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"Latar belakang: Pemfigus merupakan penyakit autoimun yang ditandai lepuh pada kulit dan/atau mukosa akibat adanya imunoglobulin terhadap permukaan sel keratinosit. Kortikosteroid KS merupakan pilihan terapi utama. Dipikirkan pemfigus berhubungan dengan sindrom metabolik SM secara langsung maupun tidak langsung. Tujuan: Mengetahui proporsi SM pada pasien pemfigus dan faktor-faktor yang berhubungan di Rumah Sakit Cipto Mangunkusumo RSCM. Metode: Studi potong lintang pada bulan September November 2016 di Poliklinik Kulit dan Kelamin RSCM. Subjek dianamnesis, dilakukan pengukuran tekanan darah dan lingkar abdomen, lalu dilanjutkan pengambilan darah untuk pemeriksaan kadar trigliserida, high density lipoprotein HDL, serta gula darah puasa. Hasil: Didapatkan 30 subjek dengan rerata usia 41,6 10,3 tahun dan sebagian besar perempuan. Sebanyak 23 subjek 76,7 terdiagnosis pemfigus vulgaris dan 7 subjek 23,3 pemfigus foliaseus. Median durasi penyakit adalah 31 bulan. Median lama penggunaan steroid adalah 16,5 bulan. Ditemukan SM pada 40 dari total SP. Didapatkan proporsi obesitas sentral adalah 63,3 , hipertensi 50, hipertrigliseridemia 50, hiperglikemia 23,3, dan hipo-HDL 43,3. Simpulan: Ditemukan proporsi yang sama antara laki-laki dan perempuan di kelompok SM. Tidak ditemukan perbedaan bermakna jenis kelamin, tipe pemfigus, usia, lama sakit, dan lama penggunaan steroid antara kelompok SM dan tidak SM.

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Background: Pemphigus is an autoimmune bullous disease characterized by blistering skin and or mucosa caused by presence of immunoglobulin against keratinocyte cell surface. Corticosteroid is the main therapy. Pemphigus has been related to metabolic syndrome MS lately.

Objective: Determine MS proportion in pemphigus patients and its associated factors.

Methods: This cross sectional study was conducted in September November 2016 in Dermatovenereology Outpatient Clinic in Cipto Mangunkusumo Hospital. Subjects history was taken then blood pressure, and abdominal circumference were measured. Patients trigliceryde, high density lipoprotein HDL, and fasting blood glucose level were also measured.

Results: There are 30 subjects with age mean 41,6 10,3 years and mostly women, 23 patients 76,7 are diagnosed as pemphigus vulgaris while 7 patients 23,3 are pemphigus foliaceus. Disease duration mean in all patients is 31 months and steroid duration mean is 16.5 months. MS was found in 40 subjects. Proportion of central obesity is 63,3, hypertension 50, hypertriglyceridemia 50, hyperglycemia 23,3, and hipo HDL 43,3.

Conclusion The same proportion of men and women are found in MS group. There is no statistically significant difference found in gender, pemphigus subtype, age, disease duration, and steroid usage duration between two groups."

"Sindrom metabolik merupakan konsekuensi dari hubungan yang kompleks antarafaktor genetik dan lingkungan, yang berhubungan dengan meningkatnya risikodiabetes mellitus, penyakit kardiovaskular dan kematian. Penelitian ini bertujuanuntuk mengetahui hubungan umur, jenis kelamin, riwayat penyakit keluarga,asupan zat gizi, aktivitas fisik, kebiasaan merokok, dan durasi tidur dengankejadian sindrom metabolik menurut kriteria NCEP ATP III pada pegawai RSUP Persahabatan. Populasi studi adalah pegawai yang melakukan pemeriksaan kesehatan pada bulan April-Mei 2017. Disain penelitian ini adalah cross sectional dengan jumlah sampel sebanyak 110 responden yang dipilih dengan consecutive sampling. Data dikumpulkan pada bulan Mei-Juni 2017, meliputi pengukurantinggi badan, berat badan, lingkar pinggang, riwayat penyakit keluarga, asupanmakanan yang terdiri dari energi, karbohidrat, protein, lemak dan serat, aktivitas fisik, kebiasaan merokok, durasi tidur dan data sekunder berupa hasil laboratorium trigliserida, kolesterol HDL, gula darah dan tekanan darah. Hasil menunjukkan bahwa 7,3% responden mengalami sindrom metabolik dan 54,5% obesitas sentral. Ada perbedaan yang signifikan antara umur pada responden sindrom metabolik dengan yang tidak sindrom metabolik p=0,01 . Tidak ada hubungan yang bermakna antara jenis kelamin, asupan makanan, riwayat penyakit keluarga dan gaya hidup dengan sindrom metabolik. Meskipun demikian disarankan agar pegawai menjaga pola hidup sehat dengan olah raga teratur, makan makanan gizi seimbang dan rutin melakukan pemeriksaan kesehatan.

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Metabolic syndrome is a consequence of the complex relationship betweengenetic and environmental factors, which is associated with increased risk ofdiabetes mellitus, cardiovascular disease and mortality. This study aims todetermine the relationship between age, sex, family disease history, nutrientintake, physical activity, smoking habits, and sleep duration with the incidence ofmetabolic syndrome according to NCEP ATP III criteria on Persahabatan Hospital staff. The study population is an employee who performs a medical examinationin April May 2017. The design of this study is cross sectional with the number of samples of 110 respondents with selected with consecutive sampling. Data werecollected in May June 2017, including measurement of height, weight, waist circumference, family disease history, food intake consisting of energy, carbohydrate, protein, fat and fiber, physical activity, smoking habit, sleepduration and secondary data In the form of laboratory results triglycerides, HDLcholesterol, blood sugar and blood pressure. Results showed that 7.3% ofrespondents had metabolic syndrome and 54.5% of central obesity. There was significant association between age and metabolic syndrome and no significant association between sex, food intake, family disease history and lifestyle with metabolic syndrome. Never the less it is recommended that employees maintain ahealthy lifestyle with regular exercise, eating balanced nutrition and routine medical checks up."

"Latar belakang: Obesitas dan sindrom metabolik (SM) yang terjadi pada usia dini akan menjadi faktor risiko diabetes melitus tipe 2 dan penyakit jantung koroner. Prevalens SM meningkat secara paralel dengan peningkatan obesitas. Penelitian mengenai SM pada anak dan remaja sangat terbatas. Tujuan: Mengetahui prevalens SM pada remaja obes usia 12-16 tahun dan faktor-faktor yang memengaruhinya. Metode: Sebuah penelitian potong lintang pada tiga sekolah menengah pertama negeri di Jakarta yang dipilih secara purposive sampling (remaja dan obes). Dilakukan pengukuran antropometri, tekanan darah dan pemeriksaan laboratorium darah. Diagnosis SM ditentukan sesuai kriteria International Diabetes Federation (IDF), yaitu lingkar pinggang > persentil 90 menurut usia dan jenis kelamin, dan memenuhi > 2 kriteria sebagai berikut: trigliserida > 150 mg/dl, HDL > 40 mg/dl, glukosa darah puasa > 100 mg/dl atau terdiagnosis diabetes melitus tipe 2 (DMT2), tekanan darah > 130/85 mmHg. Penyakit kardiovaskular atau DMT2 orangtua, riwayat diabetes pada ibu selama kehamilan, bayi berat lahir rendah (BBLR), pola makan tinggi lemak dan gula, aktivitas sedentari, orangtua obes, dan pajanan asap rokok diduga meningkatkan kejadian SM. Data diolah dengan tes Pearson atau Fisher untuk menentukan faktor-faktor yang memengaruhi dan angka kejadian SM ditampilkan dalam prevalens.Hasil: Prevalens obes pada penelitian ini adalah 5,9%. Penelitian dilakukan pada 95 subyek obes usia 12-16 tahun. Sebanyak 35,8% subyek memiliki IMT >p95-p97 dan 64,2% memiliki IMT >p97, semuanya telah mengalami pubertas. Prevalens SM adalah 15,8% dan meningkat hingga 21,3% pada kelompok super-obes. Terdapat perbedaan bermakna prevalens SM pada kedua kelompok IMT (p=0,048). Hipertrigliseridemia dan kadar HDL rendah adalah kriteria diagnosis terbanyak pada remaja obes dengan SM. Tidak ditemukan hubungan yang bermakna antara faktor-faktor yang memengaruhi terhadap kejadian SM. Simpulan: Prevalens SM pada penelitian ini 15,8% dan meningkat hingga 21,3% pada remaja super-obes. Tidak ditemukan hubungan yang bermakna antara faktor-faktor yang memengaruhi dengan kejadian SM. Dislipidemia adalah perubahan metabolik yang paling sering dijumpai pada remaja obes dengan SM.

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Background: Obesity and metabolic syndrome (MS) beginning in childhood lead to a substansial risk for type 2 diabetes mellitus and coronary heart disease. Prevalence of MS increases accordingly with the incidence of obesity. The study of the MS among children and adolescents were limited. Aim: The purpose of this study is to define the prevalence and factors that affect the incidence of MS among obese adolescents. Methods: A cross-sectional study selected by purposive sampling was conducted on three junior high school in Jakarta. The anthropometric, blood pressure, lipid profile, and glucose serum level from venous blood sample were taken. The definition of MS was made according to criteria of IDF. Parental history of cardiovascular disease or type 2 diabetes mellitus, history of maternal diabetes during pregnancy, low birth weight, high-fat and sugar diet, sedentary lifestyle, obese parents, and cigarette smoke expossure are considered as the factors affected the incidence of MS. Pearson or Fisher test was used to determine the factors that affect MS and the prevalence of MS were described as descriptive data.Results: Prevalence of obese were 5.9%. A total of 95 subjects with median age 12-16 years, were enrolled into the study. All subjects were obese, and 64.3% of them were superobese (BMI >p97 for age and sex). The prevalence of MS was 15.8% and increased to 21.3% among superobese group. There was a significant difference in the prevalence of MS in obese and super-obese (p = 0.048). Hypertriglyceridemia and low HDL levels are the diagnostic criteria found the most in MS subjects. There was no significant association between factors affecting MS. Conclusion: The prevalence of MS was 15.8% and increased to 21.3% among superobese. There was no significant association between factors affecting MS in adolescents. Dyslipidemia is the most common metabolic change in obese adolescents with MS."

"ABSTRAK Latar Belakang: Hingga saat ini belum ada panduan mengenai paduan terapiantiretroviral (antiretroviral therapy/ART) terpilih pada pasien HIV dewasadengan riwayat interupsi tidak terencana. Kondisi pasien pada saat reintroduksiART perlu dievaluasi sebagai dasar pemilihan paduan ART Tujuan: Mengetahui proporsi keberhasilan virologis pada reintroduksi ART linipertama pasca interupsi tidak terencana. Mengetahui hubungan antara berbagaifaktor klinis dan laboratoris dengan keberhasilan virologis pada reintroduksi tersebut. Metode: Penelitian kohort retrospektif dilakukan pada pasien HIV yangmendapatkan reintroduksi ART lini pertama pasca interupsi tidak terencanaselama minimal 1 bulan. Data didapatkan dari rekam medis RS dr. CiptoMangunkusumo di Jakarta. Viral load (VL) dinilai 6-18 bulan setelah reintroduksiART lini pertama, dinyatakan berhasil bila VL <400 kopi/ml. Dilakukan analisisterhadap faktor yang berhubungan dengan keberhasilan virologis tersebut.Hasil: Selama periode Januari 2005 s.d. Desember 2014 terdapat 100 subjek yangmendapatkan reintroduksi ART lini pertama dan memiliki data viral load 6-18bulan pasca reintroduksi. Pasca reintroduksi ART didapatkan keberhasilanvirologis pada 55 (55%) subjek. Pada analisis didapatkan dua faktor yangberhubungan dengan keberhasilan virologis pada reintroduksi ART lini pertama,yaitu frekuensi interupsi satu kali (adjusted OR/aOR 5,51; IK95% 1,82-16,68;p=0,003), nilai CD4 saat reintroduksi ≥200 sel/mmxi 3 (aOR 4,33; IK95% 1,1416,39,p=0,031).Simpulan:Proporsi keberhasilan virologis pada reintroduksi ART lini pertamapasca interupsi tidak terencana adalah 55%. Pasien dengan frekuensi interupsi 1kali dan pasien dengan nilai CD4 saat reintroduksi ≥200 sel/mm3 memiliki kecenderungan untuk mencapai keberhasilan virologis pada reintroduksi ART.ABSTRACT There is no guideline concerning antiretroviral therapy (ART) ofchoice for adult HIV patients after unplanned interruption. Hence, patients?conditions at time of ART reintroduction need to be evaluated as a basis forselecting ART regiment. Objectives: To know the proportion of virological success of first line ARTreintroduction after unplanned interruption. To know the association betweeneither clinical or laboratory factors and virological success in reintroduction. Methods: We conducted a retrospective cohort study in HIV patients that werereintroduced to first line ART after having unplanned interruption for at least onemonth period. The data were collected from medical records of Dr. CiptoMangunkusumo Hospital in Jakarta. Viral load (VL) was evaluated at 6-18months after first line ART reintroduction, declared as a success if VL <400copies/mL. Analysis was done to factors associated with such virological success.Results: Between January 2005 and December 2014, 100 subjects werereintroduced to first line ART and having VL data in 6 to 18 months after thereintroduction. Virological success was achieved in 55 (55%) subjects. In theanalysis we found that virological success was associated with interrupted once(adjusted OR/aOR 5.51%, 95%CI 1.82-16.68, p=0.003) and CD4 ≥200 cell/mmxii Universitas Indonesia 3at the time of reintroduction (aOR 4.33, 95%CI 1.14-16.39, p=0.031).Conclusions: Proportion of virological success on first line ART reintroductionafter unplanned interruption was 55%. Patients who were having interrupted onceand patients with CD4 ≥200 cell/mm3 at the time of reintroduction would havehigher odds of virological success on first line ART reintroduction.;Background: There is no guideline concerning antiretroviral therapy (ART) ofchoice for adult HIV patients after unplanned interruption. Hence, patients?conditions at time of ART reintroduction need to be evaluated as a basis forselecting ART regiment. Objectives: To know the proportion of virological success of first line ARTreintroduction after unplanned interruption. To know the association betweeneither clinical or laboratory factors and virological success in reintroduction. Methods: We conducted a retrospective cohort study in HIV patients that werereintroduced to first line ART after having unplanned interruption for at least onemonth period. The data were collected from medical records of Dr. CiptoMangunkusumo Hospital in Jakarta. Viral load (VL) was evaluated at 6-18months after first line ART reintroduction, declared as a success if VL <400copies/mL. Analysis was done to factors associated with such virological success.Results: Between January 2005 and December 2014, 100 subjects werereintroduced to first line ART and having VL data in 6 to 18 months after thereintroduction. Virological success was achieved in 55 (55%) subjects. In theanalysis we found that virological success was associated with interrupted once(adjusted OR/aOR 5.51%, 95%CI 1.82-16.68, p=0.003) and CD4 ≥200 cell/mmxii Universitas Indonesia 3at the time of reintroduction (aOR 4.33, 95%CI 1.14-16.39, p=0.031).Conclusions: Proportion of virological success on first line ART reintroductionafter unplanned interruption was 55%. Patients who were having interrupted onceand patients with CD4 ≥200 cell/mm3 at the time of reintroduction would havehigher odds of virological success on first line ART reintroduction.;Background: There is no guideline concerning antiretroviral therapy (ART) ofchoice for adult HIV patients after unplanned interruption. Hence, patients?conditions at time of ART reintroduction need to be evaluated as a basis forselecting ART regiment. Objectives: To know the proportion of virological success of first line ARTreintroduction after unplanned interruption. To know the association betweeneither clinical or laboratory factors and virological success in reintroduction. Methods: We conducted a retrospective cohort study in HIV patients that werereintroduced to first line ART after having unplanned interruption for at least onemonth period. The data were collected from medical records of Dr. CiptoMangunkusumo Hospital in Jakarta. Viral load (VL) was evaluated at 6-18months after first line ART reintroduction, declared as a success if VL <400copies/mL. Analysis was done to factors associated with such virological success.Results: Between January 2005 and December 2014, 100 subjects werereintroduced to first line ART and having VL data in 6 to 18 months after thereintroduction. Virological success was achieved in 55 (55%) subjects. In theanalysis we found that virological success was associated with interrupted once(adjusted OR/aOR 5.51%, 95%CI 1.82-16.68, p=0.003) and CD4 ≥200 cell/mmxii Universitas Indonesia 3at the time of reintroduction (aOR 4.33, 95%CI 1.14-16.39, p=0.031).Conclusions: Proportion of virological success on first line ART reintroductionafter unplanned interruption was 55%. Patients who were having interrupted onceand patients with CD4 ≥200 cell/mm3 at the time of reintroduction would havehigher odds of virological success on first line ART reintroduction.;Background: There is no guideline concerning antiretroviral therapy (ART) ofchoice for adult HIV patients after unplanned interruption. Hence, patients?conditions at time of ART reintroduction need to be evaluated as a basis forselecting ART regiment. Objectives: To know the proportion of virological success of first line ARTreintroduction after unplanned interruption. To know the association betweeneither clinical or laboratory factors and virological success in reintroduction. Methods: We conducted a retrospective cohort study in HIV patients that werereintroduced to first line ART after having unplanned interruption for at least onemonth period. The data were collected from medical records of Dr. CiptoMangunkusumo Hospital in Jakarta. Viral load (VL) was evaluated at 6-18months after first line ART reintroduction, declared as a success if VL <400copies/mL. Analysis was done to factors associated with such virological success.Results: Between January 2005 and December 2014, 100 subjects werereintroduced to first line ART and having VL data in 6 to 18 months after thereintroduction. Virological success was achieved in 55 (55%) subjects. In theanalysis we found that virological success was associated with interrupted once(adjusted OR/aOR 5.51%, 95%CI 1.82-16.68, p=0.003) and CD4 ≥200 cell/mmxii Universitas Indonesia 3at the time of reintroduction (aOR 4.33, 95%CI 1.14-16.39, p=0.031).Conclusions: Proportion of virological success on first line ART reintroductionafter unplanned interruption was 55%. Patients who were having interrupted onceand patients with CD4 ≥200 cell/mm3 at the time of reintroduction would havehigher odds of virological success on first line ART reintroduction."

"Latar Belakang: Pemahaman tentang non-alcoholic fatty pancreas disease NAFPD dan makna klinisnya perlu terus ditingkatkan mengingat NAFPD diduga dapat berlanjut menjadi pankreatitis kronik dan memicu terjadinya kanker pankreas. NAFPD berhubungan erat dengan diabetes melitus tipe 2 DMT2 dan pasien diabetes berisiko 2x lipat untuk mengalami kanker pankreas. Proporsi dan faktor-faktor yang berhubungan dengan NAFPD pada populasi DMT2 belum pernah diteliti.Tujuan: Mengetahui proporsi dan faktor-faktor yang berhubungan dengan NAFPD pada populasi DM tipe 2.Metode: Pasien DMT2 dewasa yang berobat di poliklinik metabolik endokrin Rumah Sakit Cipto Mangunkusumo RSCM direkrut secara konsekutif pada studi potong lintang ini. Data usia, jenis kelamin, lama DM, komorbid, obat-obatan, lingkar pinggang, profil lipid dan HbA1C dikumpulkan. Ultrasonografi hepatobilier dilakukan pada setiap pasien untuk menentukan adanya NAFPD dan non-alcoholic fatty liver disease NAFLD . Hubungan NAFPD dengan parameter usia, jenis kelamin, lama DM, hipertensi, NAFLD, trigliserida dan HbA1C diuji kemaknaanya.Hasil Penelitian: Dari 171 pasien DMT2 yang direkrut dalam studi ini didapatkan proporsi NAFPD sebesar 48,5% (95%IK=41,2-55,9%). Analisis univariat menunjukkan perbedaan signifikan di antara kelompok NAFPD dan non-NAFPD dalam hal proporsi NAFLD (PR=1,96; 95%IK=1,41-2,74; p<0,001) dan hipertrigliseridemia (PR=1,38; 95%IK=1,02-1,86; p=0,042). Pada analisis multivariat usia lanjut (OR=2,15; 95%IK=1,10-4,23), NAFLD (OR=3,65; 95%IK=1,90-6,99) dan hipertrigliseridemia (OR=2,03; 95%IK=1,02-4,05) menunjukkan hubungan yang signifikan dengan kejadian NAFPD. Tidak ditemukan hubungan yang bermakna antara jenis kelamin, lama DM, hipertensi, serta kadar HbA1C dengan kejadian NAFPD.Kesimpulan: Proporsi NAFPD pada populasi DMT2 sebesar 48,5%. Usia lanjut, NAFLD dan hipertrigliseridemia merupakan faktor-faktor yang berhubungan dengan kejadian NAFPD pada pasien DMT2.

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Background: Understanding of non alcoholic fatty pancreas disease NAFPD and its clinical significance needs to be continuously improved as NAFPD might allegedly develop into chronic pancreatitis and further leads to pancreatic cancer. NAFPD is strongly associated with type 2 diabetes mellitus T2DM and long term T2DM is associated with a 1.5 to 2.0 fold increase in the risk of pancreatic cancer. The proportion of NAFPD and its associated factors in T2DM population has not been well investigated.

Aim: To investigate the proportion of NAFPD and its associated factors in type 2 DM population.

Methods: Adult T2DM patients who visited Diabetes Clinic, Cipto Mangunkusumo Hospital were consecutively recruited in this cross sectional study. Information about age, sex, duration of diabetes, komorbidities, medication, waist circumference, lipid profile and HbA1C were collected. Abdominal ultrasonography was performed on each subject to diagnose NAFPD and non alcoholic fatty liver disease NAFLD . Association of NAFPD with age, sex, duration of diabetes, hypertension, NAFLD, triglyceride and HbA1C were examined.

Study Results: From total of 171 T2DM patients in this study, the proportion of NAFPD was 48.5% (95%CI= 41.2 to 55.9%). Univariate analysis showed significant differences between NAFPD and non-NAFPD group regarding proportion of NAFLD (PR=1.96; 95%CI=1.41-2.74; p<0.001) and hypertriglyceridemia (PR=1.38; 95%CI=1.02-1.86; p=0.042). On multivariate analysis older age (OR=2.15; 95%CI=1.10-4.23), NAFLD (OR=3.65; 95%CI=1.90-6.99), and hypertriglyceridemia (OR=2.03; 95%CI=1.02-4.05) showed significant association with NAFPD. There were no significant association found among sex, duration of diabetes, hypertension and high levels of HbA1C with NAFPD.

Conclusion: The proportion of NAFPD in T2DM population is 48.5%. Older age, NAFLD and hypertriglyceridemia are associated factors of NAFPD in T2DM patient."

"Sindrom metabolik merupakan istilah untuk sekumpulan faktor risiko penyakitjantung dan diabetes mellitus. Pekerja memiliki perilaku pola hidup dan pola kerjayang bervariasi yang berisiko menyababkan sindrom metabolik. Penelitian inidilakukan untuk menjelaskan faktor-faktor yang berhubungan dengan sindrommetabolik pada pekerja tambang. Design penelitian cross sectional digunakandengan menganalisis data hasil kuesioner pola hidup dan pola kerja dan MedicalCheck Up yang meliputi Obesitas Sentral, Trigliserida, HDL, Tekanan Darah danGula Darah Puasa. Berdasarkan hasil penelitian didapatkan hubungan yangsignifikan antara faktor aktivitas fisik p value 0,032; OR 3,030 dan riwayatpenyakit pada orang tua p value 0,026; OR 0,282 dengan sindrom metabolikyang dialami pekerja. Tidak ditemukan hubungan yang signifikan antarapengetahuan, durasi kerja, shift kerja, durasi tidur, dan pola makan dengansindrom metabolik. Upaya promotif dan preventif perlu dilakukan untukmencegah terjadinya sindrom metabolik populasi pekerja.

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Metabolic syndrome is a term for risk factors for heart disease and diabetesmellitus. Workers have different lifestyle behaviors and work patterns that cancausing metabolic syndrome. This study was conducted to explain the factorsrelated with metabolic syndrome in miner workers. Cross sectional design is usedby analyzing lifestyle and work patterns questionnaire and Medical Check Up datawhich includes Central Obesity, Triglycerides, HDL, Blood Pressure and FastingBlood Sugar. Based on the research results, there were significant relationshipbetween physical activity factor p value 0,032, OR 3,030 and parents rsquo history ofdisease p value 0,026 OR 0,282 with metabolic syndrome. No significantrelationship was found between knowledge, work duration, shift work, sleepduration, and diet pattern with metabolic syndrome. Promotion and preventivecontrols are needed to prevent the metabolic syndrome in population."

"Faktor-Faktor Yang Berhubungan Dengan Sindrom Metabolik pada Masyarakat di Wilayah Kerja Puskesmas Cimanuk dan Saketi, Kabupaten Pandeglang, Banten Tahun 2017 Analisis Lanjut Deteksi Dini Penyakit Jantung dan Pembuluh Darah Kementerian Kesehatan Republik Indonesia Tahun 2017 rdquo; Skripsi ini bertujuan untuk mengetahui faktor-faktor yang berhubungan umur, jenis kelamin, pendidikan, pekerjaan, riwayat penyakit tidak menular dalam keluarga, Perilaku merokok, konsumsi buah dan sayur, aktivitas fisik, stress, dan Indeks Massa Tubuh dengan sindrom metabolik pada masyarakat di wilayah kerja Puskesmas Cimanuk dan Saketi, Kabupaten pandeglang, Banten tahun 2017. Penelitian ini bersifat deskriptif analitik dengan menggunakan desain Cross sectional. Penelitian dilaksanakan dari bulan Maret-Juni 2017 dengan menggunakan data dari deteksi dini Program Pencegahan dan Pengendalian Penyakit Jantung dan Pembuluh Darah Kementerian Kesehatan RI tahun 2017 dengan sampel sebanyak 359 sampel. Hasil penelitian menunjukkan sebesar 38,2 masyarakat di wilayah kerja Puskesmas Cimanuk dan Saketi, Kabupaten Pandenglang, Banten mengalami sindrom metabolik. Uji chi-square menunjukkan adanya hubungan signifikan secara statistik antara umur p value=0,001 , pendidikan p value=0,023 , pekerjaan p value=0,041 , dan Indeks Massa Tubuh p value=0,001 terhadap sindrom metabolik. Sedangkan melalui uji multivariat didapatkan variabel yang paling berpengaruh adalah indeks massa tubuh POR=0,334 . Melalui penelitian ini dapat memberikan informasi terutama masyarakat di Kecamatan Cimanuk dan Saketi, Kabupaten Pandeglang, Banten agar dapat menjaga kesehatan melalui pola hidup sehat, serta ikut serta dalam kegiatan Posbindu maupun Penyuluhan yang dilakukan oleh penyedia layanan kesehatan terkait.

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Factors Associated with Metabolic Syndrome in Communities of Cimanuk and Saketi Health Center Working Area, Pandeglang Regency, Banten 2017 Advanced Analysis of Early Detection of Heart Disease and Blood Vessels Ministry of Health of the Republic of Indonesia 2017 This thesis aims to know the related factors age, sex, education, occupation, history of non communicable diseases in the family, smoking behavior, consumption of fruits and vegetables, physical activity, stress, and body mass index with metabolic syndrome in the community in the working area of puskesmas cimanuk and saketi, pandeglang district, banten in 2017. This study is analytical descriptive using cross sectional design. The study was conducted from March to June 2017 using data from the early detection of the program of prevention and control of heart and vein disease the Ministry of Health Republic of Indonesia in 2017 with a sample of 359 samples. The results showed that 38.2 of people in the working area of cimanuk and saketi health center, pandenglang district, banten had metabolic syndrome. Chi square test showed a statistically significant correlation between age p value 0.001 , education p value 0.023 , occupation p value 0.041 , and body mass index p value 0.001 against metabolic syndrome. While through multivariate test, the most influential variable is body mass index POR 0,334 . Through this research can provide information, especially the community in district cimanuk and saketi, pandeglang regency, banten in order to maintain health through healthy lifestyles, and participate in activities Posbindu and counseling conducted by health related providers. "

"Penyakit tidak menular (PTM) telah menjadi sebab dari morbiditas dan mortalitas utama di dunia. Sindrom metabolik adalah sekumpulan gejala klinis yang akan meningkatkan risiko berkembangnya PTM, khusunya penyakit kardiovaskular dan diabetes melitus tipe 2. Hasil analisis Riskesdas menemukan bahwa prevalensi sindrom metabolik di Indonesia meningkat dari 10,8% (2013) menjadi 24,4% (2018). Pegawai kantoran sering dikaitkan dengan perilaku sedentari sehingga berpeluang untuk mengembangkan sindrom metabolik lebih tinggi. Tujuan penelitian ini adalah untuk mengetahui prevalensi dan faktor-faktor yang berhubungan dengan kejadian sindrom metabolik pada kelompok pegawai Organisasi Perangkat Daerah (OPD) Pemerintah Kota Depok tahun 2022. Penelitian dengan desain cross-sectional ini menganalisis data hasil skrining PTM pegawai Pemerintah Kota Depok tahun 2022. Sebanyak 1.128 responden yang berasal dari 21 OPD diikutkan dalam penelitian ini. Prevalensi sindrom metabolik sebesar 33,2%. Hasil analisis bivariat menunjukkan bahwa variabel yang berhubungan signifikan secara statistik dengan kejadian sindrom metabolik meliputi usia, jenis kelamin, IMT, riwayat PTM dalam keluarga, kadar kolesterol total, rasio kadar kolesterol total terhadap kolesterol HDL, dan aktivitas fisik. Pada analisis multivariat, variabel yang memiliki hubungan bermakna dengan sindrom metabolik adalah usia, IMT, dan rasio kadar kolesterol total terhadap kolesterol HDL. IMT merupakan faktor dominan yang memiliki hubungan bermakna dengan sindrom metabolik (PR: 3,128, 95% CI: 2,396 – 4,085).

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Non-communicable diseases (NCDs) have become a leading cause of morbidity and mortality in the world. Metabolic syndrome is a group of clinical symptoms that can increase the risk of developing NCDs, especially cardiovascular disease and type 2 diabetes mellitus. The results of Riskesdas analysis found that the prevalence of metabolic syndrome in Indonesia went from 10.8% (2013) to 24.4% (2018). Office employees are often associated with sedentary behavior so that the chances of developing metabolic syndrome are higher. The objective of this study is to determine the prevalence and the factors associated with metabolic syndrome among Regional Device Organizations (OPDs) employees of Depok City Government in 2022. This cross-sectional study included secondary data from the result of health screening of Depok City Government employees in 2022. A total of 1,128 respondents from 21 OPDs were included in this study. Prevalence of metabolic syndrome was 33.2%. Bivariate analysis shows that the variables that were statistically significant with the metabolic syndrome included age, sex, BMI, family history of PTM, total cholesterol level, total-cholesterol-to-HDL ratio, and physical activity. In multivariate analysis, variables found to have significant association with metabolic syndrome were age, BMI, and total-cholesterol-to-HDL ratio. BMI was the dominant factor associated with metabolic syndrome (PR: 3,128, 95% CI: 2,396 – 4,085)."

"ABSTRAK Tujuan. Mengetahui proporsi depresi pada pasien TB paru tidak resisten obat di RS Cipto Mangunkusumo serta mengetahui faktor-faktor apa saja yang berhubungan dengan kejadian depresi pada pasien TB paru. Metode. Studi dengan desain potong lintang terhadap 122 pasien TB paru tidak resisten obat yang berobat jalan di poliklinik paru RS Cipto Mangunkusumo dari bulan Agustus hingga Oktober 2018. Diagnosis depresi ditegakkan dengan wawancara menurut kriteria diagnosis dari Diagnostic and Statistical Manual of Mental Disorder-V (DSM-V) dan derajat depresi ditentukan menggunakan kuesioner Beck Depression Inventory-II (BDI-II). Analisa bivariat dan multivariat dengan uji regresi logistik dilakukan dengan menggunakan SPSS. Hasil. Dari 122 pasien dengan TB paru tidak resisten obat yang menjadi subyek penelitian, didapatkan proporsi depresi sebesar 48,4%. Terdapat dua faktor yang berhubungan dengan kejadian depresi pada pasien TB paru tidak resisten obat yaitu adanya efek samping obat anti TB (p < 0,001; OR 7,13; IK 95% 2,67 - 19,03), dan adanya komorbiditas penyakit kronik (p < 0,001; OR 12,90; IK 95% 4,01 - 41,50). Simpulan. Proporsi depresi pada pasien TB paru tidak resisten obat di RS Cipto Mangunkusumo sebesar 48,4%. Adanya efek samping obat anti TB dan komorbiditas penyakit kronik berhubungan dengan kejadian depresi pada pasien TB paru tidak resisten obat.

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ABSTRACT

Aim. To determine the proportion of depression in non multidrug-resistant pulmonary TB patients at Cipto Mangunkusumo General Hospital and also its related factors. Method. A cross-sectional study of 122 non multidrug-resistant pulmonary TB patients was done at outpatient department of Cipto Mangunkusumo General Hospital from August to October 2018. The diagnosis of depression was made by interview according to Diagnostic and Statistical Manual of Mental Disorder-V (DSM-V) criteria, and severity of depression is determined using Beck Depression Inventory-II (BDI-II). Bivariate and multivariate analysis using the logistic regression test was done using SPSS. Results. From 122 patients with non multidrug-resistant pulmonary TB, the proportion of depression is 48,4%. There are 2 factors related to depression in non multi-drug resistant pulmonary TB patients, which are the occurrence of side effects from TB treatment (p < 0,001; OR 7,13; 95% CI 2,67 - 19,03), and the presence of other chronic disease (p < 0,001; OR 12,90; 95% CI 3,87 - 4,01 - 41,50). Conclusion. The proportion of depression in non multidrug-resistant pulmonary TB patients at Cipto Mangunkusumo General Hospital is 48,4%. The occurrence of TB treatment side effects, and the presence of chronic disease comorbidities are related to depression in non multidrug-resistant pulmonary TB patients."

"Latar belakang: Psoriasis adalah suatu penyakit inflamasi kulit yang kronik, ditandai oleh plak eritematosa dan skuama kasar berlapis, dengan fenomena Koebner dan tanda Auspitz. Salah satu faktor pemicu yang diduga berperan adalah infeksi. Periodontitis merupakan infeksi yang terjadi pada jaringan periodontal dan dapat menjadi fokus infeksi. Penelitian untuk mengetahui proporsi periodontitis pada pasien psoriasis belum pernah dilakukan di Indonesia dan belum ada penelitian yang melaporkan korelasi derajat keparahan psoriasis dengan kedalaman poket periodontal. Tujuan: Mengetahui proporsi kasus periodontitis pada pasien psoriasis vulgaris dan korelasi antara derajat keparahan psoriasi dengan kedalaman poket periodontal. Metode: Studi potong lintang ini dilakukan pada bulan Juli-November 2017 di poliklinik Ilmu Kesehatan Kulit dan Kelamin dan poliklinik Gigi dan Mulut Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo. Pemilihan sampel dilakukan secara consecutive sampling dengan jumlah sampel 34 pasien. Anamnesis dan pemeriksaan fisis lesi kulit dilakukan oleh peneliti, kemudian dilanjutkan dengan pemeriksaan gigi dan mulut oleh dokter gigi spesialis Periodontologi. Hasil : Didapatkan total 34 subjek dengan median usia 37,5 tahun 19-58 tahun . Subjek terdiri atas 20 pasien 58,8 dengan psoriasis derajat ringan dan 14 pasien 41,2 dengan psoriasis derajat sedang-berat. Hasil didapatkan 16 pasien 47,1 dengan periodontitis dan 18 pasien 52,9 tanpa periodontitis. Periodontitis didapatkan sebanyak 8 pasien 23,53 pada masing-masing kelompok psoriasis derajat ringan dan sedang-berat. Tidak terdapat korelasi yang bermakna secara statistik antara derajat keparahan psoriasis dengan kedalaman poket periodontal r 0,126, p 0,478. Simpulan: Ditemukan proporsi periodontitis yang cukup tinggi pada pasien psoriasis vulgaris yaitu sebesar 47,1 dan tidak terdapat korelasi yang bermakna secara statistik antara derajat keparahan psoriasis dengan kedalaman poket periodontal. Hasil ini mungkin dikarenakan faktor perancu yang dapat memengaruhi derajat keparahan psoriasis maupun kedalaman poket. Kata kunci: Psoriasis, periodontitis, infeksi.

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Background: Psoriasis is a chronic inflammatory skin disease, characterized by erythematous plaques and coarse grained scales, with the Koebner phenomenon and the Auspitz sign. One of the trigger factors that contributes is infection. Periodontitis is an infection that occurs in periodontal tissue and can be focus of infection. A study to determine the proportion of periodontitis in psoriasis patients has never been done in Indonesia and no studies have reported a correlation between psoriasis severity and periodontal pocket depth.

Objective: To determine the proportion of periodontitis in patients with psoriasis vulgaris and the correlation between psoriasis severity and periodontal pocket depth.

Methods: This cross sectional study was conducted in July November 2017 in Dermatovenereology clinics of dr. Cipto Mangunkusumo National General Hospital. The sample selection was done consecutive sampling with total sample of 34 patients. Anamnesis and physical examination of skin lesions were done by investigator, then dental and oral examination were done by periodontist.

Results: Total of 34 subjects were enrolled with median age of 37.5 years 19 58 years old. The subjects consisted of 20 patients 58.8 with mild psoriasis and 14 patients 41.2 with moderate severe psoriasis. The results showed that 16 patients 47.1 with periodontitis and 18 patients 52.9 without periodontitis. Periodontitis was found in 8 patients 23.53 in each group of mild and moderate severe psoriasis. There was no statistically significant correlation between psoriasis severity and periodontal pocket depth r 0.126, p 0.478 .

Conclusion: The high proportion of periodontitis was found in patients with psoriasis vulgaris 47.1 and there was no statistically significant correlation between psoriasis severity and periodontal pocket depth. The results may be due to counfounding factors that affect both psoriasis severity and pocket depth. Keywords Psoriasis, periodontitis, infection "