pria di Indonesia. Skor Gleason digunakan untuk mengklasifikasi tingkat diferensiasi dari tumor sedangkan menghitung kadar PSA digunakan sebagai salah satu cara untuk mendiagnosis kanker prostat.

Tujuan: Riset ini bertujuan untuk mengetahui korelasi antara skor Gleason dengan kadar PSA pada pasien adenokarsinoma prostat di departemen Patologi Anatomik RSCM.

Metode Penelitian: Data dikumpulkan dari 77 sampel yang didapat dari form pemeriksaan hasil diagnosis pasien adenokarsinoma prostat tahun 2011 sampai 2014 di arsip Department Patologi Anatomik RSCM. Data diolah menggunakan analisis uji korelasi Kendall Tau-b di program SPSS 20.

Hasil: Sebagian besar pasien datang dengan skor Gleason yang sudah tinggi skor Gleason >7. Nilai PSA terkecil yang didapat dari arsip departemen Patologi Anatomik sebesar 2,73 ng/ml, nilai tertinggi mencapai 7100 ng/ml. Nilai rata-rata PSA meningkat dengan meningkatnya skor Gleason. Rata-rata nilai PSA dari skor Gleason 6, 7, 8, 9, dan 10 adalah 46,641 ng/ml, 63,935 ng/ml, 231,762 ng/ml, 542,146 ng/ml, and 1044,348 ng/ml p = 0,003, r = 0,254.

Kesimpulan: Terdapat korelasi yang lemah antara skor Gleason dengan nilai PSA pada pasien adenokarsinoma prostat di Department Patologi Anatomik RSCM. Nilai PSA meningkat seiring meningkatnya skor Gleason.

Background: Prostatic adenocarcinoma is the second most frequent malignancies occur in men in Indonesia. Gleason score is used to classify the grading of the tumor and PSA is used as one of diagnostic tools for prostate cancer.
Aim: To identify the correlation between Gleason score and PSA level in patients with prostate adenocarcinoma at Department of Anatomical Pathology Cipto Mangunkusumo Hospital. Method The data was obtained from 77 samples taken from request forms from patients with prostatic adenocarcinoma from 2011 to 2014 in the archive of Department of Anatomical Pathology and analyzed using Kendall Tau b rsquo s Rank Correlation in SPSS 20.
Result: Most patient came with high Gleason Score Gleason score 7 . The minimum PSA level obtained from the arcieve in Department of Anatomical Pathology is 2.73 ng ml and the highest value reached up to 7100 ng ml. The average PSA level increased with the Gleason score. Gleason score 6, 7, 8, 9, and 10 has the average PSA level of 46.641 ng ml, 63.935 ng ml, 231.762 ng ml, 542.146 ng ml, and 1044.348 ng ml respectively p 0.003, r 0.254.
Conclusion: There is statistically weak significant correlation between Gleason score and PSA level in patients with prostatic adenocarcinoma in Department of Anatomical Pathology Cipto Mangunkusumo Hospital. PSA increased as the Gleason score increase."

Depok: Fakultas Kedokteran Universitas Indonesia, 2015

S-Pdf

UI - Skripsi Membership Universitas Indonesia Library

Tatin Rustin Hartiarsah

Gambaran CT scan toraks adenokarsinoma paru berdasarkan status mutasi epidermal growth factor receptor di Rumah Sakit Cipto Mangunkusumo = CT characteristics of lung adenocarcinoma based on epidermal growth factor receptor mutation status at Ciptomangunkusumo Hospital

Depok: Fakultas Kedokteran Universitas Indonesia, 2018

T-Pdf

UI - Tesis Membership Universitas Indonesia Library

Fatan Abshari

Validasi indonesian prostate cancer risk calculator (IPCRC) dalam memprediksi kanker prostat di RSUPN Cipto Mangunkusumo Jakarta = Validating Indonesian prostate cancer risk calculator (IPCRC) for predicting prostate cancer risk in Cipto Mangunkusumo Hospital Jakarta

"Kanker prostat adalah penyakit progresif yang menghasilkan moribiditas dan mortalitas yng tinggi. Penelitian ini berutujuan untuk menilai ketepatan dari Indonesian Prostate Cancer Risk Calculator IPCRC dalam memprediksi risiko kanker prostate. Data penelitian didapatkan secara retrospektif selama periode Agustus 2014 hingga Desember 2015 dari rekam medis pasien terduga kanker prostat. Pemeriksaan colok dubur, Prostate specific antigen PSA, dan volume prostat digunakan sebagai parameter prediktif dalam IPCRC. Biopsi prostat digunakan sebagai standar baku. Akurasi IPCRC divalidasi dengan menggunakan analisis ROC. Penelitian ini memiliki 127 subjek penelitian dengan median usia pasien BPH dan pasien kanker prostat adalah 66 52-85 dan 69.5 50-100 tahun. Pemeriksaan colok dubur yang tidak normal ditemukan pada 2 pasien 2. Median dari PSA dari pasien BPH dan kanker prostat dalah 10.2 1.6-203.1 dan 74.06 6.94-1412. Volume prostate pasien BPH memiliki median sebesar 47.9 13.774-108 dibandingkan 50.25 19.2-107 pada pasien kanker prostate. Area tersebesar dibawah kurva probabilitas kanker prostat adalah 0.907 95 CI 0.84-0.97. Jika probabilitas kanker prostate lebih dari 15 pada IPCRC, sensitivitas IPCRC mencapai 88.5 dan spesifitas IPCRC mencapai 81.8, dimana bila ditemukan probabilitas kanker prostate lebih dari 20 dengan menggunakan IPCRC, sensitivitasnya mencapai 80.8 dengan spesifitas sebesar 89.9. Dan bila probabilitas kanker prostate lebih dari 25 dalam IPCRC, sensitivitas sebesar 65.4 dan spesifisitas sebesar 89.9. Sehingga, dapat disimpulkan IPCRC merupakn perangkat yang akurat dalam prediksi kanker prosate pada populasi ini. Validasi lebih lanjut masih dibutuhkan pada populasi lain.

Prostate cancer is a progressive disease resulting in morbidity and mortality. The aim of this study is to assess the accuracy of Indonesian Prostate Cancer Risk Calculator IPCRC in predicting prostate cancer risk. Data were obtained retrospectively during August 2014 to December 2015 from medical records of suspected prostate cancer patients. Digital rectal examination, Prostate Specific Antigen PSA, and prostate volume PV were used as predictive parameters in IPCRC. Prostate biopsy was used as the diagnostic gold standard. The accuracy of IPCRC was validated using the ROC analysis. Our study included 127 subjects. Median age of BPH patients and prostate cancer patients were 66 52-85 and 69.5 50-100. The digital rectal examination was found abnormal in 2 patients 2. Median of PSA of BPH patients and prostate cancer patients were 10.2 1.6-203.1 and 74.06 6.94-1412 respectively. The prostate volume of BPH patients 47.9 13.74-108 median compared to prostate cancer patients 50.25 19.2-107 median. The largest area under the curve of the probability of prostate cancer using IPCRC is 0.907 95 CI 0.84-0.97. If the probability of prostate cancer more than 15 using IPCRC, the sensitivity is 88.5 and specificity is 81.8, besides, if the probability of prostate cancer more than 20 using IPCRC, the sensitivity is 80.8 and specificity is 89.9 and if the probability of prostate cancer more than 25 using IPCRC, the sensitivity is 65.4 and specificity is 89.9 IPCRC is accurate for predicting prostate cancer in our population. Further validation is needed in other population. "

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018

SP-Pdf

UI - Tugas Akhir Universitas Indonesia Library

Jessica Prisscila

Profil Ekspresi pVHL (von Hippel-Lindau Gene Product) pada Adenokarsinoma Duktal Pankreas dan Pankreas Non-Neoplastik serta Hubungannya dengan Profil Klinikopatologi = The von Hippel-Lindau Gene Product (pVHL) Expression Profile in Pancreatic Ductal Adenocarcinoma and Non-Neoplastic Pancreatic Tissue and Its Correlation with Clinicopathological Factors

"Keganasan pankreas merupakan keganasan dengan angka kematian yang tinggi, dengan Adenokarsinoma Duktal Pankreas/Pancreatic Ductal Adenocarcinoma (PDAC) mencakup 85-90% kasus. PDAC memiliki perjalanan penyakit yang sangat agresif, dan seringkali baru terdiagnosis pada stadium lanjut. Penegakan diagnosis pasti PDAC seringkali hanya dapat dilakukan melalui sediaan terbatas baik berupa biopsi maupun endoscopic ultrasound-guided fine-needle aspiration/EUS-FNA. Salah satu tantangannya adalah membedakan PDAC dari jaringan pankreas non-neoplastik/reaktif. Penelitian ini akan membahas mengenai peran von Hippel-Lindau gene product/pVHL dalam membedakan PDAC dengan jaringan pankreas non-neoplastik, serta hubungannya dengan profil klinikopatologiradira PDAC. Penelitian ini merupakan penelitian observasional analitik dengan desain cross-sectional pada kasus PDAC dan jaringan pankreas non-neoplastik yang dilakukan di RSCM pada sampel yang diperoleh pada bulan Januari 2012 hingga September 2023. Sampel penelitian dibagi menjadi 2 kelompok besar, yaitu kelompok PDAC dan pankreas non-neoplastik. Pemilihan sampel dilakukan dengan menggunakan simple random sampling dari kasus-kasus yang memenuhi kriteria inklusi dan tidak termasuk dalam kriteria eksklusi. Dilakukan pulasan imunohistokimia pVHL dan perhitungan Histoscore/H-score serta penentuan cut-offnya untuk membagi ekspresi pVHL menjadi tinggi dan rendah dan hubungannya dengan PDAC dan non-neoplastik, serta profil klinikopatologi pada kelompok PDAC. Penelitian ini menunjukkan tidak terdapat perbedaan ekspresi pVHL pada kelompok PDAC dan non-neoplastik, dan staging pN memiliki hubungan bermakna dengan ekspresi pVHL pada PDAC. Ekspresi pVHL yang rendah lebih banyak ditemukan pada PDAC berdiferensiasi sedang, tidak ditemukan invasi limfovaskular maupun invasi perineural, memiliki batas sayatan yang tidak bebas, memiliki staging pT2, pN0, M0, dan kesintasan > 7 bulan. Sebaliknya, ekspresi pVHL yang tinggi juga lebih banyak ditemukan pada PDAC berdiferensiasi sedang, ditemukan invasi limfovaskular, tidak ditemukan invasi perineural, status batas sayatan yang bebas, staging pT2 dan pT3, pN1 dan pN2, M0, dengan kesintasan ≤ 7 bulan. Temuan ini berbeda dengan penelitian sebelumnya yang mendapati hilangnya ekspresi pVHL pada tumor PDAC, dan sebaliknya pada duktus pankreas non-neoplastik. Hal ini kemungkinan disebabkan oleh perbedaan klon antibodi yang digunakan pada penelitian ini dibandingkan dengan penelitian sebelumnya. Klon antibodi yang digunakan adalah VHL40, sedangkan penelitian-penelitian sebelumnya menggunakan klon FL-181 yang berikatan dengan asam amino yang berbeda dan memiliki klonalitas yang berbeda pula. Selain itu, pada PDAC dapat terjadi mutasi pada gen VHL yang menghasilkan protein VHL yang non-fungsional yang kemungkinan masih dapat terdeteksi dengan ikatan antigen-antibodi pada penelitian ini.

Pancreatic malignancy is a malignancy with a high mortality rate, with Pancreatic Ductal Adenocarcinoma (PDAC) accounting for 85-90% of cases. PDAC has a very aggressive disease course, and is often only diagnosed at an advanced stage. Establishing a definite diagnosis of PDAC can often only be done through limited sample from biopsy or endoscopic ultrasound-guided fine-needle aspiration/EUS-FNA. In such limited sample, differentiating PDAC from non-neoplastic/reactive pancreatic tissue can be challenging. This research will discuss the role of von Hippel-Lindau gene product/pVHL in PDAC and non-neoplastic pancreatic tissue, as well as their relationship with PDAC pathological factors. This research is an analytical observational study with a cross-sectional design on cases of PDAC and non-neoplastic pancreatic tissue conducted at RSCM on samples obtained from January 2012 to September 2023. The research samples were divided into 2 large groups, namely the PDAC and non-neoplastic pancreatic groups. Sample selection was carried out using simple random sampling from cases that met the inclusion criteria and were not included in the exclusion criteria. Immunohistochemistry of pVHL was performed along with calculation of Histoscore/H-score and determination of cut-offs to divide pVHL expression into high and low and its relationship with PDAC and non-neoplastic, as well as pathological factors in the PDAC group. This study shows that there is no difference in pVHL expression in the PDAC and non-neoplastic groups, and pN staging has a significant relationship with pVHL expression in PDAC. Low pVHL expression is more often found in moderately differentiated PDAC, no lymphovascular invasion or perineural invasion, non-free incision margins, staging pT2, pN0, M0, and survival > 7 months. In contrast, high pVHL expression was also found more frequently in moderately differentiated PDAC, lymphovascular invasion was found, no perineural invasion was found, free incision margin status, pT2 and pT3 staging, pN1 and pN2, M0, with survival ≤ 7 months. This finding is different from previous studies which found loss of pVHL expression in PDAC tumors, and vice versa. This difference in results is likely due to differences in the antibody clones used in this study compared to previous studies. The antibody clone used was VHL40, whereas previous studies used the FL-181 clone which binds to different amino acids and has different clonality. In addition, in PDAC there is a mutation in the VHL gene which may produce a non-functional VHL protein that still be detectable by antigen-antibody binding in this study."

Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023

SP-pdf

UI - Tugas Akhir Universitas Indonesia Library

Gusyani Rahmawati

Analisis Asuhan Keperawatan pada Pasien Adenokarsinoma Kolon Desendens Pasca End Colostomy dan Laparatomi Adhesiolisis dengan Intervensi Teknik Relaksasi Napas Dalam di RSUPN Cipto Mangunkusumo Jakarta = ANALYSIS OF NURSING CARE IN DECENDENCE COLLON ADENOCARSINOMA PATIENTS POST END COLOSTOMY AND ADHESIOLYSIS LAPARATOMY WITH INTERVENTION DEEP BREATHING RELAXATION TECHNIQUES IN CIPTO MANGUNKUSUMO HOSPITAL, JAKARTA

"Kanker kolorektal merupakan jenis kanker terbanyak ketiga di Indonesia. Hal ini disebabkan oleh pola hidup yang tidak sehat seperti merokok, pola makan yang mengadopsi makanan cepat saji, kegemukan, dan kurangnya aktivitas fisik. Penatalaksanaan medis utama pada kasus kolorektal yaitu pembedahan dengan cara mereseksi kanker, kemudian membuat stoma, dan penyambungan kembali usus yang disebut anastomosis. Salah satu masalah utama pada pasien postoperasi adalah nyeri akut. Penelitian ini bertujuan untuk menyajikan hasil analisis asuhan keperawatan pada pasien post operasi close colostomy dan dan laparatomi adhesiolisis. Metode yang digunakan adalah studi kasus. Adapun intervensi berbasis bukti yang diterapkan yaitu intervensi manajemen nyeri berupa teknik relaksasi napas dalam guna menurunkan intensitas nyeri pada pasien post operasi close colostomy dan laparatomi adhesiolisis. Penerapan teknik relaksasi napas dalam diharapkan dapat diaplikasikan oleh perawat bedah di ruangan khususnya untuk mengurangi nyeri akut post operasi close colostomy dan laparatomi adhesiolisis. Kata kunci : kanker kolorektal, close colostomy, laparatomi adhesiolisis, nyeri akut, relaksasi napas dalam.

Colorectal cancer is the third most common type of cancer in Indonesia. This is caused by unhealthy lifestyles such as smoking, eating patterns that adopt fast food, obesity, and lack of physical activity. The main medical management in colorectal cases is surgery by resecting the cancer, then making a stoma, and reconnecting the intestine which is called anastomosis. One of the main problems in postoperative patients is acute pain. This study aims to present the results of the analysis of nursing care in postoperative patients with close colostomy and adhesiolysis and laparotomy. The method used is a case study. The evidence-based intervention applied is pain management intervention in the form of deep breathing relaxation techniques to reduce pain intensity in postoperative close colostomy and adhesionic laparotomy patients. It is hoped that the application of deep breathing relaxation techniques can be applied by surgical nurses in the room especially to reduce acute pain after close colostomy surgery and adhesiolysis laparotomy. Keywords : colorectal cancer, close colostomy, laparotomy adhesiolisis, acute pain, deep breat relaxation."

Depok: Fakultas Ilmu Keperawatan Universitas Indonesia , 2020

PR-Pdf

UI - Tugas Akhir Universitas Indonesia Library

<< 1 2 3 4 5 6 7 8 9 10 >>

Hasil Pencarian :: Simpan CSV :: Kembali

Hasil Pencarian