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""Mineralized Tissues in Oral and Craniofacial Science" is a major comprehensive update on knowledge in the field of mineralized tissues in the oral and craniofacial region. Drs. McCauley and Somerman assembled an international team of researchers and clinicians, offering a global perspective on the current knowledge in this field. Basic and clinical correlates reinforce the significance of research to clinical diagnoses and therapies, written in a manner that lends easily to their use for case study teaching venues.Section 1 features the many aspects of bone in the craniofacial region, including embryology, cell biology, and stem cell biology. Section 2 focuses on teeth-tooth development, dentin, enamel, cementum, and tooth regeneration. Section 3 discusses the interaction between bones and teeth, including those associated with inflammatory processes, periodontal ligaments, biomechanics, and other impact factors-such as nutrition, metabolic bone diseases and therapeutic modalities.The novel approach of linking the basic principles of the cell and molecular biology of hard tissues to clinical correlates will appeal to readers at all levels of their research careers, both students and faculty; faculty interested in a comprehensive text for reference; and clinicians interested in the biologic aspects of bones and teeth."

"extracted from Lumbricus rubellus, with fibrinogenolytic, fibrinolytic and anti-aggregation activities reported in an in vitro study. Plasma half-life is an important parameter to calculate its dose. This study was conducted to evaluate the biological half-life of DLBS1033 by measuring serial plasmin-antiplasmin (PAP) complex. PAP complex is a stable and inactive compound as a result of fibrinolysis process. Methods: this was an open-label clinical trial in healthy adult subjects. Subjects were divided into two groups to receive single dose drugs (received 3 x 490 mg) or repeated administration until steady state conditions (3 x 490 mg/day for 3 days). Blood samples for PAP complex measurement were collected at time 0 (before drug administration for single dose group), then at 0.5, 1, 1.5, 2, 3, 6, 8, 10, 12, and 24 hours after drug administration. Safety parameters used in this study were creatinine, prothrombin time (PT), activated partial thromboplastin time (aPTT), SGOT, and SGPT. Results: the biological half-life of DLBS1033 was calculated based on the mean of PAP complex concentration on each time sampling. In single dose group, the highest mean of PAP complex concentration was reached before drug administration. Our result showed that the activity of DLBS1033 could not be determined after single dose administration. In steady state condition, the PAP complex concentration increase in 2 hours after last drug administration. The biological half-life of DLBS1033 was 8.6 hours. There were no significant safety findings on all laboratory parameters and no serious adverse events. Conclusion: it is concluded that the fibrinolytic effects of DLBS1033 can be measured in steady state condition. The biological half-life of DLBS1033 in steady state condition was 8.6 hours. There were no serious adverse events on two groups of subjects.

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Latar belakang: DLBS1033 adalah fraksi protein bioaktif yang diekstraksi dari Lumbricus rubellus, dan dari studi in vitro diketahui memiliki aktivitas fibrinogenolitik, fibrinolitik dan antiagregasi. Waktu paruh obat dalam plasma merupakan parameter yang penting dalam menghitung dosis obat. Studi ini dilakukan untuk mengevaluasi waktu paruh biologis DLBS1033 melalui pengukuran kadar plasmin-antiplasmin complex (PAP complex). PAP complex adalah senyawa hasil proses fibrinolisis yang stabil dan inaktif. Metode: desain studi ini adalah uji klinik terbuka pada subyek dewasa sehat. Subyek dibagi menjadi dua kelompok, kelompok yang mendapatkan dosis tunggal (diberi obat 3 x 490 mg) dan kelompok yang mendapatkan dosis berulang hingga mencapai steady state (diberi obat 3 x 490 mg/hari selama 3 hari). Sampel darah untuk pemeriksaan konsentrasi PAP complex diambil pada jam ke-0 (sebelum pemberian obat pada kelompok dosis tunggal), jam ke-0,5, 1, 1,5, 2, 3, 4, 6, 8, 10, 12, dan 24. Parameter keamanan yang diperiksa pada penelitian ini adalah kreatinin, prothrombin time (PT), activated partial thromboplastin time (aPTT), SGOT, dan SGPT. Hasil: waktu paruh biologis DLBS1033 dihitung berdasarkan rerata kadar PAP complex pada tiap waktu pengambilan sampel darah di tiap kelompok. Pada kelompok dosis tunggal, rerata tertinggi konsentrasi PAP complex tercapai sebelum pemberian obat. Hasil ini menunjukkan bahwa aktivitas DLBS1033 tidak bermakna ketika diberikan sebagai dosis tunggal. Pada keadaan steady state, konsentrasi PAP complex meningkat dalam 2 jam setelah pemberian obat terakhir. Waktu paruh biologis DLBS1033 adalah 8,6 jam. Pada penelitian ini tidak didapatkan hasil laboratorium yang bermakna dan kejadian tidak diinginkan yang serius. Kesimpulan: pada penelitian ini disimpulkan bahwa efek fibrinolitik DLBS1033 dapat diukur pada keadaan steady state. Waktu paruh biologis DLBS1033 pada kelompok steady state adalah 8,6 jam. Tidak ditemukan kejadian tidak diinginkan yang serius pada kedua kelompok subyek."

"Sistem Informasi telah menjadi penunjang di era modern, termasuk di dunia medis, salah satunya di bidang pendidikan kedokteran. Dalam pendididkan kedokteran, Sistem Informasi digunakan dalam membantu kelancaran pendidikan kedokteran, baik untuk pengajaran, pengujian hingga penilaian. Salah satu metoda pengujian dalam Pendidikan kedokteran yaitu OSCE (Objective Structured Clinical Examination). Dalam OSCE membutuhkan sumber daya yang besar. Sistem Informasi diintegrasikan dengan sistem audio visual diterapkan untuk meningkatkan efisiensi. Sistem Informasi dikembangkan untuk pelaksanaan OCSE di fakultas Kedokteran Unswagati. Kemudian desain yang dibuat diujicobakan untuk melihat pengaruhnya terhadap reliabilitas, validitas dan efisiensi. Hipotesis awal mengharapkan bahwa tidak ada perbedaan dalam reliabilitas dan validitas OSCE, tetapi ada perubahan peningkatan efisiensi. Hasil pengujian menunjukan bahwa dengan penerapan Sistem Informasi terintegrasi audiovisual, menjadikan pelaksanaan OSCE reliabel, valid tetapi dengan peningkatan efisiensi.

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Information system has been suppoting this modern era, including in the medical world, such as in medical education. In medical education, information system is being used to assist its fluency, such in teaching, examining and grading. One of the method to exam in medical education is called OSCE (Objective Structured Clinical Examination. OSCE requires massive resources. An information system integrated with audiovisual system is applied to enhance the efficiency.

This Information system is developed for implementation of OSCE in Medical Faculty of Unswagati. The design is tested to see the influence to its reliability, validity and efficiency. Early hypothesis is there will be no significant difference on OSCE?s Reliability and Validity, but there will be a significant improvement on efficiency. The test result shows that with implementation of Audiovisual integrated Information system, causing a reliable and valid OSCE with improved eviciency."

"Penggunaan teknologi informasi di bidang kesehatan bertujuan untuk meningkatkan kualitas pelayanan kesehatan dan meningkatkan efisiensi dan efektivitas proses pelayanan kesehatan. Rekam Medis Elektronik (RME) adalah salah satu subsistem dari SIMRS yang dijalankan dan berhubungan dengan subsistem atau modul lain yang ada di rumah sakit. RME juga merupakan dokumen pencatatan seluruh kegiatan pelayanan yang diberikan kepada pasien secara terintegrasi dan berkesinambungan serta melibatkan seluruh profesi yang terlibat dalam pelayanan rumah sakit. Standar dalam pelayanan ini dikenal dengan alur klinis atau clinical pathway. Clinical pathway merupakan dokumen dan alat penting dalam mewujudkan tata kelola klinis yang baik di rumah sakit. Dalam penerapannya memadukan RME dan clinical pathway dalam satu sistem diharapkan dapat membantu professional pemberi asuhan dalam mematuhi clinical pathway yang ditetapkan dalam memberikan pelayanan yang efektif dan efisien dengan menjaga mutu pelayanan rumah sakit. Penelitian ini merupakan pengembangan Rekam Medis Elektronik dalam mempermudah penerapan clinical pathway di RSUD Kembangan dengan menggunakan pendekatan metode design thinking. Design thinking melalui lima tahapan yaitu: Empathize, Define, Ideate, Prototype, dan Test. Setelah dibuat pengembangan rekam medis elektronik terpadu  clinical pathway di lakukan testing pada 15 profesional pemberi asuhan dengan System Usability Scale (SUS) dengan nilai 77, berarti sistem ini tergolong baik (good), sehingga dapat diterima oleh professional pemberi asuhan. Pada Evaluasi User Experience Questionnaire yang excellent pada . Sistem RME terpadu clinical pathway dapat menjadi solusi dalam penerapan clinical pathway di RSUD Kembangan.

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The use of information technology in the health sector aims to improve the quality of health services and increase the efficiency and effectiveness of the health service process. Electronic Medical Record is one of the subsystems of SIMRS that is run and related to other subsystems or modules in the Hospital. The Electronic Medical Record is also a document for recording all service activities provided to patients in an integrated and continuous manner and involves all professions involved in hospital services. Standards in this service are known as clinical pathways or clinical pathways. Clinical pathways are important documents and tools in realizing good clinical governance in hospitals. In its application, combining RME and clinical pathway recording in one system is expected to help care-giving professionals comply with the established clinical pathways to provide effective and efficient services by maintaining the quality of hospital services. Utilization of Electronic Medical Records in facilitating the application of clinical pathways at Kembangan Hospital. This study uses a design thinking method approach to create a prototype for the development of an integrated clinical pathway electronic medical record, where design thinking goes through five stages, namely: Empathize, Define, Ideate, Prototype, and Test. After the development of an integrated electronic medical record clinical pathway was made, testing was carried out on 15 professional care providers with the System Usability Scale (SUS) with a value of 77, meaning that this application was classified as good (good), so that it could be accepted by professional care providers. And Evaluation of a good and excellent User Experience Questionnaire. The integrated clinical pathway RME system can be a solution in the application of clinical pathways in Kembangan Hospital."